I-AASraw ivelisa i-NMN kunye ne-NRC powders ngobuninzi!

β-Nicotinamide Mononucleotide

Akukho kalo Udidi:

I-AASraw ine-qualification yokubonelela ngemveliso yokuguga-i-NMN Powder ngobuninzi kunye nommiselo weCGMP kunye nolawulo lwekhwalithi ephezulu. Imveliso yethu ephakathi yenyanga inokufikelela kwi-1500kg. Wamkelekile ukuba unxibelelane nathi ngolwazi oluthe kratya lokuthenga:
Isimo: Isisitokhwe

Icandelo leepakethe: 1kg / ingxowa, 25kg / igubu

Ingcaciso yeMveliso

Iimpawu ezisisiseko

Igama lemveliso β-Nicotinamide Mononucleotide (NMN)
Inani leCAS 1094-61-7
I-Molecular Formula C11H15N2O8P
Ubukhulu beFormula 334.22
Iintetho ezifanayo I-NMN;

β-D-NMN;

I-BETA-NMN;

I-beta-D-NMN;

Umgubo we-NMN;

Ukucocwa kweNMN;

I-NICOTINAMIDE RIBOTIDE;

INicotinamide nucleotide;

INicotimide mononucleotide.

Kubonakala Powder
Ukugcina nokuPhatha 2-8 ° C kwindawo eyomileyo

Indawo ephambili:

♣ I-NAD + yinto ebalulekileyo yecoenzyme efunekayo ebomini nakwimisebenzi yeselula.

Amanqanaba eNAD +, ngakumbi ifom ye-NAD +, ukwehla ngokwendalo kunye nobudala kwizicubu ezininzi.

Body Umzimba wenza i-NMN njengenyathelo eliphakathi okanye "umanduleli" kwi-NAD +. Beka ngokulula: amanqanaba aphezulu eNMN athetha amanqanaba aphezulu eNAD +.

Yaziswa: Kumanqaku alandelayo, I-NMN esetyenzisiweyo endaweni ye-β-Nicotinamide Mononucleotide (NMN)


 

Imvelaphi ye-NMN- NAD + kunye neNMN

I-NAD + yindawo ekhethekileyo, eyenziwa ngokuqhubekayo emzimbeni wethu kwaye isetyenziswe zii-enzyme ezininzi eziphambili ukunceda ukukhuthaza ukusebenza kweselfowuni. Nangona kunjalo, kuba i-NAD + isetyenzisiwe kwinkqubo yokunyusa ezi nkqubo ze-enzyme, siqala ukungena kwi-NAD + intsilelo kwiindawo ezahlukeneyo kubomi bethu, ngokunyuka rhoqo njengoko sikhula. Kuba ezi NAD + zinikwe amandla enzymes zidlala indima ebalulekileyo ekugcineni amandla eselula, kunye nokukhuthaza impilo yeselfowuni, ukwehla kwe-NAD + kunokuba yingozi enkulu kwimpilo yethu iyonke.

Ngenxa yoku, uphando oluninzi luqalisiwe ekukhuthazeni amanqanaba e-NAD + emzimbeni. Ithiyori emva kokukhuthaza amanqanaba e-NAD + kukuba iya kuba nefuthe elixhasayo kwimisebenzi emininzi ebalulekileyo yomzimba, kwaye ke inokunceda ukukhuthaza ubomi obude. Eyona nto ibaluleke kakhulu, amanqanaba aphuculweyo e-NAD +, akufuneki akhuthaze kuphela ubomi obude, inokunceda ekuphakamiseni umgangatho wobomi obungcono njengoko sikhula!

Ke siphakamisa njani amanqanaba e-NAD +? Oku kubonakala ngathi kunzima. Nangona kunjalo, uphando lwakutsha nje luveze ikhompawundi eyahlukileyo ebizwa ngokuba yiNicotinamide Mononucleotide (NMN), enokuthi isetyenziswe ngumzimba njengesandulela esisebenza kakuhle kwiNAD +. Kwithiyori, oku kuthetha ukuba i-NMN inokukhuthaza ubomi obude nobusempilweni!

Nangona kunjalo, i-NMN ayisiyiyo kuphela impilo ende ekhuthazayo yokuxhasa. Ngapha koko, i-NMN sisongezo esimnandi kubo bobabini abantu abancinci nabadala, njengoko inefuthe elibalulekileyo nokuba ungakanani na. Abantu abancinci nabadala bobabini badinga amanqanaba aphezulu eNAD + kwimizimba yabo nakwiingqondo zokubaleka kwintsebenzo ephezulu. Amanqanaba akho aphezulu e-NAD +, amandla esisele ngakumbi uya kuba nawo, kwaye ngcono umzimba nengqondo yakho ziya kuba nakho ukusebenza kwiimeko ezifuna kakhulu. Masithembeke, ngubani ongenakukwazi ukusebenzisa umda omncinci kweli hlabathi likhawulezayo nelinyanzelisayo? Ke, ukuba ufuna ukuhlawulisa iiseli zakho, kwaye unomdla wokuzuza emzimbeni nasengqondweni yakho nge-NAD + eyongezelelweyo xa ukhaba, siya kukukhuthaza ukuba uqhubeke ufunda le bhlog ibanzi kakhulu eyilelwe ukukunceda ufumane olona ngaphandle kokongezwa kweNMN!

