Ingcaciso yeMveliso
Alpha GPC Powder Ividiyo-AASraw
Iimpawu ezisisiseko zeAlpha GPC Powder
| igama: | Alpha GPC powder |
| CAS: | 28319-77-9 |
| Ifomula yeMolekyuli: | C8H20NO6P |
| Ubunzima Ezinto: | 257.22 |
| Melt Point: | 142.5-143 ° |
| Isitoreji sokugcina: | -20 ° C |
| umbala: | Powder |
Yintoni iAlpha GPC Powder?
I-Alpha GPC, eyaziwa ngokuba yi-Alpha-glycerophosphocholine (aGPC), i-phospholipid ene-choline ephuma kwi-soy. Izifundo ezahlukeneyo kule khemikhali zibonisa indima ekuphuculeni umsebenzi wokuqonda, ukomeleza amandla, kunye nokubangela ukuveliswa kwehomoni yokukhula.
I-AASraw ye-Alpha GPC Powder sisixhobo esisebenza ngokumangalisayo sokuphucula imemori nokufunda, kunye nokulwa nokuncipha kwengqondo kunye neempawu ze-Alzheimer's disease. Xa isigulane sibonisa iimpawu zokuncipha kokusebenza kwengqondo, ngamanye amaxesha eyaziwa ngokuba yi "Brain Fog," ukuxhaswa kwe-Alpha GPC kunceda ukunika ukucinga okucacileyo kunye nokucacileyo. Lo mthombo omangalisayo we-choline ungaphinda usetyenziswe ngabantu abanempilo ukwandisa ukusebenza kwengqondo. Isibindi kunye nezinye izitho zomzimba, ezingaseyona nto iphambili kwi-North America yokutya, izidlo ezityebileyo ze-choline. Ngenxa yoko, sifumanise ukuba abantu abaninzi bayasilela kwaye banokuzuza kakhulu ekuncediseni nge-Alpha GPC. Ngumthombo olungileyo wamafutha kwimisebenzi yengqondo yengqondo. Imini yonke, abantu abaninzi batsala nzima ngamandla kunye nokugxila. Ngenxa yoko, abantu abaninzi bafuna isisombululo sokudodobala kwemva kwemini ukuze baphucule ingqondo yabo. I-Alpha GPC powder evela kwi-AASraw yongezelela enceda ngokugxila kwengqondo kunye nokusebenza.
Qhubeka ufunda ukuze ufunde ukuba isebenza njani iAlpha GPC, izibonelelo zayo kunye nobungozi obunokubakho, kunye nedosi.
Isebenza njani iAlpha GPC Powder emzimbeni?
I-Alpha GPC powder isebenza ngokuphakamisa amanqanaba e-acetylcholine (ACh) kwingqondo. I-Acetylcholine yi-neurotransmitter ebandakanyekayo ekubunjweni kwememori nokufunda, kunye nokunyanzeliswa kwemisipha.
Imizimba yethu yenza i-acetylcholine encinci nangaphantsi njengoko sikhula. Oku kunokukhokelela kwimiba yememori kunye nokukhubazeka okuphakathi kwengqondo. I-Alpha GPC powder ithathwa njengenceda ukukhusela ukuncipha kwengqondo enxulumene neminyaka ngokunyusa amanqanaba e-acetylcholine kwingqondo kunye nokusebenza njengeyeza le-nootropic ye-pro-cholinergic. Oku kuthetha ukuba inceda ekudaleni i-acetylcholine, enokuthi ibe negalelo ekwandeni kokusebenza kwengqondo.
I-Phosphatidylcholine (i-PC), icandelo elisisiseko leembrane zeseli, likwangumphambili we-Alpha GPC powder. I-PC iyimfuneko kwimpilo kunye nokuguquguquka kweembrane zeseli. Ikwanegalelo ekubunjweni kwe-myelin sheath, isigqubuthelo samafutha esigquma kwaye sikhusele i-neurons. Ingqondo yenziwe ngeebhiliyoni zee-neuron ezihambisa kwaye zifumane amandla ombane ngalo lonke ixesha. Ukuze ubuchopho bethu busebenze ngokuchanekileyo, le miyalezo kufuneka ikhawuleze kwaye isebenze. Ingubo ye-myelin isebenza njenge-insulator, ikhusela imicu ye-nerve kunye nokuvumela iimpawu zombane ukuba zihambe ngokukhawuleza nangempumelelo.
Apha kulapho iPhosphatidylcholine (PC) ingena khona. I-PC iyadingeka ukuze kugcinwe i-membrane yeseli enempilo kunye nophuhliso lwe-myelin sheath.
Iguqulwa ibe yiAlpha GPC ngeendlela ezimbini ezahlukeneyo:
Indlela yaseKennedy
Indlela yeMethylation
IKennedy Pathway luluhlu lweenkqubo ezithi ngokudibeneyo zibonelele ngeyona ndlela yethu ibalulekileyo yokulawula ukukhula kweeseli. I-choline yamahhala iguqulwa ibe yi-cytidine diphosphate (CDP), ethi emva koko ixutywe kunye ne-diacylglycerol ukwenza i-PC. Inkqubo ye-methylation ijika i-PC, eyenziwe nge-phosphatidylethanolamine kunye ne-choline, ibe yinto ebalulekileyo yokwakhiwa kwe-myelin insulation kwingqondo yakho. Ngesenzo sePhospholipase D, iPC iguqulwa ibe yi-1-acyl-GPC kwaye emva koko ibe yi-Alpha GPC. I-Alpha GPC emva koko ithwalwa ngaphaya komqobo wegazi-ingqondo, apho iphakamisa amanqanaba e-acetylcholine engqondweni.
Ziziphi iiNzuzo zeMpilo ze-Alpha GPC?
· Alpha GPC njenge nootropic.
Abantu abaninzi basebenzisa iAlpha GPC kwinkumbulo kuba izifundo zokuqala zibonisa ukuba inokunceda ekufundeni. I-AASraw Alpha GPC yandisa ukubunjwa kwe-acetylcholine, ebalulekileyo kwimemori kunye nokulawulwa kwengqondo. Olunye uphononongo lujonge kwi-Alpha GPC ukuze kugxilwe kuyo kwaye lufumanise ukuba luyasebenza. Ngenxa yoko, i-Alpha GPC powder ingaba luncedo ekuphuculeni ingqalelo.
· Alpha GPC kunye nempilo yentliziyo.
Amanqanaba e-Homocysteine aphakama xa udla inyama eninzi. Amanqanaba e-Homocysteine ephezulu kakhulu anokuba nefuthe eliyingozi kwimpilo yentliziyo. I-Choline incedisa ukuguqulwa kwe-homocysteine kwi-methionine, i-amino acid ebalulekileyo encedisa kwi-protein biosynthesis. Ukongezelela, uphando oluthile lufumene ukuba i-choline yexesha elide inceda ukuvuvukala okuphantsi kunye nezinye iingozi ezonakalisa impilo yentliziyo. Ngelixa uphononongo olongezelelweyo lufuneka, iAlpha GPC inokuzuza impilo yentliziyo.
· Alpha GPC kunye noxinzelelo.
Xa utya inyama eninzi, amanqanaba akho e-homocysteine ayanda. Inqanaba le-homocysteine elingenampilo linokuba yingozi kwimpilo yentliziyo. I-Homocysteine iguqulwa yi-choline ibe yinto ebalulekileyo ye-amino acid methionine, eyimfuneko kwi-protein synthesis. Ukongezelela, uphando oluthile lufumene ukuba ukusetyenziswa kwe-choline engapheliyo kunciphisa ukuvuvukala kunye nezinye iingozi kwimpilo yentliziyo. I-Alpha GPC inokuphucula impilo ye-cardiovascular, kodwa uphando olongezelelweyo luyafuneka.
· Alpha GPC kunye ukusebenza komzimba.
Ngokutsho kophando, iAlpha GPC yindlela emangalisayo yokuphucula amandla emisipha kunye namahomoni akhuthaza ukuphuhliswa kwemisipha. Ngokophononongo lwe-2015, abo bathatha i-Alpha GPC powder rhoqo baqaphela ukunyusa okukhulu kumandla emisipha emva kweentsuku ze-6. Kolunye uphando, i-Alpha GPC powder yafunyanwa ukukhulisa ukuveliswa kwehomoni yokukhula kunye ne-oxidation yamafutha kubantu abancinci abanempilo. Ihomoni yokukhula komntu (HGH) ikhuthaza ukukhula kwezihlunu, ukuncipha kwamafutha, kunye nokulungiswa kwemisipha ngokukhawuleza.
(Inkqubo ye-Alpha GPC yokulungisa izihlunu)
Ngaba kukho umngcipheko womonakalo wexesha elide ekuthatheni iAlpha GPC?
Uphononongo lubonise ukuba i-Alpha GPC ayinayo impembelelo embi kwiiparamitha zegazi ezifana noxinzelelo lwegazi okanye izinga lentliziyo. Imilinganiselo ephezulu ye-Alpha GPC (i-1000 mg okanye ngaphezulu) inokubangela intloko kwabanye abantu de ukunyamezela kwabo kwi-supplementation kusekwe. Idosi esezantsi esebenzayo kwaba bantu ukuba baqale ngayo yi-300 mg ngosuku.
Uyithatha njani iAlpha GPC Powder?
Ekubeni i-Alpha GPC iqulethe malunga ne-40% ye-choline ngesisindo, i-1,000 mg ye-Alpha GPC powder evela kwi-AASraw inikezela ngokumalunga ne-400 mg ye-choline yokutya. Ngokwamaxabiso eeleyibhile aqhelekileyo, umthamo oqhelekileyo we-Alpha GPC ngu-300-600 mg. Esi sixa sinokuthi idosi efanelekileyo ithathelwe iimbaleki, njengoko ilandela uphando olusebenzisa i-Alpha GPC ukuphucula imveliso yamandla (600 mg) kunye nezifundo ezimbini ezibonisa ukwanda kwemveliso yehomoni yokukhula.
Phantse zonke izifundo zisebenzisa idosi ye-1,200 mg yonke imihla, yahlulwe ibe ngamathamo amathathu e-400 mg, ukunciphisa iimpawu zokuphazamiseka kwengqondo. Akucaci ukuba amanani amancinci anokunceda njani ukuqonda, nangona kunjalo inqanaba elibonakala lihambelana ngokuqhubekayo kunye nenzuzo yi-1,200 mg. Ngokutsho kwezifundo zegundane, iziphumo ze-Alpha GPC yokuthatha ngomlomo i-peak malunga ne-300-600 mg / kg, ehambelana nomlinganiselo oqikelelwayo womntu we-48-96 mg / kg (kunye ne-150lb yomntu, i-3,272-6,545 mg imihla ngemihla).
Ukusetyenziswa kwe-nootropic stack, sincoma ukuqala nge-300-600 mg kwaye ngokuthe ngcembe ukwandisa ukuba uvakalelwa kukuba uya kuzuza ngakumbi. I-Alpha GPC inyamezeleka kakuhle xa ithathwa kumanqanaba amiselweyo. Uluhlu lwedosi efanelekileyo kubantu abaninzi bukhulu; idosi yemihla ngemihla eyongezelekayo ye-300-1200 mg, elawulwa kwidosi enye okanye ezimbini, ikhuselekile kwaye iyasebenza.
Njengazo naziphi na izongezo, kungcono ukuqala ngedosi esezantsi esebenzayo kwaye ngokuthe ngcembe wonyuke njengoko kufuneka.
Alpha GPC Vs. CDP Choline
Masiqale ngezinto ezisisiseko. I-CDP choline, eyaziwa ngokuba yi-citicoline, yenziwe nge-choline (amaqela amabini e-phosphate) kunye ne-cytidine, kanti i-Alpha GPC yenziwe nge-choline (iqela elinye le-phosphate) kunye ne-glycerol. Oku kunokubonakala kufana, kodwa kuvelisa ezinye izinto ezinomdla kunye nezahlukeneyo emzimbeni.
Enye into, i-Alpha GPC iphakamisa amanqanaba e-choline yegazi ngaphezu kwe-CDP ye-choline. Ngenxa yoko, inempembelelo enamandla ekunciphiseni kwengqondo enxulumene neminyaka kunye nokusebenza komzimba. Okwesibini, i-Alpha GPC inokunyusa ukutshisa amanqatha kunye nesizukulwana sokukhula kwehomoni, inika inzuzo ngaphezu kwe-CDP ye-choline kubakhi bomzimba.
