I-urolithin ye-powder echanekileyo yokuthengiswa kwexabiso jikelele
I-AASraw ngumenzi oqeqeshiweyo we-anabolic steroid powder kunye nokuhanjiswa okukhuselekileyo!

I-AASraw inikezela ngeentlobo ze-Urolithin Powder kunye nokubonelela okuzinzile, sinokuthumela i-anabolic steroid eluhlaza kuwo wonke umhlaba, ngokukodwa kwi-USA, iYurophu, inkonzo ye-remail isebenza kakuhle kwaye luhlobo lokuhanjiswa kwekhaya, lukhuselekile kakhulu. Ukongeza, umyalelo omkhulu unokuxhaswa ngexabiso elikhuphisanayo.

Phosphatidylserine(PS) Umgubo 01

Thenga i-Urolithin Powder

I-Urolithin A yangemva

Izibonelelo zentliziyo yePomegranate zikhokelele kubaphandi ukuba baphande ngeendlela esi siqhamo sibomvu sinokusigcina sisempilweni ngayo. Kuphando lwakutsha nje, abaphandi baseSwitzerland bachonge imolekyuli entsha ebangelwa kukwetyisa iikhompawundi ezimbini ezifumaneka kwiirharnate: i-punicalagins kunye ne-ellagitannins. Le molekyuli iyingqayizivele, eyaziwa ngokuba yi-urolithin A, inceda ukuvuselela i-mitochondria, izindlu zethu zamandla zeselula. I-Urolithin A ivula ucango lonyango olunokubakho kunyango ngokuchasene nokuphazamiseka okunxulumene nobudala, kubandakanya ubuthathaka, okuyimeko yomngcipheko wokukhubazeka, ukulaliswa esibhedlele, kunye nokufa.

Urolithin Isishwankathelo

I-Urolithin A yinkomfa yemetabolite, eyiklasi yeekhompawundi eziphilayo ezibizwa ngokuba yi-benzo-coumarins. Yimveliso yokugqibela eveliswa kukutya okuqulathe i-ellagitannins (polyphenols) kwaye inyanzeliswa ngumzimba wamathumbu. Ngamanye amagama, i-Urolithin A iveliswa xa umntu engenisa imithombo yokutya ene-ellagitannins.

I-Urolithin A ayenzeki ngokwendalo kwifom yayo yokugqibela. Imithombo yokutya ye-Ellagitannin, njengeentlobo ezithile zamajikijolo kunye neerharnati, kufuneka zixutywe namathumbu ebacteria ukuba enziwe. Ukuze ikhompawundi ibe nokusetyenziswa okusebenzayo, kufuneka yenziwe elebhu, okanye ngamanye amagama, i-Urolithin A engeyiyo kufuneka iveliswe ukuze isetyenziswe.

Izifundo zesayensi zibonise ukuba i-Urolithin A inezinto ezichasene nokwaluphala. Kuthiwa iyanceda ekubunjweni kobunzima bemisipha, ineempawu ezichasayo, kwaye ikwabonakalise amandla ekuphuculeni impilo yokuqonda kubantu abadala.

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I-Urolithin Indlela yokuSebenza

Urolithin usebenza njani? I-Ellagic acids kunye nee-Ellagitannins zii-Urolithin A zandulelayo.

I-Ellagitannins ifakwe i-hydrolyzed ukusuka emathunjini ukuze ikhuphe i-Ellagic acid, kwaye oku kuyasetyenzwa ukusuka kwi-gut microflora ukuya kwii-urolithins ngokulahleka okwandayo kwi-1 yayo yelactones ukususwa ngokulandelelana kwamaqela ehydroxyl. Nje ukuba ityiwe emathunjini, emva koko i-Urolithin A powder ingena kwinkqubo yokuhamba kwesi sifo.

IMitophagy, ngokwenkcazo yeWikipedia, kukuthotywa okukhethiweyo kwemitochondria yakho ngokuzimela. Ihlala isenzeka kwi-mitochondria enesiphene kulandela umonakalo okanye uxinzelelo. Nangona kunjalo, njengoko sikhula, umsebenzi weMitophagy uye ungasebenzi kakuhle. Ngethamsanqa, i-Urolithin A ivunyiwe ukukhuthaza i-mitophagy ngendlela egciniweyo kwiindidi ezahlukeneyo.

