Ingcaciso yeMveliso
1. J147 Umda yokuzonwabisa-AASraw
2. J147 Umda Abalinganiswa abasisiseko
| igama: | J 147 powder |
| CAS: | 1146963-51-0 |
| Ifomula yeMolekyuli: | C18H17F3N2O2 |
| Ubunzima Ezinto: | 350.3349896 |
| Melt Point: | 177-178 ° C |
| Isitoreji sokugcina: | 4 ° C |
| umbala: | I-White okanye i-powder emhlophe |
Yintoni i-J147 Powder?
I-J147 Powder yi-derivative derivative ye-curcumin, eyinxalenye ye-curry spice turmeric. I-J147 Powder ngokuqinisekileyo i-Curcumin kunye ne-Cyclohexyl-Bisphenol A (CBA) i-derivative ene-neurogenic kunye ne-neuroprotective.
I-J147 Powder ibonakaliswe ekuphuculeni kakhulu ukuphazamiseka kwengqondo kwizigulane ze-Alzheimer ezisebekhulile. Ezi ziphumo zisekwe kwimodeli yezilwanyana ezaluphala ngokukhawuleza. I-J147 Powder yonyango yomlomo esebenzayo ye-neurotrophic ebuyisela ukukhubazeka kwengqondo.
I-Curcumin yi-polyphenol efumaneka kwi-turmeric kunye ne-ginger.
I-Curcumin ineenzuzo ezininzi ezibonakalisiweyo kunyango lwezifo ezahlukeneyo, nangona kunjalo kukho imida ebonakalayo ngenxa yobuthathaka bayo bokudlula i-Blood-Brain Barrier (BB).
I-J147 Powder inokuwela i-BBB kwingqondo (yomelele) kwaye ibangele ukuveliswa kweeseli ze-neuronal stem.
I-J147 Powder, ngokungafaniyo neyeza ze-Alzheimer's Disease yangoku, ayikho i-acetylcholinesterase inhibitor okanye i-phosphodiesterase inhibitor, kodwa iphucula ukuqonda kunye nonyango olufutshane.
Le nootropic ifumana ukuthandwa njengonyango lwe-Alzheimer's disease. I-J-147 Powder iphinde yabamba umdla wabasebenzisi abasempilweni ngenxa yesakhono sayo sokuphucula imemori, ukwanda kwesakhono sokufunda, kunye nempilo yonke yengqondo. Umsebenzisi okhangela ukuthenga i-J147 Powder, kufuneka ayithenge kunye nomenzi wokuqala, ukuze ufumane i-factory J-147 ixabiso le powder ukugcina imali.
Isebenza njani i-J-147?
Impembelelo ye-J-147 kwiiseli yayingaziwa kwaze kwaba yilapho i-Salk Institute neurobiologists isombulula i-puzzle ngo-2018. I-J-147 isebenza ngokubophelela kwi-ATP synthase. Le proteni ye-mitochondrial ilawula inkqubo yokuguga ngokumodareyitha ukuveliswa kwamandla eselula. Ubukho be-J-147 Powder kwisistim somntu buphepha ubuthi obudala obubangelwa yi-mitochondria engasebenziyo kunye nokuveliswa kwe-ATP.
Indlela yokusebenza ye-J-147 Powder iya kwandisa amanqanaba ee-neurotransmitters ezahlukeneyo ezifana ne-NGF kunye ne-BDNF. Ngapha koko, kunciphisa amanqanaba e-beta-amyloid, ahlala ephakanyiswe kwi-Alzheimer's kunye nezigulane ezinesifo sengqondo esiyingozi. Iziphumo ze-J-147 ziquka ukunciphisa ukuqhubela phambili kwesifo se-Alzheimer, ukunciphisa ukulahleka kwememori, kunye nokwandisa i-neuronal cell cell.
Izifundo ezininzi kunye ne-J-147 Powder ziqhutywe kwiimpuku. Ulingo lomntu lwenziwa ngo-2020, nangona kunjalo, iziphumo ezipheleleyo azikabiwa.
benefits of J147 Umgubo
①Yandisa uMsebenzi weMitochondrial kunye Umsebenzi wobomi
I-J147 Powder iphumelele kakhulu ekunciphiseni uxinzelelo lwe-oxidative kunye nokuphucula ukusebenza kwe-mitochondrial.
Ngokomzekelo, i-J147 Powder yandisa umsebenzi we-mitochondrial ngokuphucula amanqanaba e-ATP (inhibiting ATP synthase, ngokukodwa i-ATP5A).
