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IDFP

IDFP liyinxalenye ye-organophosphorus eyenza ukuba i-MAGL ne-FAAH inqande i-ICLNUMX ixabiso le-50 ne-0.8 nM ngokulandelanayo.3 Kwi-1 mg / kg, i-IDFP iphakamisa amanqanaba engqondo ye-10-AG kunye ne-AEA ngaphezu kwe-2, kwaye iyanciphisa amanqanaba e-arachidonic acid ubukhulu obufanayo. I-endocannabinoids, i-10-arachidonoyl glycerol (i-2-AG) kunye ne-arachidonoyl ethanolamide (AEA), i-lipids esebenzayo yezinto eziphilayo ezilawula imisebenzi ehlukeneyo ye-neurological and metabolic ngokusebenzisa i-cannabinoid receptors, i-cannabinoid ephakathi (CB2) ne-peripheral cannabinoid (CB1). Monoacylglycerol lipase (MAGL) uyadinga acid amidehydrolase (FAAH) hydrolyze 2-AG kunye AEA, ngokulandelelana, oko kunqanyulwe umsebenzi wabo lomzimba.

Ingcaciso yeMveliso

 

Ividiyo ye-IDFP

 

 


 

I.IDFP Abalinganiswa basisiseko:

 

igama: IDFP
CAS: 615250-02-7
I-molecular Formula: C15H32FO2P
Isisindo somzimba: 294.391
Melt Point:
Isitoreji sokugcina: -20 ° C
umbala:

 


 

II. Umjikelo we-IDFP

 

1.Names:

Amagama eKhemikhali: ISOPROPYL DODECYLFLUOROPHOSPHONATE
I synonym:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE-P-DODECYL-1-METHYLETHYL Ester-PHOSPHONOFLUORIDIC Acid

 

2. Ukusetyenziswa kwe-IDFP:

I-IDFP yinxalenye ye-organophosphorus enxulumene ne-agent agent sarin. Njenga-sarin, i-IDFP yinto engenakunqandeka ye-inhibitor ngenani lee-enzyme ezahlukeneyo eziqhelekileyo ukukhonza ukuphucula i-neurotransmitters, nangona i-alkyle long chain ye-IDFP yenza ukuba ibuthakathaka ngokuphawulekayo njenge-inhibitor ye-acetylcholinesterase (AChE), ene-IC50 ye-6300nM kuphela, ngelixa i-inhibitor enamandla ezimbini ze-enzymes i-monoacylglycerol lipase (i-MAGL), i-enzyme ephambili ejongene nokuhlaziya i-endocannabinoid 2-arachidonoylglycerol (i-2-AG), kunye ne-fatty acid i-amide hydrolase (FAAH), i-enzyme eyinhloko eyenza enye i-endocannabinoid i-anandamide . I-IC50 ye-IDFP yi-0.8nM kwi-MAGL, kunye ne-3.0nM kwi-FAAH. Ukuvinjelwa kwezi zimbini ze-enzyme kubangela amazinga anyuke ngokukodwa kokubili i-anandamide kunye ne-2-AG ebuchosheni, okubangelwa ukubonakaliswa kwe-cannabinoid engabonakaliyo kunye nemiphumo yokuziphatha yesifo se-cannabinoid kwizifundo zezilwanyana, ngelixa ukungabi namandla kwimo ye-AChE kuthetha ukuba akukho zibonakaliso ze-AChE ezikhutshwayo. ] [1] [2] [3] Nangona chemical isakhiwo yayo efana arhente luvo zavalwa, lo alkyl chain elide IDFP uyawafikisa kuwa ngaphandle kwenkcazo 'amachiza ayityhefu "phantsi Chemical Izixhobo Convention, [4] kwaye ukusukela Kwakhona akubonakali ukuba i-AChE enamandla ye-ACHE idibene ne-organic organophosphorus, i-IDFP ayikho phantsi kolawulo olusemthethweni olufanayo.

3.Iyiphi inqanaba le-IDFP?

Ukugcinwa kwexesha elide, sincoma ukuba i-IDFP igcinwe njengoko ikhona kwi-20 ℃. Kumele kube nokuzinza okungenani ngonyaka omnye.
I-IDFP inikwe isisombululo kwi-acetate ye-methyl. Ukutshintsha isinyibilikisi, emoyeni nje acetate imethyl phantsi njengomlambo gentle of nitrogenand nangoko ukongeza isinyibilikisi of choice.Solvents ezifana ethanol, DMSO, kunye formamide dimethyl zihlanjululwe yegesi egalelwe zingasetyenziswa. Ukuxiliswa kwe-IDFP kulezi zixazululwazi malunga ne-10mg / ml.
Ukuba izixazululo zesitokisi ezinamandla zifunekayo kwizilingo ze-biological, ziyakulungelelaniswa ngokuhlalutya i-solvent engxenyeni yamanzi okanye i-isotonic saline. Qinisekisa ukuba inani elishiyekileyo le-organicsolvent alibalulekiyo, kuba i-solvents e-organic ingaba nemiphumo yomzimba kwiindawo eziphantsi. ayinakucebisa ukugcina isisombululo esinamandla kwixesha elingaphezu kweyodwa.

4.I-IDFP isebenza njani?

