Ngaba i-MK-677 (Ibutamoren) isebenza kakuhle kulwakhiwo lweMisipha? Ukuhlolwa kwakhona
I-AASraw ivelisa i-Cannabidiol (CBD) ipowder kunye ne-Hemp ebalulekileyo yeoyile ngobuninzi!

 

Ngaba i-MK-677 (i-Ibutamoren) isebenza kakuhle kuVavanyo lweMisipha yeZakhiwo [2019 KUSHA]

 

 

I-1.Yintoni iMK-677 (Ibutamoren)?

I-MK-677 (i-Ibutamoren) i-powder (159752-10-0) yinto entsha ye-hormone yokukhula kwe-siriagague (GHS). I-hormone yokukhula eyimfihlo luyinto eyenzelwe ukusebenza njenge-secagague yokuncedisa ukunyusa amanqanaba okukhula kwehomoni. Ukukhula kweehomoni kuyimfuneko ukuze umzimba wakho usebenze ngokufanelekileyo. Oku kuya kukunceda ukuba uphucule ukukhula kwezicubu zomzimba.

I-MK-677 (Ibutamoren) ipowder ayiphazamisi ezinye iinkqubo zomzimba kunye zebhayiloji njengemveliso yehomoni yendalo. Kuthetha ntoni oku ukuba uya kuba nakho ukunyuka kwamanqanaba okukhula kwamahomoni ngaphandle kokufumana iziphumo ezibi njengokucinezelwa kwe testosterone. I-MK 677 izibonelelo zokwakha umzimba zininzi kodwa siza kuzixoxa zonke kamva kweli nqaku.

2. Kutheni iMK-677 (Ibutamoren) inegama elahlukileyo?

I-Ibutameron ikwabizwa ngokuba yi-mk677 i-nutrobal, i-Ibutamoren Mesylate kwaye abanye abantu banokuyibiza ngokuba yi-MK 677 (Ibutamoren) i-powderarm. Onke la magama abhekisa kumatshini omnye. Kungenxa yokuba abanye abantu bayayithengisa indawo njengesixhobo kodwa ezinye iingcali zithi ayisiyohlobo losapho lweemarmu.

I-Ibutamoren ikwajongwa njengechiza elikhethekileyo kuba kunqabile ukufumana ichiza elinamandla okukhuthaza amanqanaba okukhula kwehormoni kunye ne-IGF-1 (insulin-like ukukhula factor).

 

Ngaba i-MK-677 (i-Ibutamoren) isebenza kakuhle kuVavanyo lweMisipha yeZakhiwo [2019 KUSHA]

 

3. Isebenza njani iMK-677 (Ibutamoren)?

I-MK-677 (Ibutamoren) ipowder (159752-10-0) Isondlo sisebenza ngokwandisa imfihlo yehomoni yokukhula (GH) kunye nezinto ezikhulayo- 1 (IGF-1) .Kukwenza oku ngokuxelisa indlela esebenza ngayo i-hormone yegrelin. IGhrelin yi-hormone eyenzeka ngokwendalo ukuba awuzange uvele kuyo ngaphambili.

Oku kuyenza ukuba ibophe ngokulula kwenye ye-GHSR (i-ghrelin receptors) yengqondo. Nje ukuba ivuselelwe, i-ghrelin receptors emva koko isebenze ukukhula kwemveliso ye-hormone kwingqondo. Isebenza njenge-neuropeptide kwi-CNS (inkqubo yangaphakathi yeeseli). Le hormone ithandwa ngamandla ayo okukhuthaza umdla.

Ikwalawula ukuhanjiswa kwamandla kwimizimba yethu kwaye inefuthe kwindlela umzimba ugaya ngayo amafutha. Kananjalo inokuchaphazela amandla omzimba ukuba abuyele kwimeko ezinjengokukhuluphala kunye nesifo seswekile se-2.

Xa isetyenziswa ngokwayo, i-mk 677 inamandla okunyusa ukuvelisa kwe-HGH ngaphandle kokuphazamisa nayiphi na i-hormone. Uninzi lwabo bayithathileyo bayakudumisa nokongezwa kwe-mk 677 kuba ayicinezeli amanqanaba akhoyo e-testosterone kunye namahomoni okukhula, okuyibhonasi enkulu ukuba ucinga ngezibonelelo.