I-J147 Powder inokunciphisa i-metabolites eyingozi ekhokelela kwi-excitotoxicity ngokuvimbela i-ATP synthase.
Kwinqanaba le-biochemical, oku kukhuthaza ngakumbi ulutsha / i-mitochondria enempilo (ngokuguqula indlela ye-AMPK / mTOR).
② Ikhusela isifo sika-Alzheimer
I-J147 Powder iphilisa ukuphazamiseka kwengqondo kwimodeli yeegundane zesifo se-Alzheimer (AD).
I-J147 Powder inokukhuthaza i-Amyloid-Beta (A) imetabolism kunye nokunciphisa amanqanaba kwingqondo ngokunciphisa amanqanaba eprotheyini ye-Secretase (BACE).
I-J147 Powder inokukhusela i-BBB yokungena kwi-homeostasis kunye nokuphucula umsebenzi we-vascular kwiimodeli zezilwanyana ze-Alzheimer's disease.
I-J147 Powder inokunyusa kakhulu amanqanaba e-Docosahexaenoic Acid (DHA) engqondweni.
Inokukunceda ukubuyisela amanqanaba e-Glutamate kwingqondo (eveliswa kwi-TCA ephakathi -ketoglutarate).
③Iphucula Inkumbulo
Iphucula ukuqonda kuzo zombini iimpuku zesifo se-Alzheimer kunye nemifuziselo yezilwanyana ezineminyaka eqhelekileyo.
I-J147 Powder inokubuyisela ukuphazamiseka okuphawulekayo kwengqondo nakwiimodeli zezilwanyana ezindala kakhulu.
I-J-147 inokunceda kwakhona ngememori yendawo kunye ne-Long-Term Potentiation (LTP).
④Ukukhula kwengqondo
I-J 147 Powder inamandla okuphucula kunye nokuvuselela i-synaptic plasticity kwingqondo.
I-J 147 Powder ikhuthaza i-synaptic plasticity ngokugcina i-Synaptophysin expression (iprotein ye-synaptic vesicle eyancitshiswa kokubili ukuguga kunye ne-AD kwaye ithathwa njenge-biomarker yokulahleka kwe-synapse).
I-J-147 Powder ikhuthaza ukukhula kwengqondo ngokunyusa amanqanaba eNerve Growth Factor (NGF) kunye ne-Brain-Derived Neurotrophic Factor (BDNF) (BDNF).
⑤Ikhusela iiNeurons
I-J 147 Powder ayifuni ukuba i-BDNF ibe neuroprotective.
I-J 147 Powder iphinda ikhusele i-neurons kwi-glutathione (GSH) yokusilela.
I-J-147 Powder ikhusela ingqondo malunga nokunqongophala kweglucose.
Kwingqondo ye-AD, i-5-Lipoxygenase (i-5-LOX) ifumana iiseli ezininzi ze-immune ukuze zenze impendulo yokuvuvukala, kwaye i-Heme Oxygenase 1 (HO-1) yenza njenge-pro-oxidant kunokuba i-antioxidant.
I-Curcumin derivative J147 Powder inamandla okunciphisa amanqanaba e-HO-1 kunye nokuvimbela i-5-LOX.
⑥Ngamana Ukuphucula isifo seswekile
Kwiimodeli zezilwanyana, i-J147 Powder ibonise ukunciphisa i-Glucose yegazi kunye namanqanaba e-HbA1c ngokunyusa i-AMPK.
Nangona ingabalulekanga, i-J147 Powder inokunyusa umsebenzi weeseli ze-beta eziseleyo kwi-diabetes.
⑦Ukulwa Intlungu kunye Neuropathy
I-J-147 Powder ibonakaliswe ukuba iyasebenza ekuphatheni i-Diabetic Neuropathy kwimodeli yezilwanyana kunye nohlobo lwe-1 yeswekile.
Inokunceda ukunciphisa isifo seswekile-eyenziwe yi-motor nerve dysfunction, uvelwano lweperipheral, kunye namanqanaba eentlungu.
⑧Angaphucula ixhala
I-J147 Powder inamandla okunciphisa amanqanaba okuxhalaba.
I-J147 Powder yakwazi ukunciphisa amanqanaba okuxhalaba ngexesha lovavanyo lwe-maze kwiimodeli zezilwanyana ezine-AD.
