Ingcaciso yeMveliso
Yintoni iHexarelin?
Ngenxa yokukwazi kweHexarelin ukunyusa ukukhuselwa kweHormone yokuKhula kwendalo, uninzi lweziphumo zalo zifana nezo ze-GH zokwenziwa, nangona kuncinci kancinci. ubungakanani be-fibers ye-muscle esele ikhona, ukukhuselwa kwe-neural, ukuvuselela ngokubambisana, ukukhuselwa kunye nokuphulukiswa.Kwakhona, i-GH receptors kwi-adipose (amafutha) izicubu zivumela ukunciphisa amafutha kunye nokusetyenziswa kwe-Hexarelin. -Njenge-Growth Factor (IGF-1) ukunyuka kwisibindi.IGF-1 yimbangela ephambili yokukhula kwemisipha ekuphenduleni ukuvuselela i-GH.
Akukho mdla wokutya kunye nokusetyenziswa kwe-Hexarelin (ngokuchaseneyo nokunyuka okugqithisileyo kwe-GHRP-6) ngenxa yokungakwazi ukunyusa kakhulu amanqanaba e-Ghrelin anoxanduva lokongezwa kwendlala kunye nokukhupha isisu esikhawulezayo.
Kwizifundo apho i-Hexarelin ifakwe ngaphantsi kwe-subcutaneously, i-Growth Hormone, ilinganiswe nge-plasma concentrations, inyuke kakhulu kwaye ingakapheli imizuzu engamashumi amathathu yokujova. kg, nakuphi na ukonyuka kwedosi kwafunyaniswa kungasebenzi ekudaleni impendulo ye-GH.
Uphando lubonise ukuba umphumo we-Hexarelin kwi-GH stimulation tapered phakathi kweeveki ze-4 ukuya kwi-16.Ukwahlula imijikelezo ngeeveki ze-4 ngaphandle kwexesha, ukuphepha i-loop yempendulo engalunganga kunye nomjikelezo olandelayo we-Hexarelin uvelise inqanaba elifanayo leziphumo njengomjikelezo wokuqala.
I-Hexarelin (i-Hexarelin Acetate) yi-hexapeptide yokwenziwa kwintsapho yokukhula ekhuthaza ukukhululwa kwe-hormone yokukhula (GH) kwaye ayiphazamisi amandla omzimba wokuvelisa i-GH. I-GHRP-6 kodwa ngaphandle kokunyuka kwesidlo ngenxa yokungakwazi ukunyusa kakhulu amanqanaba e-Ghrelin enoxanduva lokunyusa ukutya kunye nokukhupha isisu esikhawulezayo.I-Hexarelin yi-hormone yokukhula eyenziwe nge-secretagogue eyenziwe kwii-amino acids ezintandathu.Iqulethe i-hormone yokukhula enamandla ekhupha iipropati umzimba womntu.I-Hexarelin kwizifundo kwixesha elithile ibonise ukuba iyanciphisa i-visceral fat.I-Hexarelin (i-Hexarelin Acetate) njengezinye i-Growth Hormone Releasing Peptides isebenza kakhulu ngokubambisana xa ilawulwa nge-GHRH njenge-Sermorelin okanye i-Modified GRF 1-29.
Isebenza njani iHexarelin?
I-Hexarelin esuka kwi-AASraw ayifani nezinye ii-GHRP ezikhoyo namhlanje.Abaninzi bacinga i-hexarelin njenge-underdog.Inye yezinto ezininzi ezingakhange zifumane ingqwalasela kuba kucingelwa ukuba ayinazo iimpawu ezibalulekileyo ekufuneka zibe nazo i-peptides.Kufanelekile ukuthetha ukuba i-hexarelin yipeptide ebikade ijongelwe phantsi kakhulu.Namhlanje, nangona kunjalo, siza kukuxelela ukuba kutheni le peptide ithile kufuneka ingatyhalelwa ecaleni.
Kufuneka ukwazi ukuba i-hexarelin ayiyona i-GHRP yakho eqhelekileyo. Isakhiwo sayo njenge-hexapeptide yenza ukuba ibe yitshaneli ebalaseleyo yokukhuthaza ukukhululwa kwe-hormone yokukhula.Nangona indlela yokusebenza kwayo ayizange iqondwe ngokupheleleyo kwiingcali, iyaziwa kakuhle ukuba iyasebenza. kuzo zombini indawo ye-hypothalamic kunye ne-pituitary gland.Okubaluleke ngakumbi, yeyona peptide ikwaziyo ukuvelisa ezona zixa zikhulu zehomoni zokukhula.
