Ingcaciso yeMveliso
Yintoni i-GHRP-6?
I-GHRP-6, okanye i-Growth Hormone Releasing Peptide-6, yi-synthetic hexapeptide, nto leyo ethetha ukuba iqulethe i-amino acids ezintandathu. Le peptide isebenza njenge secretagogue, into leyo ebangela ukukhutshwa kwenye into. Kwimeko ye-GHRP-6, ivuselela ukukhululwa kwehomoni yokukhula.
I-GHRP-6 isebenza ngokulinganisa imiphumo ye-hormone ghrelin, eyi-hormone elawula indlala kwaye idlala indima ekusasazeni kunye nesantya sokusetyenziswa kwamandla.Xa i-GHRP-6 ibophelela kwi-ghrelin receptors, ivuselela ukukhululwa kwehomoni yokukhula idlala lepituitary. Oku kukhutshwa kwehomoni yokukhula, kunye nendima yokulinganisa i-ghrelin, kukhokelela ekwandeni kokutya, okunokuba luncedo kubantu abafuna ukufumana ubunzima bezihlunu.
Ukongeza, i-GHRP-6 iye yaphawulwa ngamandla ayo okuphucula ukulala, ukukhuthaza ukulahleka kwamafutha, ukuxhasa amajoni omzimba, kunye nokunceda ukukhusela intliziyo. Ihlala isetyenziswa ngabakhi bomzimba kunye neembaleki ngenxa yempembelelo yayo kumanqanaba ehomoni yokukhula.
Isebenza njani iGHRP-6?
I-GHRP-6 (i-Growth Hormone Releasing Peptide-6) isebenza ngokuxelisa i-hormone ghrelin, ebangela ukwanda kwe-endogenous (eveliswa ngaphakathi) ukukhululwa kwe-hormone yokukhula emzimbeni.Nantsi ukujonga ngokusondeleyo kwindlela yokusebenza kwayo.
Ukuvuselela iGhrelin
I-Ghrelin, eyaziwa ngokuba yi "hormone yendlala," yihomoni eveliswa sisisu ekuphenduleni ukuzila ukutya okuvuselela umdla wokutya, okukhokelela ekutyeni kokutya okwandisiweyo. I-GHRP-6 isebenza njenge-ghrelin agonist, okuthetha ukuba ibophelela kwaye ivuselele i-ghrelin receptors kwingqondo, inyusa ukuvakalelwa kwendlala.
Ukukhutshwa kweHormone yokuKhula
Xa i-GHRP-6 isebenzisana ne-ghrelin receptors, i-pituitary gland ikhupha i-hormone yokukhula. Le hormone inceda ekukhuleni, ekubunjweni komzimba, ukulungiswa kweeseli, kunye nemetabolism. Ikhuthaza ubunzima be-muscular, yongeza amandla emisipha, kwaye inceda ekubuyiseleni iingozi kunye nokuphazamiseka.
I-Somatostatin Inhibition
I-GHRP-6 inokucinezela i-somatostatin, ihomoni evimbela ukuveliswa kwehomoni yokukhula. Ngokuthintela i-somatostatin, i-GHRP-6 iqinisekisa ukuba i-hormone yokukhula ayithintelwanga ukuba ikhululwe, okubangelwa ubuninzi bale hormone emzimbeni.
I-Synergistic Effect ene-GHRH
Xa kuthathwa nge-hormone yokukhula-ekhulula i-hormone (GHRH), i-GHRP-6 inefuthe le-synergistic. Xa zidityanisiwe, zonyusa ubungakanani behomoni yokukhula ekhutshwa lidlala lepituitary ngaphezulu koko kunokukhutshwa ukuba enye i-peptide inikwe yodwa.
Kubalulekile ukuthenga i-GHRP-6 kumthengisi owaziwayo ukuze kuqinisekiswe umgangatho we-peptide GHRP-6.AASraw, umenzi we-GHRP-6 oyingcali kunye nomthengisi, unokubonelela ngekhwalithi ephezulu ye-GHRP-6 kwiziko elizimeleyo le-R&D kunye Ifektri.Ukuba unemfuno, i-GHRP-6 i-wholesale esuka kwi-AASraw yinto ekhethekileyo yokukhetha.
Izibonelelo zeGHRP-6
I-GHRP-6 (i-Growth Hormone Releasing Peptide 6) yi-peptide yokwenziwa ekhuthaza ukukhululwa kwe-hormone yokukhula emzimbeni. Iinzuzo zayo ezinokuthi zihlolwe kwiintlobo ezahlukeneyo zophando kunye nezifundo. Nangona kunjalo, kubalulekile ukuqaphela ukuba uninzi lwezi zibonelelo ezinokubakho zisekwe ikakhulu kwizifundo zezilwanyana kunye nobungqina be-anecdotal obuvela kubasebenzisi babantu. Ulingo lwezonyango olungqongqo ngakumbi luyafuneka ukuqinisekisa ezi ziphumo ebantwini. Nazi ezinye iinzuzo ezinokubakho ze-GHRP-6 ngokophando olukhoyo.