 

Yintoni i-NMN?

I-NMN (iNicotinamide Mononucleotide) yeyosapho lwee-nucleotides, iimolekyuli eziphilayo ezifumaneka kuninzi lokutya esikutyayo. Njengazo zonke i-nucleotides, i-NMN inamalungu ama-3: isiseko se-nitrogen, iswekile, kunye neqela le-phosphate.

Ngelixa uninzi lwee-nucleotide zisetyenziselwa ukwakha i-DNA, i-NMN isetyenziselwa ukwenza i-nicotinamide adenine dinucleotide (NAD +) kunye nokulungelelanisa ulungelelwaniso lwamandla. Umzimba wenza i-NMN njengenyathelo eliphakathi okanye "umanduleli" kwi-NAD +. Beka ngokulula: amanqanaba aphezulu eNMN athetha amanqanaba aphezulu eNAD +.

I-NAD + yonyusa eyona mali iphambili yamandla omzimba (i-ATP), ilinganisa isingqisho se-circadian, kwaye yenza amandla okuphendula kwe-enzymatic-uninzi lwayo olulibazisa ukuguga. Amanqanaba eNAD +, ngakumbi ifom ye-NAD +, ukwehla ngokwendalo kunye nobudala kwizicubu ezininzi.

 

Isebenza njani i-NMN? / Kutheni ufuna isongezelelo seNMN?

I-NR kunye ne-NMN zombini ziluncedo kuba ziphakamisa amanqanaba e-NAD +, ancipha ngokobudala. I-NAD + ibalulekile kwimetabolism yeselula, ijika izakhamzimba zibe ngamandla eselfowuni, kwaye ikwasebenza nee-sirtuins, iseti yeeproteni ezilawula impilo yeselula. Sonke sifumana i-NAD + kwimizimba yethu ngenxa yokutya kwethu, ngokutya ukutya kunye ne-NAD + eyandulelayo. Ngelixa i-NR kunye ne-NMN zifumaneka kumkhondo wokutya kwiindidi ngeendidi zokutya, nangona kunjalo, umntu akanakutya ngokwaneleyo kuyo nantoni na yokunyusa amanqanaba e-NAD +. Ngenxa yoko, ukongeza kwisandulelo se-NAD + kunokunceda ukunciphisa ukwehla.

 

Izibonelelo zeNMN

  • I-NMN yonyusa ubonelelo lwamandla kwiiseli ezigugayo:

Iiseli zithatha kwaye zilungisa amafutha ukuze zenze imisebenzi yazo. Njengokuba uneminyaka yobudala baphulukana nobuchule, bebanyanzela kwimeko eyaziwa ngokuba yi-cellular senescence okanye ukuguga kwezinto eziphilayo eziza nezinye iziphumo eziyingozi. Oku kuthetha ukuba ukongeza nge-NMN kunika iiseli zakho indlela ekhawulezayo yokufaka i-refuel kunye nokukhuthaza ukwahlukana kweseli kunye nokukhula.

 

  • I-NMN iyanceda ekulweni nezifo ze-metabolic:

Njengoko uneminyaka yobudala, iimeko ezifana nesifo sikashukela, ukukhuluphala, i-dyslipidemia, kunye ne-non-alcohol alcohol fatty disease (NAFLD) iya kuba yinto exhaphakileyo. Zibangelwa kukuncitshiswa kwamanqanaba eNAD +. I-NMN isebenza ngendlela yokuhlangula ukonyusa amanqanaba e-NAD + ngokwenza njalo ukuphucula ezi kunye nezinye izifo ze-metabolic.

 

  • I-NMN ivuselela ukuhamba gwenxa kwegazi:

Njengokuba umzimba udala, inani kunye nemisebenzi yeeseli ze-endothelial (ECs) ezifaka imithambo yegazi ziyancipha. iinqanawa.

 

  • I-NMN icinezela ukufumana ubunzima obunxulumene nobudala:

Njengokuba abantu bekhula, baya besisindo. Kwisifundo se-2016, kwafunyaniswa ukuba izifundo ezinikwe i-NMN zabona ukutyeba kwabo kwehla kunye nokunyuka kobunzima. Ngokuxhasa nge-NMN, unganciphisa ubunzima kwaye wakhe izihlunu -indlela ezimbini ezinamandla zokuphucula impilo yemisipha kwaye ujongeke kwaye uzive umncinci!

