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Alfaxalone

Akukho kalo Udidi:

IAlfaxalone yimolekyuli ye-neuroactive steroid eneempawu ze-anesthetic ngokubanzi. I-Alfaxalone ichazwa ngekhemikhali njenge-3-α-hydroxy-5-α-pregnane-11, 20-dione, kwaye inobunzima beemolekyuli ezingama-332.5…

Ingcaciso yeMveliso

Iimpawu ezisisiseko

Igama lemveliso Alfaxalone
Inani leCAS 23930-19-0
I-Molecular Formula C21H32O3
Ubukhulu beFormula 332.48
Iintetho ezifanayo IAlfaxalone;

Alfaxalone;

23930-19-0;

5alpha-Pregnan-3alpha-ol-11,20-dione;

IAlfaxalonum.

Kubonakala Powder
Ukugcina nokuPhatha Gcina kubushushu begumbi elilawulwayo -20 ° C

 

Inkcazo yeAlfaxalone

IAlfaxalone yimolekyuli ye-neuroactive steroid eneempawu ze-anesthetic ngokubanzi. I-Alfaxalone ichazwa ngekhemikhali njenge-3-α-hydroxy-5-α-pregnane-11, 20-dione, kwaye inobunzima beemolekyuli 332.5. Indlela ephambili yentshukumo ye-anesthetic ye-alfaxalone kukumodareyitha kwe-neuronal cell membrane chloride ion zothutho, ezibangelwa kukubopha kwe-alfaxalone kwi-GABAA (gamma-aminobutyric acid) receptors kumphezulu weseli.

 

Indlela yeAlfaxalone yesenzo

IAlfaxalone ivelisa ukungabikho zingqondweni ngokwenza i-gamma aminobutyric acid subtype A (GABAA) receptors kwinkqubo ye-nervous system (CNS). Ezi receptors yimijelo ye-ionotropic yegand-gated, kwaye i-GABA yeyona ligand yayo yokuphela. I-GABA yeyona nto iphambili ekuthinteleni i-neurotransmitter kwi-CNS. Emva kokuba i-receptor yenziwe yasebenza, ijelo liyavula kwaye likhuthaze ukuhanjiswa kwe-chloride kwiseli, kubangele i-hyperpolarization ye-postynaptic membrane. Kwiindawo eziphantsi, i-alfaxalone ngokuqinisekileyo imodareyitha i-chloride yangoku ngejelo le-chloride; kodwa kwiindawo eziphezulu, isebenza njenge-GABA agonist, ngendlela efanayo ne-barbiturates. Iziphumo zokugqibela kukuthomalalisa ngokunzulu okanye ukwenziwa kweanesthesia, kuxhomekeke kwidosi kunye nendlela yolawulo.

 

Isicelo seAlfaxalone

I-Alfaxalone, ekwabizwa ngokuba yi-alphaxolone okanye i-alphaxalone kwaye isetyenziswa phantsi kwegama lorhwebo i-Alfaxan, yi-neuroactive steroid kunye ne-anesthetic drug jikelele esetyenziswa ezinjeni nasezikati. Ingasetyenziselwa njengearhente yoqheliso okanye i-anesthesia ngokubanzi.

 

Alfaxalone Izibonelelo kunye nezinto ezingalunganga

  • eziluncedo:

IAlfaxalone ibangela utshintsho oluncinci kwimveliso yentliziyo okanye uxinzelelo lwegazi xa idosi ezifanelekileyo zeklinikhi zenziwa kwizigulana ezisempilweni. I-Alfaxalone inesalathiso sonyango oluphezulu, isenzo esifutshane, kunye nokunganyusi. Ezi mpawu zenza ukuba i-alfaxalone ilungele ukusetyenziswa njenge-arhente yoqheliso okanye ukubonelela nge-anesthesia enesitofu.

