I-Hydroxypinacolone Retinoate powder-Umthengisi weFektri yoMvelisi
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IHydroxypinacolone iRegino

Akukho kalo Udidi:

I-Hydroxypinacolone i-Retinoate powder iyisithako esichasene nokuguga, esixhunywe kwi-retinoic acid. I-Hydroxypinacolone Retinoate yindawo ye-cosmetic grade ester yayo yonke i-trans retinoic acid eyee-retinoids, ezizezendalo kunye nezinto ezivela kwivithamini A.

Ingcaciso yeMveliso

Iimpawu ezisisiseko

Igama lemveliso IHydroxypinacolone iRegino
Inani leCAS 893412-73-2
I-Molecular Formula C26H38O3
Ubukhulu beFormula 398.6
Iintetho ezifanayo I-Hydroxypinacolone retinoate

893412-73-2

I-UNII-NJ3V2F02E1

NJ3V2F02E1

(2E,4E,6E,8E)-3,3-Dimethyl-2-oxobutyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate

Kubonakala Iphunga eliphuzi
Ukugcina nokuPhatha Ubushushu obomileyo, obumnyama nobuphantsi.

 

Inkcazo yeHydroxypinacolone Retinoate

I-Hydropinazone retinoic acid ester (HPR) yindawo yokuthambisa ye-ATRA. Into eyingqayizivele kukuba iqhubekeka nomsebenzi we-retinoic acid kwaye ibophelela ngokuthe ngqo kwii-retinoid receptors ngaphandle kokubola kwemetabolism ukuze ibe yimo esebenzayo ngakumbi kwezendalo. I-Hydroxypinacolone retinoate (HPR) inezinto eziphezulu kakhulu zokubuyisela kwimeko yesiqhelo kunye nezibonelelo ezichasene nokwaluphala.

 

I-Hydroxypinacolone Retinoate Mechanism yesenzo

I-Hydroxypinacolone Retinoate sisixhobo esichasene nokuguga, esidityaniswe kwi-retinoic acid. I-Hydroxypinacolone Retinoate ikwangumlinganiso webanga lezithambiso kuyo yonke i-trans retinoic acid eyee-retinoids, ezizezendalo kunye nezinto ezivela kwivithamini A.

I-Hydroxypinacolone Retinoate endaweni yokuba iguqulwe ibe sisithako esisebenzayo, i-retinoic acid, ngokusebenzisa i-retinal, njenge-retinol, i-Hydroxypinacolone Retinoate (HPR) isebenza ngokuthe ngqo, kwaye i-SKINWELL HPR nayo izinzile kwaye ayinabungozi kwimpilo yabantu.

 

Iimpawu ze IHydroxypinacolone iRegino

I-Hydroxypinacol retinoic acid ester (HPR) sisiphumo se-retinols, esinokubopha ngokuthe ngqo kwii-cellular retinoic acid receptors (RARs), kwaye inomsebenzi wokulawula imetabolism ye-epidermis kunye ne-stratum corneum. Uncedo lwayo kukuba:

Anti-ukwaluphala,

Inokunciphisa i-seborrhea

Il Nciphisa i-pigment yesikhumba

Thintela ukwaluphala kolusu

♦ Nyanga amabala

Ening Ukwenza mhlophe nokubala

Xa kuthelekiswa ne-retinol, inokuqina okuzinzileyo kwaye ayinakufane yenziwe i-oxidized. Iyakwazi ukunciphisa ngokufanelekileyo imigca emihle kunye nemibimbi kunye nokukhanyisa amabala. Ngelixa kuqinisekiswa iimpembelelo ezinamandla ze-retinoic acid, ikwanciphisa kakhulu ukucaphuka kwayo. Isetyenziselwa ikakhulu imibimbi yokulwa ukuguga kunye nokuthintela ukuphindaphinda kwamabala.