Ngokufana neepeptide ezininzi, i-hexarelin iyakwazi ukunyusa ukukhululwa kwamahomoni okukhula kwendalo.Okubaluleke ngakumbi, ayinciphisi amandla endalo omzimba ukukhulula amahomoni okukhula.Izifundo ezininzi ziye zabonisa ukuba kwandisa ukulahleka kwamafutha, ukomeleza izicubu ezixhumeneyo, ukuphucula ukunwebeka kolusu kunye nokwandisa i-mitosis, i-meiosis kunye nokuxinana kweeminerali zamathambo.
Izifundo, nangona kunjalo, zibonise ukuba xa i-hexarelin ijojowe ngendlela engaphantsi kwe-subcutaneous, ivuselela ukusebenza kwe-pituitary gland ngokusebenzisa i-pulse.Ngokufana ne-GHRP-6, inceda ukuphucula ukujikeleza kwe-hormone yokukhula ngaphakathi komzimba. I-GHRP-6, yenza ngokwahlukileyo ngeendlela ezithile. Enye into, ayibangeli nayiphi na imiba yendlala. Kuyinyani ukuba i-hexarelin iyakwazi ukunyusa izinga le-hormone yokukhula emzimbeni nangona kunjalo, iyakwazi ukunciphisa i-somatostati-enye izizathu eziphambili zokungavelisi amahomoni okukhula.Oku kuthetha ukuba kuya kubakho amanqanaba okwanda kwamahomoni okukhula.
Ngokukwazi kwayo ukunyusa i-IGF-1 kunye namanqanaba e-hormone yokukhula, inokusebenza njengezixhobo ezigqwesileyo zePCT kubantu abahamba ngeebhayisekile nge-IGF-1 okanye ezinye iihomoni zokukhula. amanqanaba akhulayo eprolactin kunye ne-cortisol.Inobudlelwane obuqinileyo bokunyusa i-cortisol kunye neprolactin xa kuthelekiswa nezinye ezikhoyo ze-GHRP.
Izibonelelo zeHexarelin
①Ukukhula kwezihlunu ezibhityileyo
Awuwedwa ukuba uziva ungonwabanga malunga nobunzima bakho okanye ukwakheka komzimba wakho.Noko kunjalo, ukufumana isongezelelo esikhuselekileyo nesithembekileyo sokufumana isihlunu esibhityileyo akusoloko kulula.Kukho ichiza elininzi kakhulu kwimarike kwaye ezinye zazo zibonisa iziphumo ebezingalindelekanga eziyingozi kunezo imeko izama ukuyinyanga.
Ngethamsanqa, uphando lokuqala kwi-Hexarelin luthembisa kwaye abaninzi bama emva kwe-peptide kwindawo yokuphakamisa ubunzima.I-Hexarelin iyaziwa ngokuvuselela imveliso ye-hormone yokukhula yendalo eyenza igalelo ekukhuleni kwemisipha ephilileyo.I-peptide isebenza njenge-agonist ekhethiweyo kakhulu ye-GHSR kunye ne-insulin. -njenge-Growth Factor 1 (IGF-1) .Ikwasebenza ngokuthelekiswa ne-ghrelin ekusebenziseni i-hormone yokukhula i-secretagogue receptor ngelixa i-inhibitors icinezela njenge-somatostatin.Abo basebenzisa i-Hexarelin kwi-fitness kunye ne-bodybuilding isaziso esichukumisayo ngokubhekiselele kwi-muscle kunye namandla okuzuza.
②Ukutshiswa kwaManqatha kunye nokuNcipha
Ukwakha izihlunu ezibhityileyo kunokwenzeka kuphela ngokususa amanqatha angafunekiyo kuqala. Yingxaki uninzi lwethu olusokola nayo ngelixa sizama ukugcina ukutya okunempilo nokuzilolonga.
Ngethamsanqa, iHexarelin iyakwazi ukukhawulezisa ukwehla kobunzima ngokujolisa kwiinkqubo ezibalulekileyo zendalo emzimbeni.Isiphumo sokuphulukana kwamafutha ngokukhawuleza sinokukunceda ekufikeleleni kwiinjongo zakho zokuncipha kobunzima ngokukhawuleza kunangaphambili. Okubaluleke ngakumbi, uya kukwenza oko ngokukhuselekileyo ngakumbi indlela esebenzayo xa kuthelekiswa namanye amachiza ayingozi okanye iinkqubo zokutya.Ukudibanisa kwamafutha okutshisa kunye nokuzuza kwemisipha enqabileyo evela kwi-Hexarelin kunokukhokelela ekugqityweni okupheleleyo komzimba.