Ukukhutshwa kweHormone yokuKhula
I-GHRP-6 ikwandisa ukukhululwa kwe-hormone yokukhula (GH) kwi-pituitary gland. I-hormone yokukhula iyimfuneko ekukhuleni komntwana kwaye inceda abantu abadala bagcine ukubunjwa komzimba okunempilo kunye nokuphila kakuhle. Ukwanda kwe-GH kunokubangela ukwanda kwemisipha kunye namandla. Oku kwenzeka ngenxa yokuba i-GH ikwandisa ukudalwa kwe-Insulin-like Growth Factor 1 (IGF-1) esibindi, eyona hormone ebalulekileyo yokukhula kwemisipha. Ngenxa yezi nzuzo, i-GHRP-6 lukhetho oludumileyo phakathi kwabakhi bomzimba kunye neembaleki ezijonge ukuphucula ukusebenza kwazo ngokomzimba kunye nomzimba.
Ukuhla ukusinda
I-GHRP-6 ikhuthaza ukukhuselwa kwehomoni yokukhula, enokunceda ekukhuleni kobunzima bemisipha. Ukwandisa ubunzima bezihlunu ezibhityileyo kunokunyusa izinga le-metabolic kuba isihlunu sitshisa iikhalori ezininzi kunamanqatha nokuba uphumle. Ngenxa yoko, ukwanda kwemisipha ye-muscle kunokubangela ukutshiswa kwekhalori ephuculweyo kunye nokulahlekelwa kwesisindo ngexesha.
Ngapha koko, ezinye izifundo zibonisa ukuba ihomoni yokukhula inokunceda ekuqhekekeni kweeseli ezinamafutha (inkqubo eyaziwa ngokuba yi-lipolysis), enokunceda kwiinzame zokuncipha kobunzima. Uphando olongezelelekileyo, nangona kunjalo, luyafuneka ukuqonda ubuchwephesha obuthile kunye nokusebenza kwale nkqubo.
Ukuphiliswa Okuphilayo
I-GHRP-6 ibonakaliswe ukukhawuleza ukuphulukiswa kwesilonda kunye nokubuyiselwa kwezicubu. Oku kunokuba ngenxa yendima yayo ekukhuthazeni ukukhutshwa kwe-GH, eyaziwa njengedlala indima ekuhlaziyweni kweeseli kunye ne-protein synthesis - zombini zibalulekile kwiinkqubo zokuphilisa umzimba. Olu ncedo lunokubakho lunokuba luncedo kubantu abachacha kuqhaqho, ukothuka, okanye abanamanxeba aphola kancinci ngenxa yezigulo ezifana nesifo seswekile.
Iziphumo zokuthintela ukudumba
Olunye uphononongo lucebisa ukuba i-GHRP-6 inokuba neempawu ezichasayo ukudumba, ezinokunceda iintlobo ngeentlobo zezifo zempilo eziphawulwa kukudumba, okufana nesifo samathambo, isifuba, kunye nesifo samathumbu.
Iimpembelelo zeCardio-zokukhusela
Uphando olutsha lubonisa ukuba i-GHRP-6 ingaba neepropati zokukhusela intliziyo. Inokunceda ukunciphisa umonakalo kwiithishu zentliziyo, ngakumbi emva kweziganeko ezifana nesifo sentliziyo. Le mpembelelo yokukhusela inamandla okunciphisa umngcipheko wesifo senhliziyo kunye nokuphucula impilo yentliziyo, ngakumbi kubantu abasele besengozini.
Kubalulekile ukuqonda ukuba baninzi abavelisi be-GHRP-6 kunye nababoneleli abakhoyo kwi-intanethi kunye ne-intanethi; nangona kunjalo, ayizizo zonke ezinokuthenjwa.Thenga i-GHRP-6 kumvelisi ohloniphekileyo kunye nomthengisi wezona ziphumo zigqwesileyo.I-AASraw igxile ekuveliseni nasekuboneleleni nge-GHRP-6 ngokuhambelana neemfuno zokuvelisa zeCGMP, kunye nebhetshi nganye yeemveliso eziphantsi kovavanyo lomgangatho. phambi kokuthengisa.
Imiphumo emibi ye-GHRP-6
I-GHRP-6 (i-Growth Hormone Releasing Peptide 6) ngokuqhelekileyo inyamezeleke kakuhle, kodwa njengawo nawaphi na amayeza okanye isongezelelo, inokuba nemiphumo emibi. Kuhlala kubalulekile ukubonisana nomboneleli wezempilo phambi kokuba uqalise naluphi na unyango olutsha.
