Iimpawu ezisisiseko

Igama lemveliso	I-Nicotinamide riboside chloride
Inani leCAS	23111-00-4
I-Molecular Formula	C11H15ClN2O5
Ubukhulu beFormula	290.7
Iintetho ezifanayo	23111-00-4 I-Nicotinamide riboside chloride Inicotinamide riboside (ikloride) 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride INicotinamide ribose chloride
Kubonakala	Powder
Ukugcina nokuPhatha	0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga).

 

Inkcazo yeNicotinamide riboside chloride

Nicotinamide Riboside chloride (NIAGEN) na uhlobo chloride yetyuwa nicotinamide riboside (NR) .NR yindlela entsha pyridine-nucleoside ivithamin B3 esebenza njengesandulela ukuba nicotinamide adenine dinucleotide (NAD) okanye NAD + .NIAGEN yaziwa ngokubanzi ekhuselekileyo (GRAS) eMelika ukuze isetyenziselwe iimveliso zokutya. INicotinamide riboside chloride yicristal form yeNicotinamide riboside (NR) chloride. I-Nicotinamide riboside chloride inyusa amanqanaba e-NAD [+] kwaye isebenze i-SIRT1 kunye ne-SIRT3, ifikelela esiphelweni ngokuphucula imetabolism ye-oxidative kunye nokukhuselwa ngokuchasene nokutya okunamafutha okuphezulu. I-Nicotinamide riboside chloride powder isetyenziswa kwizongezo zokutya.

 

INicotinamide riboside chloride Mechanism yokuSebenza

I-Nicotinamide Riboside Chloride (NIAGEN) yifom yetyuwa ye-chloride ye-nicotinamide riboside (NR). I-NR yifom ye-pyridine-nucleoside ye-vitamin B3 esebenza njenge-precursor ye-nicotinamide adenine dinucleotide okanye i-NAD +. I-NR ibhloka ukonakala kweengcambu ze-ganglion neurons zenziwe ngotyando kwaye ikhusela ngokuchasene nokulahleka kwendlebe kwiimpuku eziphilayo. I-Nicotinamide riboside powder ithintela umsipha, i-neural kunye ne-melanocyte stem cell senescence. Ukonyuka kokuhlaziywa kwemisipha kwiimpuku kuye kwabonwa emva konyango nge-nicotinamide riboside, ekhokelela kwingqikelelo yokuba inokuphucula ukwenziwa ngokutsha kwamalungu afana nesibindi, izintso kunye nentliziyo. I-Nicotinamide riboside ikwathoba iswekile yegazi kunye nesibindi esinamanqatha kwi-prediabetic kunye nohlobo lwe-2 yemodeli yeswekile ngelixa kuthintela ukukhula kwesifo seswekile sepheripheral neuropathy. Qaphela: INicotinamide Riboside chloride ngumxube we-α / β.

 

Isicelo seNicotinamide riboside chloride

I-Nicotinamide riboside chloride powder ibhalisiwe kunye nenombolo ye-CAS 23111‐00‐4 kunye nenombolo ye-EC 807‐820. Igama layo le-IUPAC ngu-5 - [(1R, 2R, 3S, 4R) ‐5 ‐ dihydroxy ‐ 3,4‐ (hydroxymethyl) oxolan ‐ 5 ‐ yl] pyridin ‐ 2 ‐ ium ‐ 1 ‐ carboxamide; chloride. Ifomula ye-nicotinamide riboside chloride yi-C3H11N15O2Cl, kunye nobunzima bayo be-molekyuli 5 g / mol. I-Nicotinamide Riboside Chloride (NIAGEN) yindlela yetyuwa ye-chloride ye-nicotinamide riboside (NR) .NR yifom entsha ye-pyridine-nucleoside ye-vitamin B290.7 esebenza njenge-precursor ye-nicotinamide adenine dinucleotide (NAD) okanye i-NAD +. Umzimba udinga i-NAD + ukuze usebenze ngokwesiqhelo. Amanqanaba asezantsi e-NAD + anokubangela iingxaki zonyango. Ukuthatha i-nicotinamide riboside kunokunceda ukuphakamisa la manqanaba asezantsi e-NAD +.

 

iinzuzo I-Nicotinamide riboside chloride

I-Nicotinamide riboside Chloride, eyandulelayo ngomlomo ye-NAD +, inyusa amanqanaba e-NAD + kwaye isebenze i-SIRT1 kunye ne-SIRT3. I-Nicotinamide riboside I-chloride powder ngumthombo we-vitamin B3 (niacin) kwaye usebenzisa i-Nicotinamide riboside i-Chloride powder inokuphucula i-metabolism ye-oxidative, ukukhusela ngokuchasene nokutya okunamafutha. INicotinamide riboside Chloride inciphisa ukonakala kwengqondo kwimodeli ye-transgenic yegundane yesifo se-Alzheimer's.

 

isingqiniso

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[8] Bing Gong, okqhubekayo. INicotinamide Riboside ibuyisela ukuqonda ngokuGunyazisa iProciferator-activated Receptor-γ Coactivator 1α elawulwayo β-Secretase 1 Ukuthotywa kunye neMitochondrial Gene expression kwiAlzheimer's Mouse Models. Ukwaluphala kweNeurobiol. Ngo-2013 uJuni; 34 (6): 1581-8.

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