Ingcaciso yeMveliso
Yintoni i-CJC-1295?
I-CJCI-peptide ye-1295 i-peptide ye-synthetic ukukhula ekhupha (GHRH) i-peptide equlethwe ngama-amino acids angama-30. Iyabonwa njengeyona GHRH isebenzayo esetyenziselwa ukulungelelaniswa kwe-hormone yokukhula kwaye inokudibaniswa (ifakwe) kunye nezinye iipeptide, ezifana ne-Ipamorelin, kuba impembelelo enamandla ye-synergistic, kwaye isoloko ifakwe kwiprogram ye-HRT yokulawula ukuguga, kunye neprogram ye-TRT yokuphucula ukusebenza okuphuculweyo.I-CJC-1295 ibonise amandla okunyusa ukulahlekelwa kweoli kunye nokuqinisa ubunzima bemisipha ngelixa ivumela umzimba ukuba usebenze ngokufanelekileyo iprotheni. Ukongezelela ekukhuliseni ngokukhawuleza ukuveliswa kwe-GH, i-CJC-1295 iphinda ikhulise imfihlo ye-insulin-efana nokukhula kwe-1 (IGF-1) .Ngokuyinhloko ifihliwe yisibindi, i-IGF-1 i-hormone ye-anabolic enceda ukukhuthaza ukukhula komntu kuwo wonke umzimba. I-IGF-1 iphinda incedise kwi-bone density kunye ne-filtration yezintso.Enye yeenzuzo eziphambili ze-CJC-1295 kukuba ayinyusi ukuveliswa kweehomoni ezinokuthi zichaneke njengeprolactin.CJC-1295 ngokuqhelekileyo ilawulwa nge-subcutaneous. isitofu.
Isebenza njani i-CJC-1295?
I-peptide ye-CJC-1295 isebenza ngokusebenza kwi-receptor ye-GHRH kunye nokubophelela kwi-pituitary gland receptors ukukhuthaza ukukhululwa kwe-GH kunye ne-insulin-efana ne-insulin factor 1 (IGF-1) .Iye yavavanywa kwizilwanyana kunye nezifundo zovavanyo lwabantu.
Uphononongo lwezilwanyana lwe-2005 lufumene ukuba i-CJC-1295 ivuselele "ukwanda kwe-4" kumanqanaba e-GH xa ilawulwa kwindoda ye-Sprague Dawley iigundane. "I-acuteGH secretions" kuzo zonke izilwanyana kwaye yavelisa "i-plasma enkulu ye-AUC ye-GH kwixesha le-1295-h" yazo zonke iipeptides.
Ukongezelela, izifundo ezibini zabantu ezibandakanya izifundo zovavanyo olunempilo zifumene ukuba ulawulo lwe-CJC-1295 DAC luvelise ukunyuka kwe-2- ukuya kwi-10-fold-fold in mean plasma GH concentrations for six days or more and a 1.5- to 3-fold-fold-fold in mean plasma IGF-1 ugxininiso lweentsuku ezingama-9-11.
Izibonelelo ze-CJC-1295
①Iphucula iMetabolism & Yandisa amandla
I-CJC-1295 esuka kwi-AASraw iphakamisa i-metabolism yakho ngokungathanga ngqo ngokuthumela i-peptides kwi-pituitary gland ukukhulula i-hormone yokukhula kunye nokwandisa isondlo sokutya. kuyo yomibini imisebenzi yesiqhelo kunye nokuzivocavoca okukhulu.
②Yehlisa amanqatha oMzimba
I-hormone yokukhula eyongeziweyo ikhuthaza ukunciphisa umzimba kunye nokunciphisa ipesenti ye-fat body. kwaye ikhuthaza ukunyibilika kwamafutha esiswini.
③Yandisa ubunzima bezihlunu
I-CJC-1295 isebenzisana kunye kwaye isebenze inani le-receptors kuwo wonke umzimba, ukuchaphazela uluhlu olubanzi lwemisebenzi ye-physiological.Inducing isibindi ukwenza i-IGF-1 eninzi ivuselela ukuphuhliswa kwemisipha kunye ne-protein synthesis, okubangelwa ubunzima obukhulu be-muscular.Akunjalo kuphela, kodwa, kodwa ikwakhuthaza ukulahleka kwamafutha, ivumela ubunzima bemisipha yakho ukuba bukhule ngakumbi.
