Dapoxetine iHCL powder

1. Dapoxetine hydrochloride Umda yokuzonwabisa-AASraw

 

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2. Dapoxetine hydrochloride Umda Abalinganiswa abasisiseko

igama:	Dapoxetine hydrochloride
CAS:	129938-20-1
Ifomula yeMolekyuli:	C9H7ClN2O5
Ubunzima Ezinto:	258.62
Melt Point:	175-179 ° C
Isitoreji sokugcina:	-20 ° C Ifreezer
umbala:	Powstalline powder

 

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3. Dapoxetine hydrochloride Umda Ingxelo yoVavanyo-HNMR

Yintoni i-HNMR kwaye ikuxelela ntoni i-spectrum ye-HNMR? H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bohlalutyo lwekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokufumanisa umxholo kunye nokusulungeka kwesampulu kunye nokwakheka kwemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.

4.Yintoni iDapoxetine?

I-Dapoxetine, edla ngokubizwa ngokuba yi-Priligy, isilwanyana esisetyenziselwa ukuphatha i-ejaculation ngaphambi kwexesha (PE) kumadoda aneminyaka eyi-18 ukuya kwi-64. I-Dapoxetine Hydrochloride Powder ikhuthaza i-ejaculatory latency ngokuvimba umthuthi we-serotonin kunye nokunyusa umsebenzi we-serotonin kwi-postsynaptic cleft. I-Dapoxetine yaphuhliswa njenge-antidepressant njengenxalenye yeklasi ekhethiweyo ye-serotonin reuptake inhibitor (SSRI). Nangona kunjalo, ngokungafaniyo nezinye ii-SSRIs, i-Dapoxetine Hydrochloride Powder ixutywa ngokukhawuleza kwaye isuswe emzimbeni. Ngenxa yokuqalisa kwayo ngokukhawuleza, ifanelekile kunyango lwe-ejaculation ngaphambi kwexesha kodwa kungekhona njenge-antidepressant. Kukho amazwe amaninzi avunyiweyo i-Dapoxetine Hydrochloride Powder ukuze ithengiswe kubantu abangaphezu kweminyaka eyi-18. Nangona kunjalo, okwangoku akuvunywanga nguLawulo lokuTya kunye neDrugs (FDA) eUnited States. Oku kuthetha ukuba awukwazi ukufumana umyalelo we-dapoxetine e-US

Nangona kunjalo, oku akuyi kukuchaphazela ukuba uthenge i-Dapoxetine Hydrochloride Powder kwi-intanethi. Kulo mhlaba ofike ngexesha, kulula kakhulu ukufumana i-Dapoxetine Hydrochloride Powder suppliers kwi-intanethi. Ubunzima kukuthenga umgangatho ophezulu we-Dapoxetine Hydrochloride Powder kunye nomthengisi othembekileyo.

5. Iyenza njani iDapoxetine Hydrochloride (Priligy) ukusebenza?

Indlela yokwenza iyeza ithathwa ukuba ihambelana nokunyanzeliswa kwe-neuronal serotonin reuptake kunye nesiphumo sokusebenza kwe-serotonin. I-central ejaculatory neural circuit ibandakanya iiyunithi zomgogodla kunye neengqondo ezenza inethiwekhi edibeneyo. Ngaphantsi kwempembelelo ye-sensory ye-genital kunye ne-cerebral impulses edibeneyo kwaye iqhutywe kwinqanaba le-spinal cord, i-sympathetic, i-parasympathetic, kunye ne-somatic spinal centres yenza i-synergy ukuyalela iziganeko ze-physiologic ezenzeka ngexesha le-ejaculation. Ubungqina bovavanyo bubonisa ukuba i-serotonin (i-5-HT) inqanda ukuphuma kwe-ejaculation ngokusebenzisa iindlela zokuhla kwengqondo. Ukuza kuthi ga ngoku, ii-subtypes ezintathu ze-5-HT (5-HT (1A), 5-HT (1B), kunye ne-5-HT (2C)) ziye zacetywa ukuba zidibanise i-5-HT ye-ejaculatory modifying function.

