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Apatinib (811803-05-1)

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 811803-05-1. Udidi:

I-AASraw ihamba kunye nokukwazi ukuvelisa kwigram ukuya ku-Apatinib (i-CAS 811803-05-1), phantsi kolawulo lweCGMP kunye nolawulo lwekhwalithi ephezulu.

Apatinib, inomathotholo encinane ye-molecule i-tyrosine kinase inhibitor evimbela i-receptor-2 ye-vastotic endothelial factor receptor-i-2014, ivunyiwe kwi-metastatic gastric adenocarcinoma eChina ngo-Oct XNUMX. Le yile ngxelo yokuqala ekusebenziseni kwayo umhlaza we-colorectal ephakamileyo njengoluhlobo lwesiphatho lesithathu lomgca.

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Ividiyo yeApatinib


Apatinib ezisemqoka

igama: Apatinib
CAS: 811803-05-1
I-molecular Formula: C24H23N5O
Isisindo somzimba: 397.47232
Melt Point: 111-114 ° C
Isitoreji sokugcina: -20 ° C
umbala: I-Yellow Yellow to Yellow Solid


I-Apatinib (811803-05-1) ekusebenziseni umjikelezo we-steroids

Amagama

I-Apatinib (i-CAS 811803-05-1), eyaziwa nangokuthi yiYN968D1, iMesylate.

Usetyenziso lweApatinib

Izigulane ze-Cancer zalawulwa ngamayeza ahlukeneyo ka-Apatinib imihla ngemihla ye-28. I-Apatinib yayinyamezeleke kwiimeko ezingaphantsi kwe-750 mg / ngosuku, i-3 ye-3 umthamo wokunciphisa i-toxicity yaxelwa kwi-1000 mg / ngosuku kwaye i-dose ephakamileyo yokunyamezela izimisele ukuba yiXXUMUMX mg / ngosuku.

Isexwayiso ku-Apatinib

Umele wazi iziphumo zecala xa uthatha uApatinib. Iziphumo eziqhelekileyo zeziphumo ze-apatinib ziyi-hypertension kunye ne-foot foot syndrome; nangona kunjalo, inetyhefu ye-apatinib yayilawulwa kwaye ibekezeleke.

I mi yalelo

I-Rivoceranib (i-Apatinib, i-YN968D1) i-candidate ye-drug candidate ye-drug-test candidate eyenziwa ngaphandle kweChina yi-LSK BioPharma, ukwenzela unyango lwezondo ezinzulu kuquka umdlavuza osisigxina okanye isifo somdlavuza, umhlaza we-colorectal, kunye ne-hepatocellular carcinoma. I-YN968D1 yaqala ukuhlanganiswa kunye ne-patented nge-Advenchen Laboratories e-Southern California. I-Apatinib okwangoku ithengiswa eChina ngenxa yomhlaza wesibeleko esiphezulu ngumnikazi welayisenisi waseTshayina-yintsimi, i-Jiangsu Hengrui MedicineCo., Ltd phantsi kwegama elithi Aitan®. I-LSK i-BioPharma inamalungelo omhlaba (ngaphandle kweTshayina) kwaye ihlangene nophuhliso kunye nokuthengiswa kwe-rivoceranibin yaseMzantsi Korea.

I-Rivoceranib yindlela ekhethileyo yokukhusela i-vascular endothelial growth receptor-2 (eyaziwa nge-VEGFR2) ejongene nomzila oyintloko wokuba i-tumor-mediatedangiogenesis. Kuye kwavavanywa ngekliniki kwizigulane ze-1,000 emhlabeni wonke kwaye usebenze ngokuphumelelayo kwiisifo ezinomdlavuza ezininzi, kuquka umdlavuza wesisu, umhlaza omnxeba, i-hepatocellular carcinoma, umhlaza ongaphantsi weeseli wamaphaphu, umdlavuza we-esophageal, thyroidcancer, mesothelioma, kunye ne-neuroendocrine tumors. Kuye kwabonisa ukuba kunokukwazi ukuphucula iziphumo ngokubambisana ne-chemotherapeutics kunye ne-immunotherapy, kunye nokulungiselela unyango.


Indlela yokuthenga i-Apatinib kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


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