 

4. Izibonelelo ze-MK-677 (Ibutamoren)

  • Ukukhula kweMisipha kunye nokuBuyisa

Enye yeenzuzo eziphambili ze-mk 677 kukuphucula ukukhula kwemisipha kunye nokufumana kwakhona. Ukusukela ukuba ukongezwa kwe-mk 677 kunyusa i-IGF-1 kunye namanqanaba e-GH umsebenzisi anokubeka kubungakanani obukhulu ngokulula. Oku kuxhaswe luphando kunye nesayensi. Izifundo ezenziweyo zibonise ukonyuka okukhulu kubunzima be-mussle ngakumbi kubantu abanesiphene sokukhula kwehomoni kunye namadoda amadala ngakumbi iminyaka engama-60 nangaphezulu. Uninzi lophononongo lwe-mk 677 olusuka kubasebenzisi lukwacebisa ukuba eli chiza linesiphumo esihle kwisakhiwo sezicubu zomzimba.

  • Ukwanda kweethambo

Njengezilonda zobudala, uxinzelelo lwethambo luyancipha. Uninzi lwabantu abadala luhlushwa bubuthathaka bethambo kunye nethambo elibangela ukungabikho kokuhamba kunye nentlungu. Abanye abantwana kunye nabantu abadala abancinci banokuhamba nakule nto kodwa kunokubangelwa kukuncipha koxinano lwethambo. MK-677 isongezelelo somgubo ivuselela ukukhula kwehomoni kwaye kusebenze ukuguquka kwamathambo. Yile ndlela ichiza elikwazi ngayo ukuncedisa ukuqinisa amathambo.

  • Ukuthintela ukugqobhoza kwemisipha

Kwisifundo sophando lwenzululwazi olwenziwe kubantu abasibhozo bokuzila ukutya, u-Ibutamoren mk 677 wakwazi ukubuyisa ukubhuqwa kwezihlunu kunye nokulahleka kweprotein. Olunye uphononongo lubonakalisile ukuba iyeza lanceda izigulana ezalupheleyo ezazaphuke amanqindi ukufezekisa amandla emisipha kunye nokuzuza okungcono.

  • Ukukhula kweTendon kunye noThintelo olubi

Phantse wonke umntu owakha umzimba uvuma indlela ukonzakala okuthile okulibazise ngayo inkqubela-phambili yakhe ngokubavalela ngaphandle kwejimini kangangeentsuku, okanye iiveki. Ukuba uqhubeka uchitha ixesha lakho kwindawo yokuzivocavoca, ukwenzakala akunakuphepheka. Kwakhona, ukwanda ngokukhawuleza kwemisipha kubangelwa ziiseshoni zoqeqesho olunzima, kunokubeka uxinzelelo olukhulu kwizicubu zakho kubandakanya amathambo akhokelela ekonzakaleni.

Xa kuziwa kulungiso lwee-tendon ezonakalisiweyo, i-ligaments, kunye namathambo, ukukhula kwehomoni kubalulekile. Ngokonyusa amanqanaba okukhula kwehomoni, i-mk 677 eyongezayo iqinisekisa ukuba izicubu ezihlangeneyo ziyalungiswa kwaye zigcinekile zisempilweni. Ukuxinana kwamathambo kuphuculwe kakhulu kwaye ke ngenxa yoko amathambo akho aya kuphucula amandla okwenza ukuba ubambe ubunzima bemisipha emininzi. Ngenxa yoko, awuyi kuphinda ubenokulimala okuqhelekileyo.

  • Ukulahleka kwamafutha

Uninzi lwabasebenzisi bayavuma ukuba mk677 ibancede ukuba khawulezisa ukulahleka kwamafutha. Iziphumo zokulahleka kwe-Mk 677 zichazwe ukuba ziyamangalisa mhlawumbi kuba i-GH kuphela kwehomoni enokukunceda utshise amanqatha angaphantsi kunye ne-visceral fat ngelixa ikwenza ukuba ukhulise ubunzima bemisipha. Ngenxa yoko, i-Ibutamoren ihlala yongezwa kwiinkqubo zokuphindaphinda umzimba.