- Ukugcinwa kwamanzi
- Ukonyuka Komdla Wokutya
- Hypoglycemia
- Ukuphendula kwendawo yenaliti
- ICarpal Tunnel Syndrome
- Gynecomastia
Khumbula, olu ayiloluhlu olubanzi kwaye iziphumo ebezingalindelekanga zinokwahluka kumntu nomntu ngokusekwe kwizinto ezininzi, kubandakanywa impilo iyonke, umthamo, kunye nempendulo yomntu kunyango. Hlala udibana nomboneleli wezempilo ukuze uqonde iingozi ezinokuthi zibekho kunye neenzuzo ngaphambi kokuba uqale i-GHRP-6 okanye nayiphi na irejimeni entsha yonyango.
Ngaphambi kokusebenzisa i-GHRP-6, njengayo nayiphi na i-peptide okanye ungenelelo lonyango, kungcono ukudibana nengcali yokhathalelo lwempilo.Banokunika iingcebiso, bavavanye iingozi ezinokubakho, kwaye balandelele inkqubela yakho ukuqinisekisa ukusetyenziswa okukhuselekileyo nokufanelekileyo.Ngaphezu koko, ukuthenga iipeptides kwi umthombo ofanelekileyo ubalulekile.I-AASraw igcina ulawulo oluluqilima lomgangatho kwaye yenze ibhetshi ye-GHRP-6 ephezulu yokuthengisa.Ukuba kuyimfuneko, wamkelekile ukuthenga i-peptide GHRP-6.
I-GHRP-6 vs GHRP-2
I-GHRP-6 kunye ne-GHRP-2 zombini iipeptide zokwenziwa zeqela le-peptides ekhupha i-hormone yokukhula (GHRPs). Zikhuthaza ukuveliswa komzimba kwehomoni yokukhula (GH), enokuthi ikhokelele ekwandeni kobunzima bezihlunu kunye namandla, kunye nokuphucula ukubuyiswa kunye nokulahleka kwamafutha. Nalu uthelekiso lwezi peptides zimbini.
| GHRP-6 | GHRP-2 | |
| itheko | Ivuselela ukukhutshwa kwehomoni yokukhula | Ivuselela ukukhutshwa kwehomoni yokukhula |
| Usetyenziso oluphambili | Isetyenziselwa ukwakha izihlunu, uphuculo lokusebenza, kwaye njengenxalenye yemigaqo yokuchasana nokuguga | Isetyenziselwa ukwakha izihlunu, uphuculo lokusebenza, kwaye njengenxalenye yemigaqo yokuchasana nokuguga |
| GH Ukukhutshwa | Ukukhutshwa kwe-GH okubalulekileyo, kodwa kuncinci kancinci kune-GHRP-2 | Ukukhutshwa kwe-GH okunamandla ngakumbi xa kuthelekiswa ne-GHRP-6 |
| Imiphumela | Ithuba lokugcinwa kwamanzi, ukunyuka kokutya, u-hypoglycemia, ukusabela kwendawo yokutofa, amathuba okuphuhliswa kwe-carpal tunnel syndrome, kunye neemeko ezinqabileyo ze-gynecomastia | Imiphumo efanayo efanayo kwi-GHRP-6, kodwa inokuba nesantya esiphezulu seziphumo ebezingalindelekanga ngenxa yokwanda kwamandla. |
Izitaki zeGHRP-6 kunye nezinye iipeptides
I-GHRP-6, uhlobo lwe-peptide ekhupha i-hormone yokukhula, isoloko isetyenziselwa ukudibanisa, okanye "ifakwe," kunye nezinye iipeptides ukunyusa ukusebenza kwayo. Oku kungenxa yokuba i-GHRP-6 isebenza ngokubambisana nezi peptides, oko kuthetha ukuba umphumo odibeneyo mkhulu kunesimbuku semiphumo yazo. Nazi iipeptides ezimbalwa eziqhele ukupakishwa nge-GHRP-6.