③Ukuphucula ukomelela kunye nokuba bhetyebhetye
Ngelixa ufumana i-makeover epheleleyo yomzimba ufumana izibonelelo zamandla aphuculweyo kunye nokuguquguquka.
I-Hexarelin yaziwa ngokuyiphucula kakhulu i-tendon kunye namandla e-ligament.Ukongezelela, i-peptide inxulunyaniswe nokuguquguquka okuphuculweyo kunye nempilo yonke edibeneyo.Kubalulekile ukugxila kwi-tendon, ligaments, kunye nezihlunu njengoko ukhula ngenxa yokuba zisengozini yokwenzakala.
Ngenxa yoko, uya kuzuza kancinane ukuba ubambekile ecaleni ngenxa yokwenzakala okungapheliyo.I-Hexarelin ayikuvumeli nje ukuba ululame kwaye ubethe ijim kwakamsinya kodwa inqanda ukwenzakala okumandundu kwindawo yokuqala ngenxa yeenzuzo zokuguquguquka.
④UBuyiselo obunamandla kunye nokuSebenza kweembaleki
Kukho izibonelelo ezongezelelweyo ekunciphiseni ubunzima, ukufumana isihlunu esibhityileyo, kunye nokuphucula amandla / ukuguquguquka ngokubanzi.
Ukuqala, uya kuchacha ngokukhawuleza okukunika ithuba lokubuyela kwindawo yokuzivocavoca kwaye ubuyele emsebenzini. Ukubuyiswa kubalulekile ekunciphiseni ubunzima kunye nokuzuzwa kwezihlunu, ngoko ke ukufumana izongezo ezinceda kuloo nkqubo kubalulekile.
I-Hexarelin yaziwa ngokukhuthaza ukuchacha ngokukhawuleza kukulimala kunye noqeqesho.Inganyangeki ngakumbi kukulimala kwe-musculoskeletal ethintela inkqubela phambili kwindawo yokuzivocavoca.
Ngaphezu koko, uya kungqina uphuculo olupheleleyo ekusebenzeni kwembaleki ngenxa yoko.
⑤ Uphucula uMgangatho wokuLala kunye neNhlalakahle iyonke
Olunye uncedo kwi-Hexarelin bubungqina obumalunga nendlela i-peptide ephucula ngayo umgangatho wokulala ngokubanzi.Uphuculo lwesakhono somzimba kunye nomgudu wendabuko wokusebenza ngokubanzi kukhokelela kubusuku obunoxolo.
Kwaye, njengoko ukulala kubaluleke kakhulu kwimpilo iyonke, i-peptide inegalelo kwimvakalelo eyomeleleyo yokuphila kakuhle. Ukuncipha komzimba nokomelela kukhokelela ekuphuculeni ukuzithemba nokuzithemba.
Awuzulala ngcono kuphela kodwa uzive ungcono ngenxa yeziphumo ezilungileyo zeHexarelin.
Iziphumo ebezingalindelekanga zeHexarelin
Ngombulelo, iziphumo ebezingalindelekanga ezixeliweyo ze-Hexarelin zincinci.
Ezona ziphumo zixhaphakileyo zibandakanya iimvakalelo zokudinwa okanye ukutyhafa.Kungenxa yesakhono sehomoni yokukhula ekwandiseni umnqweno wokulala.Nangona kunjalo,ukugcina idosi isezantsi kunokuphelisa lo mba ngokulula.Ukugqithisa/idosi ephezulu ye-Hexarelin inokuba negalelo ukugcinwa kwamanzi.
Omnye umphumo oye waxelwa kukuntlithwa okanye ukuba ndindisholo ezandleni okanye ezinyaweni.
Abo bafumana iimpawu kufuneka banciphise idosi okanye bacinge ngokususa kwi-supplementation ngokupheleleyo.
Kungcono ukuthetha nogqirha phambi kokuba uwasebenzise ukuba sele uwathathile amayeza kagqirha.