6. Ziziphi iziphumo eziqhelekileyo eziqhelekileyo kwi-Dapoxetine Hydrochloride Powder?

Isicaphucaphu, isiyezi, intloko ebuhlungu, isiqaqa, kunye norhudo zezona zixhaphakileyo iziphumo ezibi. Ukuba uziva unesiyezi okanye utyhafile emva kokuthatha i-Priligy, musa ukuqhuba, ukusebenzisa oomatshini abakhulu, okanye ubandakanyeke kwimisebenzi eyingozi. Ukuthenga umgangatho ophezulu we-Dapoxetine Hydrochloride Powder uya kukunceda ugweme ezinye iziphumo ezingafunekiyo.

7. Ihlala ixesha elingakanani i-Dapoxetine Hydrochloride Powder?

I-Dapoxetine Hydrochloride Powder idla ngokusebenza kwiiyure ze-1-3 emva kokuyithatha, nangona kunjalo ngamanye amaxesha inokuhlala kwiiyure ze-12.

I-Dapoxetine Hydrochloride Powder iyasebenza malunga ne-8 kwi-10 amadoda. La madoda kufuneka aqaphele ukuphindwa kabini okanye ukuphinda kathathu kwexesha lokumiswa kwawo phambi kokuba aphume. I-Dapoxetine Hydrochloride Powder ayinyangeki kwaye isebenza kuphela xa ithathwa.

Nceda ugcine engqondweni ukuba akubona bonke abantu abazuzayo kwi-Dapoxetine Hydrochloride Powder. Mhlawumbi uthenge i-Dapoxetine Hydrochloride Powder embi yingcinga yokuqala, indlela yokufumana i-Dapoxetine Hydrochloride Powder yangempela umenzi, kufuneka ulahle amandla akho kuyo. Ukuba uyithenga kwi-AASRAW, uya kufumana ixabiso elihle le-Dapoxetine Hydrochloride Powder.

8. I-Dapoxetine (Priligy) Isistim

I-dose ye-pharmacological ye-Dapoxetine yi-30mg kanye imihla ngemihla, kwaye kwiimeko ezinzima ze-ejaculation ngaphambi kwexesha, i-Dapoxetine 30mg kabini imihla ngemihla iyanconywa. (Kuphela ngengcebiso kaGqirha). Kufuneka inikwe ngomlomo kwiiyure ezi-1-3 ngaphambi kwesenzo esifunwayo.

9. I-Dapoxetine hydrochloride powder inqwaba kunye namanye amachiza

①Sildenafil + Dapoxetine

I-Sildenafil + i-Dapoxetine yindibaniselwano yamayeza amabini: I-Sildenafil Powder kunye ne-Dapoxetine hydrochloride Powder, ephethe i-erectile dysfunction kunye nokuphuma kwangaphambi kwexesha. I-Sildenafil Powder i-phosphodiesterase type 5 (PDE 5) inhibitor esebenza ngokunyusa ukuhamba kwegazi kwi-penis ngexesha lokuvuselela ngokwesondo kwaye yenza ukuba ukulungiswa kwayo kulandela ukuvuselela ngokwesondo. I-Dapoxetine hydrochloride Powder yinto ekhethiweyo ye-serotonin reuptake inhibitor (SSRI) eyandisa inqanaba le-serotonin kwiimbilini zokwandisa ixesha elithathiweyo ukukhupha kunye nokuphucula ukulawula ukukhupha.