④Ikhuthaza ukuBunjwa kwamathambo
I-CJC-1295 iphinda ikhulise isizukulwana se-insulin-efana nokukhula kwe-1 (IGF-1), i-hormone efana neproinsulin evuselela i-osteoblast kunye nomsebenzi we-chondrocyte, ngoko ke ikhuthaza ukubunjwa kwamathambo.
⑤Iphucula inkqubo yamajoni omzimba
Ngapha koko, xa i-CJC-1295 ingena emzimbeni wakho, yenza amajoni akho omzimba alwe nabahlaseli bangaphandle njengeentsholongwane kunye neebhaktheriya. .Ikwanokunceda abantu abanamajoni omzimba awomeleleyo.
⑥Ikhuthaza iSex Drive
Le amino acid ethandwayo inciphisa iimpawu ezahlukeneyo ezinxulumene nokungabikho komdla kwintsebenzo yesondo okanye ngesondo ngokunyusa amanqanaba e-hormone yokukhula komntu, ephucula zonke iindawo ezisebenza kuzo. ezibalulekileyo ekusebenzeni kwe-erectile.Eminye imiphumo emibi ibandakanya i-libido ephuculweyo kunye nengqiqo yokuphila kakuhle.
⑦Ukulungiswa okuKhawuleza kunye nokuBuyiswa kokwenzakala
Abantu abakhutheleyo, ngakumbi iimbaleki, bahlala beziva bengonwabanga kwiindawo ezininzi zomzimba ngenxa yokulimala okuqhubeka ngexesha lokuzilolonga. Bafuna amandla okulungisa nokuchacha kukwenzakala kwabo. Ihomoni yokukhula yomeleza amajoni omzimba, okukhokelela ekuphuculweni kokuvuselelwa kwamaseli kunye nokuphilisa ngokukhawuleza kunye ukubuyiswa kokulimala.I-CJC-1295 ikhetha ngokukhetha i-protein anabolism kwii-tissue ezahlukahlukeneyo, oku kuthetha ukuba inokunyusa ngokuthe ngqo amandla kunye nokukhawuleza izinga lokuphulukisa ukulimala kunye nokubuyisela.
Iziphumo ebezingalindelekanga zeCJC-1295
Ithuba eliphantsi leempembelelo zecala esinye sezizathu eziphambili zokuba i-peptide ye-CJC-1295 evela kwi-AASraw yamkelwa ngabantu abaninzi.CJC-1295 inyamezeleke kakuhle luninzi lwabantu, kwaye iziphumo zecala zihlala zithobekile, ukuba zikhona zonke iziphumo ezibi kakhulu ze-CJC-1295 zibandakanya iimpendulo zesayithi yokutofa njengokungakhululeki, ubomvu, i-edema, i-flushing, isiyezi, intloko ebuhlungu, okanye i-hyperactivity.
Xa ithathwa ngokuchanekileyo okanye ngokugqithisileyo, iziphumo ezingalunganga zinyuka ziye kumaqondo ahlukeneyo, kuxhomekeke kumntu. yeziphumo ezibi.
Umahluko phakathi kwe-CJC-1295 kunye ne-DAC kwaye ngaphandle kwe-DAC
Umahluko ophambili phakathi kwe-CJC-1295 kunye ne-DAC kunye ne-CJC-1295 ngaphandle kwe-DAC ibonakala kwizakhiwo zabo ezahlukeneyo kunye nesiqingatha sobomi.
Ulwakhiwo: Zombini i-CJC-1295 kunye ne-DAC kunye ne-CJC-1295 ngaphandle kwe-DAC ziyi-peptides zokwenziwa ezivela kwi-hormone yokukhula yendalo ekhupha i-hormone (GHRH) .Nangona kunjalo, bahluke kwiinguqu zabo zeekhemikhali.
