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IDFP (615250-02-7)

Akukho kalo SKU: 615250-02-7. Udidi:

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya kwi-IDFP (615250-02-7), phantsi kolawulo lweCGMP kunye nolawulo lwekhwalithi ephezulu.

Ingcaciso yeMveliso

 

Ividiyo ye-IDFP

 

 


 

IDFP Abalinganiswa basisiseko:

 

igama: IDFP
CAS: 615250-02-7
Ifomula yeMolekyuli: C15H32FO2P
Ubunzima Ezinto: 294.391
Melt Point:
Isitoreji sokugcina: -20 ° C
umbala:

 


 

I-IDFP (615250-02-7) umjikelezo

 

Amagama

Amagama eKhemikhali: ISOPROPYL DODECYLFLUOROPHOSPHONATE
I synonym:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE-P-DODECYL-1-METHYLETHYL Ester-PHOSPHONOFLUORIDIC Acid

 

IDFP (615250-02-7) Ukusetyenziswa

I-IDFP yinkomfa ye-organophosphorus ehambelana ne-agent ye-sarin ye-nerve. Njenge-sarin, i-IDFP sisithintelo esingenakuphikiswa senani lee-enzymes ezahlukeneyo ezithi ziqhele ukusebenza ukophula ii-neurotransmitters, nangona kunjalo ikhonkco elide le-alkyl le-IDFP liyenza buthathaka ngokuphawulekayo njenge-inhibitor ye-acetylcholinesterase (AChE), ene-IC50 ye-6300nM kuphela, ngelixa Isithinteli esinamandla se-enzymes ezimbini ze-monoacylglycerol lipase (MAGL), i-enzyme ephambili ejongene nokuthotywa kwe-endocannabinoid 2-arachidonoylglycerol (2-AG), kunye ne-fatty acid amide hydrolase (FAAH), i-enzyme ephambili eyehlisa enye i-endocannabinoid anandamide . I-IC50 ye-IDFP yi-0.8nM kwi-MAGL, kunye ne-3.0nM e-FAAH. Ukuthintela ezi zimbini i-enzymes kubangela amanqanaba okwanda okubonakalayo kwe-anandamide kunye ne-2-AG kwingqondo, okukhokelela ekwandeni kokutyikitywa kwe-cannabinoid kunye nefuthe lokuziphatha kwe-cannabinoid kwizifundo zezilwanyana, ngelixa ukusilela kwayo kwi-AChE kuthetha ukuba akukho zimpawu ze-cholinergic eziveliswayo. [1 [2] [3] [4] Ngaphandle kobume bayo beekhemikhali obufanayo neearhente zemithambo-luvo ezivaliweyo, ikhonkco le-alkyl elide le-IDFP libangela ukuba liwele ngaphandle kwenkcazo "yemichiza enetyhefu" phantsi kwesiVumelwano seZixhobo zeMichiza, [5] kwaye kuba nayo ayibonisi kuthintelwa kwe-AChE iikhompawundi ezinxulumene ne-organophosphorus, i-IDFP ayixhomekekanga kulawulo olufanayo lomthetho.

 

Iyiphi imilinganiselo ye-IDFP

Ukugcinwa kwexesha elide, sincoma ukuba i-IDFP igcinwe njengoko ikhona kwi-20 ℃. Kumele kube nokuzinza okungenani ngonyaka omnye.
I-IDFP inikwe isisombululo kwi-acetate ye-methyl. Ukutshintsha isinyibilikisi, emoyeni nje acetate imethyl phantsi njengomlambo gentle of nitrogenand nangoko ukongeza isinyibilikisi of choice.Solvents ezifana ethanol, DMSO, kunye formamide dimethyl zihlanjululwe yegesi egalelwe zingasetyenziswa. Ukuxiliswa kwe-IDFP kulezi zixazululwazi malunga ne-10mg / ml.
Ukuba izixazululo zesitokisi ezinamandla zifunekayo kwizilingo ze-biological, ziyakulungelelaniswa ngokuhlalutya i-solvent engxenyeni yamanzi okanye i-isotonic saline. Qinisekisa ukuba inani elishiyekileyo le-organicsolvent alibalulekiyo, kuba i-solvents e-organic ingaba nemiphumo yomzimba kwiindawo eziphantsi. ayinakucebisa ukugcina isisombululo esinamandla kwixesha elingaphezu kweyodwa.

