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MMAD (Demethyldolastatin 10)

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 203849-91-6. Udidi:

I-AASraw inokusetyenziswa kunye nokukwazi ukuvelisa kwigram ukuya kwi-MMAD (i-Demethyldolastatin 10) (i-CAS 203849-91-6), phantsi kolawulo lweCGMP kunye nolawulo lwekhwalithi ephezulu.

Ukongezelela, MMAD Kubikwa ukuba kusetyenziswe kwimveliso ye-anti-drug conjugates (NDCs). Kwii-NDC, i-MMAD idibene ne-anti-5T4 anti-anti-anti-Her2. Kuboniswa ukuba ii-NDC zibonakalisa ukusebenza kakuhle kunye ne-pharmacokinetics.

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I-MMAD (Demethyldolastatin 10) ividiyo


I-MMAD (iDemethhyldolastatin 10)

igama: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
I-molecular Formula: C41H66N6O6S
Isisindo somzimba: 771.06
Melt Point: N / A
Isitoreji sokugcina: Ubukhulu -20 ° C iminyaka eyi-3
4 ° C iminyaka eyi-2
Kwi-solvent -80 ° C iinyanga ze-6
-20 ° C ngenyanga ye-1
umbala: Ukumhlophe ukuya kumhlophe (okuqinileyo)


I-MMAD (i-Demethyldolastatin 10) (i-203849-91-6) ukusetyenziswa kumjikelezo we-steroids

Amagama

Iintetho: I-Demethyldolastatin 10 (203849-91-6); i-Monomethylauristatin D; i-Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Isixwayiso kwi-MMAD (iDemethhyldolastatin 10)

Umkhiqizo awuqinisekanga ngokugcwele kwizicelo zonyango. Ukusetyenziswa kophando kuphela

Ukuze ufumane ubunqamle obuphezulu, nceda ushuthule ityhubhu kwi-37 ℃ kwaye uyigubungele kwibhanki ye-ultrasonic kwithuba elithile. Isisombululo sendawo singagcinwa ngezantsi -20 ℃ ngeenyanga eziliqela.

I mi yalelo

In Vitro: I-MMAD (iDemhyhyldolastatin 10) (i-203849-91-6) idityaniswe kwinkqubo enqinileyo ye-oxime-ligation ukuvelisa i-ADCs ezinokuthi-zi-anti-man-antibody ratio ze ~ 2.0. Iziphumo ezibonayo zibonisa iimpawu ezifanelekileyo ze-pharmacokinetic, umsebenzi osebenzayo kwi-vitro cytotoxic ngokubhekiselele kumaseli omhlaza we-HER2 +. Xa kuthelekiswa nee-ADC ezilungiselelwe i-cysteine ​​alkylation emva kokunciphisa i-disulfide yokutshatyalaliswa kwemvelo, indawo ekhethekileyo ye-AD-amino-acid-based-ADCs ayibonakalisiwe yanda kwi-vitro cytotoxicity

KuVvivi: Iziphumo zokusetyenziswa kwamachiza e-anti-drug (ADCs) zibonisa ukugqitywa kwe-tumor epheleleyo kwiirandi. Baye bafumana iphrofayili ephuculweyo yeexicology kwiigos.


Indlela yokuthenga i-MMAD; ukuthenga i-Demethyldolastatin 10 kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


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