  • Ulusu olungcono, izipikili kunye neenwele

Ukukhula kwehomoni kuye kwangqinwa ukuphucula iiseli zolusu. Ukusukela i-MK-677 isebenzisa i-GH, yiyo loo nto ichiza likwazi ukuvuselela kunye nokuvuselela ukubonakala kweenwele, izikhonkwane kunye nolusu.

  • Iziphumo zeNootropic

Enye inzuzo ye-mk 677 kukuba ivuselela i-ghrelin receptor kwaye inokubangela nootropic iziphumo. Ngokutsho kophando olwenziwe yi-NCBI kunokunceda ukuphucula ukusebenza kwengqondo ngokuphembelela iindlela ezimbini ngokungangqalanga. Ezi ndlela zibandakanya ukonyusa i-IGF-1 enceda ekuphuculeni ukugcinwa kwememori kunye namandla okufunda. Kwaye, ngokwandisa umgangatho kunye nobungakanani bokulala kwe-REM. Ukulala kubalulekile kuba kuqinisekisa ukusebenza kakuhle kwengqondo.

  • Ukuthintela ukukhula kwe-hormone yokukhula

I-Mk 677 inyusa i-IGF-1, IGFBP-3, kunye nokukhula kwamanqanaba ehomoni kubantwana abanesiphene sokukhula kwehomoni ngaphandle kokuguqula ukugxila kwecortisol, insulin prolactin, glucose, thyroxine (T4), i-thyrotropin okanye i-triiodothyronine (T3).

I-Ibutamoren ibonakalise umphumo ofanayo kumadoda angenanto ye-GH, kodwa iswekile kunye ne-insulin inyukile, nayo.

  • Pholisa amanxeba

Ukukhula kwehomoni kunyusa inxeba lokuphilisa kunye nokuvuselelwa kwezicubu, ke ngoko i-Mk 677 inceda kwezi ngokwandisa amanqanaba okukhula kwamahomoni. Oku kuxhaswa ziingxelo zabakhi bomzimba ababesebenzisa ibutamoren ngaphambili.

  • Ukunyanga iiHangovers

Abantu abasebenzise i-MK-677 ngaphambi kokuxela imvakalelo yokukhululeka kwii-hangovers.

  • Yenza umdla wokutya

Ukuba yi-Ghrelin Mimetic kuya kufuneka ulindele ukuthatha ukutya okuninzi ngelixa uphantsi kwe-Ibutamoren. Nokuba oku kuluncedo okanye kuyasilela ngokweenjongo zakho, kuyakufuneka uqonde ukuba sesinye seziphumo ezingangqubaniyo ze-mk 677.

  • Ukuphila kakuhle

I-Ibutamoren isebenza kakuhle ekomelezeni ukhuseleko kunye nokuba sempilweni. Amandla omzimba wakho okulwa kunye nokuhlala kude nokuphazamiseka kwamaxesha onyaka kunye ne-allergies kuphuculwe kakhulu. Uya kuqala ukuphila ubomi obutofotofo obuzele luxolo lwengqondo.

5. Umjikelo we-MK-677 (Ibutamoren)

Umjikelo 1: Ukufezekisa eyona MK 677 (Ibutamoren) yomgubo, kufuneka uqale nge-10mg ngeyure ezingama-24 kwiiveki zokuqala ezili-11 zokusetyenziswa ngaphambi kokuba ungeze kwi-20-25mg ngeyure ezingama-24 kamva kwi-12th iveki. Oku kunokuthathwa njengamanzi, ngomlomo okanye nge-capsule.

Umjikelo 2: Ungaqala nge-15mg ngeyure ezingama-24 kwaye wandise ubude bomjikelo wakho weMK 677 ngaphaya kweeveki ezili-12. Ngokwenza njalo, awuzukuba nexhala malunga neengxaki zepituitary gland okanye ezinye iziphumo ebezingalindelekanga.