Izibonelelo / Iziphumo ze-Urolithin A.

❶ I-Urolithin A inceda ukulwa umhlaza

Ngaphandle kokhathalelo olunobundlongondlongo kunye ne-chemotherapy, phantse iipesenti ezingama-50 zabantu abanomdlavuza ongqalileyo bakhula amathumba aphindaphindiweyo. Oku kusenokubangelwa yinxalenye yokusinda kweeseli ezinomhlaza zomhlaza wekolon ezinqanda ichemotherapy eqhelekileyo kwaye isebenze njenge `` mbewu '' yeekhensa ezilandelayo.
Ekufumaniseni okunomdla, abaphandi baveza iiseli ezinomhlaza womhlaza wekolon ukusuka kwisigulana esinomhlaza ocoliweyo ukuya kumxube one-85% ye-urolithin A okanye i-30% ye-urolithin A. Iziphumo zazimangalisa. Umxube ophezulu we-urolithin Umxube woxinaniso ubusebenza kakhulu ekuthinteleni inani kunye nobungakanani beeseli ezinomhlaza womhlaza kunye nokuthintela umsebenzi wealdehyde dehydrogenase, umakishi wokuchasa.

❷ I-Urolithin A - I-Neuroprotective Effects

Unxibelelwano phakathi kwepomegranate kunye neempembelelo zalo zokuthintela isifo se-Alzheimer sele zimiselwe kakuhle kwizifundo zezilwanyana.8 Nangona kunjalo, izinto ezazisenziwa yile nto ayaziwa kude kube ngoku.
Isifo i-Alzheimer kulindeleke ukuba sichaphazele ngaphezulu kwezigidi ezili-115 zabantu kwihlabathi liphela ngonyaka wama-2050, Iqela labaphandi lijonge kwisifundo sangaphambili sezilwanyana esichaze ngeziphumo ezichasene ne-Alzheimer kwiziphumo zerharnate.
Iqela livavanye amandla ala macandelo okuwela isithintelo segazi-ngengqondo kwaye lafumanisa ukuba uhlobo lwe-methylated ye-urolithin A (mUA), ethathwe kwirharnate, kunye nezinye ii-urolithin zazinokwenza njalo.
Kwaye, nangona uphando oluthe kratya luyafuneka, ababhali baqukumbele ukuba ii-urolithins zezona zinto zinokubangela uxinzelelo lwe-Alzheimer ezibandakanya ukukhuselwa kwi-neurotoxicity kunye ne-b-amyloid fibrillation. Ezi ziphumo ziyathembisa, kwaye ziphakamisa isidingo sokujonga ezinye iindlela zongenelelo ezisekwe kwindalo zokuthintela okanye ukucothisa ukuqhubela phambili kwe-Alzheimer's.
Iziphumo kunye nedatha evela kwezi zifundo zahlukeneyo ukuxhasa ngakumbi ukubaluleka kwe-polyphenol metabolite iikhompawundi ezinje nge-urolithin A evela kwirharnate nendima yabo kumlo wokulwa nomhlaza wekolon kunye nezifo ezingenayo imithambo-luvo.
Izifundo zikwabonakalisile ukuba i-Urolithin A inokuphucula amandla emisipha kunye nokunyamezela kubantu abalupheleyo. Uphando lwamva nje lubonisa ukuba ubungqina bokuqala bunika ezinye izibonelelo ze-Urolithin A, ezibandakanya oku kulandelayo:

-Anti-ukudumba
-Anticarcinogenic
-Izinto ezichasayo
-Ukucingela
-Iintsholongwane

I-Urolithin A ikwabonwa ngokuqinileyo njengesongezelelo kwiimveliso zeprotein zokuphucula iziphumo zokuzilolonga, kunye nokunciphisa ukutyeba kakhulu.