②Tadalafil + Dapoxetine

Ukusetyenziswa okuphambili kweyeza elidibeneyo i-Tadalafil + i-Dapoxetine, equlethe "ii-agent ezingenamandla," yonyango lwe-erectile dysfunction (ukungabi namandla) kunye nokukhutshwa kwangaphambili kwamadoda. I-Tadalafil powder kunye ne-Dapoxetine hydrochloride Powder zombini izithako kwi-Tadalafil + Dapoxetine. I-Tadalafil Powder isebenza ngokuthintela i-enzyme ye-phosphodiesterase ekuphuleni i-cGMP, nto leyo eyenza ukuba izihlunu ezigudileyo ziphumle kunye nemithambo yegazi kwi-penis ukuba i-vasodilate (ibanzi). Ngenxa yoko, inceda kunyango lweempawu ezandisiweyo zedlala lobudoda kunye nokungasebenzi kakuhle kwe-erectile. Ngokuphakamisa amanqanaba e-serotonin kwimithambo-luvo, i-Dapoxetine hydrochloride Powder iphucula ulawulo phezu kwe-ejaculation kwaye yandisa ixesha elithathayo ukukhupha.

10. Indlela yokuthenga i-Dapoxetine Hydrochloride Powder Kwi-Intanethi?

Xa ufuna iyeza elithile, kunokuba nzima ukufumanisa ukuba ingaba iyeza likhuselekile na kwaye liluncedo kwiimfuno zakho. Iindaba ezimnandi zezokuba amanye amayeza anokufunyanwa kuphela ngomyalelo kagqirha, kodwa amanye anokufunyanwa ngokusemthethweni kwi-Intanethi ngaphandle komyalelo kagqirha. Ukuba ukhangele i-Dapoxetine hydrochloride Powder, ungayithenga kwi-AASRAW. Ungathenga i-wholesale Dapoxetine hydrochloride Powder ukuze ufumane ixabiso elihle.

11. Ngaba i-Dapoxetine hydrochloride Powder iyasebenza?

Idatha ye-Dapoxetine ibonisa ngokucacileyo ukuba amadoda athatha i-dapoxetine yonyango lwe-ejaculation ngaphambi kwexesha afumana ukuphuculwa okuphawulekayo kumsebenzi wesondo, kunye nokulawulwa kwe-ejaculation, ukwaneliseka ngokwesondo kumadoda kunye namaqabane abo, kunye ne-IELT (I-Intravaginal Ejaculatory Latency Time).

12.Iinkcazo

[1] Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, et al. Ukusebenza kunye nokunyamezela kwe-dapoxetine kunyango lwe-ejaculation ngaphambi kwexesha: uhlalutyo oludibeneyo lwezilingo ezimbini ezingaboniyo. Lancet 2006;368:929-37.

[2] I-Buvat J, i-Tesfaye F, i-Rothman M, i-Rivas DA, i-Giuliano F. I-Dapoxetine yonyango lwe-ejaculation ngaphambi kwexesha: iziphumo ezivela kwi-randomized, i-double-blind, i-placebo-controlled controlled phase 3 kwi-22 kumazwe. I-Eur Urol 2009;55:957-67.

[3] Ingubo, MJ; UDesai, D.; Gidwani, S.; Seftel, AD & Modi, NB (2006). "I-Dapoxetine, unyango olunoveli lwe-ejaculation ngaphambi kwexesha, alukho ukusebenzisana kwe-pharmacokinetic kunye ne-phosphodiesterase-5 inhibitors". Ijenali yeHlabathi yoPhando lokungabi namandla. 18 (1): 104–110. doi:10.1038/Sj.Ijir.3901420. PMID 16307008.

[4] McMahon, CG (Oct 2012). "I-Dapoxetine: inketho entsha ekulawuleni unyango lwe-ejaculation ngaphambi kwexesha". Inkqubela phambili yoNyango kwi-Urology. 4 (5): 233–51. doi:10.1177/1756287212453866. PMC 3441133. PMID 23024705.

[5] "I-Priligy isetyenziselwa ukuNyanga i-Ejaculation ngaphambi kwexesha". deutschemedz.de (ngesiJamani). 10 Agasti 2015. Ibuyiselwe 19 Novemba 2018.

13. Indlela yokuthenga I-Dapoxetine Hydrochloride Powder ukusuka kwi-AASraw?

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