ISouth Africa Delivery, iDaily Domestic Delivery, I-European Domestic Delivery

Osimertinib (AZD-9291) ipowder

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 1421373-65-0. Udidi:

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya ku-Osimertinib (AZD-9291) powder (1421373-65-0), phantsi komgaqo weCGMP kunye nolawulo lwekhwalithi ephezulu.

Osimertinib (AZD-9291) ipowder ngumlomo womlomo, ongenakunqandeka we-epidermal growth factor receptor (EGFR) ukukhuthaza nokutshintshwa kwe-T790M ukutshintsha (IC50s = 15-17 nM) ngelixa ubeka ifom yefom ye-receptor (IC50 = 480 nM) .1 Ibopha i-IGF1R ehlobene Kwaye i-HERG receptors eneempembelelo ezincitshisiweyo (IC50s = 2.9 kunye ne16.2 μM, ngokulandelanayo) .1 AZD 9291 iboniswe ukuvimbela ukukhula kwesisu kwi-xenograft imodeli yemouse kwimilinganiselo yomlomo ye-5-10 mg / kg kwaye ihlolwe kwiikliniki kwizigulane. I-EGFR ehamba phambili engumlwanyana omncinci wesifo somhlaza wamaphaphu.

Ingcaciso yeMveliso

I-Osimertinib (AZD-9291) ividiyo ye powder


Osimertinib (AZD-9291) ipowder Abalinganiswa basisiseko

igama: Osimertinib (AZD-9291) ipowder
CAS: 1421373-65-0
I-molecular Formula: C28H33N7O2
Isisindo somzimba: 499.61
Melt Point: > 188ºC
Isitoreji sokugcina: -20 ° C
umbala: Ukukhanya okuluhlaza okwesibhakabhaka


Osimertinib (AZD-9291) ipowder ekusebenziseni

igama

AZD-9291 powder (CAS 1421373-65-0), N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide

Ukusetyenziswa kwePowder ye-AZD-9291

I-AZD-9291 powder elawulwa kanye ngenyanga nge-5 mg / kg ibangele i-regression ye-tumors kwi-EGFRm + (i-PC9; i-178% ukukhula kwe-inhibition) kunye ne-EGFRm + / T790M (i-H1975; i-119% ukukhutshwa kwe-%)
emva kweentsuku ze-14 i-dosing. Ngaphezu koko i-5 mg / kg i-AZD-9291 powder yayanele ngokwenza ukuba kuhluthe okuphawulekayo kwe-EGFRm + kunye ne-EGFRm + / T790M i-tumor tump tumic tumors. Ukukhutshwa kwe-tumor ukuxhatshazwa kwahlanganiswa ne-inhibition enzulu ye-EGFR i-phosphorylation kunye neendlela eziphambili zokubonakalisa i-AKT ne-ERK. Ukunyanga okusisigxina kwexesha elide le-PC9 kunye ne-H1975 xenograft izidumbu kunye ne-AZD-9291 powder ekhokelela ekuphenduleni okupheleleyo kunye okuqhubekayo, kungekho zicubu ezibonakalayo emva kweentsuku ze-40, kwaye zigcinwe ngaphaya kweentsuku ze-100. Ngaphezu koko, idatha yangaphambili yeklinikhi ibonisa ukuba i-AZD-9291 powder ingajolisa izigulane ezithe zaxhatshazwa kwindlela esandul 'i-HER2-amplification esandula kutshatyalaliswa kungekudala, ngaloo ndlela iyakwandisa inzuzo yayo kwizigulane ezingapheliyo zeTKI.

Isilumkiso kwi-AZD-9291 powder

I-AZD-9291 powder (i-CAS 1421373-65-0) yonyango evunyiweyo kuphela eboniswe kwizigulane ezine-metastatic EGFR T790M nomhlaza omninzi wesifo somhlaza wamaphaphu. Esi sibonakaliso sivunyiwe phantsi kwenkqubo yokuvunywa ngokukhawuleza ka-FDA ngokusekelwe kwisilinganiselo sokuphendula ngesisu kunye nexesha lokuphendula (DoR).

