I-NR powder - Umthengisi weFektri yoMvelisi
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I-Nicotinamide riboside chloride

Akukho kalo Udidi:

I-AASraw ine-qualification yokubonelela ngemveliso yokuguga-i-NRC Powder ngobuninzi kunye nommiselo weCGMP kunye nolawulo lwekhwalithi ephezulu. Imveliso yethu ephakathi yenyanga inokufikelela kwi-2100kg. Wamkelekile ukuba unxibelelane nathi ngolwazi oluthe kratya lokuthenga:
Isimo: Isisitokhwe

Icandelo leephakeji: 1kg / ingxowa, 25kg / igubu

Ingcaciso yeMveliso

Iimpawu ezisisiseko

Igama lemveliso I-Nicotinamide riboside chloride
Inani leCAS 23111-00-4
I-Molecular Formula C11H15ClN2O5
Ubukhulu beFormula 290.7
Iintetho ezifanayo 23111-00-4

I-Nicotinamide riboside chloride

Inicotinamide riboside (ikloride)

3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

INicotinamide ribose chloride

Kubonakala Powder
Ukugcina nokuPhatha 0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga).

 

Inkcazo yeNicotinamide riboside chloride

Nicotinamide Riboside chloride (NIAGEN) na uhlobo chloride yetyuwa nicotinamide riboside (NR) .NR yindlela entsha pyridine-nucleoside ivithamin B3 esebenza njengesandulela ukuba nicotinamide adenine dinucleotide (NAD) okanye NAD + .NIAGEN yaziwa ngokubanzi ekhuselekileyo (GRAS) eMelika ukuze isetyenziselwe iimveliso zokutya. INicotinamide riboside chloride yicristal form yeNicotinamide riboside (NR) chloride. I-Nicotinamide riboside chloride inyusa amanqanaba e-NAD [+] kwaye isebenze i-SIRT1 kunye ne-SIRT3, ifikelela esiphelweni ngokuphucula imetabolism ye-oxidative kunye nokukhuselwa ngokuchasene nokutya okunamafutha okuphezulu. I-Nicotinamide riboside chloride powder isetyenziswa kwizongezo zokutya.

 

INicotinamide riboside chloride Mechanism yokuSebenza

I-Nicotinamide Riboside Chloride (NIAGEN) yifom yetyuwa ye-chloride ye-nicotinamide riboside (NR). I-NR yifom ye-pyridine-nucleoside ye-vitamin B3 esebenza njenge-precursor ye-nicotinamide adenine dinucleotide okanye i-NAD +. I-NR ibhloka ukonakala kweengcambu ze-ganglion neurons zenziwe ngotyando kwaye ikhusela ngokuchasene nokulahleka kwendlebe kwiimpuku eziphilayo. I-Nicotinamide riboside powder ithintela umsipha, i-neural kunye ne-melanocyte stem cell senescence. Ukonyuka kokuhlaziywa kwemisipha kwiimpuku kuye kwabonwa emva konyango nge-nicotinamide riboside, ekhokelela kwingqikelelo yokuba inokuphucula ukwenziwa ngokutsha kwamalungu afana nesibindi, izintso kunye nentliziyo. I-Nicotinamide riboside ikwathoba iswekile yegazi kunye nesibindi esinamanqatha kwi-prediabetic kunye nohlobo lwe-2 yemodeli yeswekile ngelixa kuthintela ukukhula kwesifo seswekile sepheripheral neuropathy. Qaphela: INicotinamide Riboside chloride ngumxube we-α / β.

 

Isicelo seNicotinamide riboside chloride

I-Nicotinamide riboside chloride powder ibhalisiwe kunye nenombolo ye-CAS 23111‐00‐4 kunye nenombolo ye-EC 807‐820. Igama layo le-IUPAC ngu-5 - [(1R, 2R, 3S, 4R) ‐5 ‐ dihydroxy ‐ 3,4‐ (hydroxymethyl) oxolan ‐ 5 ‐ yl] pyridin ‐ 2 ‐ ium ‐ 1 ‐ carboxamide; chloride. Ifomula ye-nicotinamide riboside chloride yi-C3H11N15O2Cl, kunye nobunzima bayo be-molekyuli 5 g / mol. I-Nicotinamide Riboside Chloride (NIAGEN) yindlela yetyuwa ye-chloride ye-nicotinamide riboside (NR) .NR yifom entsha ye-pyridine-nucleoside ye-vitamin B290.7 esebenza njenge-precursor ye-nicotinamide adenine dinucleotide (NAD) okanye i-NAD +. Umzimba udinga i-NAD + ukuze usebenze ngokwesiqhelo. Amanqanaba asezantsi e-NAD + anokubangela iingxaki zonyango. Ukuthatha i-nicotinamide riboside kunokunceda ukuphakamisa la manqanaba asezantsi e-NAD +.