 

  • I-NMN yonyusa imetabolism yamandla:

Ngokulamla ukuhlanganiswa kwe-NAD +, i-NMN inceda ekophuleni izakhamzimba kumandla, inika amandla imisebenzi yeseli ebalulekileyo kunye nokunciphisa uxinzelelo lwe-oxidative. Ezi nkqubo zebhayoloji ziyacotha kwaye zinokumisa inkqubo yokuguga. I-NMN ayikhulisi kuphela amandla akho kodwa iyanceda ekulungiseni iiseli zakho!

 

Ukhuseleko lweNMN kunye neziphumo ebezingalindelekanga

I-NMN ithathwa njengekhuselekileyo kwizilwanyana, kwaye iziphumo zithembisa ngokwaneleyo ukuba kuvavanywa izilingo zabantu. Le molekyuli ikakhulu ithathwa njengekhuselekileyo kwaye ayinetyhefu, kwanaxa kugxilwe kwiimpuku nakwisifundo somntu. Ixesha elide (unyaka omnye) ukulawulwa ngomlomo kwiimpuku akunaziphumo zetyhefu. Olona vavanyo lokuqala lwezonyango ebantwini lwagqitywa kwaye ubungqina buxhasa umbono wokuba ayiyityhefu kwiidosi enye.

Nangona isifundo esinye samadoda aseJapan apapashwa ngo-Novemba ngo-2019 aqaphele ukuba izifundo zonyuse amanqanaba e-bilirubin egazini labo kulandela ukulawulwa kwe-NMN, la manqanaba ahlala kuluhlu oluqhelekileyo. Izifundo ezizayo kufuneka zijolise kukhuseleko lwexesha elide kunye nokusebenza kokusetyenziswa. I-NMN ayinxulumene nayo nayiphi na eminye imiphumela emibi eyaziwayo.

 

I-NMN njengeNAD + yokuXhasa-ethandwa kakhulu

Ukugxilwa kwe-Intracellular ye-NAD + kuncipha ekugugeni njengesiqhelo imisebenzi yeselfowuni ichitha i-NAD + yokuhambisa ixesha. Amanqanaba aphilileyo eNAD + acingelwa ukuba abuyiselwe ngokuxhaswa nge-NAD + zangaphambili. Ngokophando, i-precursors ezinje nge-NMN kunye ne-nicotinamide riboside (NR) ijongwa njengezongezo zemveliso ye-NAD +, inyusa ukugxila kwe-NAD +. UDavid Sinclair, umphandi we-NAD + waseHarvard, uthi, "Ukondla okanye ukusebenzisa i-NAD + ngqo kwizinto eziphilayo ayisiyonto ilungileyo. Imolekyuli ye-NAD + ayinakukwazi ukuwela ngokukhawuleza inwebu yeseli ukungena kwiiseli, kwaye ke ngenxa yoko ayinakufumaneka ngokuchaphazela ngokuqinisekileyo imetabolism. Endaweni yoko, iimolekyuli ezingaphambili kwi-NAD + kufuneka zisetyenziselwe ukunyusa amanqanaba e-bioava ezikhoyo e-NAD +. Oku kuthetha ukuba i-NAD + ayinakusetyenziswa njengesongezelelo esithe ngqo, kuba ayifakwanga lula. I-NAD + zangaphambili zifunxeka ngokulula kune-NAD + kwaye zisebenza ngokufanelekileyo.

 

Kuya kufuneka uyazi ngaphambi kokuba uthenge iPowder yeNMN kwi-Intanethi

 

Isakhiwo esingazinzanga.

Isizukulwana sokuqala se-NMN esinoxinano oluphantsi sasingenakulunga kakhulu. Inguqulelo ephuculweyo ye-AASraw yeNMN izakuhlisa iindleko zokuvelisa ngokuhamba kakuhle komgubo okhokelela ekwandeni kwamandla emveliso njengoko kuya kuba lula ukuqhuba ngoomatshini. Ngaphezulu, le nguqulo iya kukhokelela kumthamo ofanayo weepilisi njengenguqulelo ephantsi yoxinano kunzima ukudibanisa ngokufanayo. Okokugqibela, uxinizelelo lwe-NMN oluxineneyo kwifom yecwecwe lunokusasazeka ngokulula ngexesha lokuhamba.

Abathengi abaninzi bazama ukuyisombulula le nto ngokuthi bongeze ezinye izongezo kodwa oko kukhokelela kumacwecwe amakhulu, angalunganga kubathengi kubantu ekujoliswe kubo abadala. Ke, uxinizelelo oluphantsi lwe-NMN lulungele kuphela ukwenziwa kwemveliso ye powder.

