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Apixaban powder

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 503612-47-3. Udidi:

I-AASraw inokusetyenziswa kunye nokukwazi ukuvelisa kwigram ukuya ku-Apixaban powder (503612-47-3), phantsi komgaqo we-CGMP kunye nolawulo lwekhwalithi ephezulu.

Ingcaciso yeMveliso

Apixaban powder ividiyo


Apixaban powder Abalinganiswa basisiseko

igama: Apixaban powder
CAS: 503612-47-3
I-molecular Formula: C25H25N5O4
Isisindo somzimba: 459.50
Melt Point: 238-240 ° C
Isitoreji sokugcina: 20 ° C ukuya kwi-25 ° C
umbala: I-White powder-yellow yellow


I-Apixaban powder powder eluhlaza

Amagama

Apixaban powder

I-Apixaban powder Usetyenziso lwefowuni eluhlaza

Isisombululo seMilinganiselo
Ulawulo kunye ne-inhibitors ezimbini ze-CYP3A4 kunye ne-P-gp

Ukuba uthatha> 2.5 PO BID, ukunciphisa umthamo nge-50%
Ukuba uthatha i-2.5 mg BID, thintela ulawulo lokulawula kunye ne-inhibitors eziqinileyo
I-nonvalvular fibrillation yelifa

Nciphisa umthamo kwi-2.5 mg PO BID kwizigulane ezine-2 zezi zilandelayo mpawu:
Ubudala ≥ iminyaka engu -80
Isisindo ≤60 kg
I-Serum creatinine ≥1.5 mg / dL

  • Ukunciphisa Ubungozi bokuqhaqhazela / ukuQinisekisa ukuSungula kwi-Fibrillation ye-Atrivular ye-Nonvalvular, i-5 mg (abadala) kabini imihla ngemihla; Nayiphi na i-2 yezi zilandelayo: ubudala ≥80 yr, isisindo ≤60 kg, i-serum creatinine ≥1.5 mg / dL- 2.5 mg kabini imihla ngemihla; Ukusetyenziswa ngokufanayo kwe-inhibitors ezinamandla zombini i-CYP3A4 kunye ne-P-gp- 2.5 mg kabini imihla ngemihla; ukuba isigulane esele sithathe i-2.5 mg kabini imihla ngemihla, gweba ukusebenzisa.
  • Ukukhubazeka kweReal, HD- 5 mg (abadala) kabini imihla ngemihla; I-HD kunye nokuba iminyaka yobudala ≥80 yr okanye isisindo ≤60 kg- 2.5 mg kabini imihla ngemihla.
  • Ukuthintela i-Vein Vein I-Thrombosis Emva kwe-Knee okanye i-Hip Replacement Surgery, i-2.5 mg (abadala) kabini imihla ngemihla, iqaliswe i-12-24 hr emva kokusebenza (xa i-hemostasis ifumaneka) yaqhubeka kwiintsuku ze-35 emva kokutshintshwa kwe-hip okanye i-12 iintsuku emva kokuguqula idolo.
  • Unyango lwe-DVT okanye i-PE, i-10 mg (abadala) ngeentsuku ezimbini ngeentsuku ze-7, ngoko-5 mg kabini imihla ngemihla.
  • Ukunciphisa Ingozi yokuphindaphinda kwe-DVT okanye i-PE, i-2.5 mg (abadala) kabini imihla ngemihla emva kwe- ≥6 kunyango lwe-DVT okanye i-PE.

Isilumkiso kwi-Apixaban powder powder eluhlaza

Iziphumo eziqhelekileyo ezibhekiselele kwimiphumo yecala liye laphuma kunye ne-Spinal puncture, xela ugqirha okanye ufumane uncedo lwezonyango ngokukhawuleza ukuba unayo na le miqondiso okanye iimpawu ezilandelayo ezinxulumene nemiphumo emibi kakhulu:

  • Izibonakaliso zempendulo ezithintekayo, njengokugqithisa; mihlathi; ukubetha; obomvu, ukuvuvukala, ukukhenkceza, okanye ukukhupha isikhumba kunye okanye ngaphandle kwemfiva; ukujikeleza; ukuqina kwisifuba okanye emqaleni; ingxaki yokuphefumla, ukugwinya, okanye ukuthetha; ukuthoba okungavamile; okanye ukuvuvukala komlomo, ubuso, imilomo, ulwimi, okanye umqala.
  • Iimpawu zokuphuma kwegazi njengokuphosa igazi okanye ukuphosa phezulu ebonakala njengeziko lekhofi; ukukhwehlela igazi; igazi kumchamo; amnyama, obomvu, okanye iitars; ukuphuma kumagundane; ukuphuma kwintsholongwane engavamile; izibhamu ngaphandle kwesizathu okanye ukuba zikhule; okanye nayiphi na igazi elibi kakhulu okanye ukuba awukwazi ukuyeka.
  • Utywala okanye ukuphuma.
  • Intlungu kunye okanye ukuvuvukala.
  • Intlungu yesifuba okanye uxinzelelo.
  • Ndiziva ndidiniwe okanye ndibuthathaka.
  • Uziva udidekile.
  • Intloko.
  • Ukugubha.

