ISouth Africa Delivery, iDaily Domestic Delivery, I-European Domestic Delivery

Mitoxantrone HCL powder

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 70476-82-3. Udidi:

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya ku-mass order ye-Mitoxantrone HCL powder (70476-82-3), phantsi kolawulo lweCGMP kunye nolawulo lwekhwalithi ephezulu.

Mitoxantrone hydrochloride powder yimiyeza yomhlaza ephazamisa ukukhula nokusabalala kwamaseli omhlaza emzimbeni. I-Mitoxantrone i-HCL powder isetyenziselwa ukhathaza umdlavuza wesibeletho kunye neentlobo ezithile ze-leukemia. I-Mitoxantrone i-HCL powder isetyenziselwa ukunyanga iimpawu zokubuyiselwa kwe-multiple sclerosis. Eli nyanga aliyi kunyanga i-sclerosis.

Ingcaciso yeMveliso

Mitoxantrone hydrochloride powder ividiyo


Mitoxantrone hydrochloride powder Abalinganiswa basisiseko

igama: Mitoxantrone hydrochloride powder
CAS: 70476-82-3
I-molecular Formula: C22H30Cl2N4O6
Isisindo somzimba: 517.4
Melt Point: 160-162 ° C
Isitoreji sokugcina: Ifriji
umbala: I-White okanye i-white powstalline powder


I-Mitoxantrone hydrochloride powder ekusebenziseni

Amagama

Igama leBrama: Novantrone
Igama leKhemikhali: 1,4-dihydroxy-5,8-bis [[2- [2-hydroxyethyl) amino] ethyl] amino] 9,10-anthracenedione dihydrochloride

Ukusetyenziswa kweMitoxantrone hydrochloride powder

I-Lyeloid Leukemia

Icandelo leempawu ezihlukahlukeneyo ze-chemotherapy regimens ukwenzela ukukhutshwa kwe-remyeloid (i-myelogenous, nonlymphocytic) ye-leukemia (AML, ANLL). I-AML ibandakanya i-promyelocytic, i-monocytic, i-myelomonocytic, i-megakaryoblastic kunye ne-erythroid leukemias.

Isetshenziselwa ukudibanisa namanye ama-antinoplastic agents kwiinkqubo zonyango oluhlanganisiweyo emva kokuqulunqwa kokuxolelwa ngokupheleleyo.

Cancer Cancer
Isetyenziswe njengenye irejimenti yokwenza unyango olusisigxina lwe-advanced, ephawulekayo (oko kukuthi, olubuhlungu) umdlavuza we-prostate-refractory prostate (kunye ne-prednisone). Umgca wokuqala wonyango we-hormone-refractory metastatic prostate umdlavuza i-docetaxel ngokudibanisa ne-prednisone.

Multiple Sclerosis (MS)
Unyango lwesibini (esingapheliyo) oqhubekayo, ukuqhubeka kwakhona, okanye ukuqhubela phambili ukubuyisela kwakhona iMMS. Ukusetyenziswa ukunciphisa ukukhubazeka kwe-neurologic kunye / okanye ukuphindaphinda kokuphindaphinda.

Kuye kwafundwa kwizigulane ezineendlela ezilandelayo zezifo: Ukukhula kakhudlwana ukukhubazeka okanye ngaphandle kokuhlaziywa kweklinikhi ephezulu (ukuhamba ngokuphindaphindiweyo nokuqhubekayo okuqhubekayo kwakhona) kunye nokunyuka kwekliniki okubangelwa ukunyuka ngokukhawuleza kwimeko yokukhubazeka, kunye nesimo esingaqhelekanga se-neurologic phakathi kokuphindaphinda- ukubuyisela izifo).

Akukhuthazwa ukusetyenziswa kwizigulane ezine-MS eziphambili.

Akufanele isetyenziswe unyango lwe-MS kwizigulane ezineziseko ze-LVEF <50% (bona iMyocardial Toxicity kwi-Boxed Warning). Ngokuqhelekileyo ayikhuthazwa ukuba isebenziswe kulabo abanokukhubazeka kwe-hepatic (bona i-Hepatic Impairment phantsi kweeCautions) okanye kulabo abane-neutrophil count <1500 / mm3.

I-Lodphoma engekho yeHodgkin
Isetyenziswe njengenxalenye yokudibanisa i-chemotherapy regimens ekwenzeni unyango olungaphantsi kwe-non-Hodgkin's lymphoma †.

Yiyiphi imilinganiselo ye-Mitoxantrone hydrochloride powder

Ifumaneka njengeMitoxantrone hydrochloride powder; umlinganiselo ochazwe ngokwemveliso ye-mitoxantrone i-HCL powder.

abadala
I-Lyeloid Leukemia
Ukunyangwa kwamayeza
IV
12 mg / m2 imihla ngemihla i-1-3 ngokudibanisa ne-cytarabine 100 mg / m2 imihla ngemihla (njenge-infusion eqhubekayo kwi-24 iiyure) kwiintsuku ze-1-7.