 

Ingredients Izithako zeNMN ezingcolileyo.

Ngelishwa imarike izaliswe ngamanzi ngeNMN engeyonyani. Ukusukela oko i-NMN yangena kwimakethi kunyaka ophelileyo uninzi lweempawu zeNMN zivele zilandelelana. Kunzima kakhulu kubavelisi kunye nabaxumi bethu ukuba baxelele izinto zokwenyani ezikumgangatho ophezulu ezivela kwizinto ezingezizo nezokucoceka ezithengiswa kwi-Intanethi.

Ezinye iimveliso ze-NMN ezithengisiweyo zinobunyulu obungaphantsi kwama-80%. Abathengi kunye nabathengi abazi nje ukuba zeziphi izinto ezizalisa okanye ezingcolisayo ezikhoyo kwenye i-20% yemveliso.

Ngokwenyani sifumanise ukuba abathengisi be-NMN abaninzi bathengisa i-nicotinamide (ivithamin B3 ebiza ixabiso eliphantsi) okanye i-nicotinamide riboside endaweni ye-NMN. Abanye abathengisi bongeza umgubo wokunciphisa i-NMN kwaye bakhohlise abathengi babo. Ezi mveliso zihlala zingabizi kodwa ngaphandle kweziphumo eziluncedo.

 

Ukungabikho kokhuseleko kunye nedatha efanelekileyo.

I-NMN iya ithandwa ngakumbi e-US, eYurophu, eJapan nase China, njlnjl, kodwa ukhuseleko oluninzi kunye nedatha efanelekileyo isasilela. Abantu abaninzi abasayithembi le mveliso, ke intengiso ye-NMN ihlala isikelwe umda. Ngokwenyani i-NMN ekuqaleni ibikho emzimbeni womntu kunye nemifuno efana ne-broccoli, ke ayinangxaki yokhuseleko. Kodwa lixesha eliphezulu ledatha eqhubeka nokuqinisekisa ukusebenza kwayo.

 

isingqiniso

[1] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC, et al. [2018] (UCanzibe 27). "+ Yehla". Iseli Metabolism. 5 (1081): 1095-10.e10.1016. ikhonkco: 2018.03.016 / j.cmet.5935140. I-PMID 29719225.

[2] Stipp D (Matshi 11, 2015). "Ngaphandle kweResveratrol: Inkqubo yokulwa nokuguga yeNAD". Inethiwekhi yeNzululwazi yaseMelika.

[3] ICambronne XA, iKraus WL (Okthobha 2020). "+ Synthesis kunye neMisebenzi kwiiseli zeMammalian". Iindlela eziqhubekayo kwiNzululwazi yeBhayiloji. Ezama-45 (10): 858-873. ikhonkco: 10.1016 / j.tibs.2020.05.010. I-PMC 7502477. PMID 32595066.

[4] IBogan KL, iBrenner C (2008). "I-Nicotinic acid, i-nicotinamide, kunye ne-nicotinamide riboside: uvavanyo lweemolekyuli ze-NAD + zandulela iivithamini kwisondlo sabantu". Uphengululo lonyaka lweZondlo. 28: 115-30. ikhonkco: 10.1146 / annurev.nutr.28.061807.155443. IINKCUKACHA:

[5] Yue Yang, Anthony A. Sauve. I-NAD + imetabolism: I-Bioenergetics, ukutyikitya kunye nokunyanzeliswa konyango. IBiochim Biophys Acta, 2016; INGXELO: 10.1016 / j.bbapap.2016.06.014.

[6] Izigayo KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Ulawulo lwexesha elide lweNicotinamide Mononucleotide Lunciphisa ukwehla okuhambelana nomzimba kwiimpuku. Iseli yeMetab, ngo-2016; INGXELO: 10.1016 / j.cmet.2016.09.013.

[7] UNiels J. Connell, uRiekelt H. Houtkooper, uPatrick Schrauwen. I-NAD + imetabolism njengethagethi yempilo ye-metabolic: siyifumene imbumbulu yesilivere? Iswekile, 2019; INGXELO: 10.1007 / s00125-019-4831-3.

[8] UAnn Katrin-Hopp, uPatrick Grüter, uMichael O. Hottiger. Ummiselo weGlucose Metabolism yi-NAD + kunye ne-ADP-Ribosylation. Iiseli, 2019; INGXELO: 10.3390 / iiseli8080890.

[9] IShuang Zhou, iXiaoqiang Tang, iHou-Zao Chen. I-Sirtuins kunye ne-Insulin Resistance. Ngaphambili Endocrinol (Lausanne), 2018; INGXELO: 10.3389 / fendo.2018.00748.