I-DAC(Drug Affinity Complex): I-CJC-1295 kunye ne-DAC inokuguqulwa okongeziweyo okubizwa ngokuba yi-Drug Affinity Complex.Olu luhlu luyi-molecular structure eyongeziweyo kwi-peptide yokuphucula ukuzinza kunye nokwandisa isiqingatha sobomi emzimbeni.
Ubomi obulicla: Ubukho be-DAC kwi-CJC-1295 kunye ne-DAC iphumela kwi-half-life ngokuphawulekayo xa kuthelekiswa ne-CJC-1295 ngaphandle kwe-DAC.
Ubungakanani bedosi:Ngenxa yolwandiso lwesiqingatha sobomi, i-CJC-1295 kunye neDAC ifuna i-dosing engaphantsi rhoqo.Idla ngokulawulwa kanye okanye kabini ngeveki.Kwelinye icala, i-CJC-1295 ngaphandle kwe-DAC inobomi obufutshane obufutshane kwaye isoloko ilawulwa ngokuphindaphindiweyo. amaxesha ngosuku ukugcina amanqanaba angaguqukiyo.
Administration:Zombini i-CJC-1295 kunye ne-DAC kunye ne-CJC-1295 ngaphandle kwe-DAC zivame ukulawulwa ngee-injection ezingaphantsi kwe-subcutaneous.I-injection site ngokuqhelekileyo indawo yesisu okanye ithanga.
Ukusetyenziswa kweKlinikhi: I-CJC-1295 kunye ne-DAC kunye ne-CJC-1295 ngaphandle kwe-DAC inezicelo ezahlukeneyo.I-CJC-1295 kunye ne-DAC isetyenziselwa ngokuyinhloko kwiipropati zayo zokukhula kwe-hormone kumxholo wonyango lwezonyango, ukuphuculwa kokusebenza, okanye ukuguga.CJC-1295 Ngaphandle kweDAC, kwelinye icala, isetyenziswa kakhulu ngeenjongo zophando kunye nophando lwezenzululwazi.
Nceda uqaphele ukuba i-AASraw inikezela zombini i-CJC-1295 kunye ne-DAC kunye ne-CJC-1295 ngaphandle kwe-DAC.
FAQ
①Yeyiphi eyona ndlela yokulawula i-CJC-1295?
Ukuqala, inaliti ivumela ukufunxwa ngokuthe ngqo kwi-bloodstream.Ukufumana iziphumo ezilungileyo,tofa i-CJC ngexesha elinye yonke imihla, kwisisu esingenalutho, kwisixa esichaziweyo.
Emva koko, iindawo ezifanelekileyo zokutofa sisisu esisezantsi, ithanga, okanye ingalo engaphezulu. Kufuneka ulinde ubuncinane imizuzu engama-30 ulandela inaliti yakho ngaphambi kokuba utye okanye usele nantoni na. iiyure phakathi kweedosi.
Okokugqibela, ukuba unqwenela ukufezekisa iziphumo ozinqwenelayo, kufuneka ungaguquguquki.
②Ifanele igcinwe njani i-CJC-1295?
Xa kuziwa kubomi beshelufu, i-CJC-1295 peptide kufuneka isoloko igcinwe ngononophelo kwaye isetyenziswe.Kufuneka uyisebenzise ngomhla othile okanye iya kuphulukana nokusebenza kwayo kwaye ibe yingozi.
Ubomi bethala leengqayi bunokwandiswa ngokuzikhenkceza. I-CJC-1295 iya kuhlala kuphela iiveki ezimbalwa kwiqondo lobushushu begumbi, nangona kunjalo ukukhenkceza kunokwandisa ubomi beshelufu ukuya kwinyanga enye.Xa utofa, soloko uthobela iingcebiso zikagqirha wakho.
③INGABA I-CJC-1295 ISEBENZA KUWO WONKE UMNTU?
Ukufumana ukwehla kobunzima kunye nokutshisa amanqatha omzimba, kuya kufuneka wenze uhlengahlengiso kwindlela ophila ngayo xa kuziwa kukutya kunye nokuzilolonga.