Ukuba impendulo yokuguquka kwinqanaba lokuqala lokungeniswa kwiphepha lingaphelelanga, inqanaba lesibini lokubumba elinesibini ye-2 ye-mitoxantrone i-HCL powder (i-12 mg / m2 imihla ngemihla) kunye neentsuku ze-5 ze-cytarabine (100 mg / m2 imihla ngemihla) zinokunikwa.

Ukuba isifo esinobungozi okanye obunobungozi obunobungozi obunobomi buyabonwa ngexesha lokuqala lokungeniswa, unqande inkqutyana yesibini yokuqhelanisa ukuya kutshatyalaliswa isicatshulwa.

Ulwaphulo lweNyango
IV
12 mg / m2 imihla ngemihla kwi-1 kunye ne-2 kunye kunye ne-cytarabine 100 mg / m2 imihla ngemihla (njenge-infusion eqhubekayo yeeyure kwi-24 iiyure) kwiintsuku ze-1-5. Ukulawula ikhosi yokuqala yokuhlanganiswa malunga neveki ze-6 emva kwekhosi yokugqibela yokubumba; Ukulawula ikhosi yesibini yokuhlanganiswa ngokubanzi kwiiveki ze-4 emva koqeqesho lokuqala.

Cancer Cancer
IV
12-14 mg / m2 emva kweentsuku ze-21; kunika njengesigxina kwi-corticosteroid therapy (umzekelo, i-prednisone 5 mg ngomlomo kabini imihla ngemihla, i-hydrocortisone 40 mg ngomlomo ngosuku). Ezinye iikliniki zincoma ukuyeka ukukhishwa kwe-HCL powder (kunye nokuqhubeka kwe-corticosteroid therapy yedwa) kwizigulane ezasabela emva kwe-mitoxantrone i-HCL powder dose ye-140 mg / m2 ngenxa yobungozi besifo sobungozi benhliziyo.

Isifo sokugubhuka
IV
12 mg / m2 kanye emva kweenyanga ze-3.

Ukubhala imiqathango
abadala
Isifo sokugubhuka
IV
Ubuninzi bexesha lokuphila elilodwa lokugqibela: 140 mg / m2.

IiNdawo eziZodwa
Impembelelo yeHepatic
Ukunciphisa ukususwa; ukulungiswa kwemilinganiselo kunokufuneka, nangona kunjalo, akukho ziphakamiso ezithile zokulungiswa kweelayi. (Jonga ukukhubazeka kwe-Hepatic phantsi kweeNgcebiso.)

Ukukhubazeka kwamaReal
Ukunciphisa umlinganiselo akudingeki.

isilumkiso

Amava oLondolozo lweKliniki

Ukulawula kuphela phantsi kolawulo lweekliniki ezifanelekileyo ezibonelele ekusebenziseni unyango lwe-cytotoxic.

Ulawulo lweeNgcebiso
Ukulawula ngokukhawuleza kwisisombululo sokukhupha i-IV. Musa ukulawula i-IM, i-sub-Q, inject-arterial, okanye intrathecal injection.

I-necrosis yendawo yecala ifanelekileyo xa i-extravasation ivela. (Jonga Imiphumo Yengingqi phantsi kweeNkolelo.)

I-neurotoxicity engapheliyo kwaye ngezinye izihlandlo engabonakaliyo ilandelwe emva kokulawulwa kwe-intrathecal. (Jonga i-Neurotoxicity phantsi kweeNgcebiso.)

Myelosuppression
Ukutshatyalaliswa okuninzi kunokwenzeka. Ngokuqhelekileyo ugweme ukusetyenziswa kwizigulane ezinomlinganiselo we-neutrophil we-baseline <1500 / mm3, ngaphandle kokunyanga kwe-myeloid (i-myelogenous, nonlymphocytic) ye-leukemia. Gcina imeko ye-hematologic ngokucophelela. (Jonga Imiphumo ye-Hematologic phantsi kweCaution.)

I-Myocardial Toxicity
I-cardiotoxicity kunye ne-CHF enokubulawa ngexesha okanye kwiinyanga emva kweyonyango; umngcipheko ukwandiswa ngokunyuka kwamaqondo.

Iziganeko zobungozi (imbali okanye isifo sesifo senhliziyo yesifo, isandulela okanye i-irradiation ehambelanayo kwi-mediastinal / pericardial, indawo yokwelapha yangaphambili kunye nezinye i-anthracyclines okanye i-anthracenediones, okanye ukusetyenziswa kwamanye amayeza e-cardiotoxic) kunokunyusa umngcipheko we-cardiotoxicity. Nangona kunjalo, inetyhefu inokuthi yenzeke kungakhathaliseki ukuba iimeko zengozi yomzimba zikhoyo. (Jonga iCardiotoxicity phantsi kweCaution.)

Umngcipheko CHF asakhulayo izigulane ezinomhlaza Kuqikelelwa ukuba 2.6% xa umthamo ezongezelelekileyo ukuya 140 mg / m2.