I-CDP ye-choline, ngakolunye uhlangothi, iyadingeka ukuze kuqulunqwe i-phosphatidylcholine. Inoluhlu olukhulu lweemetabolites ezisebenzayo kwaye inokuba neenzuzo zempilo yengqondo.
Ungayithenga phi iAlpha GPC Powder?
Kulula ukulibala ukuba umzimba wakho usebenza njengomatshini. Xa kufikelelwa ekusebenzeni komatshini, ufuna isibaso esifanelekileyo, esibaluleke ngakumbi ukuba uyasebenza ngokwasemzimbeni. Kukuphi ukutya okufuneka ukutye ukuze uphembelele umthambo wakho? Iza kwenzeka nini le nto?
Nceda ugcine engqondweni ukuba ayingabo bonke abantu abaxhamlayo kwi-Alpha GPC Powder. Mhlawumbi uthenge i-Alpha GPC Powder embi yingcinga yokuqala, indlela yokufumana umenzi wePowder we-Alpha GPC wangempela, kufuneka ulahle imizamo yakho kuyo. Ukuba uthengela i-Alpha GPC powder kwi-AASraw, uya kufumana i-Alpha GPC Powder ixabiso elihle.
Zonke izongezo ezivela kumthengisi we-AASraw zenziwa kwaye zivavanywe ukhuseleko kunye nomgangatho, ukuqinisekisa ukuba kuphela izithako eziphezulu eziphezulu zihanjiswa kuwe. I-Alpha GPC powder inokufumaneka ngobuninzi kwi-AASraw kwi-wholesale izithako.
Ingxelo yoVavanyo lwePowder yeAlpha GPC ekrwada-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
I-Alpha-GPC(28319-77-9)-COA
Indlela yokuthenga i-Alpha GPC Powder kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. Ling Langa
ILabhoratri yoHlalutyo lweMichiza, iShanghai Institute of Materia Medica, iAcademy yaseTshayina yeSayensi, eShanghai 201203, eTshayina
2. Antonia Di Mola
Dipartmento Di Chimica kunye neBiologia “A. Zambelli”, Università degli studi di Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy
3. Ingoma ethi Hee Lee
ISebe le-Neurology, iYunivesithi yaseHallym, iKholeji yezoNyango, iChuncheon, iRiphabhlikhi yaseKorea
4. ULacomba C.
Iziko le-Pharmecology, kwiYunivesithi yaseBari, eItali
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
isingqiniso
[1] De Jesus Moreno Moreno M (Januwari 2003). "Ukuphuculwa kwengqondo kwi-Alzheimer's mild to moderate emva konyango kunye ne-acetylcholine precursor choline alfoscerate: i-multicenter, i-double-blind, i-randomized, isilingo esilawulwa yi-placebo". Unyango lwezonyango. 25 (1): 178–93. PMID 12637119.
[2] Parnetti L, Mignini F, Tomassoni D, Traini E, Amenta F (Juni 2007). "I-Cholinergic precursors kunyango lokuphazamiseka kwengqondo yemvelaphi ye-vascular: iindlela ezingasebenziyo okanye imfuno yokuphononongwa kwakhona?". Ijenali yeNzululwazi yeNzululwazi. 257 (1–2): 264–9. PMID 17331541.
[3] Doggrell SA, Evans S (Okthobha 2003). "Unyango lwe-dementia kunye ne-neurotransmission modulation". Uluvo lweNgcali kwiZiyobisi zoPhando. I-12 (10): 1633–54. PMID 14519085.
[4] Wallace, TC et al. (2019). I-Choline: I-Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists. Ijenali yezongezo zokutya, i-17 (6), iphepha 733-752.
[5] Moreno, M. (2003). Ukuphuculwa kwengqondo kwi-dementia encinci ukuya kwimodareyitha ye-Alzheimer emva konyango kunye ne-acetylcholine precursor choline alfoscerate: i-multicenter, i-double-blind, i-randomized, isilingo esilawulwa yi-placebo. I-Clinical Therapeutics, [kwi-intanethi] 25 (1), iphe.178-193.