J147 Umgubo dose kunye nesitaki
Izifundo ezahlukeneyo zisebenzise iidosi ezahlukeneyo kwiimpuku, kodwa esinye sezifundo ezijongwa ngcono sanika iimpuku 10 mg / kg yesisindo somzimba ngosuku. Olunye uphononongo lusebenzise iidosi ze-1, 3 okanye 9 mg / kg, kwaye zafumana iziphumo ezixhomekeke kwidosi, kunye needosi eziphezulu ezisebenza ngcono.
Nangona kunjalo, ukuguqulela oku kumthamo womntu kufuna uhlengahlengiso kumphezulu womzimba. Ngokwendlela yokuguqula esetyenziswa ngokuxhaphakileyo, idosi elingana nomntu kufuneka ilingane idosi yemouse eyahlulwe ngo-12.3 – okanye .81 mg nge-kg yomzimba ngosuku.
Ezinye zezibonelelo ziya kubonakala nje ukuba uqalise ukuyisebenzisa. Nangona unyango lwexesha elifutshane, i-J-147 yenza i-antidepressant-efana neempembelelo ezikhawulezayo kwiigundane kwixesha le-3-day ngaphandle kokumisela ukunyamezela kweziyobisi okanye ukwanda kokuqonda. Kukho ezininzi i-J147 Powder ezithengiswa kwi-intanethi, kubalulekile ukuthenga imveliso yangempela kunye nekhwalithi ephezulu. Unokuthenga i-J147 Powder Wholesale kunye nomthengisi we-AASRAW.
I-J147 ayizange idume phakathi kwabantu abasempilweni ixesha elide ngokwaneleyo ukuba sincome ngokuzithemba naziphi na izitaki. Ayizizo zonke ii-nootropics ezinokuthi 'zixutywe kwaye zifaniswe' ngokukhuselekileyo.
J147 Umgubo humntu tiirials and uukuba eamava
Uphononongo lokuqala lwabantu lwe-J147 Powder lubhalisiwe kwaye lulindeleke ukuba lugqitywe ngo-2020. Kubonakala ngathi lwenziwe uvavanyo lwesigaba se-1 kubantu abanempilo ye-64, ngenjongo ephambili yokuhlola ukhuseleko kunye ne-pharmacokinetics (isiqingatha sobomi, icala. iziphumo, i-tissue concentrations) ye-J147 Powder, kunokuba luncedo ekuphatheni nayiphi na imeko.
Nangona iziphumo zolu phando zingekabhengezwa esidlangalaleni, siyazi ukuba kubonakala ngathi kugqitywe ngaphandle kweengxaki ezinkulu.
Nangona i-J147 Powder iyikhemikhali yophando kwaye ixoxwe kwiindawo ezininzi ze-nootropics, akuzange kubekho iingxelo ezininzi zabasebenzisi ezinikezelweyo ngoku, kwaye abantu abaninzi balindele ukubona uphononongo olongezelelweyo ngaphambi kokuyisebenzisa. Ngokutsho kwabasebenzisi be-J-147 Powder, Kulula ukuthenga i-J147 powder kwi-intanethi, ukufumana umthengisi we-J147 Powder othembekileyo uya kuchitha amaxesha athile. Umthengisi we-AASRAW unikezela ngekhwalithi ephezulu ye-J-147 Powder. Ukuba wenza izongezelelo ze-J-147, ungathenga ubuninzi be-J147 Powder ukuze ujabulele ixabiso elihle.
Uninzi lwabantu lubonakala lungaboni ziphumo zibonakalayo kumava ambalwa omsebenzisi axeliweyo. Nangona abasebenzisi bekholisa ukuba bancinci kwaye basempilweni kwaye ixesha lokusetyenziswa lifutshane kakhulu kunezifundo, i-curcumin derivative J147 Powder isenokungabi neziphumo ezibalulekileyo ze-nootropic kubantu abadala abasempilweni.
Sinokwenza kuphela uqikelelo olufundisiweyo malunga nokuba i-J147 Powder iya kuba luncedo kangakanani ngokungabikho kophando lwabantu okanye ii-anecdotes ezidumileyo. Kwithiyori, nantoni na eyandisa i-neuronal energy metabolism kufuneka ibe neziphumo ze-nootropic, nangona kunjalo umsebenzi wakho wokuqonda awunakuthintelwa ngokwenyani ngokusetyenziswa kwamandla. Inokuxhomekeka ekubeni izondlo zikhawuleza kangakanani ukungena kwaye ziphume ebuchotsheni bakho okanye ukuba zidityaniswe kakuhle kangakanani na iingcinga zakho.
