I-γ-Aminobutyric acid (GABA) powder - Umthengisi weFektri yoMvelisi
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I-γ-Aminobutyric acid (GABA)

Akukho kalo Udidi:

GABA ithathwa ngomlomo yokuphelisa unxunguphalo, ukuphucula imeko, ukunciphisa iimpawu zesifo sokuqala (PMS), kunye nokunyanga ukungahambi kakuhle (i-ADHD). Isetyenziselwa ukukhuthaza ukukhula kwemisipha engatyebanga, ukutshisa amanqatha, ukuzinzisa uxinzelelo lwegazi kunye nokunciphisa iintlungu.

Ingcaciso yeMveliso

Iimpawu ezisisiseko

Igama lemveliso I-γ-Aminobutyric acid (GABA)
Inani leCAS 56-12-2
I-Molecular Formula C4H9NO2
Ubukhulu beFormula 103.12
Iintetho ezifanayo I-4-aminobutyric acid

I-4-Aminobutanoic acid

i-gamma-aminobutyric acid

GABA

56-12-2

Kubonakala Powder
Ukugcina nokuPhatha Okomileyo, omnyama kunye no-0 - 4 C okwexeshana elifutshane, okanye -20 C ixesha elide.

 

I-γ-Aminobutyric acid (GABA)inkcazelo

I-γ-aminobutyric acid, okanye i-gamma-Aminobutyric acid, okanye i-GABA, yeyona nto iphambili ekuthinteleni i-neurotransmitter kwinkqubo yokukhula yovimba mammalian. Indima yayo ephambili kukunciphisa ukonwaba kwe-neuronal kuyo yonke inkqubo yeemvakalelo.

I-GABA ithengiswa njengesongezelelo sokutya kumazwe amaninzi. Bekucingelwa ngokwesiko ukuba i-GABA exogenous (okt ithathwa njengesongezelelo) ayiweleli isithintelo segazi-lobuchopho, nangona kunjalo idatha efunyenwe kuphando lwangoku ibonisa ukuba kunokwenzeka.

 

I-γ-Aminobutyric acid (GABA) Indlela yokuSebenza

Iziyobisi ezisebenza njengemodyuli ye-allosteric ye-GABA receptors (eyaziwa ngokuba yi-GABA analogue okanye iziyobisi ze-GABAergic), okanye yonyusa inani elikhoyo le-GABA, elinokuphumla, uxinzelelo kunye neempembelelo ezichasayo. Uninzi lwezinto ezingezantsi ziyaziwa ukuba zibangela i-anterograde amnesia kunye ne-retrograde amnesia.

Ngokubanzi, i-GABA ayiweleli isithintelo segazi-nengqondo, nangona iindawo ezithile zobuchopho ezingenasithintelo sisebenzayo segazi-ngengqondo, ezinje nge-periventricular nucleus, zinokufikelelwa ngamachiza afana ne-GABA ejoyiweyo. Ubuncinci uphando lubonisa ukuba i-GABA elawulwa ngomlomo inyusa inani lokukhula komntu (HGH). I-GABA itofelwe ngqo kwingqondo kuye kwaxelwa ukuba ineziphumo ezikhuthazayo kunye nezithintelayo kwimveliso yokukhula kwehomoni, kuxhomekeke kubume bomntu. Ezinye iziyobisi ze-GABA (ex. Picamilon) ziye zaphuhliswa ukugcwala isithintelo segazi-ngengqondo, emva koko zahlulwe zibe yi-GABA kunye nemolekyuli yenethiwekhi kanye ngaphakathi kwengqondo.

I-GABA iphucule i-catabolism ye-serotonin kwi-N-acetylserotonin (umanduleli we-melatonin) kwiigundane. Kuyakrokrelwa ukuba i-GABA iyabandakanyeka kulungelelwaniso lwe-melatonin kwaye ngenxa yoko kunokuba nefuthe kulawulo kwimisebenzi yokulala kunye nokuzala.