Ukuhlamba
I-Apixaban powder inokunyusa umngcipheko wokuphuma kwegazi onokuba yingozi kwaye ingaba yingozi. Ukusetyenziswa ngokufanayo kunye neziyobisi ezichaphazela i-hemostasis kunokunyusa ukwanda kweli mngcipheko. Oku kubandakanya iziyobisi ezifana nezinye i-anticoagulants, i-heparin, i-aspirin, izidakamizwa ze-antiplatelet, i-serotonin i-reuptake inhibitors ekhethiweyo, i-serotonin norepinephrine reuptake inhibitors, kunye nezidakamizwa ezingekho ukuvuvukala (i-NSAID).

Enye inkxalabo yokusetyenziswa kwe-Apixaban powder kunye namanye ama-antiticoagulants amasha kukungabikho komgaqo-nkqubo ochanekileyo wokuguqulwa komsebenzi wabo (akukho-antidote iyatholakala). Oku kubaluleke kakhulu ngokumalunga ne-warfarin xa kwenzeka iingxaki zegazi, okanye xa abantu bethatha iziyobisi badinga ukuhlinzwa ngokukhawuleza.

Ukugqithisa umgca
Xa i-anesthesia yomgulane / i-epestural okanye i-punestration isetyenziswe, izigulane ezonyangwa ngama-anti-thrombotic agents ukwenzela ukuthintela iingxaki ze-thromboembolic zisengozini yokuphuhlisa i-hematoma, enokubangela ukukhubazeka kwexesha elide. Umngcipheko wale nto unako ukwandiswa ngokusebenzisa i-epidural or intrathecal catheters emva kokuqhutyelwa kokuhlinzwa okanye ukususela ngokusetyenziswa kwamaxesha athile amayeza achaphazela i-hemostasis.

I mi yalelo

I-Apixaban powder yi-anticoagulant yomlomo kunye ne-inhibitor ngqo ye-Factor Xa esetyenziselwa ukunciphisa umngcipheko we-thrombosis, i-systemic embolization kunye ne-stroke kwizigulane ezine-fibrillation ye-agrifu, kwaye unciphise umngcipheko we-thrombosis ye-veinism kunye ne-pulmonary embolus emva kokugqithiswa kwamadolo . I-Apixaban powder iye yadibaniswa nesilinganiso esincinane se-serum aminotransferase ngexesha lokunyanga kunye neemeko ezingavamile zokulimala kwesibindi.

Ukusetyenziswa kwezonyango:
I-Apixaban powder iboniswe kule zilandelayo:

Ukunciphisa umngcipheko wesifo kunye nokuxhamla kwizigulane ezingenayo i-non-ravular fibrillation.
I-deep vein thrombosis (DVT) prophylaxis. I-DVTs inokukhokelela ekugqibeleni i-pulmonary embolism (PE) emadolweni okanye kwi-hip.
Unyango lwe-DVT kunye ne-PE.
Ukunciphisa umngcipheko we-DVT kunye ne-PE emva kokuba unyango lokuqala.

Apixaban Powder

I-Apixaban powder yimibala emhlophe ephuzi. Kwi-physiological pH (1.2-6.8), i-Apixaban powder ayifuni; uhlalutyo lwawo olunobuncwane kumgangatho we-pH womzimba ngu ~ 0.04 mg / mL.

Iipilisi ze-ELIQUIS ziyafumaneka ekulawuleni komlomo kwizikhwepha ze-2.5 mg kunye ne-5 mg ye-Apixaban powder kunye nalezi zithako ezingasebenzi: i-lactose e-anhydr, i-microcrystalline cellulose, i-croscarmellose sodium, i-lauryl sulfate kunye ne-magnesium stearate. Iingubo zefilimu ziqukethe i-lactose monohydrate, i-hypromellose, i-titanium dioxide, i-triacetin kunye ne-yellow oxide (i-2.5 mg iipilisi) okanye i-oxide ye-iron oxide (iipilisi ze-5 mg).

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umlinganiselo omkhulu (ngaphakathi kwe-1kg) ungathunyelwa kwimihla yokusebenza ye-3 emva kokuhlawula.

Apixaban powder Ukuthengisa

Ukubonelelwa kwikamva elizayo.


Indlela yokuthenga i-Apixaban powder kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.


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HNMR

I-Apixaban powder (503612-47-3) hplc =98% | IAraraw HNML

Recipes

Apixaban Raw Powder Recipes:

Ukubuza ummeli wethu ummeli (Representative Representative) (CSR) ngeenkcukacha, ngokubhekiselele kuyo.

Iziqulatho kunye nokuqulunqwa kwemveliso

Apixaban (Eliquis): isebenzisa, ukusebenzisana, iziphumo ezibi, izilumkiso