Nokuba ulandela inkqubo yonyango ecetyiswayo, ukutya okungalunganga kunye nokungabikho kokuzivocavoca kunokuba nefuthe elibi kwimpilo yakho kwaye ube negalelo ekufumaneni ubunzima. Nangona kunjalo, xa udityaniswa nokutya okuchanekileyo kunye nokuzilolonga, le peptide ye-CJC-1295 inokukunceda ufezekise iinjongo fitness ngempumelelo ngakumbi!Ukuba kuyimfuneko, wamkelekile ukuthenga CJC-1295.
Indawo yokuthenga i-CJC-1295?
I-CJC-1295 unyango lwe-peptide lunempembelelo enkulu kwimpilo yonke.Inceda ekufumaneni imisipha, i-fat metabolizing, ukwandisa amandla, kunye nokunye okuninzi.Ifezekisa zonke ezi zinto ngokuncedisa umzimba wakho wokwanda kwe-hormone yokukhula.Apha kwi-AASraw, sizinikele kuyo Ukubonelela ngeepeptide ezininzi kubandakanya ukwehla kobunzima, unyango lwempilo yesondo, kunye nezinye iihomoni.Ukuba unomdla kwi-wholesale CJC-1295 okanye nayiphi na enye i-peptides, gcwalisa ifomathi engezantsi ukucwangcisa ukubonisana kwakho kwaye uthethe nabasebenzi bethu abakhethekileyo.Asikwazi kulinda ukuva kuwe!
Ingxelo yoVavanyo lwe-CJC-1295-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
Indlela yokuthenga i-CJC-1295 kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. Bernd Peschke
IKhemistri yoKhathalelo lwezeMpilo, iNovo Nordisk A/S, iNovo Nordisk Park, 2760 Måløv, Denmark
2. UPetros B. Johansen
Isebe loPhando lwePharmacological, Novo Nordisk A/S, Bagsværd, DK-2880, Denmark
3. QAPHELA UAndersen
ISebe le-Connective Tissue Biology, iZiko le-Anatomy, iYunivesithi yaseAarhus, i-Aarhus C, i-DK-8000, eDenmark
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
Ucaphulo
[1] Henninge J, Pepaj M, Hullstein I, Hemmersbach P (2010). "Ukuchongwa kwe-CJC-1295, i-peptide ekhupha i-hormone yokukhula, kwilungiselelo elingaziwayo lonyango". Uvavanyo lweziyobisi kunye nohlalutyo. 2 (11–12): 647–50. doi:10.1002/dta.233. PMID 21204297.
[2] Hartvig RA, Holm NB, Dalsgaard PW, Reitzel LA, Müller IB, Linnet K (2014). "Ukuchongwa kwe-peptide kunye neprotheyini ye-doping enxulumene neziyobisi ezithathwe eDenmark phakathi kwe-2007-2013". Ijenali yaseScandinavia yeSayensi yezoPhando. 20 (2): 42–49. doi:10.2478/sjfs-2014-0003. ISSN 2353-0707.
[3] Ionescu M, Frohman LA (Disemba 2006). "I-pulsatile secretion ye-hormone yokukhula (GH) iqhubeka ngexesha lokuvuselela ngokuqhubekayo yi-CJC-1295, i-analog ye-hormone yokukhulula ixesha elide". Ijenali yeClinical Endocrinology kunye neMetabolism. 91 (12): 4792–7. doi:10.1210/jc.2006-1702. PMID 17018654.
[4] Thorner MO (Juni 2008). "Ukufunyanwa kwehomoni yokukhula ekhupha ihomoni: ukuhlaziywa". Ijenali yeNeuroendocrinology. 20 (6): 653–4. doi:10.1111/j.1365-2826.2008.01740.x. PMID 18601685. S2CID 29788809.
[5] Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA (Matshi 2006). "Ukukhuthaza ixesha elide lokukhula kwehomoni (GH) kunye ne-insulin-efana ne-insulin yokukhula kwe-I secretion yi-CJC-1295, i-analog yexesha elide ye-GH-releasing hormone, kubantu abadala abaphilileyo". Ijenali yeClinical Endocrinology kunye neMetabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. PMID 16352683.