| Stack | Izibonelelo ezinokubakho | Stack |
| GHRP-6 + CJC-1295 | Ukonyuka kwe-GH secretion, ukukhula kwemisipha okuphuculweyo, ukuphucula ukulahleka kwamafutha, kunye nokuchacha ngokukhawuleza | GHRP-6 + CJC-1295 |
| GHRP-6 + Ipamorelin | Ukukhutshwa kwe-GH okunamandla ngakumbi, ukulala okungcono, ukukhula kwemisipha okuphuculweyo, kunye nokulahleka kwamafutha | GHRP-6 + Ipamorelin |
| GHRP-6 + IGF-1 | Ukukhula kwezihlunu okuphuculweyo, ukuchacha okuphuculweyo, ukonyuka kokulahleka kwamafutha, izibonelelo ezinokuthi zichane nokuguga | GHRP-6 + IGF-1 |
| GHRP-6 + Hexarelin | Ukukhutshwa okunamandla ngakumbi kwe-GH, ukukhula kwemisipha okuphuculweyo, kunye nokulahleka kwamafutha | GHRP-6 + Hexarelin |
Nceda uqaphele ukuba olu lwazi lwenzelwe ireferensi, hayi ingcebiso yonyango yobuchwephesha.Khumbula, ngelixa ezi zixa ziqhele ukusetyenziswa, kufuneka zisetyenziswe phantsi kweliso lomboneleli wezempilo okanye ingcali kumayeza ezemidlalo. Ukusetyenziswa kakubi kunokukhokelela kwimiphumo emibi yempilo, kwaye iinzuzo ezinokuthi zibekho kunye neengozi kufuneka zilinganiswe ngononophelo.
Isilumkiso:Xa uthenga iGHRP-6 kumthengisi, kubalulekile ukubeka phambili umgangatho kunye nokhuseleko lwemveliso. Qinisekisa ukuba umthengisi we-GHRP-6 uthembekile kwaye uhlaziywe kakuhle, kwaye banikezela ngolwazi olubanzi malunga nokukhangela, ukuvelisa, kunye neenkqubo zokulawula umgangatho weemveliso zabo. Kufuneka kwakhona zicace malunga nezithako kunye noxinzelelo lwepeptide. Soloko udibana nochwepheshe bezempilo ngaphambi kokuba uqalise nasiphi na isongezelelo esitsha okanye iyeza, kwaye khumbula ukuba ezi zinto kufuneka zisetyenziswe kuphela phantsi kweliso likagqirha.
Ingxelo yoVavanyo lwe-GHRP-6-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
Indlela yokuthenga i-GHRP-6 kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. UMiriam Granado
Isebe le-Endocrinology, kwisibhedlele i-Infantil Universitario Niño Jesús, eMadrid, eSpain
2. uLiz Hernández
Isibhedlele saseYunivesithi yaseSt. James, eLeeds, e-UK,
3. UGeneviève Frégeau
IFaculty of Pharmacy, Université de Montréal, Montreal, Québec, Canada4.
4. UAndrea Giustina
Icandelo le-Endocrine, iSebe leMithi yangaphakathi, iBrescia, eItali
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
Ucaphulo
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[2] Cabrales A,Gil J,Fernández E,Valenzuela C,Hernández F,García I,Hernández A,Besada V,Reyes O,Padrón G,Berlanga J,Guillén G,González LJ (2013). "Uphononongo lwe-Pharmacokinetic lwe-Growth Hormone-Releasing Peptide 6 (GHRP-6) kumavolontiya angamadoda alithoba". I-Eur J Pharm Sci. 48 (1–2): 40–6.
[3] Argente,J.,García-Segura,LM,Pozo,J.,&Chowen,JA (1996). I-peptides ekhupha ihomoni yokukhula: imiba yeklinikhi kunye nesiseko. Uphando lweHormone,46 (4-5),155-159.
[4] U-Chen, C., uPullar, M., Loneragan,K.,Zhang,J.,&Clarke,IJ (1998). Impembelelo ye-hormone yokukhula-ekhupha i-peptide-2 (GHRP-2) kunye ne-GH-ikhulula ihomoni (GHRH) kumanqanaba e-camp kunye nokukhululwa kwe-GH kwi-culture acromegalic tumors. Ijenali ye-Neuroendocrinology, i-10 (6), i-473-480.
[5] Peñalva,A; Carballo,A; Pombo,M; eCasanueva,FF; UDieguez, C (1993). "Impembelelo ye-hormone yokukhula (GH) -ikhulula i-hormone (GHRH), i-atropine, i-pyridostigmine, okanye i-hypoglycemia kwi-GHRP-6-induced GH secretion emntwini". Ijenali yeClinical Endocrinology kunye neMetabolism. 76 (1): 168–71.
[6] McGirr,R; McFarland,MS; McTavish,J; ILuyt,LG; Dhanvantari,S (2011). "Uyilo kunye nokubonakaliswa kwe-fluorescent ghrelin analog yokucinga i-hormone yokukhula secretagogue receptor 1a". IiPeptides eziLawulayo. I-172 (1–3): 69–76.
[7] Ghigo,E.,Arvat,E.,Muccioli,G.,&Camanni,F. (1997). Iipeptides ezikhupha ihomoni yokukhula. I-European Journal ye-Endocrinology, i-136 (5), i-445-460.