Umjikelo 3: Uninzi lwabakhi bomzimba abaphuma kumjikelo we-opts yokwandisa idosi ye-MK 677 ukuya kwi-50mg ngosuku kunye nokugcina ubude be-MK 677 yeeveki ezisibhozo.

Umjikelo 4: Ukuba ufuna ukwakha izihlunu, abasebenzisi bacebisa ukuthatha idosi ye-Ibutamoren ye-30mg ngeyure ezingama-24.

Umjikelo we-5: Ukuba eyona njongo yakho iphambili kukususa amanqatha, uninzi lwabasebenzisi abanamava bacebisa ukuthatha i-20mg ngeyure ezingama-24.

Umjikelo we-6: Ukuba eyona njongo iphambili kukuphilisa ukonzakala, idosi ye-MK 677 ye-10-20mg ngosuku iyacetyiswa.

Iindaba ezimnandi zezokuba awuyi kuyidinga i-PCT (iTranscycy Therapy) ye-mk 677 njengoko ingaphazamisi nayiphi na ihomoni.

 

Ngaba i-MK-677 (i-Ibutamoren) isebenza kakuhle kuVavanyo lweMisipha yeZakhiwo [2019 KUSHA]

 

6. Yeyiphi eyona dosage ye-MK-677 (Ibutamoren)?

Uphando lwethu kunye neengxelo ezivela kubasebenzisi abanamava zibonisa ukuba i-20mg ukuya kwi-30mg yeyona idosi ilungileyo ye-MK 677. Abanye abasebenzisi baxele ukuthatha ngaphezulu kwe-30mg ye-ibutamoren ngosuku, kodwa oku akuzange kunike ziphumo zibhetele. Ubude be-MK 677 yomjikelo bubonakalise bubaluleke ngakumbi kunedosi ye-ibutamoren.

Kubalulekile ukuba uthathe i-ibutamoren ixesha elide. Amanqanaba okukhula kwehomoni kufuneka akhule kancinci emzimbeni wakho. Ukukhula kancinci kwamahomoni kunokuthatha ukuya kwiiveki ezimbalwa ngaphambi kokuba uqalise ukuziva iziphumo.

Injongo yakho ikwamisela inani le-mk 677 ekufuneka uyithathile. Nazi iidosi eziphakanyisiweyo zeenjongo ezahlukeneyo.

  • Ukwakhiwa kwemisipha: 30mg ngemini
  • Ukuphulukana namafutha: 20mg ngosuku
  • Ukuphiliswa okwenzakeleyo: I-10-20mg ngosuku

Ukuba awuzange usebenzise Ibutamoren powder (I-159752-10-0) ngaphambili, kuyacetyiswa ukuba uqale nge-10mg ukubona indlela umzimba ophendula ngayo kuyo.

 

7. Ngaba i-MK-677 (Ibutamoren) ineziphumo ezibi?

I-Mk-677 ineziphumo ezimbalwa kakhulu kwaye zincinci iziphumo ebezingalindelekanga ukuba zikhona, kwaye ukuba zenzeka zilawuleke ngokulula. Nazi ezinye zeziphumo ebezingalindelekanga:

Ubuthongo obude

Abanye abasebenzisi banokulala bengaphazanyiswa kangangeyure ezingama-12 emva kokuthatha i-ibutamoren okukhokelela kwimvakalelo yokudinwa ngokubanzi ngosuku olulandelayo. Ukuba udibana noku, kufuneka ulinganise idosi okanye uyihlule ibe kabini ngemini kwaye le mpembelelo ye-MK 677 izakuya ngokwayo.

Cramps

Nangona isenokungafumaneki kubo bonke abasebenzisi, abanye abasebenzisi bayifumana imisipha ethambileyo xa uthatha ibutamoren. Esi siphumo secala leMK 677 siza kukuphelisa wakuyeka ukuthatha ibutamoren.

Unokuva ukugcinwa kwamanzi kunye nokunyuka komnqweno wokutya kodwa oku kuhlala kuphakama xa uthatha i-ibutamoren dosage ephezulu. Emva kwexesha elithile, zonke iziphumo ebezingalindelekanga ziya kuhamba ngokwazo xa uyeka ukuthatha i-X 677.

