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I-Dolastatin 10 (110417-88-4)

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5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 110417-88-4. Udidi:

I-AASraw ihamba kunye nokukwazi ukuvelisa kwigram ukuya ku-Dolastatin 10 (i-CAS 110417-88-4), phantsi kolawulo lweCGMP kunye nolawulo lwekhwalithi ephezulu.

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Ividiyo ye-Dolastatin 10


I.Dolastatin 10 Abalinganiswa basisiseko:

igama: Dolastatin 10
CAS: 110417-88-4
I-molecular Formula: C42H68N6O6S
Isisindo somzimba: 785.09g / mol
Melt Point: 94-95oC
Isitoreji sokugcina: Gcina kwindawo epholile kunye eyomileyo kunye ne-0 - 4 ℃ kwithuba elifutshane (iintsuku ukuya kwiiveki) okanye -57 ℃ ixesha elide (inyanga ukuya kwiminyaka)
umbala: I-White ukuya kwi-sollid emhlophe


II. I-Dolastatin 10 (110417-88-4) ekusebenziseni umjikelezo we-antitumor cycle

1. Amagama:

Igama leKhemikhali:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

Ukusetyenziswa kwe2.Dolastatin 10:

Injongo: Usosayensi wezonyango uphando ngempumelelo kunye nobunobunzima be-anti-microtubule i-dolastatin-i-10 kwizigulane ezinomdlavuza ophezulu.

Izindlela: Izigulane ezingama-twenty-one ezineesifo somhlaza wesifo se-metastatic se-metastatic ziphathwa nge-dolastatin-10 kwiqondo le-400 mcg / m2 nge-intravenous bolus emva kweeveki ze-3.

Iziphumo: Omnye wezigulane ze-21 (5%; 95% CI: 0-24%) iphumelele ukuxolelwa ngokukodwa kwithuba leentsuku ze-113. Izigulane ezine zigcinwe izifo ezizinzileyo kwiintsuku ze-87. Izigulane zanikwa i-median ye-dolastatin-10. Ukutywala kwe-Hematologic kwakungqinelana, kunye nezigulane ze-8 zikhula nge-4 neutropenia, kunye ne-5 kunye ne-grade 3 neutropenia; elinye ibanga le-3 febrile neutropenia labonwa. Ezi ziqendu zeBakala 3 kunye ne-4 neutropenia zafumana ama-36% kwimijikelezo yonyango. Ubunzima be-hematologicalic toxicity ayiqhelekanga.

Isiphetho: Nangona iphrofayili yobunyoyiko be-dolastatin-10 yamkelekile, yayinomsebenzi omncinane kule sifundo somhlaza wesifuba.

In Vitro: i-Dolastatin 10 yipenteapeptide ekhethekileyo eyahlukana nolwandle eDolabella auricularia. Kufumanisa ukuba ezi nkcukacha ze-vitro zifana nezo ze-Dolastatin 10 kunye ne-Auristatin PE, nganye leyo inexabiso le-GI50 ye-10-5-10-6 μg / mL (10-2-10-3 nM) ngokufanayo i-minipanel yamacandelo eseli yoluntu. I-anti-drug conjugate (ADC) iqulethe anti-CD30 antioclonal antibody cAC10 ixiliswe kwi-agent ye-cytotoxic i-monomethyl auristatin E (i-MMAE), isalogue yokwenziwa kwe-tubulin polymerization inhibitor i-Dolastatin 10 (110417-88-4).

3.Xelela kwi-Dolastatin 10

Le mveliso yenzelwe uphando kuphela, kungekhona ukusetyenziswa kwabantu okanye ukusetyenziswa kwezilwanyana.

Ukuze ufumane ubunqamle obuphezulu, nceda ushuthule ityhubhu kwi-37 ℃ kwaye uyigubungele kwibhanki ye-ultrasonic kwithuba elithile. Isisombululo sendawo singagcinwa ngezantsi -20 ℃ ngeenyanga eziliqela.

4.Iminye imiyalelo:

I-Dolastatin 10 yokuqala
I-total synthesis ye-Dolastatin 10 (110417-88-4) yagqitywa ngokuphuhlisa ukuhlanganiswa kakuhle kwezinto ezimbini eziphambili ze-amino acid, i-Dil (i-6) ne-Dap (i-11), kunye nokulandelana ngokulandelelana kwezinto ezinhlanu ze-amino acid ukusuka kwi-C-terminal Doe .

I-synthesis kunye noVavanyo lwe-Dolastatin 10 Analogues equlethe i-Heteroatoms kwi-Amino Acid Side Chains.
Iimpawu ezifanayo zendalo ezenza i-dolastatin i-10 zinomdla omkhulu kumdlavuza ngenxa yemisebenzi yabo enamandla ye-vitro kunye nokusetyenziswa kwabo njengemali yokuhlawula kwi-anti-drug conjugates (ADCs). Ukuguqulwa kwe-dolastatin I-scaffold yengundoqo ye-10 igxininise ukuguqulwa kwe-P1, N-terminus, kunye ne-P5, i-C-terminus, ngokuqwalasela okuncinci kwi-subXI ye-P2.

Kwisilingo yeselula, i-Dolastatin 10 (i-110417-88-4) ibonisa umsebenzi ngokuchasene ne-leukemia yesifo somntu, i-lymphoma kunye nemigca yesigxina ye-tumor (njenge-OVCAR-3 kunye ne-NSCLC) ngexabiso lee-IC50 ezivela kwi-0.1nM ukuya kwi-10nM. Okwangoku ivavanywa kwizilingo zeklinikhi.


III. I-Dolastatin 10 (110417-88-4) i-HCML

Siyi-Aprepitant powder supplie, i-Aprepitant powder yokuthengisa, i-Raw Aprepitant powder (170729-80-3) hplc =98% | Ukurhoxisa iR & D Reagents


IV. Indlela yokuthenga i-Dolastatin 10 kwi-AASraw?

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.


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