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I-LCZ696 powder (936623-90-4)

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 936623-90-4. Udidi:

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya ku-LCZ696 powder (936623-90-4), phantsi komgaqo we-CGMP kunye nolawulo lwekhwalithi ephezulu.

LCZ696 powder (sacubitril / valsartan powder) ilungu leklasi elitsha lee-agents ezibizwa nge-angiotensin receptor-neprilysin inhibitors (ARNIs) ezidibanisa i-neprilysin inhibitor kunye ne-angiotensin receptor blocker (ARB). I-LCZ696 powder njengamanje iboniswa ukunyanga izigulane ezinokuphelelwa yintliziyo ngeqhekeza elincinciweyo (HFrEF) endaweni ye-angiotensin yokuguqula i-enzyme (ACE) inhibitor okanye i-ARB yodwa. Igama lezorhwebo le-LCZ696 powder yi-Entresto.

Ingcaciso yeMveliso

LCZ696 powder ividiyo


LCZ696 powder Abalinganiswa basisiseko

igama: LCZ696 powder
CAS: 936623-90-4
I-molecular Formula: C24H29N5O3.C24H29NO5.5/2H2O.3Na
Isisindo somzimba: 915.98
Melt Point: 137-140 ° C
Isitoreji sokugcina: kwi -20 ° C iminyaka eyi-3 Ubuninzi
umbala: Powder


I-LCZ696 powder ekunciphiseni umngcipheko wokufa kwentliziyo kunye nentliziyo

Amagama

I-LCZ696 powder, i-sacubitril powder, i-valsartan, i-LCZ 696, iLCZ-696

I-Raw LCZ696 Ukusetyenziswa kwePowder

I-LCZ696 powder (ilungu le-sacubitril / valsartan powder) ilungu leklasi elitsha lee-agents ezibizwa nge-angiotensin receptor-neprilysin inhibitors (ARNIs) ezidibanisa i-neprilysin inhibitor kunye ne-angiotensin receptor blocker (ARB). I-LCZ696 powder njengamanje iboniswa ukunyanga izigulane ezinokuphelelwa yintliziyo ngeqhekeza elincinciweyo (HFrEF) endaweni ye-angiotensin yokuguqula i-enzyme (ACE) inhibitor okanye i-ARB yodwa. I-LCZ696 powder (i-sacubitril / i-valsartan powder) yavunywa yi-FDA ngoJulayi 2015 ukunciphisa umngcipheko wokufa ngenxa yezizathu zomoya kunye nokulaliswa kwezibilini kwimeko yezigulane ezinokukhubazeka kwintliziyo, i-NYHA i-II-IV, kunye necandelo elincinci le-ejection. Ukudibanisa kwe-neprilysin inhibition kunye ne-renin-angiotensin i-aldosterone system (RAAS) ziye zaboniswa ziphezulu kunezo ze-ACE inhibitor. Igama lezorhwebo le-LCZ696 powder yi-Entresto.

Umgangatho oqala wokuqala umthamo ngu-49 / 51 mg kabini imihla ngemihla.
I-dose yokuqala ye-LCZ696 powder (sacubitril / valsartan powder) I-24 / 26 mg kabini imihla ngemihla inconywa kwezi zi gulane zilandelayo:

• I-ACE Inhibitor okanye i-ARB engenakho
• Umthamo ophantsi we-ACE inhibitor okanye unyango lwe-ARB: i-dose ephantsi ye-ACE inhibitor elilinganayo: i-enalapril <= 10 mg imihla ngemihla, i-dose ephantsi i-ARB efanayo: valsartan <= 160mg nsuku zonke
Umsebenzi ophezulu we-renal (GFR <30ml / min / 1.73m 2)
• Ukukhubazeka okuphezulu kwe-hepatic (Child-Pugh eklasini B)

Isilumkiso kwi powder LCZ696 eluhlaza

I-LCZ696 powder (i-sacubitril / valsartan powder) iboniswe ukunciphisa umngcipheko wokufa kwe-cardiovascular and failure of heart hospitalizations ukwenzela ukuhluleka kwentliziyo kwizigulane ezine-HFrEF ezingapheliyo, i-NYHA i-II-IV. I-LCZ696 powder eluhlaza (sacubitril / valsartan powder) kufuneka isetyenziswe ngokubambisana nezinye i-GDMTs endaweni ye-ACE inhibitor okanye i-ARB.

Ukungqinelana kuquka:
• Ukunyanzeliswa kwamanzi kwiyiphi na inxalenye.
Ukusetyenziswa okuhambisanayo kwe-ACE inhibitor: I-LCZ696 powder (sacubitril / valsartan powder) akufanele ilawulwe kwiiyure ze-36 zokufumana i-ACE inhibitor.
• Ukusetyenziswa ngokufanelekileyo kwe-aliskiren kwizigulane ezineesifo seswekile.
• Imbali ye-angioedema enxulumene nophuhliso lwangaphambili kunye ne-ACE inhibitor okanye unyango lwe-ARB.

Imiphumo engathandekiyo

(1) Inetyhefu yobushushu: Zonke iziyobisi ezisebenza kwi-RAAS zingabangela ingozi kwi-fetus xa kunikwa ngexesha lokukhulelwa. Baya kunciphisa umsebenzi we-fetal umsebenzi wesibini kunye neyesithathu kwi-trimester yokukhulelwa kunye nokwandisa ukukhulelwa komntwana kunye nokufa komntwana. I-LCZ696 powder eluhlaza (sacubitril / valsartan powder) kufuneka inqunywe xa kutholakala ukukhulelwa.

(2) I-Angioedema: I-Angioedema ibikwa njenge-0.5% kunye ne-LZC696 (i-sacubitril / valsartan powder) kunye ne-0.2% kunye ne-enalapril ngexesha le-double-blind in PARADIGM-HF. Kwakukho negalelo elongeziweyo kwiMnyama ngokungafani nabangabomnyama kunye nalabo abanembali engaphambili ye-angioedema. Ukuba i-angioedema ivela, i-LCZ696 powder (sacubitril / valsartan powder) kufuneka ishiywe kwaye akufanele i-rechallenged. I-LCZ696 powder eluhlaza (sacubitril / valsartan powder) akufanele isetyenziswe kulabo abanembali ye-angioedem ehambelana ne-ACE yangaphambili ye-inhibitor okanye i-ARB yonyango. Ukuba ukutshintshela okanye ukusuka kwi-ACE inhibitor, i-36-hour-clock time ishout efunekayo phakathi kweziyobisi.

(3) I-Hypotension: I-LCZ696 ipowder eluhlaza (sacubitril / valsartan powder) iyanciphisa uxinzelelo lwegazi ngenxa yokuvinjelwa kwayo kwe-RAAS kwaye inokubangela ukuba i-hypotension ibonakalise. Kwixesha elimbini eliyimfama le-PARADIGM-HF, i-18% yezigulane kwi-LCZ696 powder eluhlaza (sacubitril / valsartan powder) yabika umphumo ongathandekiyo we-hypotension kunye ne-12% kwizigulane nge-enalapril. Ekubeni kunomngcipheko omkhulu kulawo gulane ane-RAAS esebenzayo, kucetyiswa ukuba ulungise ityuwa okanye ukutshabalalisa ivolumu ngaphambi kokuqalisa. Ukuba kukho i-hypotension yeempawu, hlengisa i-diuretics nezinye i-antihypertensives, kwaye uphathe ezinye izizathu ze-hypovolemia kunye / okanye ukunciphisa umthamo we-LCZ696 powder (sacubitril / valsartan powder). Ukuba i-hypotension yeempawu iyaqhubeka naphezu kokuncipha kwe-LCZ696 powder (sacubitril / valsartan powder), isilwanyana singadinga ukuma.

(4) Umsebenzi ongenakonakalisa umhlathi: I-LCZ696 powder (sacubitril / valsartan powder) yi-agent ye-RAAS evimbelayo; Ngoko ke, ukuncipha komsebenzi wenzalo kunokulindelwa kubantu abaphezulu bengozi kubandakanya abo abane-stalosis ye-renal. Kwixesha elimbini eliyimfama le-PARADIGM-HF, i-5% yalabo baphathwa nge-LCZ696 powder eluhlaza (sacubitril / valsartan powder) kunye ne-enalapril yabika ukungaphumeleli kwe-renal njengesiganeko esibi. Ukongeza, ukwanda kwi-Scr> = i-50% yabonwa kwi-16% yalabo baphathwa nge-LCZ696 powder (sacubitril / valsartan powder) kunye ne-enalapril. Umsebenzi we-Renal kufuneka uhlolwe ngokusondeleyo kwaye i-LCZ696 powder (sacubitril / valsartan powder) kufuneka iyancipha okanye imiswe ukwenzela ukuba ukunciphisa okwenyukayo kwi-functional renal.

(5) I-Hyperkalemia: Ngeempembelelo zayo kwi-blocked RAAS, i-LCZ696 powder (sacubitril / valsartan powder) inakho ukudala i-hyperkalemia. Kwixesha elimbini eliyimfama le-PARADIGM-HF, i-12% yezigulane eziphathwe nge-LCZ696 powder eluhlaza (sacubitril / valsartan powder) yabika umphumo ongathandekiyo we-hyperkalemia. Ukongeza, i-potassium concentrations> i-5.5 mEq / L yabonwa kwi-16% yabathengiswayo kunye ne-LCZ696 powder (sacubitril / valsartan powder) kunye ne-enalapril. Ukuvavanywa okuvaliweyo kunikwa iingcebiso kwizigulane ezinomngcipheko ezinjengokukhubazeka kwesibindi, isifo sikashukela, i-hypoaldosteronism, okanye ukutya okuphezulu kwe-potassium. Ukunciphisa umthamo okanye ukuyeka ukusetyenziswa kweziyobisi kunokuba kuyimfuneko ukwenyuka kwenyango kwi-potassium.

Ngokusekelwe kwisilingo sovavanyo lwe-PARADIGM-HF apho izigulane zifunwa ukuba zikwazi ukunyamezela i-enalapril kunye ne-LCZ696 powder eluhlaza (sacubitril / valsartan powder) ngexesha lokungahambi komfama ongaboniyo, mhlawumbi ukuba ezi ziphumo ziphantsi kwaye ingaba phezulu kwiinkqubo zekliniki.

I mi yalelo

I-LCZ696 powder yabangela ukunciphisa okukhulu kweBP kunokuba i-valsartan kwi-SHR kungakhathaliseki ukuba isantya yetyuwa, ehambelana nokuphuculiswa okuphawulekayo kwi-urinary excretion kunye nokunyanzeliswa komsebenzi. Ukongezelela, isiphumo sokuphuhlisa i-BP ye-LCZ696 ipowusi eluhlaza ibangele ukukhuselwa kwe-cardiovascular in rats.

LCZ696 Powder

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umlinganiselo omkhulu (ngaphakathi kwe-1kg) ungathunyelwa kwimihla yokusebenza ye-3 emva kokuhlawula.

I-LCZ696 yokuthengisa

Ukubonelelwa kwikamva elizayo.


Indlela yokuthenga i-LCZ696 powder kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.


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I-COA 936623-90-4 LCZ696 powder I-AASRAW

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Recipes

I-LCZ696 Raw Powder Recipes

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