I-Alfaxalone nayo inokwenziwa nge-intramuscularly, yiyo loo nto inokusetyenziselwa ukuthomalalisa izigulana ezingasebenziyo. Xa i-alfaxalone isetyenziselwa ukuthomalalisa isigulana idosi yi-1-3mg / kg IM kwaye ihlala ilawulwa ngokudibeneyo kunye ne-opioid yokufumana isidanga esifanelekileyo.

Xa i-alfaxalone isetyenziselwa amacandelo e-caesarean iinjana ziye zilumke ngakumbi kwaye zinomdla wokufumana amanqaku aphuculweyo e-AGPAR xa kuthelekiswa nepropofol.

 

  • Ilishwa:

I-Alfaxalone ibangela uxinzelelo kuxinzelelo lokuphefumla, kunye ne-apnea enokwenzeka ukuba yenzeke emva kwenaliti ye-IV ekhawulezileyo. Zilungiselele ukubola, ukubonelela ngenkxaso yeoksijini, kunye nokufaka umoya xa usebenzisa i-alfaxalone kuyo nayiphi na into yokungenisa okanye yokuthambisa.

Ukulawulwa okugqithileyo kwe-alfaxalone kunokubangela idosi exhomekeke kwintliziyo, kunye nokuhla okukhulu kwiziphumo zentliziyo kunye noxinzelelo lwegazi. Umthamo wealfaxalone kufuneka ubhalwe ngocoselelo kwizigulana ezinciphise oovimba bentliziyo okanye ezingazinzanga ngokwasemzimbeni.

I-Alfaxalone ayiboneleli nge-analgesia, ke ngoko kufuneka isetyenziswe ngokudibeneyo ne-opioid efanelekileyo yeenkqubo ezibuhlungu.

Xa i-alfaxalone ilawulwa intramuscularly umthamo wenaliti unokuba mkhulu, unokubangela iintlungu kwinaliti. Umthamo omkhulu unokwenza ucelomngeni kulawulo xa kukho ifestile encinci yenaliti ngenxa yesigulana. Ulawulo lwe-Alfaxalone lunokubangela ukubuyela kwimeko yesiqhelo okuphawulwa ngamanqanaba ahlukeneyo okubhexa, ukwenza ilizwi kunye / okanye i-myoclonus.

 

isingqiniso

[1] I-Whittem T, Pasloske KS, Heit MV okqhubekayo. (2008) I-pharmacokinetics kunye ne-pharmacodynamics ye-alfaxalone kwiikati emva kolawulo olunye kunye ne-intravenous ye-Alfaxan kwiklinikhi nakwidosi ye-supraclinical. J Vet Pharmacol Ther 31 (6), 571-579.

[2] UFerre PJ, uPasloske K, uWhittem T okqhubekayo. I-Plasma pharmacokinetics ye-alfaxalone ezinjeni emva kwe-bolus yegazi ye-Alfaxan-CD. I-Vet Anaesth Analg 2006, 33-229.

[3] UMuir W, uLerche P, uWiese A okqhubekayo. Iziphumo ze-Cardiorespiratory kunye ne-anesthetic yeeklinikhi kunye needosi ze-alfaxalone. I-Vet Anaesth Analg 2009, 36-42.

[4] I-Clarke KW, i-Trim CM, iHolo LW, ii-eds. (2014). "Isahluko se-15: Ukubulawa kwenja". I-Anesthesia yezilwanyana (i-11th ed.). I-Oxford: WB Saunders. iphepha. 135-153.

[5] UVarga M (2014). "Isahluko 4: I-Anesthesia kunye ne-Analgesia". Incwadi yesicatshulwa seMichiza (i-2nd ed.). EGcuwa-Heinemann. iphepha. 178-202.

[6] UNieuwendijk H (Matshi 2011). "Alfaxalone". I-Anesthesia yeZilwanyana kunye neQela leNkxaso yeLangesia. Ibuyiswe ngoJulayi 14, 2017.

[7] UZeltzman P (Novemba 17, 2014). "Kutheni ukulawulwa kweAlfaxalone kufuna iMfundo encinci". Iindaba zokuQeqeshelwa kwezilwanyana. Ibuyiswe ngoJulayi 14, 2017.