I-Urolithin A Iziphumo ebezingalindelekanga

Kolu vavanyo lweklinikhi luchazwe apha ngasentla, akukho miphumo mibi ichaziweyo. Kuphando ngaphezulu kothotho lwezifundo zangaphambi kokubeleka kunye neklinikhi, kubonakala ngathi kukho ubungqina benkxaso kukhuseleko lwe-Urolithin A yokusetyenziswa.

Akukho ziphumo zinetyhefu zixeliweyo, nkqu nakwizifundo ezibandakanya idosi ephezulu enikwe iigundane kwezi zifundo.

I-Urolithin A isetelwe ukuguqula ishishini lokulwa ukwaluphala. Izifundo zeklinikhi zisekwinqanaba labo lokuqala kodwa uninzi lwezilingo lubonisa iziphumo ezilungileyo ngaphandle kweziphumo ebezingalunganga. Ukusuka ekutyeni ukuya kwizongezelelo, i-Urolithin A inyanzelekile ukuba ibe yinto entsha elandelayo yokufumanisa ukutya okuphezulu ekufuneka kuthathwe ngumntu wonke.

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I-Urolithin A Imithombo yokutya

Njengoko sele kukhankanyiwe, iUrolithin A kwifom yayo yokugqibela ayiveli ngokwendalo. Ayaziwa ukuba ifumaneka kuyo nayiphi na imithombo yokutya. Nangona kunjalo, i-precursor ye-compound ingafumaneka kwiziqhamo ezithile kunye namantongomane. Imithombo yokutya equlathe i-ellagitannins enjengeerharnate, iirasibheri, amaqunube, i-cloudberries kunye nama-walnuts yimizekelo ethile.

I-ellagitannins kwezi ziqhamo kunye namandongomane afakwe i-hydrolyzed emathunjini ukuze avelise i-ellagic acid, ethi ke iphinde iqhubekeke emathunjini kwaye yenziwe ityhubele microflora iye kwi-Urolithin A.

Kubalulekile ukuba uqaphele ukuba i-Urolithin A ayisoloko isenzeka xa ungenile. Amathumbu abanye abantu awanawo umxube osempilweni we-microflora efunekayo ukuguqula i-ellagic acid kwi-Urolithin A. Oku kuthetha ukuba ayinguye wonke umntu oya kuvelisa i-Urolithin A emathunjini abo ukuba batya iirharnate, i-walnuts, okanye amaqunube. Konke kuxhomekeke kumathumbu ebacteria akhoyo emzimbeni wakho.

Inkqubo ye-Urolithin A yokuThengisa

I-Urolithin A yenziwa ngokudityaniswa kweekhemikhali kusetyenziswa enye yeenkqubo ezimbini ezichazwe apha ngezantsi. Zombini ezi nkqubo zibandakanya ukuphendula ngokudibanisa u-Ullmann, kulandele unyango lwe-asidi ye-asidi ukuvelisa imveliso ye-urolithin ecoceke kakhulu.

Imveliso yokugqibela ihlanjululwa ngeendlela zonyango olusulungekileyo kwisinyibilikisi, sihluziwe, sihlanjwe, kwaye somiswe ukuze sifumane i-urolithin emsulwa A. Imveliso kamva iphantsi kokuncitshiswa kobungakanani bamasuntswana.

Ngokwenkqubo esekwe kakuhle, i-Urolithin A powder yenziwe yenziwa kwaye yahlanjululwa kumanyathelo aphambili ukuya kwinkcazo emsulwa ye-99%. Izinto zokwenza imveliso kunye namanyathelo okulungisa abandakanyekayo kuthungelwano lwe-urolithin A ibandakanya i-2-Bromo-5-methoxy benzoic acid, 2-Bromo-5-hydroxy benzoic acid, Resorcinol, 50% sodium hydroxide, Copper sulfate pentahydrate, Methanol, Aluminium chloride, Toluene , DMSO, Methanol, Acetic Acid, kunye ne-TBME (tert-butyl-methyl ether).

