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Levonorgestrel powder

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 797-63-7. iindidi: ,

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya kwi-masson ye-Levonorgestrel powder (i-797-63-7), phantsi komgaqo weCGMP kunye nolawulo lwekhwalithi ephezulu.

Levonorgestrel powder i-white crystalline powder yokwenziwa kwe-progestational hormone, isebenza ngokuthintela ukukhululwa kweqanda kwi-ovary okanye ukuthintela ukuchumisa kweqanda ngedoda (isetyhini zesalato zokuzala). Kwakhona kunokusebenza ngokuguqula umgca wesibeleko (isizalo) ukukhusela ukuphuhliswa kokukhulelwa. I-Levonorgestrel ngokuyinhloko isetyenziselwe ukuthintela ukukhulelwa, Idla ngokuxhomekeka kumxube we-racemic (Norgestrel, 6533-00-2).

Ingcaciso yeMveliso

Levonorgestrel powder ividiyo


Levonorgestrel powder Abalinganiswa basisiseko

igama: Levonorgestrel powder
CAS: 797-63-7
I-molecular Formula: C21H28O2
Isisindo somzimba: 312.45
Iintetho: 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one ;13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one ;13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1 ;17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one ;17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one ;17-ethynyl-18-methyl-19-nortestosteron ;17-ethynyl-18-methyl-19-nortestosterone ;18-methyl-17-alpha-ethynyl-19-nortestosterone
Melt Point: 206 ° C
Indawo yokubilisa: 459.1 ° C kwi-760 mmHg
Indawo yokuflasha: 195.4 ° C
Isitoreji sokugcina: 2-8 ° C
umbala: Powstalline powder


Iinkcukacha ezingakumbi. Ukugqithisa i-Levonorgestrel powder Ukwazi

igama

Levonorgestrel powder

Ukusetyenziswa kwe-Levonorgestrel kunye ne-dosing

I-1.
Kwizilwanyana eziphantsi, i-Levonorgestrel powder isetyenziswe kwi-monophasicand triphasiculations of combinations of contraceptive pills, kunye nezifo ezikhoyo ezivela kwi-100-250μg, kunye neendlela ezintathu ze-50μg / 75μg / 125μg. Idibene ne-estrogen ethinylestradiol kule mi qathango.
Kwi-dose yemihla ngemihla ephantsi kakhulu ye-30μg, i-Levonorgestrel powder isetyenziswe kwezinye iprogestogen kuphela ipilformulations.

Ukukhulelwa kwangokukhawuleza

I-powon Levonorgestrel isetyenziswe kwiipilisi zokukhusela ngokukhawuleza (ECPs), zombini kwi-regimen edibeneyo ye-Yuzpe equka i-estrogen, kwaye njengendlela ye-Levonorgestrel eyiluqu kuphela. Indlela ye-Levonorgestrel-powder kuphela isebenzisa i-Levonorgestrel i-powder eluhlaza i-1.5 mg (njengomlinganiselo omnye okanye i-0.75 mg imizuzu ye-12 iiyure ngaphandle) ezithatyathwe kwiintsuku ze-3 zesini esingakhuselekanga, kunye novavanyo olulodwa olubonisa ukuba liqala ngokukhawuleza njengeeyure ze-120 (iintsuku ze-5) emva kokulalana kunokusebenza.
Inkqubo ephambili yezenzo ze-Levonorgestrel ipowder eluhlaza njengepilisi ye-progestogen-yodwa yempilisi yokukhusela iimeko eziphuthumayo, ngokutsho kwe-International Federation of Gynecology kunye ne-Obstetrics (FIGO), ukukhusela ukukhulelwa ngokumelana nokuvuthwa kwe-ovulation kunye nokuqina kwe-mucus yomlomo. Ukuphononongwa kobungqina kubonisa ukuba i-LNG [levonorgestreol] i-ECP ayikwazi ukukhusela ukufakelwa kweqanda elikhulelweyo. Ulwimi ngokufakela ukufakela imveliso akufanele lufakwe kwi-LNG EC label labeling. "NgoNovemba 2013, i-Arhente Yamayeza EYurophu (EMA) yavuma ukutshintsha kwileyibhile ethi ayikwazi ukukhusela ukufakelwa kweqanda elikhulelweyo. Ezinye izifundo zifumanisa ukuba ubungqina abucacanga. Nangona kungenakwenzeka ukuba ukukhulelwa kwexesha eliphuthumayo kuthintela ukufakelwa komsebenzi, akunakwenzeka ukuba ungabandakanyi ngokupheleleyo umphumo wokusulela umquba. NgoNovemba 2013, i-EMA nayo ivume iinguqu kwilebula ye-HRA Pharma ka-NorLevo ithi: "Kwiimvavanyo zesikliniki, ukuphumelela kokukhulelwa komzimba kwancitshiswa kwabasetyhini abanomlinganiselo we-75 kg [ii-165 iilidi] okanye ngaphezulu, kwaye i-Levonorgestrel powder yayingazange isebenze kwabasetyhini abalinganisa ngaphezu kwe-80 kg. "NgoNovemba 2013 noJanuwari 2014, i-FDA kunye ne-EMA bathi bahlaziya ukuba isisindo sokunyuka kunye nesigxina somzimba (BMI) sincitshiswe ukuphumelela kokukhulelwa kwexesha eliphuculweyo.