 

Iziphumo ze IHydroxypinacolone iRegino

I-Hydropinazone retinoic acid ester (HPR) yindawo yokuthambisa ye-ATRA. Umsebenzi wayo owahlukileyo kukuba iqhubekeka nemisebenzi ye-acid engaphakathi emzimbeni kwaye ibophelela ngokuthe ngqo kwii-retinoid receptors ngaphandle kokubola kwemetabolism ukuze isebenze ngakumbi ngokwebhayoloji. ifom. Kufunyaniswe ukuba izinze ngakumbi kune-retinol kwaye ayicaphukisi kakhulu kulusu. Apha, sisebenzisa i-RARE ukuvavanya ukubopha kwe-retinoic acid receptors kwinto yokuphendula i-acid (RARE) kwi-DNA, kwaye uthelekise i-HPR, i-ATRA, i-retinol (i-Rol), i-retinal (i-Ral) kunye ne-retinol palmitate inqanaba lokukhuphela u-esters. (RP). Ukongeza, sithelekise iipropathi zokulwa ukwaluphala ze-HPR kunye ne-ATRA ngokuvavanya iimpembelelo zeemodeli zolusu ze-organotypic kumanqanaba e-collagen kunye nokucaphuka kolusu.

 

isingqiniso

  1. Abc uNora Ruth, uThomas Mammone (2018). "Iziphumo zokuguga ze-retinoid hydroxypinacolone retinoate kwiimodeli zolusu". Ijenali yeAmerican Academy yeDermatology 79 (3): AB44. ikhonkco: 10.1016 / j.jaad.2018.05.215.
  2. UKatie Rodan, uKathy Fields, uGeorge Majewski, uTimothy Falla (2016-12). "I-Skincare Bootcamp: Indima yokuvela kweScincare". Unyango lweplastiki kunye nolwakhiwo kwakhona. I-Global evulekileyo 4 (i-12 Suppl Anatomy kunye noKhuseleko kwiNyango yeCosmetic: I-cosmetic Bootcamp): e1152. doi: 10.1097 / GOX.0000000000001152. PMC: 5172479. PMID28018771.
  3. UTruchuelo, uMaria Teresa; UJiménez, uNatalia; UJaén, uPedro (2014). "Ukuvavanywa kokusebenza kunye nokunyamezelana kwendibaniselwano entsha yee-retinoids kunye neearhente zokuthambisa kunyango lwe-melasma". Ijenali yeDermatology yeCosmetic 13 (4): 261-268. ikhonkco: 10.1111 / jocd.12110.
  4. Veraldi, M. Barbareschi, E. Guanziroli; okqhubekayo (2015-4). "Unyango lwe-acne encinci ukuya kumodareyitha ngokudibanisa okungagungqiyo kwehydroxypinacolone retinoate, retinol glycospheres kunye nepain glycospheres". Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 150 (2): 143-147. IINKCUKACHA:
  5. URuth, N., kunye noT. Mammone. "1310 Iziphumo ezichasene nokuguga ze-retinoid hydroxypinacolone retinoate kwiimodeli zolusu." Ijenali yoPhando ngeDermatology 138.5 (2018): S223.
  6. Giornale italiano di dermatologia e venereologia, 2015 Apr; 150 (2): 143-7., Unyango lwamaqhakuva amancinci ukuya kumodareyitha ngokudityaniswa okumiselweyo kwehydroxypinacolone retinoate, retinol glycospheres kunye nepain glycospheres.
  7. Giornale Italiano di Dermatologia e Venereologia, 2016/03, Ukusebenza kunye nokukhuseleka kunyango lweenyanga ezili-12 ngokudibanisa i-hydroxypinacolone retinoate kunye ne-retinol glycospheres njengonyango lokugcina kwizigulana ezinamabala emva komlomo isotretinoin.

 

I-AASraw ngumenzi onokuthenjwa kwaye unelayisensi esemthethweni yomgangatho ophezulu weHydroxypinacolone Retinoate  umgubo. Wamkelekile ukubeka umyalelo kuthi!