I-Urolithin ye-Synthetic A VS Urolithin A yendalo

Njengoko sele kukhankanyiwe apha ngasentla, i-Urolithin A sisisu se-bacterial metabolite ye-ellagitannins (ET) okanye i-ellagic acid (EA). Ukuba ufuna ukufumana isixa esikhulu se-Urolithin A, kufuneka uqale utye iziqhamo ezinobuninzi, emva koko ulinde ukuba badlulise ukusuka kwi-ellagitannins kunye ne-ellagic acid ukuya kwi-Urolithin A. Le nkqubo inde, kwaye isulungekile iphantsi, kwaye okona kubaluleke kakhulu , kuyakubiza kakhulu ukwenza njalo.

Asinguye wonke umntu onemicroflora elungileyo enokwenza imetabolite. Ukongeza, le nkqubo ayinakuze isetyenziswe kwimveliso yobuninzi kwindawo yokuvelisa ehambelana ne-GMP.

Iindaba ezimnandi zezokuba, njengesithako esinoveli, i-Urolithin A ekugqibeleni iyathengiswa ngo-2019 kwi-Cima Science. Ngoku inokudityaniswa elebhu kunye nomzi mveliso. I-urolithin A yokwenziwa iyafana nokwakheka kwe-urolithin yendalo A. Amandla okuvelisa afikelela kwi-3000 kgs okanye kwiitoni ezi-2.5 / ngenyanga.

Urolithin ukhuseleko

I-Urolithin A yamkelwe yi-EU njengesixhobo sokutya esinoveli.

I-US Food and Drug Administration (i-FDA) ngo-2018 inike i-urolithin A imeko yayo ye-GRAS esetyenziswa kwifomula yokutya. I-GRAS ithetha ukuba i-Urolithin A ithathwa ngokubanzi njengekhuselekileyo nge-500mg ukuya kwi-1 gram ngokusebenza.

I-Urolithin Ukhuseleko lwaphandwa kuthotho lwezilingo zangaphambi kokubeleka kunye neeklinikhi, ezikhuthaza ukhuseleko lwempilo yazo kusetyenziselwa iinjongo zayo. Ukuphindaphinda idosi yeentsuku ezingama-28 kunye nezifundo zeentsuku ezingama-90 ze-urolithin A kwiigundane azibonisanga nayiphi na ifuthe lobungozi kwezinye zeeparameter ezilinganiswe nangayiphi na indlela iidosi ezivavanyiweyo.

Ukongezwa ukuya kwiintsuku ezingama-90 nge-urolithin A ayikhokelelanga kuyo nayiphi na imiqondiso yetyhefu ye-neurological okanye yokuzala kumaxesha ophuculo oluphuculweyo lwezifundo zedosi ephindiweyo njengokuvavanywa kweespermatogenesis okanye imijikelezo ye-oestrus, iimviwo ze-ophthalmoscopic, ukuboniswa kwebhetri yokusebenza, kunye nokusebenza kwemoto iimvavanyo.

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Wamkelekile ukuthenga i-Urolithin A / Urolithin i-8-Methyl Ether Bulk Powder evela kwi-AASraw!

Ukufunyanwa kwe-urolithin A, ebangelwa ziipunicalagins kunye ne-ellagitannins iikhompawundi ezifumaneka kwiirharnate, kubonelela ngamathuba amatsha okulwa ukwehla okunxulumene nobudala bemisebenzi ye-mitochondrial kunye nesiphumo sobuthathaka kunye nelahleko yemisipha.

Ngokunceda iiseli zizihlaziye kwaye zisebenzise ukusebenza kwesihlunu, ukukhupha ipomegranate kunye ne-metabolite yayo esandula kuchongwa, i-urolithin A-inokuphumelela.

Kunye nezi ziphumo, kukho ubungqina obuxhasayo beziphumo ezinamandla i-urolithin A enesifo se-Alzheimer kunye nomhlaza, enikezela esinye isixhobo sokulwa nezi meko zitshabalalisayo zichaphazela abantu abaninzi abalupheleyo.

Le ndlela yokutya okunesondlo ivula amathuba okungenziwa ziindlela zokuxuba amayeza emveli. Ukuba ufuna ukuthenga i-Urolithin A powder / Urolithin I-8-Methyl Ether powder, i-AASraw mhlawumbi ilungile.

Urolithin A VS Urolithin B

Zombini i-Urolithin B kunye ne-Urolithin A powder zisetyenziselwa izongezo, kodwa ngeenzuzo ezahlukeneyo zokusebenza. Basebenza ngendlela eyahlukileyo yokusebenza. I-Urolithin A yenzelwe ikakhulu i-Anti-aging formula ye-mitophagy mechanism ngelixa i-urolithin B ikwifomula yesondlo sezemidlalo njengesithako sokwakha izihlunu.

I-Urolithin A yikhompawundi ephandwe kakuhle kakhulu, ngokuqhelekileyo ithathwa njengekhuselekile (GRAS) yi-FDA, ngelixa i-urolithin B ingekho. Kukho iibrand ezongezelelekileyo ezisebenzisa i-urolithin A kune-urolithin B.

Urolithin A kunye Urolithin B zivaliwe ezinxulumene. I-pomegranate extract iqulethe zombini ezi urolithins. Iirharnati yeyona nto iphambili kwiziqhamo. Emva kokugaywa, iindawo zabo ezisisiseko zinokuguqulwa ngamathumbu zibe yi-urolithin C kwaye emva koko iguqulwe ibe yi-Urolithin D kunye no-A, kwaye emva koko i-Urolithin B. Ngale ndlela, i-urolithin A inokuguqulwa ibe yi-urolithin B.

Ngenxa yoko, ixabiso elincinci le-urolithin B linokufumaneka kwigazi labantu abondliwe nge-extract pomegranate; nangona kunjalo, iipropathi zayo ze-antioxidant kunye ne-anti-inflammatory zibuthathaka kakhulu kune-urolithin A. Nangona kunjalo, i-urolithin B inenzuzo yayo ngaphezu kwe-urolithin A. Iyakwazi ukwandisa ubukhulu beeseli zemisipha kunye nokukhawulezisa ukukhula kwezihlunu.

Inkcazo ye-Urolithin B

I-Urolithin B yi-urolithin, luhlobo lwezinto ezixutywe kwi-gut yomntu emva kokufakwa kweellagitannins-enokutya okufana nepomegranate, amagwebu, iidpons ezibomvu, iialnuts okanye i-oak-ubudala ebomvu yeewayini. I-Urolithin B ifumaneka kumchamo ngendlela ye-urolithin B glucuronide.

I-Urolithin B nayo iyimveliso yendalo ene-antiproliferative kunye ne-antioxidant. I-Urolithin B yenziwa yimetabolism evela kwiipolyphenol ezifumaneka kumantongomane nakwiziqhamo, ngakumbi iirharnate. I-Urolithin B ibonakalisiwe ukuba inqumle isithintelo sobuchopho begazi, kwaye inokuba nefuthe le-neuroprotective ngokuchasene neSifo se-Alzheimer's.

Indlela yeUrolithin B yokuSebenza

Iyanciphisa ukonakaliswa kweprotein kwaye inciphisa i-hypertrophy yemisipha. I-Urolithin B inqanda umsebenzi we-aromatase, i-enzyme eguqula i-estrogen kunye ne-testosterone.

I-Urolithin B yimveliso yendalo ene-antiproliferative kunye ne-antioxidant. I-Urolithin B yenziwa yimetabolism evela kwiipolyphenol ezifumaneka kumantongomane nakwiziqhamo, ngakumbi iirharnate. I-Urolithin B ibonakalisiwe ukuba inqumle isithintelo sobuchopho begazi, kwaye inokuba nefuthe le-neuroprotective ngokuchasene neSifo se-Alzheimer's.

I-Urolithin B inqanda umsebenzi we-NF-κB ngokunciphisa i-phosphorylation kunye nokuthotywa kwe-I VerBcy, kwaye icinezela i-phosphorylation ye-JNK, i-ERK, ne-Akt, kwaye yonyusa iphosphorylation ye-AMPK. I-Urolithin B ikwangumlawuli wesixokelelwano samathambo, kwaye i-Urolithin B yenye yeethumbu zeemilabolites ze-ellagitannins, kwaye inefuthe lokuchasana nokudumba kunye ne-antioxidant.