Into ebalulekileyo ye-Levonorgestrel powder

  • Ukuphucula ubomi belolufu
  • Ukwakhiwa okuchanileyo
  • Ukucutshungulwa ngokwenyama
  • Ezinganyelwanga

Isilumkiso kwi-Levonorgestrel powder

I-Levonorgestrel ipowder eluhlaza iyafana nazo zonke izicucu, ezinye iimpembelelo ezingafunekiyo zivela kwi-Levonorgestrel powder. Njalo udibanise ugqirha okanye unonophelo lwezempilo kwiingcebiso zonyango ngaphambi kokusetyenziswa. Iziphumo eziqhelekileyo ezichaphazelekayo zokuthatha i-1.5 mg Levonorgestrel ipowder eluhlaza kwizilingo zonyango (ezichazwe ngu-10% okanye ngaphezulu) zibandakanya: ukuhlanza, ukuvuthwa, utywala, intloko, isisonguluko, ukuxinezeleka, i-acne, inzuzo yesisindo, i-HDL iyancipha, intlungu yesisu, emva kokukhonza, iintlungu zomzimba, ukuhamba kwexesha, ukuhamba kwexesha elinzima, ukuphuma kwamanzi kunye nokukhathala, i-amenorrhea. Ubundlobongela kunye neentsholongwane ezingasebenzi, izibilini zesifuba zaxhonywa; iziphumo eziqhelekileyo (ezichazwe ngu-1% ukuya kwi-10%) zibandakanya uhudo, ukuhlanza, kunye nesisu esibuhlungu; Ezi ziphumo zecala zihlala zinyamalale kwiiyure ze-48, azinakuba njengeepilisi zokulawula ngokuzalwa rhoqo, kufuneka zithathwe ngamanyathelo athile okuzithemba ezinokuthenjwa. Abasetyhini abasafuni ukuthabatha (ngenxa yobunzima besifo se-cardiovascular disease).

I mi yalelo

I-Levonorgestrel powder (okanye i-norgestrel okanye i-D-norgestrel) isizukulwana sesizukulwana sesibini seprogestogen, singenasiphelo emanzini, sinqabile kwi-chloroform, i-ethanol kunye ne-methylene chloride. Ngenxa yokusebenza kwayo kweprogestogenic, i-Levonorgestrel ipowder eluhlaza ineempembelelo ze-antigonadotropic, kwaye iyakwazi ukunqanda ukuveliswa kwe-hormone yesini kunye ne-sex hormone kubasetyhini kunye namadoda, isenzo sokuthintela i-ovulation ngokukhupha i-gonadotrophin ukukhululwa kwi-pituitary gland. Oku kuphumela kumanqanaba athatywayo e-hormone evuselela i-hormone (FSH) kunye ne-hormone ye-luteinizing (LH) kunye nokuvinjelwa okulandelelweyo kokuphuhliswa kobugqwetha kunye ne-ovulation. Isetyenziswe njengesithako esisebenzayo kwezinye iiproductive ze-hormonal, ezibandakanya iipilisi zokukhulelwa komlomo, iprogestogen kuphela iipilisi, iipilisi zokukhusela eziphuthumayo, iinkqubo ze-intrauterine, izixhobo zokukhulelwa, kunye ne-hormone yonyango yokutshintshwa, kodwa ayikwazi ukukhusela kwizifo ezithathelwana ngesondo. kwaziwa ngokuba yiD- norethindrone, i-Kanok ketone ishiywe. Ukuba ufuna ukufumana iziphumo ezifanelekileyo, kufuneka uthathwe ngokukhawuleza kwangoko kwii-72 iiyure zokulala, kwaye okwesibini ii-12 iiyure kamva. Amachiza asebenza ngokukhawuleza emva kokuba athathwe emva kwesondo.

Levonorgestrel powder eluhlaza

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umlinganiselo omkhulu (ngaphakathi kwe-1kg) ungathunyelwa kwimihla yokusebenza ye-3 emva kokuhlawula.

Levonorgestrelraw Ukukhishwa kwePowder

Ukubonelelwa kwikamva elizayo.


Indlela yokuthenga i-Levonorgestrel powder evela kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


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IAAA

I-COA 797-63-7 Levonorgestrel powder AASRAW

HNMR

I-Levonorgestrel powder (797-63-7) I-AASRAW HNMR

Iziqulatho kunye nokuqulunqwa kwemveliso

Levonorgestrel: njani isebenza ngayo, isebenzise, ​​iziphumo ezibi