 

iinzuzo I-Nicotinamide riboside chloride

I-Nicotinamide riboside Chloride, eyandulelayo ngomlomo ye-NAD +, inyusa amanqanaba e-NAD + kwaye isebenze i-SIRT1 kunye ne-SIRT3. I-Nicotinamide riboside I-chloride powder ngumthombo we-vitamin B3 (niacin) kwaye usebenzisa i-Nicotinamide riboside i-Chloride powder inokuphucula i-metabolism ye-oxidative, ukukhusela ngokuchasene nokutya okunamafutha. INicotinamide riboside Chloride inciphisa ukonakala kwengqondo kwimodeli ye-transgenic yegundane yesifo se-Alzheimer's.

 

isingqiniso

[1] I-Chi Y, iSauve AA. I-Nicotinamide riboside, isakhamzimba sokutya, ivithamin B3 eneziphumo kwimetabolism yamandla kunye ne-neuroprotection. I-Curr Opin Clin Nutr Metab Ukhathalelo. Ngo-2013 i-Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Uphononongo. I-PubMed PMID: 24071780.

[2] UBogan KL, uBrenner C. Nicotinic acid, nicotinamide, kunye nicotinamide riboside: kuvavanyo lweemolekyuli ze-NAD + zandulela iivithamini kwisondlo sabantu. Annu Rev Isondlo. Ngo-2008; 28: 115-30. ikhonkco: 10.1146 / annurev.nutr.28.061807.155443. Uphononongo. I-PMID epapashiweyo: 18429699.

[3] Ghanta S, Grossmann RE, Brenner C. I-protein acetylation ye-Mitochondrial njenge-cell-intrinsic, umqhubi wendaleko wokugcina amafutha: ikhemikhali kunye ne-metabolic logic ye-acetyl-lysine modification. Ukugxeka Rev Biochem Mol Biol. Ngo-2013 uNov-Dec; 48 (6): 561-74. ikhonkco: 10.3109 / 10409238.2013.838204. Uphononongo. Ipapashwe kwi-PMID: 24050258; Ipapashwe kwi-PMCID eseMbindini: PMC4113336.

[4] Yang Y, Gcina iAA. I-NAD (+) imetabolism: I-Bioenergetics, ukusayina kunye nokunyanzeliswa konyango. IBiochim Biophys Acta. Ngo-2016 uDisemba; 1864 (12): 1787-1800. ikhonkco: 10.1016 / j.bbapap.2016.06.014. Uphononongo. Ipapashwe kwi-PMID: 27374990.

[5] Gcina iAA. I-NAD + kunye nevithamini B3: ukusuka kwimetabolism ukuya kunyango. J Pharmacol Exp Ther. I-2008 Mar; 324 (3): 883-93. ikhonkco: 10.1124 / jpet.107.120758. Uphononongo. Ipapashwe kwi-PMID: 18165311.

[6] UKato M, uLin SJ. Ummiselo we-NAD + imetabolism, ukutyikitywa kunye nokufakwa kumagumbi kwi-Saccharomyces cerevisiae. Ukulungiswa kweDNA (Amst). NgoNovemba 2014; 23: 49-58. ikhonkco: 10.1016 / j.dnarep.2014.07.009. Uphononongo. Ipapashwe kwi-PMID: 25096760; Ipapashwe kwi-PMCID eseMbindini: PMC4254062.

[7] UCantó C, et al. I-NAD (+) eyandulela i-nicotinamide riboside iphucula imetabolism ye-oxidative kunye nokukhusela ngokuchasene nokutya okunamafutha aphezulu. Iseli yeMetab. Ngo-2012 uJuni 6; 15 (6): 838-47.

[8] Bing Gong, okqhubekayo. INicotinamide Riboside ibuyisela ukuqonda ngokuGunyazisa iProciferator-activated Receptor-γ Coactivator 1α elawulwayo β-Secretase 1 Ukuthotywa kunye neMitochondrial Gene expression kwiAlzheimer's Mouse Models. Ukwaluphala kweNeurobiol. Ngo-2013 uJuni; 34 (6): 1581-8.

[9] UCollin D Heer, et al. I-Coronavirus kunye ne-PARP Expression Dysregulate i-NAD Metabolome: Into enokwenzeka ukuba isebenze kwi-Innate Immunity. bioRxiv. 2020 ngoMatshi 30; 2020.04.17.047480.