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Cortexolone 17α-propionate powder

Akukho kalo
4.50 ngaphandle kwe 5 ngenxa ye 2 amanqaku umthengi
SKU: 19608-29-8. Udidi:

AASraw unani kuyondelelaniswe kunye nemveliso nako ukusuka gram ukuya ubunzima Cortexolone 17α-propionate umgubo (19608-29-8), phantsi komqathango CGMP kunye nenkqubo yolawulo lomgangatho zibonwe.

Ingcaciso yeMveliso

Cortexolone 17α-propionate powder ividiyo


Cortexolone 17α-propionate powder Abalinganiswa basisiseko

igama: Cortexolone 17α-propionate powder
CAS: 19608-29-8
I-molecular Formula: C24H34O5
Isisindo somzimba: 402.52
Melt Point:
Isitoreji sokugcina: Ukushisa kwamagumbi
umbala: I-White ukuya kwipowder powder


I-Cortexolone 17α-propionate cycle

Amagama

I-CAS: 19608-29-8
Amagama eKhemikhali: i-cortexolone-17--propionate,
Amanye amagama: i-CB-03-01, i-Winlevi powder, i-Breezula powder, i-11-deoxycortisol i-17--propionate, i-Cortexolone 17α-propionate powder

I-Cortexolone 17A-propionate Ukusetyenziswa

I-Cortexolone 17A-propionate yinto yokwenza i-anti -rogenal anti-steroidal - ngokukodwa, i-androgen ye-receptor antagonist-ephantsi kokuphuhliswa yiCassiopea kunye ne-Intrepid Therapeutics ekusebenziseni njengamachiza angama-topical ekwenzeni unyango lwe-androgen kunye ne-acne vulgaris kunye ne-androgenic alopecia ukulahleka kweenwele).

Iyiphi imilinganiselo ye Cortexolone 17A-propionate

I-Cortexolone 17A-propionate i-1% ukhilimu, i-antiandrogen entsha enamandla yokwelapha i-acne vulgaris. Umqhubi we-random, uvavanyo olulinganisekanga olulinganiswayo kunye ne-placebo kunye ne-trretinoin 0 · 05% ukhilimu.

INGXELO

I-Acne vulgaris yintlupheko yeyunithi ye-pilosebaceous apho i-androgens igalelo ekuqaleni kwayo nasekuphikeleni. Ukusetyenziswa kwe-antiandrogens ngoko kunokwenzeka; nangona kunjalo, i-antiandrogens yokusetyenziswa kwezinto ezisemgangathweni ayifumanekanga kwimarike. I-Cortexolone 17α-propionate yintsholongwane etsha ye-antiandrogen engasetyenziswayo kwi-acne vulgaris.

IINJONGO

Ukuvavanya ukhuseleko kunye neempembelelo ze-Cortexolone 17A-propionate 1% ukhilimu kwi-acne vulgaris xa kuthelekiswa ne-placebo kunye ne-trretinoin 0 · 05% ukhilimu.

IINDLELA

Amadoda angamashumi asixhenxe anesixhenxe anesifo somzimba we-2-3 ngokubhekiselele kuVavanyo lwe-Global Assessment (IGA) ayengenangqondo yokufumana i-placebo cream (n = 15), okanye i-Cortexolone 17A-propionate 1% ukhilimu (n = 30), okanye i-0 · 05 % ukhilimu (n = 32) kanye ngosuku ngosuku lokulala kwiiveki ze-8. Ukusebenza ngonyango kwahlolwa rhoqo kwiiveki ze-2 kubalwa inani le-lesion count (TLC), isibalo sesibalo se-inflammatory lesion (ILC), i-index ye-acne index (ASI) kunye ne-IGA. Uvavanyo lokhuseleko luquka amanqaku okungahambi kwendawo, iimvavanyo zelabhoratri, ukuhlolwa ngokomzimba, iimpawu ezibalulekileyo kunye nokurekhoda kweziganeko ezimbi.

IINKCUKACHA

I-CB-03-i-01 ukhilimu yayinyamezeleke kakhulu, kwaye yayingcono kakhulu kune-placebo malunga ne-TLC (P = 0 · 0017), i-ILC (P = 0 · 0134) kunye ne-ASI (P = 0 · 0090), kunye neekliniki kunokuba kuthelekise. Imveliso iphinde iqhube ukufumana ngokukhawuleza ukuphuculwa kwe-50% kuzo zonke iiparameter ezingentla. CB-03-01

IMISEBENZI

Olu pho nonongo luxhasa uxanduva lokusebenzisa i-antiandrogens ye-topical kwonyango ye-acne vulgaris. I-Cortexolone 17A-propionate I-1% ukhilimu ibonakala ifanelana neprofayili ye-antiandrogen efanelekileyo yokusebenzisa iifrikhi.