 

8. Buphi isiqingatha sobomi be-MK-677 (Ibutamoren)?

I-Mk 677 isiqingatha sobomi imalunga neeyure ze-24. Oku kuthetha ntoni kwithiyori kukuba umntu unokuthatha idosi yakhe yemihla ngemihla ngexesha elinye. Kodwa kuye kwaqwalaselwa ukuba, ukuba uthatha idosi enye ngosuku, amanqanaba e-hormone yokukhula kwawo anokuhamba kanye.

Oku kunokulandelwa yimvakalelo yokudinwa okanye ukunxila. Oku kunokuthintelwa kukwahlulahlula idosi yakho kubini ngalo naluphi na usuku olunye okanye usebenzise idosi ngaphambi nje kokuba ulale. Ngokwenza njalo, uyolala njengenkosi kwaye ukuvelisa kwakho akuyi kuchaphazeleka kulo lonke usuku olulandelayo.

 

9. Iziphumo zeMK-677 (Ibutamoren)

Zichanekile ukuthi iziphumo ze-Mk 677 ekwakhiweni komzimba kunye nolunye usetyenziso olukhankanywe ngaphambili zilungile. I-Ibutamoren yikhomponenti efanelekileyo kakhulu kuba iphucula ukwakhiwa kwemisipha, kunye nokuncedisa ekuphuculeni ulusu, iinwele kunye nokutsha kwamafutha ngokunjalo.

Abasebenzisi ababelane nge-Mk 677 ngaphambili nangemva kweefoto kunye neziphumo zabonisa ukuba ibutamoren yakwazi ukutshintsha ukwakhiwa komzimba wabo kakhulu. Bakwazi ukongeza isixa esikhulu semisipha ngelixa belahlekelwa ngamanye amafutha omzimba.

Xa i-ibutamoren isetyenziswa kunye nezinye ii-SARM zokwakha umzimba njengazo MK-2866 kwaye LGD-4033, iyakwazi ukutshintsha umzimba wakho ngokupheleleyo, inike iziphumo zokubetha kwengqondo. Kuya kufuneka uqaphele ukuba kufuneka usebenze kwaye ugcine ukutya okufanelekileyo ukuba ufuna ukufumana i-Ibutamoren powder (159752-10-0) yokwakha iziphumo zomzimba.

 

Ngaba i-MK-677 (i-Ibutamoren) isebenza kakuhle kuVavanyo lweMisipha yeZakhiwo [2019 KUSHA]

 

10. Ngaba i-MK-677 (Ibutamoren) FDA ivunyiwe?

Kuba ibutamoren iseliPhando elitsha leziyobisi, ayikavunywa yi-FDA. Nangona kunjalo, i-mk 677 iye yasetyenziswa kuvavanyo lweengcali zokwakha izakhiwo zomzimba eziya kuthi zivume ukuba ichiza likhuselekile. Kuye kwafundwa ngokubanzi ngabaososayensi abavuma ukuba ichiza liyasebenza.

 

11. Ngaba i-MK-677 (Ibutamoren) ikhuselekile?

I-Ibutamoren ikhuselekile ukuba ithathwe kwiidosi ezicetyiswayo. Kukhuseleke kakhulu kubantu abasempilweni. Nangona kunjalo, ukuba ichiza lithathwe kwiidosi eziphezulu kunokucetyiswa, abasebenzisi banokufumana i-edema kunye nokuqina kwemisipha. Kodwa kutheni kufuneka ufune ukuthatha iidosi eziphezulu kunethamo elicetyiswayo?

Iziphumo ezimbalwa ezinokubakho ezinokubakho zisekwa ngokwazo xa uyekile ukusebenzisa i-Ibutamoren. Ngapha koko, zilawulwa ngokulula xa usebenzisa iyeza.

12. Ngaba i-MK-677 (i-Ibutamoren) isemthethweni ukuba Uyithenge?

Uninzi lwabantu luyabuza, ngaba iMK 677 iyathengiswa? Ukuba ungomnye wabo, ungakhathazeki, siza kuwuphendula lo mbuzo apha.

