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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

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5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 681136-29-8. Udidi:

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya ku-N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) ipiperazine-i-1-carniamide powder (i-CAS 681136-29-8), phantsi komgaqo weCGMP kunye nenkqubo yokulawulwa kwekhwalithi ehambelanayo.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters

igama: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Ukucoceka: ≥99% (HPLC)
Iintetho: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
I-molecular Formula: C19H19N5OS
Isisindo somzimba: 365.459
Indawo yokunyibilika: 240.48
Iphuzu lokubilisa: 559.69 ° C kwi-760 mmHg
Ubungakanani: ~ 1.3 g / cm3
Isitoreji sokugcina: Gcina kwi-4 ° C
Umzimba: I-DMSO: ≥28mg / mL
Inkcazo yokurhola: N20D 1.68
umbala: I-crystalline eqinile
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N


I-N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) ipiperazine-1-carboxamid Ukusetyenziswa kwombhobho kumjikelezo

igama

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) ipiperazine-1-carboxamid powder, i-JNJ 166101 Powder

Usebenza kanjani kwi-N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Ukusetyenziswa komfama

I-FAAH ebanjwe yiJNJ-1661010 ibonisa ukuhlaziywa okukhawulezayo kokusebenzisana phakathi kweJNJ1661010 kunye nendawo esebenzayo, ekhawuleza kumaqondo aphezulu. I-JNJ-1661010 yindlela ephikisanayo, isistim-based based substrate inhibitor njengoko ihlolwe yi-LC-ESI-MS. I-JNJ-1661010 docks kunye ne phenylthiadiazole kwi-tunnel ye-hydrophobic kunye ne-phenylurea kwipokethi yama-hydrophili ye-FAAH, i-JNJ-1661010 (i-20 mg / kg ip) inqanda i-FAAH nge-85% ukuya kwi-4 h emva kwe-dosid, i-ethanolamides kwi-brain brain. I-JNJ-1661010 ixhomekeke ngokuxhomekeke kwi-allodynia ephathekayo enobuchule obukhulu malunga ne-90% kwi-30 min postdose kumabini omnxeba omzimba (MTI). I-JNJ-1661010 (i-20 mg / kg) ibuyisela i-allodynia yintsimbi nge-60.8% kwi-30 min kwindlela yokulimala yomlenze wesigulane. I-JNJ-1661010 (i-50 mg / kg ip) ibonisa ukunqandwa okukhulu kwe-hyperalgesia kwi-30 min postdose kwimodi ye-carrageenan yeentlungu ezivuthayo.
Amathanga aphethwe yi-JNJ-1661010 (20 mg / kg ip) ine-plasma Cmax ye-26.9 μM kwi-Tmax ye-0.75 h kunye ne-Cmax kwingqondo ye-6.04 μM kwi-Tmax ye-2 h. I-JNJ-1661010 (i-20 mg / kg ip) inqanda ingqondo ye-FAAH kwaye iphakamisa izinga le-AEA kwingqondo yesikhumba kwi-rat.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umlinganiselo omkhulu (ngaphakathi kwe-1kg) ungathunyelwa kwimihla yokusebenza ye-3 emva kokuhlawula.

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1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.

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