Indlela i-Cortexolone 17α-propionate isebenza ngayo

I-Cortexolone 17A-propionate (i-CAS 19608-29-8), okanye i-11-deoxycortisol i-17--propionate, iyinto yokwenza i-antirogenal steroidal eyenziwe yinto yokwenziwa komsebenzi-ngokukodwa, i-androgen yamkeli-mpikiswano-ephantsi kokuphuhliswa yiCassiopea kunye ne-Intrepid Therapeutics ekusebenziseni njengemithi yezolimo unyango lweemeko ezixhomekeke kwi-androgen kuquka i-acne vulgaris kunye ne-androgenic alopecia (ukulahleka kweenwele zendoda). Ngu-C17α propionate ester ye-11-deoxycortisol (cortexolone); I-C17α esters ye-11-deoxycortisol yayifumaneka ngokungalindelekanga ukuba ibe ne-antiandrogen, kwaye i-cortexolone i-17α-propionate ikhethwe ukuphuhliswa ngokusekelwe kwiprofayili yayo yezobisi.

Kwiingqungquthela, isilwanyana sitholakale sinomsebenzi ochanekileyo we-antiandrogen wendawo, kodwa umsebenzi ongenamsebenzi wokulwa ne-antiandrogen xa ulawulwa nge-injection engathandanga. Ukongezelela, i-cortexolone i-17--propionate ayiyiyo i-progonadotropic, iphakamisa ukuba ikhetha ngokukhawuleza. Kwi-bioassay, ubungqina benkcazo yezilwanyana zazikhulu kuneyona progesterone, flutamide, kunye ne-finasteride kwaye yayilingana neyo-acetate ye-cyproterone.

Icandelo lokuhlola iikliniki kwi-2011 yamadoda aphathwa nge-cortexolone ye-17A-propionate ye-1% i-cream ye-acne ifumene ukuba le nkunkuma yayinyamezeleke kwaye yanciphisa kakhulu iimpawu ze-acne. Ukongezelela, ukuphumelela kwayo kwakukhulu kakhulu kunokuba kuthelekisekile, i-XTUMX% ukhilimu. Njengoko i-0.05, isicatshulwa sisilingo sezilingo zesigaba se-III se-acne vulgaris kunye novavanyo lwezigaba ze-II ze-clinical trials ze-androgenic alopecia.

isilumkiso

I-Cortexolone 17--proprionate, i-Breezula powder kwiifom zayo zepolymorphic: intsapho yokuqala ye-patent, ephela e-United States kwi-2022 / 23 nakwi-2022 kulo lonke ihlabathi, iquka ukusetyenziswa kwezobugcisa kwinkomfa yokunyanga i-acne, i-alopecia kunye ezinye izifo; Intsapho yesibili yelungelo lobunikazi lihlanganisa zonke iifom eziqhelekileyo ze-API, iziqulatho eziqukethe i-API efanayo kunye nokusetyenziswa kwezonyango ezinxulumene nokuphatha unyango, i-AGA nezinye izifo: le ntsapho yelungelo lobunikazi sele ikhishwe eMelika, eYurophu, eCanada, eJapan kunye kwamanye amazwe, ziya kuphelelwa ngu-2030 e-United States kunye ne-2028 kulo lonke ihlabathi.I-Breezula powder

I-Cortexolone 17A-propionate Powder Raw

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umyalelo omkhulu ungathunyelwa kwiintsuku zokusebenza ze-3 emva kokuhlawula.

I-Cortexolone 17A-propionate I-Raw Powder Recipes

Ukubuza ummeli wethu ummeleli (CSR) ngeenkcukacha, ngokubhekiselele kwikhompyutheni yeWinlevi

I-Cortexolone 17A-propionate Marketing

Ukubonelelwa kwikamva elizayo.

Ngaba i-Cortexolone 17A-propionate Inayo nayiphi na imiphumo yangaphandle

I-Cortexolone 17A-propionate yindlela entsha ye-steroidal-ester, i-androgen-antagonist ekhethiweyo, ephikisana nomsebenzi onqabileyo olwachasayo, obonakala ufanelwe ukunyanga kwe-acne vulgaris. I-CB-03-01 yenza kwizinga le-androgen-receptor ngaphandle kokuvimbela i-5α-ukunciphisa kwesikhumba. I-steroid iyangena ngokukhawuleza kwesikhumba somntu kwaye ikhawuleza idibeneyo ukukhulula i-cortexolone yomzali engenazo iziphumo zesistim. Kubaluleke kakhulu, ukuza kube yimhla, ayibonwanga nayiphi na imiphumo yecalasi yendawo okanye ye-systemic.


Indlela yokuthenga i-Cortexolone 17α-propionate powder esuka kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


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Recipes

I-Cortexolone i-17A-propionate I-Raw Powder Recipes:

Ukubuza ummeli wethu ummeleli (CSR) ngeenkcukacha, ngokubhekiselele kwikhompyutheni yeWinlevi

Iziqulatho kunye nokuqulunqwa kwemveliso

Iipilisi ezingcono kakhulu zokulahleka kweenwele kubantu: i-Cortexolone 17α-propionate powder (CB-03-01)

2 kwakhona ngenxa Cortexolone 17α-propionate powder

  1. UDkt Patrick Young -

    Sizakuqhagamshelana nawe nge-imeyili.

  2. ikaliwe 4 ngaphandle 5

    Vitaliy -

    Как сделать заказ?

  3. ikaliwe 5 ngaphandle 5

    Aasraw -

    I-Cortexolone 17α-propionate ingumntu

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