 

I-γ-Aminobutyric acid (GABA) isicelo

I-Gamma-Aminobutyric Acid yenzeka ngokwendalo nge-neurotransmitter ngenkqubo ye-nervous system (CNS). I-Gamma-aminobutyric acid (i-GABA), eguqulweyo ukusuka kwi-glutamate ye-neurotransmitter eyintloko kwingqondo, idlala indima ekulawuleni ukonwaba kwe-neuronal ngokubopha kwii-receptors zayo, i-GABA-A kunye ne-GABA-B, kwaye ke oko kubangela ukuvulwa kwesitishi se-ion, i-hyperpolarization kwaye ekugqibeleni Uthintelo lwe-neurotransuction.

I-Gamma-aminobutyric acid yi-gamma-amino acid eyi-butanoic acid kunye ne-amino substitute ekhoyo kwi-C-4. Inendima njengokubonisa imolekyuli, imetabolite yomntu, iSaccharomyces cerevisiae metabolite kunye neurotransmitter. It is a gamma-amino acid kunye monocarboxylic acid. Ivela kwi-asidi ye-butyric. Yi-asidi ye-conjugate ye-gamma-aminobutyrate. Sisicoci se-gamma-aminobutyric acid zwitterion.

 

Izibonelelo ze-γ-Aminobutyric acid (GABA)

GABA ithathwa ngomlomo yokuphelisa unxunguphalo, ukuphucula imeko, ukunciphisa iimpawu zesifo sokuqala (PMS), kunye nokunyanga ukungahambi kakuhle (i-ADHD). Isetyenziselwa ukukhuthaza ukukhula kwemisipha engatyebanga, ukutshisa amanqatha, ukuzinzisa uxinzelelo lwegazi kunye nokunciphisa iintlungu.

 

isingqiniso

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3, Müller EE, Locatelli V, Cocchi D (Epreli 1999). "Ukulawulwa kwe-Neuroendocrine yokukhula kwe-hormone secretion". Uhlobo lomzimba. ISityhi 79 (2): 511-607. ikhonkco: 10.1152 / physrev.1999.79.2.511. IINKCUKACHA:

4, Amandla MNA, iYarrow JF, iMcCoy SC, iBorst SE (ngoJanuwari 2008). "I-hormone yokukhula isoform iimpendulo kwi-GABA ukungenisa ekuphumleni nasemva kokuzivocavoca". Amayeza kunye neNzululwazi kwezemidlalo kunye nokuzivocavoca. 40 (1): 104-10. ikhonkco: 10.1249 / mss.0b013e318158b518. IINKCUKACHA:

I-5, iBalemans MG, iMans D, uSmith I, uVan Benthem J (1983). "Impembelelo ye-GABA kwi-synthesis ye-N-acetylserotonin, i-melatonin, i-O-acetyl-5-hydroxytryptophol kunye ne-O-acetyl-5-methoxytryptophol kwi-pineal gland yendoda yaseWistar rat". Ukuzaliswa kwakhona, isondlo, uPhuhliso. 23 (1): 151-60. ikhonkco: 10.1051 / rnd: 19830114. IINKCUKACHA:

6, Sato S, Yinc C, Teramoto A, Sakuma Y, Kato M (2008). "Ukumodareyitha ngokwesondo kwe-GABA (A) i-receptor currents yi-melatonin kwiigundane ze-gonadotropin-ekhulula ii-hormone neurons". J uPhysol Sci. 58 (5): 317--322. ikhonkco: 10.2170 / physiolsci.rp006208. IINKCUKACHA:

I-7, i-Kuriyama K, i-Sze PY (ngoJanuwari 1971). "Umqobo wegazi nengqondo kwi-H3-γ-aminobutyric acid kwizilwanyana eziqhelekileyo ezinyangwa i-acid". Neuropharmacology. Isishumi (10): 1-103. ikhonkco: 108 / 10.1016-0028 (3908) 71-X. IINKCUKACHA:

8, Foster AC, Kemp JA (Februwari 2006). "I-Glutamate- kunye ne-GABA esekwe kunyango lwe-CNS". Ikhonkco Opin Pharmacol. 6 (1): 7-17. ikhonkco: 10.1016 / j.coph.2005.11.005. IINKCUKACHA: