Ingcaciso yeMveliso
Yintoni i-BPC-157?
I-BPC-157, emfutshane ye-"Body Protection Compound 157", yi-peptide yokwenziwa ethathwe kulandelelwano lwenxalenye ye-Body Protection Compound (BPC) ephuma kwijusi yesisu somntu. kunye neempawu zokuphilisa.I-BPC-15 iyaziwa ngemiphumo enokubakho yonyango kwiintlobo ezahlukeneyo zezicubu kunye neenkqubo zomzimba. ukuba nefuthe elihle kwindlela yesisu, inkqubo ye-musculoskeletal, kunye nenkqubo ye-nervous central.
Ekubeni uphando lubonise ukuba i-peptide BPC-157 inokukhuthaza ukulungiswa kwezicubu kunye nokuvuselelwa kwi-musculoskeletal system, kubandakanywa i-tendon, i-ligaments kunye nemisipha, kwaye ibonise iziphumo ezilungileyo kunyango lwezifo ezifana nokulimala kwe-tendon ye-Achilles, iinyembezi ze-muscle kunye ne-fractures.BPC -157 uye watsala umdla weembaleki, abakhi bomzimba, kunye nabantu abanomdla ekukhuthazeni ukubuyiswa nokuphiliswa.UMillionaire, uDan Bilzerian, wabelana nge-PED (Iziyobisi zokuphucula ukusebenza) awayeyisebenzisa kwi-Instagram, kuquka i-BPC-157.
Isebenza njani iBPC-157?
Indlela echanekileyo yesenzo se-BPC-157 ayiqondwa ngokupheleleyo kwaye isaphandwa.Iindlela ezicetywayo ziquka ukukhuthazwa kwe-angiogenesis, ukuguqulwa kwempendulo yokuvuvukala, ukuvuselela ukuveliswa kwe-collagen, ukukhuselwa kuxinzelelo lwe-oxidative, kunye nokusebenzisana nezinto ezikhulayo.BPC -I-157 ibonakaliswe ukukhuthaza ukubunjwa kwemithambo yegazi emitsha, encedisa ukulungiswa kwezicubu kunye nokuphucula ukuhamba kwegazi. imveliso ye-collagen, enegalelo ekulungisweni kwezicubu kunye nokwakhiwa kwengqibelelo.Ibonisa iipropathi ze-antioxidant, ukukhusela iiseli kunye nezicubu kumonakalo we-oxidative.
Ngaphezu koko, i-AASraw BPC-157 inokusebenzisana nezinto zokukhula ezibandakanyekayo ekulungisweni kwezicubu kunye nokuvuselelwa, ukukhuthaza ukwanda kwamaselula, ukuhlukana, kunye nokulungiswa kwezicubu.Kubalulekile ukuba uqaphele ukuba ezi ndlela zicetywayo zisekelwe kwizifundo zangaphambili eziqhutywe ngokuyinhloko kwiimodeli zezilwanyana.Uphando olongezelelweyo. iyadingeka ukuqonda ngokupheleleyo indlela i-BPC-157 esebenza ngayo ebantwini kunye nezicelo zayo zonyango ezinokubakho.
Kubalulekile ukuthenga i-BPC-157 kumthengisi ohloniphekileyo, ukwenzela ukuba umgangatho we-peptide BPC-157 uqinisekiswe.Umvelisi we-BPC-157 oyingcali kunye nomthengisi we-AASraw unokubonelela nge-BPC-157 ngekhwalithi ephezulu yokuxhasa i-R & D ezimeleyo. iziko kunye nefektri.Ukuba unezidingo, i-BPC-157 i-wholesale esuka kwi-AASraw yinto ekhethekileyo.
Izibonelelo ze-BPC-157
I-BPC-157, okanye i-Body Protection Compound 157, yi-peptide ephuma kwiprotheni efumaneka kwisisu. Kuye kwaba ngumxholo wezifundo ezininzi ngenxa yeziphumo zayo zonyango ezinokubakho. Kubalulekile ukuqaphela ukuba ngelixa uphando lwakwangoko luthembisayo, uphando oluninzi, ngakumbi ebantwini, luyafuneka ukuze kuqondwe iziphumo zalo ngokupheleleyo kunye nokusetyenziswa okunokwenzeka.Nazi ezinye iingenelo ezinokubakho ze-BPC-157.
① Ukuhlaziywa kwezicubu kunye nokulungiswa
I-BPC-157 idume ngokukwazi kwayo ukukhuthaza ukuphiliswa kwezicubu kunye nokuvuselelwa kwakhona. Le peptide inokukhawulezisa inkqubo yokubuyisela imisipha, imisipha, imisipha kunye namathambo, okwenza ukuba ibe yinto ebaluleke kakhulu ekuphatheni ukulimala kwezemidlalo, ukuphazamiseka kwemisipha kunye nezinye iimeko. ezinxulumene nomonakalo wezicubu.
②IiPropati ezichasene nokudumba
I-BPC-157 ibonisa iipropathi eziphawulekayo zokuchasana nokudumba.Ngokunciphisa ukuvuvukala kunye nokulungelelanisa impendulo yokuzivikela komzimba, ingaba sisixhobo esibalulekileyo sokulawula iimeko ezibonakaliswe kukuvuvukala okungapheliyo okufana nesifo se-inflammation (IBD), isifo samathambo, kunye nokuphazamiseka kwe-autoimmune eyahlukeneyo.
③Ukubuyiselwa kwamathumbu
I-BPC-157 iphantsi kokuhlolwa kwamandla ayo ekubuyiseleni nasekukhuseleni i-tract ye-gastrointestinal (GI) tract. , ukunciphisa ukudumba, kunye nokomeleza umsebenzi wokuthintela amathumbu.
④Izakhono zeNeuroprotective
I-BPC-157 ibonise iimpawu zokukhusela imithambo-luvo kwizifundo zokuqala.
⑤I-Angiogenesis kunye neMithombo yeGazi
I-BPC-157 ifunyenwe ukukhuthaza i-angiogenesis, okanye ukubunjwa kwemithambo yegazi emitsha.Le mpembelelo inokuphucula ukulungiswa kwezicubu kunye nokuphulukiswa kwenxeba ngokuqinisa ukujikeleza kwegazi kwiindawo ezonakeleyo.
⑥Ezinye iiNzuzo ezinokuthi zibekho
Uphononongo lokuqala lubonisa ukuba i-peptide BPC-157 inokubonelela ngeenzuzo ezongezelelweyo, kubandakanywa nokunciphisa intlungu, ukuphucula impilo edibeneyo kunye nokuguquguquka, ukwandisa ukusebenza kwe-immune, kunye nokulungelelanisa i-neurotransmitters ehambelana nomoya kunye nokuqonda.
Kubalulekile ukwazi ukuba baninzi abavelisi be-BPC-157 kunye nomthengisi kwi-intanethi okanye ngaphandle kwe-intanethi, nangona kunjalo, ayinguye wonke umntu othembekileyo. ukubonelela nge-BPC-157 ngokuhambelana neemfuno zemveliso yeCGMP, kwaye ibhetshi nganye yeemveliso kufuneka yenze uvavanyo lomgangatho phambi kokuthengisa.
Imiphumo emibi ye-BPC-157
I-BPC-157 ngokuqhelekileyo ithathwa njengekhuselekile kwaye ixhatshazwe kakuhle xa isetyenziswe ngokufanelekileyo.Nangona kunjalo, njengalo naluphi na ukungenelela kwonyango, kukho amathuba okuba nemiphumo emibi.Kubalulekile ukuba uqaphele ukuba idatha ekhoyo yesayensi kwimiphumo emibi ye-BPC-157 ebantwini ilinganiselwe. , njengoko uphando oluninzi luqhutywe kwiimodeli zezilwanyana.Iimpendulo zomntu ngamnye zinokwahluka, kwaye ezi ziphumo zilandelayo ezichaphazelekayo zisekelwe kwiingxelo ze-anecdotal kunye nophando oluncinci.
Ukucaphuka kwendawo
Abanye abasebenzisi baye baxela ukuba beva iintlungu ezingephi, ububomvu, okanye ukucaphuka kwindawo ebekuhlatywe kuyo inaliti.
Imiba yokwetyisa
I-BPC-157 inokubangela ukuphazamiseka kokwetyisa okwexeshana, okufana nesicaphucaphu, ukuqaqanjelwa sisisu, okanye urhudo.Ezi mpawu zihlala zithambile kwaye zidlula.
Ukuphendula ngokugulisayo
Nangona kunqabile, abanye abantu banokufumana ukuchasana ne-BPC-157.Iimpawu zinokubandakanya irhashalala, ukurhawuzelelwa, ukudumba, okanye ubunzima bokuphefumla.Ukuba kukho naziphi na iimpawu zokungavumelani komzimba nokubakho, kufuneka kufunwe unyango olukhawulezileyo.
Ukusebenzisana naMayeza
I-BPC-157 inokuthi isebenzise amayeza athile okanye unyango.Kubalulekile ukubonisana nochwepheshe bezempilo ukuba uthatha nawaphi na amayeza okanye uneemeko zonyango ezingaphantsi kwe-BPC-157.
Njengayo nayiphi na i-peptide okanye ungenelelo lonyango, kuyacetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokusebenzisa i-BPC-157.Banokubonelela ngesikhokelo, bavavanye ubungozi obunokubakho, kwaye babeke iliso kwinkqubela phambili yakho ukuqinisekisa ukusetyenziswa kwayo okukhuselekileyo nokufanelekileyo.Ukongezelela, ukuthenga iipeptides ukusuka kwi-peptide umthombo ochanekileyo ubaluleke kakhulu.I-AASraw ilawula ngokungqongqo umgangatho kwaye ivelise i-batch ye-BPC-157 ephezulu yokuthengisa.Wamkelekile ukuthenga i-peptide BPC-157 ukuba kuyimfuneko.
BPC-157 VS.TB 500 VS.IGF-1 LR3
I-BPC-157, i-IGF-1 LR3 (i-arginine ende 3-IGF-1), kunye ne-TB500 (i-Thymosin Beta-4) zibhekwa kakhulu iipeptides ezaziwa ngegalelo labo elibalulekileyo lokuphilisa, ukubuyisela, kunye nokulungiswa kwezicubu. ipeptide nganye ineenzuzo ezahlukeneyo kunye nemisebenzi.Nantsi isishwankathelo sezi peptides ezinokunceda ukuqonda ngcono iiyantlukwano zazo.
| Peptide | Indima eMpilweni | Iziphumo eziphambili |
| BPC-157 | Ichaphazela ukukhula kunye nokufuduka kwe-fibroblasts, iiseli ezijongene nokulungiswa kwe-matrix ye-extracellular.Isebenza kwi-hormone yokukhula (GH) receptors. | Ikhawulezisa ukuphiliswa kwenxeba (imisipha, i-ligament, i-tendon, i-nerve), iyancipha ukuvutha, iyancipha iintlungu, inyusa i-hormone receptors, ikhuthaza ukukhula kwe-tendon fibroblast. |
| IGF-1 LR3 (I-arginine ende 3-IGF-1) | Inciphisa ukulahleka komsebenzi we-muscle ezinxulumene neminyaka kwaye ikhuthaza i-hypertrophy ye-muscle.Ibandakanye ukuphilisa kunye nokulungiswa kwethambo, i-cartilage, izilonda, imisipha, ulusu, i-ligaments kunye neetoni. | Iququzelela iprotein synthesis, inyusa ukuvuselelwa kwezicubu, ilawula izibonelelo ze-antioxidant kunye namandla e-ligament, inyusa i-hyperplasia kwiiseli zemisipha. |
| I-TB500 (i-Thymosin Beta-4) | Uxanduva lokuphulukisa izicubu ezijoliswe kuyo kwiimisipha kunye nezicubu ezidibeneyo.Icandelo elibalulekileyo lokwakheka kweeseli kunye nokunyakaza, okukhokelela kwindima yayo ekulungisweni kwezicubu. | Ikhuthaza ukuphilisa, ukukhula kweeseli, ukufuduka kweeseli, kunye nokwanda kweeseli. Yakha iindlela ezintsha zemithambo yegazi, ikhuthaza ukudumba okulungileyo kokuphiliswa kwenxeba ngokukhawuleza. |
Ulwazi olunikwe apha akufunekanga luthathwe njengengcebiso yezonyango.Izibonelelo kunye neendlela zokwenza i-IGF-1 LR3,TB500, kunye ne-BPC 157 ekhankanywe ngasentla isekelwe ikakhulu kwizifundo zangaphambi kweklinikhi kunye nenani eliqingqiweyo lolingo lwezonyango.Ngeli xesha ezi zinto zibonisile amandla okuphilisa kunye nokuvuselelwa kwiimeko ezithile, ukusetyenziswa kwabo kufuneka kuhlale phantsi kwesikhokelo sokhathalelo lwezempilo ngenxa yeziphumo ebezingalindelekanga, iziphumo ezingaziwayo zexesha elide, kunye nokwahluka komntu ngamnye ekuphenduleni.
Ngaba i-BPC-157 inceda ekwakheni umzimba?
I-BPC-157 ifumene ingqwalasela kuluntu lokwakha umzimba ngenxa yeenzuzo ezinokuthi zifumaneke kwimisipha, ukuphulukiswa kokulimala, kunye nempilo edibeneyo.Nangona kukho uphando oluncinci lwezesayensi olujolise ngokukodwa kwimiphumo ye-BPC-157 ekwakheni umzimba, ezinye iingxelo ze-anecdotal zibonisa iziphumo ezilungileyo.
Ukubuyiselwa kwemisipha
I-BPC-157 inokunceda ukuvuselelwa kwemisipha ngokukhuthaza ukulungiswa kwezicubu kunye nokunciphisa ukuvuvukala.Kuye kwaboniswa ukukhawuleza ukubuyiswa kokulimala kwemisipha, ukunyanzeliswa, kunye neenyembezi.I-BPC-157 inokunceda abakhi bomzimba ukuba babuyele ngokukhawuleza ekusebenzeni okunzima ngokunyusa inkqubo yokuphulukisa, okunokubakho ukunciphisa ukuphumla phakathi kweeseshoni zoqeqesho.
Ukunyangwa Kokwenzakala
Ukwakhiwa komzimba, ngokukodwa ukuphakamisa okunzima, kunokusebenzisa ubunzima kwiimisipha, iintambo, kunye neentambo, ukwandisa amathuba okulimala. ngokukhuthaza ukulungiswa kwezicubu kunye nokunciphisa ukuvuvukala.
Impilo edibeneyo
Abakhi bomzimba badinga amajoyina aphilileyo ngenxa yokuba bakhuthaza uhlobo oluhle, uluhlu lwentshukumo, kunye nokusebenza ngokubanzi.BPC-157 iqulethe iimpawu ezichasayo kwaye iphakanyiswe njengonyango lwentlungu edibeneyo kunye nokuvuvukala.Inokuba negalelo ekuphuculeni uqeqesho kunye nokusebenza ngokubanzi ngokukhuthaza. impilo edibeneyo kunye nokunciphisa ukungakhululeki.
Kubalulekile ukuqaphela ukuba amava omntu ngamnye nge-BPC-157 anokwahluka, kwaye uphando lwezenzululwazi oluphanda ngokukodwa iziphumo zalo ekwakheni umzimba lulinganiselwe. impumelelo yokwakha umzimba.
Ukuba ucinga ukusebenzisa i-BPC-157 ngeenjongo zokwakha umzimba, kuyacetyiswa ukuba udibane nochwepheshe bezempilo abanolwazi malunga nonyango lwe-peptide.Banokubonelela ngeengcebiso zomntu, bathathele ingqalelo iinjongo zakho kunye neemeko ezithile, kwaye bakhokele ekusebenziseni ngokufanelekileyo. ye-BPC-157 ecaleni kweminye imiba yerejimeni yokwakha umzimba wakho.
Ingxelo yoVavanyo lwe-BPC-157-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
Indlela yokuthenga i-BPC-157 kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. Andrea Zemba Cilic
AmaSebe e-Pharmacology kunye ne-Pathology, iSikolo soNyango, iYunivesithi yaseZagreb, eZagreb, eCroatia
2. Anita Zenko Sever
ISebe lePathology, iSikolo seMithi, iYunivesithi yaseZagreb, eZagreb, eCroatia
3. Sanja Masnec
ISebe leYunivesithi ye-Ophthalmology, iZiko leZibhedlele zeYunivesithi yaseZagreb, eZagreb, eCroatia
4. UVedran Cesarec
ISebe le-Pharmacology, i-Faculty yezoNyango, iYunivesithi yaseZagreb, eZagreb, eCroatia
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
Ucaphulo
[1] Fosgerau K,Hoffmann T.Peptide therapeutics: imeko yangoku kunye nezalathiso zexesha elizayo.Drug Discover Today.2015;20: 122–128.
[2] Gwyer D,Wragg NM,Wilson SL.Gastric pentadecapeptide body protection compound BPC 157 kunye nendima yayo ekukhawuleziseni ukuphiliswa kwezicubu ezithambileyo ze-musculoskeletal.Cell Tissue Res.2019
[3] Amic F,Drmic D,Bilic Z,Krezic I,Zizek H,Peklic M,et al.Ngokudlula ukuvaleka okukhulu kwe-venous kunye nezilonda ze-duodenal kwiimpuku, kunye nonyango oluzinzileyo lwegastric pentadecapeptide BPC 157,L-NAME kunye ne-L-arginine. J Gastroenterol.2018;24: 5366-5378.
[4] Sikiric P,Seiwerth S,Rucman R,Turkovic B,Rokotov DS,Brcic L,et al.Toxicity yi-NSAIDs.Ukulwa nge-pentadecapeptide ezinzileyo ye-pentadecapeptide BPC 157.Curr Pharm Des.2013;19: 76-83.
[5] uJelovac, uNikola; Sikiric,Predrag; URucman, uRudolf; UPetek, uMarijan; UMarovic, uAnton; Perovic, eDarko; eSewerth, eSven; Mise,Stjepan; UTurkovic, uBranko; eDodig, eGoran; Miklic,Pavle; eBuljat, eGojko; Prkacin,Ingrid (1999).” IPentadecapeptide BPC 157 ithomalalisa ukuphazamiseka okubangelwa yi-neuroleptics: isiphumo kwi-catalepsy kunye nezilonda zesisu kwiimpuku kunye neempuku". Ijenali yaseYurophu yePharmacology. 379 (1): 19–31.
[6] Sikiric,P; Seiwerth,S; URucman,R; Kolenc,D; IVuletic,LB; Drmic,D; Grgic,T; Strbe,S; Zukanovic,G; uCrvenkovic, D; Madzarac,G; Rukavina,I; Sucic,M; Baric,M; Starcevic,N; Krstonjevic,Z; Bencic,ML; Filipcic,I; Rokotov,DS; Vlainic,J (2016). "I-Brain-gut Axis kunye ne-Pentadecapeptide BPC 157: Iimpembelelo zethiyori kunye neZenzo". I-Neuropharmacology yangoku. I-14 (8): 857–865.
