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I-MMAF (Hydrochloride) (1415246-68-2)

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 1415246-68-2. Udidi:

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya kwi-MMAF (Hydrochloride) (i-CAS 1415246-68-2), phantsi komgaqo weCGMP kunye nolawulo lwekhwalithi ephezulu.

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I-MMAF (Hydrochloride)

igama: MMAF (Hydrochloride)
CAS: 1415246-68-2
I-molecular Formula: C39H66ClN5O8
Isisindo somzimba: 768.42
Melt Point: 314.3 ° C kwi-760 mmHg (kuqikelelwe)
Isitoreji sokugcina: Ubukhulu -20 ° C iminyaka eyi-3
4 ° C iminyaka eyi-2
Kwi-solvent -80 ° C iinyanga ze-6
-20 ° C ngenyanga ye-1
umbala: Powstalline powder


Ukusetyenziswa kweMMAF (Hydrochloride) kumjikelezo we-steroids

Amagama

I-MMAF (i-Hydrochloride) (i-1415246-68-2) ibizwa ngokuba yi-Monomethylauristatin F Hydrochloride, i-MMAF HCL

I-MMAF (Hydrochloride) Ukusetyenziswa

Usosayensi wezonyango wenza i-reseach enkulu kwi-MMAF, apha ngezantsi iimbono zokubhekisela:
Kwi-Vitro: I-MMAF ibonisa i-vitro cytotoxicity malunga nepaneli yamagama eseli. Iimpawu ze-IC50 zeKaras 299, i-H3396, i-786-O ne-Caki-1 zi-119, i-105, i-257, kunye ne-200 nM, ngokulandelanayo. I-MMAF ejoliswe kuyo inamandla kakhulu kunezidakamizwa zamahhala, kwaye i-cAC10 i-conjugates ye-MMAF ibonakaliswe imisebenzi. Kwi-molar basis, i-cAC10-L1-MMAF4 inomlinganiselo we-2200 ngokuphindaphindiweyo ngaphezu kwe-MMAF yamahhala kwaye isebenzayo kuyo yonke imizila yeseli ye-CD30 evevanywe

E-Vivo: I dose ephakamileyo ebekezelweyo kwimicebe ye-MMAF (1415246-68-2) (> 16 mg / kg) iphakamileyo kakhulu kuneMMAE (1 mg / kg). I-CAC10-L1-MMAF4 ine-MTD ye-50 mg / kg kwiigundane kunye ne-15 mg / kg kumaekiti. I-CAC10-L4-MMAF4 ADC yayinobuthi obuncinane kakhulu, ibe ne-MTDs kwiimiceba kunye neengcongolo ze> 150 mg / kg kunye ne-90 mg / kg kwiekota, ngokulandelanayo

Isexwayiso kuMMAF (Hydrochloride)

Uphando olusetyenziswa kuphela

I mi yalelo

Kulotshiwe ukuba i-Monomethylauristatin F Hcl (MMAF Hcl) i-antitubulin i-agent evimbela ukwahlula iseli ngokuthintela i-polymerization ye-tubulin; kwaye umsebenzi we -cytotoxic uphantsi kwe-MMAE; kwaye yi-anti-drug anti-cytotoxin.

Assay Cell
Amaseli aphathwa ngokuxilongwa kwee-molecule ze-test kunye neentsuku ze-4-6 ngokuxhomekeke kumgca weseli. Uvavanyo lokukhula kwamaselula kunye nokunciphisa idatha ukuvelisa ixabiso le-IC50 lwenziwa ngokusebenzisa i-Alamar Blue test
I-MCE ayizimeli ngokuzimeleyo ukuchaneka kwezi ndlela. Ziyakubhaliswa kuphela.

Ulawulo lwezilwanyana
Amagundane: uphando lubonisa ukuba xa i-Karpas 299 ifomor size ifinyelela kwi-300 mm3, izilwanyana ezintathu ngalinye lifumana injoyi ye-10 mg yecandelo lomntu / kg isisindo somzimba weCAC10-L1-MMAF4 okanye i-cBR96-L1-MMAF (1415246-68-2 ) I4 ngaphakathi. Ukugqithisa kugqithiselwa kwaye kufakwe kwi-compound yokubamba ukushisa okufanelekileyo, kwaye i-5 μm-amancinci amacwecwe anqabileyo aguqulwe ngokusebenzisa i-immunohistochemistry
I-MCE ayizimeli ngokuzimeleyo ukuchaneka kwezi ndlela. Ziyakubhaliswa kuphela.


Indlela yokuthenga i-MMAF; ukuthenga i-Hydrochloride ukusuka kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


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