 

I-IDFP isebenza njani

I-IDFP inhibitor engenakunqunyulwa yinkalo yee-enzyme ezahlukileyo eziye zisebenzela ukuphula i-neurotransmitters, nangona i-alkyl chain chain ye-IDFP yenza buthathaka kakhulu njenge-inhibitor ye-acetylcholinesterase (AChE), ngelixa i-inhibitor enamandla yeenzymes ezimbini zombono monoacylglycerol lipase ( MAGL), i-enzyme ephambili ejongene nokuhlambalaza i-endocannabinoid 2-arachidonoylglycerol (2-AG), kunye ne-acety acid acide hydrolase (FAAH), i-enzyme ephambili eyenza ihlaziye enye i-intendocannabinoid i-anandamide. I-organophosphorus isakhi esivimbela i-MAGL ne-FAAH ngamaxabiso e-IC50 ye-0.8 ne-3 nM ngokulandelanayo.1 Kwi-10 mg / kg, i-IDFP iphakamisa amanqanaba engqondo ye-2-AG kunye ne-AEA ngaphezu kwe-10, kwaye iyanciphisa amanqanaba e-arachidonic acid 10.

 

isilumkiso

Le mveliso ayiyiyo yokusetyenziswa kwabantu okanye ukusetyenziswa kwezilwanyana, isilumkiso esisaqhubekayo kuphando. Gwema ukunxibelelana ngqo kwesikhumba, amehlo, indlela yokuphefumula, naluphi na ukuphazamiseka, biza ugqirha wakho ngokukhawuleza.

 

I-IDFP (615250-02-7) Ubuninzi obuninzi

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umyalelo omkhulu ungathunyelwa kwiintsuku zokusebenza ze-3 emva kokuhlawula.

I-IDFP

Ukubonelelwa kwikamva elizayo.

 

Ngaba i-IDFP inayo nayiphi na imiphumo yangaphandle

I-medalla ye-renal, ejongwa njengeyona nto ibalulekileyo ekulawuleni ityuwa kunye nokulinganisela kwamanzi kunye nokulawula uxinzelelo lwegazi lwexesha elide, kuphuculwa kwi-anandamide kunye ezimbini ze-enzyme zayo ezinkulu, i-cyclooxygenase-2 (COX-2) kunye ne-acety acid acide hydrolase (FAAH) . Ukuxhamla kwe-anandamide (15, 30, kunye ne-60 nmol min min-1 · kg-1) kwi-medalla ye-renal yeC57BL / 6J iimicebe zakhuthaza i-diuresis kunye ne-excretion kwi-COX-2-kodwa ayixhomekeke kwi-COX-1. Ukuze ubone enoba endocannabinoids iqala kwi Medulla sezintso singabangela iziphumo ezifanayo, imiphumo intramedullary isopropyl dodecyl fluorophosphate (IDFP), apho abangaphangeliyo i hydrolases ezimbini eziphambili endocannabinoid, zaye efunda. unyango IDFP wandisa umchamo rate ukubunjwa sodium zinomgutyulo kwi Cox-2- kodwa Cox-1-oxhomekeke ngendlela. I-anandamide okanye i-IDFP ayichaphazele isantya sokuhlutha kwe-glomerular. I-systemic (0.625 mg · kg-1 · 30 min-1 iv) okanye i-intramedullary (15 nmol min min-1 · kg-1 · 30 min-1) I-IDFP yangaphambili ngaphambi kokuba i-anandamide i-intramedullary (15-30 nmol · min-1 · kg-1) imiphumo eqhotyoshelweyo ye-anandamide, ebonisa ukuba i-hydrolysis ye-anandamide yayingekho imfuneko yokuba i-diuretic effect. I-IDFP ye-Intramedullary yayingazange ibe nempembelelo ekuphumeni kwegazi kwenzalo kodwa yayishukumisa ukuhamba kwegazi okuxutywa ngegazi. Imiphumo ye-IDFP kumlinganiselo wokugeleza kwamanzi kunye nokuhamba kwegazi ngokuxilongwa kwe-FAAH-kuxhomekeke ekusebenziseni ukusebenzisa i-FAAH yokhonkcoza iigundane. Uhlalutyo lwe-mouse urinary PGE2 i-HPLC-electrospray ionization tandem mass spectrometry ibonise ukuba unyango lwe-IDFP lwancipha urinary PGE2 Ezi nkcukacha zihambelana nendima ye-FAAH kunye ne-anandamide engapheliyo esebenza nge-COX-2 ethembele kwi-metabolite ekulawuleni i-diuresis kunye netyuwa mousekidney.

 


 

Indlela yokuthenga ipowder ye-IDFP (615250-02-7) esuka kwi-AASraw

 

1.Qhagamshelana nathi nge-imeyile yethu Inkqubo yokubuza, okanye i-skype ekwi-Intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.