Okwangoku, i-MK-677 powder (i-159752-10-0) ifumaneka ngokuthengiswa njengechiza lophando, ngoko ke, kunzima ukufumana eli chiza ukuba uthi ulifuna ngokwakha umzimba. Nangona kunjalo, uninzi lwabakhi bomzimba bathi bayithenga ukuze isetyenziselwe uphando kuphela ukuze bathethelele ukuthenga kwabo. Ngaphambi kokuba ucofe iqhosha elithi 'MK 677 thenga kwi-intanethi', qiniseka ukuba umthengisi othengayo kuye kusemthethweni kwaye kusemthethweni. Kuya kufuneka ukuba uqiniseke ukuba uthenga eyona yeyona chiza icocekileyo kuba uhlobo olungacocekanga lwesondlo lunokuza neziphumo ezibi kakhulu.

 

13. I-MK-677 (Ibutamoren) yokwakha umzimba

Ibutamoren kutshanje uye waduma ngokumangalisayo kulwakhiwo lomzimba. Esona sizathu siphambili sokuba i-mk677 i-nutrobal isetyenziswe kakhulu kulwakhiwo lwezihlunu ngeenjongo zokunyusa amanqanaba e-GH. Wonke umntu okwakha umzimba uhlala ejonge phambili ekubeni ngoyena mntu ungoyena uphambili kunye noyena mkhulu.

Kuba iihomoni zokukhula zidlala indima enkulu ekwakheni umzimba, bafuna ukuba kumanqanaba aphezulu kangangoko kunokwenzeka ngelixa bekhuselekile. Amanqanaba aphezulu ama-hormone okukhula, akhawuleza kwaye kulula ukuba ukwakha umzimba uyakwazi ukongeza izihlunu ezongezelelweyo.

Kuba iiHormone zokuKhula zibiza kakhulu azikho ezinye izisombululo ezisepokothweni zokunyusa ukukhula kwehomoni, ngaphandle kweNutrabol. UMk 677 yindlela efikelelekayo kakhulu xa kuthelekiswa nayo I-HGH (ii-Hormones Zokukhula koluntu) kwaye ingawandisa ngokukuko amanqanaba okukhula kwe-hormone yomntu ukuya kwinqanaba elikhulu.

Unokwenza i-odolo ye-MK-677 ye-bulk kwi-intanethi. I-MK 677 yentengiso ifumaneka ngokusemthethweni njengekhemikhali yophando. Uya kubona kwakhona abakhi abaninzi bomzimba abathenga ibutamoren kwaye babanga ukuba isetyenziselwe uphando kuphela.

Kukwabalulekile ukuba uyazi ukuba iNutrobal ihlala igcwele IiSARM. Umzekelo ogqibeleleyo yindibaniselwano ye-S23, MK-677, kunye I-RAD140 (Testolone) ipowder.

 

Ucaphulo 

  1. Ilayibrari yeSizwe kaZwelonke yezeNyango, amaZiko eSizwe wezeMpilo, uRalf Nass, uSuzan S. Pezzoli, uMary Clancy Oliveri, uJames T. Patrie, uFrank E. Harrell, Jr., Jody L. Clasey, uSteven B. HeymsfieldMark A. Bach, uMary U-Lee Vance, kunye noMichael O. Thorner, i-MB, i-BS, i-D.Sc, Iziphumo ze-Orali Ghrelin Mimetic ekubumbeni komzimba kunye neziPhumo zeKlinikhi kubantu abadala abaNempilo: Isilingo esingaLawulwa.
  2. UJanssen I, Heymsfield SB, Wang Z, Ross R. Ubunzima bemisipha kunye nokusasazwa kwamadoda nabasetyhini abangama-468 abaneminyaka eyi-18-88 yr. J Appl Physiol. Ngo-2000; 89: 81-88
  3. Adunsky A., Chandler J., Heyden N., Lutkiewicz J., Scott BB, Berd Y.,. . . IPapanicolaou DA (2011). I-MK-0677 (ibutamoren mesylate) yokunyanga abaguli abachacha ekwaphulweni kwenyonga: isifundo se-IIb esigcweleyo, esingenamkhethe. Oovimba abagciniweyo beGerontology kunye neGeriatrics, 53 (2), 183-189.
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