I-Curcumin derivative J147 Powder ikwavelisa izinto ezininzi ze-neurotrophic, okuthetha ukuba ingakwazi ukunceda ingqondo yakho iphuhlise ii-synapses kunye neeseli zengqondo. Kodwa khumbula ukuba kunokubakho ukugqithisa kwee-synapses kunye neeseli zengqondo.
Okwangoku akukho sizathu sokukholelwa ukuba i-J147 Powder iya kuba nempembelelo ebalulekileyo ye-nootropic kubantu abadala abancinci, abanempilo. Kwabo banesifo sengqondo esixhalabisayo, kunokuba luncedo kakhulu. Kubantu abadala kancinane abayaziyo into yokuba isifo sengqondo esixhalabisayo siqhuba kusapho lwabo, kunokuba luncedo njenge-nootropic kuba sinokuyeka okanye sibuyisele umva ilahleko yengqondo phambi kokuba ikhule ibe yi-dementia yasekliniki. Kuyo nayiphi na imeko, kuya kuthatha ixesha ngaphambi kokuba siqiniseke.
J-147 Umgubo risk kwaye sIDE eiimpembelelo
I-J147 Powder ihlolwe ngonyango kwaye ifunyenwe ikhuselekile ekusebenziseni ixesha elide ngamabhu azimeleyo. Iphumelele uvavanyo lwe-toxicological kwizifundo zezilwanyana ezifunwa yi-Food and Drug Administration (FDA), kwaye akukho ziphumo zibi zibhaliwe ebantwini xa zithathwa kwidosi ecetyiswayo (kuxoxiwe kamva).
apho ukuthenga iJ-147 Powder?
Ukuba semthethweni kwale nootropic kusaxoxwa, nangona kunjalo akuyi kukuthintela ekuthengeni izinto ezisemthethweni. Emva kwayo yonke loo nto, ulingo lwezonyango lwe-J-147 Alzheimer's sele luqhuba. Unokuthenga ipowder kwiivenkile ze-intanethi kuba unokuthelekisa amaxabiso e-J-147 Powder kubathengisi abaninzi. Nangona kunjalo, kuya kufuneka ukhangele kumenzi othembekileyo onovavanyo oluzimeleyo lwelabhoratri.
Ukuba ufuna i-J-147 Powder ethengiswayo, ngena kumzi-mveliso wethu. Sinikezela ngoluhlu olubanzi lwe-nootropics phantsi kolawulo olungqongqo lwekhwalithi. Ngokuxhomekeke kwinjongo yakho ye-psychonautic, unokuthenga ngobuninzi okanye ngabanye. Qaphela ukuba, ixabiso le-J-147 Powder linobubele kuphela xa uthenga ngexabiso elikhulu.
J147 Umda Ingxelo yoVavanyo-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
I-J-147 Powder (1146963-51-0)-COA
Indlela yokuthenga J147 Umda ukusuka kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. UPawulos A. Lapchak
Isazinzulu kunye nomphandi kwinkalo ye-neurology kunye nophando lwe-stroke.
2. UDavid Schubert
Iziko leSalk leZifundo zeBiological, iCellular Neurobiology Laboratory, La Jolla, California, USA.
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
Ucaphulo
[1] I-Pan X, i-Chen L, i-Xu W, i-Bao S, i-Wang J, i-Cui X, i-Gao S, i-Liu K, i-Avasthi S, i-Zhang M, i-Chen R. "Ukusebenza kwenkqubo ye-monoaminergic negalelo kwi-antidepressant- kunye ne-anxiolytic-like iziphumo ze-J147. Behav Brain Res. 2021 Agasti 6;411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 May 21. PMID: 34023306
[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. “Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-like Behavior Ngokusebenzisa i-5-HT1A-Mediated cAMP Signaling. "Front Neurosci. 2020 Jul 8;14:701. doi: 10.3389/fnins.2020.00701. I-eCollection 2020.PMID: 32733195
[3] Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. "J147 Yehlisa i-tPA-Induced Brain Hemorrhage kwi-Acute Experimental Stroke kwiiRats."I-Neurol yangaphambili. 2022 Mar 2;13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561
[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. "Kwi-Silico Repurposing ye-J147 yoNyango lwe-Neonatal Encephalopathy: Ukuphonononga iiMechanism zeMolekyuli ze-Mutant Mitochondrial ATP Synthase." Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251
[5] Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. "Imiphumo efana ne-Antidepressant-efana neveli ye-curcumin derivative J147: Ukubandakanywa kwe 5-HT1A isamkeli. I-Neuropharmacology. 2018 Jun;135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Apr 5. PMID: 29626566