Ngaphambi kokuqaliswa kweyeza, vavanya zonke izigulane ngezibonakaliso zengqondo / iimpawu ngeembali kunye nokuhlolwa komzimba kwaye ufumane isahluko esisekhohlo sokushiya i-ventricular ejection (LVEF) nge-echocardiogram okanye i-radionuclide engiography (MUGA).

Musa ukuqalisa unyango kwizigulane ezine-sclerosis ezininzi ukuba isiseko se-LVEF yi-<50%.

Kwizigulane ezine-multiple sclerosis, zivavanye i-LVEF nge-echocardiogram okanye i-MUGA phambi kwesazi nganye; ayinakho ukulawula amanani angaphezulu xa i-LVEF iyancipha kwi <50% okanye ukuba ukunciphisa okwenyuka kliniki kwi-LVEF kwenzeka.

Izigulane ezine-multiple sclerosis akufanele zithole i-dose yenyusa> 140 mg / m2.

I-Leyemia ye-Selogenous Acute (AML)
I-AML yesikolo ibhengezwe kwizigulane eziphathwe nge-mitoxantrone i-HCL powder; ingozi yokukhupha i-leukemi yecandelo lekhontrakthi yenyuka xa i-anthracyclines idibene nezinye i-DNA-ephazamisayo i-antineoplastics, emva kokuboniswa ngokubanzi kwizidakamizwa ze-cytotoxic, okanye xa i-anthracycline doses iye yanda. (Jonga iCarcinogenicity under Cautions.)

Mitoxantrone hydrochloride Raw Powder

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umyalelo omkhulu ungathunyelwa kwiintsuku zokusebenza ze-3 emva kokuhlawula.

Mitoxantrone hydrochloride powder Marketing

Ukubonelelwa kwikamva elizayo.

Ngaba i-Mitoxantrone i-HCL powder inayo nayiphi na imiphumo yangaphandle

iziphumo ebezingalindelekanga landa of mitoxantrone ziquka: usuleleko, usuleleko eliphezulu respiratorytract, usuleleko wokuchama phecana, ezinzwaneni, ezinzwaneni ulusu, nokudumba, alopecia, amenorrhea, arrhythmia kwentliziyo, ukuqhina, urhudo, ECG ukungaqheleki, Ukopha zesisu, ukwanda wesigrike-glutamyl transferase, i-leukopenia, isifo sokusesikhathini, isifo sesisu, i-stomatitis, i-urn abnormality, intlungu yesisu, i-aphthous stomatitis, i-asthenia, ukuvutha komsi wesisu, ukukhwehlela, ukunciphisa i-hemoglobin, ukunciphisa inani legazi elimhlophe, i-dyspnea, i-edema, intlungu yesigubho, isisu, i-feem, i-hematuria, i-hyperglycemia, i-hypocalcemia, i-hypokalemia, ukwandisa i-serum glucose, i-lymphocytopenia, i-mucositis, i-pharyngitis, i-rhinitis, intlungu yesisu, i-thrombocytopenia, ukuhlanza, inzuzo yesisindo, ukubala okungavamile kwe-neutrophil, i-anorexia, i-malaise ne-nailbedchanges. Ezinye iziphumo ebezingalindelekanga ziquka: inyumoniya, kwezintso ukusilela syndrome, isifo sokuwa, skininfection, ianemia, iqolo, granulocytopenia, intloko ebuhlungu, sinusitis, ixhala, arthralgia, conjunctivitis, ukudakumba, ukuqunjelwa, ukopha enzima sexesheni, legazi, lwegazi, hyponatremia, namandla, ukwanda serum aminotransferase alanine, ukwanda serum aspartate aminotransferase, isifo sentliziyo kobuchopho, myalgia, iintlungu, petechia, proteinuria, inzalo, umvumbo, kuthibaza, diaphoresis, kunye ecchymoses. Jonga ngezantsi ukuba uluhlu olungenakuqondisisa lwemiphumo emibi.


Indlela yokuthenga i-Mitoxantrone hydrochloride powder evela kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


=

IAAA

I-COA 70476-82-3Mitoxantrone i-HCL powder I-AASRAW

HNMR

Siyi-Mitoxantrone i-hydrochloride powder supplie, i-Mitoxantrone i-HCL ipowder ukuthengiswa, i-Mitoxantrone ephakamileyo i-HCL powder supplie (70476-82-3) hplc =98% | AASraw

Recipes

Mitoxantrone hydrochloride Raw Powder Recipes

Ukubuza ummeli wethu ummeli (Representative Representative) (CSR) ngeenkcukacha, ngokubhekiselele kuyo.

Iziqulatho kunye nokuqulunqwa kwemveliso

ngokutsha 1 ngenxa Mitoxantrone HCL powder

  1. ikaliwe 5 ngaphandle 5

    Aasraw -

    I-Mitoxantrone i-HCL powder iyinhlakanipho

Yongeza kwakhona

Idilesi yakho ye email aziyi kupapashwa. amasimi ezifunekayo ziphawulwa *