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Sorafenib (284461-73-0)

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 284461-73-0. Udidi:

I-AASraw inokubaniswa kunye nokukwazi ukuvelisa kwigram ukuya ku-Sorafenib (CAS 284461-73-0), phantsi komgaqo weCGMP kunye nolawulo lwekhwalithi ephezulu.

Sorafenib powder isetyenziselwa ukuphatha i-renal cell carcinoma (RCC; uhlobo lomhlaza oqala kwiintso). I-Sorafenib isetyenziselwa ukuphatha i-hepatocellular carcinoma (uhlobo lomhlaza wesibindi) olungenakuphathwa ngonyango kunye nolunye uhlobo lomhlaza we-thyroid olusasaze kwezinye iindawo zomzimba kwaye awukwazi ukuphathwa nge-iodine ye-radioactive.

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Ividiyo yaseSorafenib


Sorafenib Abalinganiswa basisiseko

igama: Sorafenib
CAS: 284461-73-0
I-molecular Formula: C21H16ClF3N4O3
Isisindo somzimba: 464.83
Melt Point: 202-204 ° C
Isitoreji sokugcina: -20 ° C Ifreezer
umbala: Ukukhanya okuKhanya okuKhanya


Ukusetyenziswa kweSorafenib (284461-73-0) kumjikelezo we-steroids

Amagama

Sorafenib (284461-73-0), igama lezorhwebo yi-Nexavar.

Usetyenziso lweSorafenib

1) Njengamacwecwe ngomlomo.
I-2) Kunconywa ukuba iipilisi zithathwa ngaphandle kokutya (ubuncinane ihora le-1 ngaphambi kweeyure ze-2 emva kokutya).
3) Imali ye-sorafenib eya kufumana iya kuxhomekeka kwizinto ezininzi. Ugqirha wakho uya kugqiba i-dosage yakho kunye neshedyuli.
4) Iipilisi ezine-sorafenib tosylate (274 mg) elingana ne-200 mg yeSorafenib (i-CAS 284461-73-0).

Isilumkiso kwiSorafenib

Tshela ugqirha wakho ukuba ubona iingxaki zesikhumba (ezifana nokugqithisa, ukuhlambalaza, ubomvu, ukuvuvukala, intlungu), ngakumbi kwiintendelezo zezandla zakho okanye kwiintendelezo zeenyawo zakho ngelixa usebenzisa i-Nexavar.

I mi yalelo

Ulwaphulo olujoliswe kuko luyimiphumo malunga ne-100 yeminyaka yophando eyenzelwe ukuqonda umahluko phakathi kweeseli zomhlaza kunye neeseli eziqhelekileyo. Okwangoku, unyango lomhlaza lujolise ngokukodwa ekubulaleni ngokukhawuleza iiseli kuba enye yentsholongwane yeeseli ekwahlukana ngokukhawuleza. Ngelishwa, ezinye zeeseli zethu eziqhelekileyo ziyahlukana ngokukhawuleza, kubangele imiphumo emibi.

Ulwaphulo olujoliswe kulo lu malunga nokuchonga ezinye iimpawu zeseli zomhlaza. Iingcali zenzululwazi zikhangelelanisa iimeko ezahlukeneyo kumaseli omhlaza kunye neeseli eziqhelekileyo. Le ngcaciso isetyenziselwa ukudala unyango olujoliswe ekuhlaseleni amangqamuzana omhlaza ngaphandle kokulimaza iiseli eziqhelekileyo, ngaloo ndlela zikhokelela kwimiphumo emibini yecala. Uhlobo ngalunye lonyango olujoliswe kuyo lusebenza kancinci kodwa lugxininise ukukwazi ukukhula, ukwahlula, ukulungiswa kunye / okanye ukunxibelelana namanye amaseli.

Kukho iintlobo ezahlukeneyo zonyango olujoliswe kuyo, ezichazwe kwiindidi ezintathu ezibanzi. Ezinye iinkqubo ezijoliswe kuzo zijolise kumacandelo angaphakathi kunye nomsebenzi weselfini somhlaza. Iipilisi ezijoliswe kuzo zisebenzisa i-molecule ezincinci ezingena kwiseli kwaye ziphazamise umsebenzi weeseli, zibangela ukuba zife. Kukho iintlobo ezininzi zonyango olujoliswe kuzo ezijolise kwiindawo zangaphakathi zeeseli. Ezinye iithagethi ezijoliswe kuzo zijoliswe kwii-receptors ezingaphandle kweseli. Iipilisi ezijoliswe kwizifunyenwe ziyakwaziwa njengama-antibodies e-monoclonal. I-Antiangiogenesis inhibitors ijolise kwimithambo yegazi eyenza i-oksijeni kwiiseli, ekugqibeleni ibangela ukuba iiselingi zilambile.

I-Sorafenib yenzelwe ukuvimba ukukhula kweseli se-tumor ngeendlela ezininzi. I-Sorafenib (i-284461-73-0) ijolise i-enzyme eziliqela kummandla wamaseli omhlaza, kunye neethagethi ngaphakathi kwiseli.Ukuphela kwezi thagethi zicingelwa ukuba zibandakanyeka kwi-angiogenesis (ukwenza imithwalo yegazi).

Uphando luyaqhubeka luchonga ukuba yiyiphi i-cancer ingaphathwa kakubi ngezilwanyana ezijoliswe kuyo kunye nokuchonga iithagethi ezongezelelweyo zezinye iintlobo zomhlaza.


Indlela yokuthenga iSorafenib ukusuka kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


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