IHexarelin ngokuchasene nezinye iipeptide
I-Hexarelin vs Ipamorelin
Nangona indlela yokusebenza kunye neenzuzo eziphambili kwiipeptide zombini zifana kakhulu, umehluko uvela kwiinzuzo zesibini.I-Ipamorelin ibonakaliswe ukuphucula ukuxinwa kwamathambo, ngelixa i-hexarelin iphucula impilo ye-cardiovascular.
I-Hexarelin vs GHRP-6
Ezi peptides zombini zisebenza ngendlela efanayo.Nangona kunjalo, i-GHRP-6 (9) ayikhuthazi lula ezinye iindlela ze-neuroendocrine njenge-hexarelin.Ngokubhekiselele kumandla, i-GHRP-6 inobomi obufutshane obufutshane bokusebenza emzimbeni kune-hexarelin. .Ngoko ke, i-hexarelin iphumelele ugqatso oluchasene ne-GHRP-6 ngokuqinisekileyo!
Ungayithenga phi iHexarelin?
I-Hexarelin yonyango ye-peptide inempembelelo ebalulekileyo kwimpilo yonke.Inceda ekufumaneni imisipha, i-metabolizing fat, ukunyusa amandla, kunye nokunye okuninzi.Apha kwi-AASraw, sizinikezele ekuboneleleni iipeptide ezininzi kuquka ukulahlekelwa kwesisindo, unyango lwezempilo zesini, kunye nezinye. ihomoni.Ukuba unomdla kwi-wholesale ye-Hexarelin okanye nayiphi na enye i-peptides, gcwalisa ifomathi engezantsi ukucwangcisa ukubonisana kwakho kwaye uthethe nabasebenzi bethu abakhethekileyo.Asikwazi ukulinda ukuva kuwe!
Ingxelo yoVavanyo lwe-Hexarelin-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
Indlela yokuthenga i-Hexarelin kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. UDavid Dahlgren
icandelo le-Pharmaceutical Biosciences, Translational Drug Discovery and Development, IYunivesithi yaseUppsala, eUppsala 752 36, eSweden
2. H. McDonald
Isikolo seSayensi yeBiomedical, kwiYunivesithi yaseQueensland, eBrisbane, eOstreliya
3. UGiuseppe Biagini
ILabhoratri yoMfuniselo we-Endocrinology, iSebe lezoNyango lwangaphakathi, iSahlgrenska Academy kwiYunivesithi yaseGothenburg, eGothenburg, eSweden.
4. Anna Barlind
ISebe lezeNgqondo, iYunivesithi yezoNyango kunye neDentistry yaseNew Jersey, iRobert Wood Johnson Medical School, iPiscataway, NJ, USA
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
Ucaphulo
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[2] U-Ezio Ghigo (1999). IiSecretagogues zokuKhula kweHormone: Iziphumo ezisisiseko kunye neziphumo zeKlinikhi. Elsevier. iphepha 178–. I-ISBN 978-0-444-82933-7.
[3] Rahim A, O'Neill PA, Shalet SM (1998). "Isimo se-hormone yokukhula ngexesha lonyango lwe-hexarelin yexesha elide". Ijenali yeClinical Endocrinology & Metabolism. 83 (5): 1644–9. doi:10.1210/jcem.83.5.4812. PMID 9589671.
[4] Ghigo E, Arvat E, Gianotti L, Imbimbo BP, Lenaerts V, Deghenghi R, et al. (1994). "Ukukhula kwehomoni-ukukhutshwa komsebenzi we-hexarelin, i-hexapeptide entsha yokwenziwa, emva kwe-intravenous, subcutaneous, intranasal, kunye nokulawulwa komlomo kumntu". Ijenali yeClinical Endocrinology & Metabolism. 78 (3): 693–8. doi:10.1210/jcem.78.3.8126144. PMID 8126144.
[5] Imbimbo, BP; Mant, T.; Edwards, M.; Amin, D.; Dalton, N.; Bougnon, F.; Lenaerts, V.; Wďż˝thrich, P.; Deghenghi, R. (1994). "Ukukhula kwehomoni-ukukhutshwa komsebenzi we-hexarelin ebantwini". Ijenali yaseYurophu yeClinical Pharmacology. 46 (5): 421–5. doi:10.1007/bf00191904. PMID 7957536. S2CID 19573322.
[6] CR Ganellin; David J. Triggle (21 Novemba 1996). Isichazi-magama se-Pharmacological Agents. CRC Press. iphepha 617–. I-ISBN 978-0-412-46630-4.