Iziphumo eziqhelekileyo eziqhelekileyo zibandakanya uhudo, i-stomatitis, i-rashes, isikhumba esomileyo okanye esinomkhuhlane, izifo apho umunwe okanye izikhonkwane zikhangela isikhumba, ukubalwa kweplatelet ephantsi, ukubalwa kwe-leukocyte ephantsi, kunye nokubala okuphantsi kwe-neutrophil.
Akukho zikhokelo ze-TAGRISSO
I-Lung Disease (ILD) ye-Interstitial (ILD) / i-Pneumonitis yenzeke kwi-3.3% yaye yayifile kwi-0.5% yezigulane ze-813 TAGRISSO. Gwebela i-TAGRISSO kwaye uphando ngokukhawuleza kwi-ILD kunoma yisiphi isigulana esibonisa ukunyuka kweempawu zokuphefumula ezibonisa i-ILD (umzekelo, i-dyspnea, ukukhwehlela kunye nomkhuhlane). Ukuyeka unaphakade TAGRISSO ukuba i-ILD iqinisekisiwe
Ixesha lexesha le-QTc elongezelelweyo lenzeke kwizigulane zikaTAGRISSO. Kwizigulane ze-411 kwizifundo ezimbini zeSigaba II, esinye isigulane (0.2%) sitholwe sibe ne-QTc enkulu kune-500 msec, kwaye izigulane ze-11 (2.7%) zanda kwenyuka kwi-QTc ephezulu kune-60 msec. Ukuqhuba iliso ngokukhawuleza kunye ne-ECG kunye ne-electrolytes kwizigulane ezine-long-term syndrome ze-congenital, i-heart failure ye-heart, i-electrolyte engafanelekanga, okanye abo bathabatha imichiza eyaziwayo ukunyusa ixesha le-QTc. Ukuyeka unaphakade I-TAGRISSO kwizigulane eziphuhlisa ixesha lokuphumla kwexesha le-QTc kunye nempawu / iimpawu zobomi bokusongela i-arrhythmia
I-Cardiomyopathy yenzeke kwi-1.4% yaye yayifile kwi-0.2% yezigulane ze-813 TAGRISSO. I-FREction ye-Ejection Ejection (Left Flection) ye-Left Venture (LVEF) yehla> 10% kunye ne-drop to <50% yenzeka kwi-2.4% ye-9 / 375) izigulane ze-TAGRISSO. Hlola i-LVEF ngaphambi kokuqaliswa kwaye emva kweenyanga ze-3 zonyango. Nciphisa i-TAGRISSO xa iqhekeza le-ejection liyancipha ngo-10% ukusuka kwindleko zokuxhatshazwa kwaye lingaphantsi kwe-50%. Ukukhubazeka kweentliziyo ezinqabileyo okanye ukungahambi kakuhle kwe-LV ukungasebenzi kwisithuba seveki ze-4, ukuyeka unaphakade i-TAGRISSO.
Ukucebisa abafazi abakhulelweyo besengozini yokufumana umntwana. Ukucebisa amabhinqa anakho ukuzala ukusetyenziswa kokubeleka ngokufanelekileyo ngexesha le-TAGRISSO unyango kunye neveki ze-6 emva kwesazi yokugqibela. Ukucebisa amadoda kunye namaqabane amabhinqa okukwazi ukuzala ukusetyenziswa kwexesha elifanelekileyo kwiinyanga ze-4 emva kwesilinganiso sokugqibela.
Impembelelo engavamile kakhulu (> 20%) iboniswe kwii-TAGRISSO izigulane zi-diarrhea (42%), i-rash (41%), isikhumba esomileyo (31%) kunye ne-toility ye-nail (25%).

I mi yalelo

I-AZD-9291 ipowder yayisebenza ngamandla kwizigulane zomhlaza womphunga kunye nomguquko we-EGFR T790M oye wafumana ukunyuka kwesifo ngexesha lokuqala kunyango kunye ne-EGFR tyrosine kinase inhibitors.

I-AZD-9291 ipowder iqhutyelwa kwisilingo esiqinisekisiweyo, iAURA3, iilebula evulekileyo, uphando olulungelelaniso lwesigaba se-III olwenzelwe ukuhlola ukusebenza nokukhuseleko kwe-AZD-9291 powder kunye ne-platinum-based doublet chemotherapy kwizigulane ezine-EGFR T790M ezintle, okanye i-NSCLC ye-metastatic eqhubekele phambili emva kweyeza kunyango nge-EGFR-TKI. I-AZD-9291 powder iphandwa kwakhona kwi-setting adjuvant kunye nendawo yokubeka umgca wokuqala, kuquka nezigulane ezineengqondo ze-brainstas, kunye nokudibanisa nezinye izixhobo.

I-AZD-9291 powder I-80mg i-tablet nganye yemihla ngemihla yonyango lokuqala elichazwe unyango lwezigulane ezine-metastatic growth growth receptor (EGFR) i-T790M-nentsholongwane-engaphantsi-encinci yesifo somhlaza wamaphaphu (NSCLC), njengoko ifunyenwe yi-FDA vavanyo, abaye baqhubela phambili okanye emva kwe-EGFR tyrosine kinase inhibitor (TKI) unyango. Ucwaningo lwe-in vitro lwe-clinic alubonisi ukuba i-AZD-9291 ipowder ine-potency ephezulu kunye nomsebenzi wokuvimbela umonakalo we-EGFR we-phosphorylation ehamba phambili kwi-EGFRm kunye ne-T790M kunye ne-TXNUMXM imizila yeseli ye-NSCLC kunye nomsebenzi ongaphantsi kwe-EGFR kwimigca yesellu esendle.

I-Osimertinib powder iye yasanduliswa yi-World Health Organisation (WHO) njengeLizwe elingabonakaliyo eliMhlaba elingenamalungelo (INN) le-AZD-9291 powder, kwaye lingamkelwa ngokusemthethweni ngoNovemba 2015. E-US, i-American Medical Association yamkela i-Osimertinib powder njenge-United States ebizwa ngokuba yi-USAN.

Ubunzima be-AZD-9291 (i-CAS 1421373-65-0)

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umlinganiselo omkhulu (ngaphakathi kwe-1kg) ungathunyelwa kwimihla yokusebenza ye-3 emva kokuhlawula.

I-Caffeic Acid iPhenethyl Ester Marketing

Ukubonelelwa kwikamva elizayo.


Indlela yokuthenga i-Osimertinib powder; athenge i-AZD-9291 powder (i-CAS 1421373-65-0) esuka kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.


=

IAAA

I-COA 1421373-65-0 Osimertinib (AZD-9291) I-AASRAW

HNMR

Recipes

I-Caffeic Acid iPhenethyl Ester Powder Recipes

Ukubuza ummeli wethu ummeli (Representative Representative) (CSR) ngeenkcukacha, ngokubhekiselele kuyo.

Iziqulatho kunye nokuqulunqwa kwemveliso