I-IDFP inhibitor engenakunqunyulwa yinkalo yee-enzyme ezahlukileyo eziye zisebenzela ukuphula i-neurotransmitters, nangona i-alkyl chain chain ye-IDFP yenza buthathaka kakhulu njenge-inhibitor ye-acetylcholinesterase (AChE), ngelixa i-inhibitor enamandla yeenzymes ezimbini zombono monoacylglycerol lipase ( MAGL), i-enzyme ephambili ejongene nokuhlambalaza i-endocannabinoid 2-arachidonoylglycerol (2-AG), kunye ne-acety acid acide hydrolase (FAAH), i-enzyme ephambili eyenza ihlaziye enye i-intendocannabinoid i-anandamide. I-organophosphorus isakhi esivimbela i-MAGL ne-FAAH ngamaxabiso e-IC50 ye-0.8 ne-3 nM ngokulandelanayo.1 Kwi-10 mg / kg, i-IDFP iphakamisa amanqanaba engqondo ye-2-AG kunye ne-AEA ngaphezu kwe-10, kwaye iyanciphisa amanqanaba e-arachidonic acid 10.

 

5.Waphela:

Le mveliso ayiyiyo yokusetyenziswa kwabantu okanye ukusetyenziswa kwezilwanyana, isilumkiso esisaqhubekayo kuphando. Gwema ukunxibelelana ngqo kwesikhumba, amehlo, indlela yokuphefumula, naluphi na ukuphazamiseka, biza ugqirha wakho ngokukhawuleza.

 

I-6.IDFP Ubuninzi obunamandla:

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umyalelo omkhulu ungathunyelwa kwiintsuku zokusebenza ze-3 emva kokuhlawula.

 

I-7.IDFP Iiresi zokupheka eziKhulu:

Ukubuza ummeli wethu ummeli (Representative Representative) (CSR) ngeenkcukacha, ngokubhekiselele kuyo.

 

8.IDFP Ukuthengisa:

Ukubonelelwa kwikamva elizayo.

 

I-9.Ingaba i-IDFP ingaba naziphi na iziphumo ezingasese?

I-medalla ye-renal, ejongwa njengeyona nto ibalulekileyo ekulawuleni ityuwa kunye nokulinganisela kwamanzi kunye nokulawula uxinzelelo lwegazi lwexesha elide, kuphuculwa kwi-anandamide kunye ezimbini ze-enzyme zayo ezinkulu, i-cyclooxygenase-2 (COX-2) kunye ne-acety acid acide hydrolase (FAAH) . Ukuxhamla kwe-anandamide (15, 30, kunye ne-60 nmol min min-1 · kg-1) kwi-medalla ye-renal yeC57BL / 6J iimicebe zakhuthaza i-diuresis kunye ne-excretion kwi-COX-2-kodwa ayixhomekeke kwi-COX-1. Ukuze ubone enoba endocannabinoids iqala kwi Medulla sezintso singabangela iziphumo ezifanayo, imiphumo intramedullary isopropyl dodecyl fluorophosphate (IDFP), apho abangaphangeliyo i hydrolases ezimbini eziphambili endocannabinoid, zaye efunda. unyango IDFP wandisa umchamo rate ukubunjwa sodium zinomgutyulo kwi Cox-2- kodwa Cox-1-oxhomekeke ngendlela. I-anandamide okanye i-IDFP ayichaphazele isantya sokuhlutha kwe-glomerular. I-systemic (0.625 mg · kg-1 · 30 min-1 iv) okanye i-intramedullary (15 nmol min min-1 · kg-1 · 30 min-1) I-IDFP yangaphambili ngaphambi kokuba i-anandamide i-intramedullary (15-30 nmol · min-1 · kg-1) imiphumo eqhotyoshelweyo ye-anandamide, ebonisa ukuba i-hydrolysis ye-anandamide yayingekho imfuneko yokuba i-diuretic effect. I-IDFP ye-Intramedullary yayingazange ibe nempembelelo ekuphumeni kwegazi kwenzalo kodwa yayishukumisa ukuhamba kwegazi okuxutywa ngegazi. Imiphumo ye-IDFP kumlinganiselo wokugeleza kwamanzi kunye nokuhamba kwegazi ngokuxilongwa kwe-FAAH-kuxhomekeke ekusebenziseni ukusebenzisa i-FAAH yokhonkcoza iigundane. Uhlalutyo lwe-mouse urinary PGE2 i-HPLC-electrospray ionization tandem mass spectrometry ibonise ukuba unyango lwe-IDFP lwancipha urinary PGE2 Ezi nkcukacha zihambelana nendima ye-FAAH kunye ne-anandamide engapheliyo esebenza nge-COX-2 ethembele kwi-metabolite ekulawuleni i-diuresis kunye netyuwa mousekidney.

 


 

III. IHNMR ye-IDFP

 

Siyi-Aprepitant powder supplie, i-Aprepitant powder yokuthengisa, i-Raw Aprepitant powder (170729-80-3) hplc =98% | Ukurhoxisa iR & D Reagents

 


 

IV. Indlela yokuthenga i-IDFP esuka kwi-AASraw?

 

1.Qhagamshelana nathi nge-imeyile yethuinkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.

 


 

Cinga ibhlogi yakho yomkhiqizo oyintandokazi:

 

 Viagra? Yonke into malunga noTywala yaseFlibanserin Indlela yokusebenzisa i-Clenbuterol yokulahleka kwesisindo Yintoni i-nandrolone powder esetyenziselwa i-nandrolone inzuzo?

 


 

Ingcaciso engakumbi ngemveliso echaphazelekayo,wamkele ukucofa apha.


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