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Isicelo seUrolithin B

Ngelixa befunda iipropathi ezichasene nokuvuvukala kunye ne-antioxidant ye-urolithins A kunye no-B, abaphandi be-UCL kwenzeke bafumanisa ukuba le yokugqibela inefuthe lokhuselo kwimisipha. Iiseli zemisipha kwinkcubeko ezazinxibelelana ne-urolithin B zaba nkulu kunezo zazingenjalo. Sasifuna ukwazi ukuba kutheni.

Kuqala, bafundisisa into kwi-vitro kwaye bafumanisa ukuba i-urolithin B ineziphumo ezibini: iyenza ukuhlanganiswa kweprotein yemisipha kunye nokucothisa ukuthotywa.

Okwesibini, abaphandi bafunda isiphumo se-urolithin B kwi-vivo, kwiimpuku. 'Kukonyuse ukukhula kwemisipha yabo', utshilo uNjingalwazi Francaux. 'Sikwayilawule nakwiimpuku nge-sciatic nerve ekhutshiweyo ekhokelela ekukhubazekeni komlenze, kwaye ukulahleka kwemisipha okulandelayo kwenzeka i-20 ukuya kwi-30% kancinci ngokukhawuleza nakwinqanaba elincinci.'

Iziphumo ze-Urolithin B

I-Urolithin B yenye yeethumbu zeemetabolites ezincinci ze-ellagitannins, kwaye ineziphumo ezichasene nokudumba kunye ne-antioxidant. I-Urolithin B inqanda umsebenzi we-NF-κB ngokunciphisa i-phosphorylation kunye nokuthotywa kwe-I VerBcy, kwaye icinezela i-phosphorylation ye-JNK, i-ERK, ne-Akt, kwaye yonyusa iphosphorylation ye-AMPK. I-Urolithin B ikwangumlawuli wobunzima bemisipha.

(1). I-Urolithin B inciphisa ukulahleka kobunzima bemisipha obangelwa kukuchongwa
(2). I-Urolithin B-inesisu semathambo sehypertrophy kwiimpuku
(3). Iziphumo ze-anabolic ze-urolithin B zixolelaniswe ne-androgen receptor
(4). I-Urolithin B ivuselela ukuhlanganiswa kweprotein kwi-C2C12 myotubes ngokwenza umqondiso we-MTORC1
(5). I-Urolithin B inqanda ukonakaliswa kweprotein ngokuhlisa umgaqo we-ubiquitin-proteasome
(6). I-Urolithin B inyusa umahluko we-C2C12 myotubes

isingqiniso

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[4] USingh, R. et al. Ukuphuculwa kokuqina kwesithintelo esiswini ngemetabolite ye-microbial ngokusebenzisa indlela yeNrf2. Nat. Commun. I-10, 89 (2019).
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[6] Gong, Z. okqhubekayo. I-Urolithin A inciphisa ukukhubazeka kwememori kunye neuroinflammation kwi-APP / iimpuku zePS1. J.Neuroinfigueation 16, 62 (2019).
[7] UFelder, TK okqhubekayo. Ukujikeleza ngokuthe ngqo kwe-phospholipids, ii-acylcarnitines, ii-amino acid kunye ne-biogenic amines ziimpawu zokuzilolonga ze-aerobic. J. Sci. IMed. Imidlalo 20, 700-705 (2017).
[8] Schooneman, MG, Vaz, FM, Houten, SM & Soeters, MR Acylcarnitines: ibonakalisa okanye ifaka ukunganyangeki kwe-insulin? Iswekile 62, 1-8 (2013).
[9] Isikhokelo kumaqhinga okuchonga kunye nokuNciphisa umngcipheko wovavanyo lokuqala lwezonyango lomntu kunye neMveliso zoPhando ngeMveliso ye-EMEA / CHMP / SWP / 28367/07 (i-Arhente yamaYeza yaseYurophu, 2007).
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