J 147 powder

J 147 powder ividiyo

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I-Raw J 147 powder ezisisiseko

igama:	J 147 powder
CAS:	1146963-51-0
I-molecular Formula:	C18H17F3N2O2
Isisindo somzimba:	350.3349896
Melt Point:	177-178 ° C
Isitoreji sokugcina:	4 ° C
umbala:	I-White okanye i-powder emhlophe

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I-Raw J 147 powder ekuphuculeni umsebenzi wengqondo kunye nomjikelezo owongezelelweyo

Amagama

J 147 powder

J 147 (1146963-51-0) Umlinganiselo wokusebenzisa

Ukusebenzisa isicatshulwa sokufumanisa izilwanyana zesifo se-Alzheimer (AD) esisekelwe kwiipathologi ezininzi zokuguga, saqaphela isakhi esinobuchule kunye nokusebenza kakuhle kwimemori ye-rodent kunye neemodeli zezilwanyana ze-AD. Ukususela kule ngqungquthela, i-J-147 powder, i-phenyl hydrazide, kukho inkxalabo yokuba iyakwazi ukuxiliswa kwamamine / ama-hydrazines ayenokubangela i-carcinogenic. Ukuphonononga oku, kungenzeka sihlolisise i-metabolites ye-J 147 powder kwi-microsomes yabantu kunye ne mouse kunye ne-plasm mouse. Kuboniswa ukuba i-J-147 (1146963-51-0) ipowder ayinakulinganiswa kunye nama-amines adibeneyo okanye i-hydrazines, ukuba i-scaffold isisigxina kakhulu, kwaye i-metabolites ene-oxidative nayo i-neuroprotective. Kugqitywa ukuba i-metabolites enkulu ye-J 147 (1146963-51-0) ipowder inokufaka isandla kwimisebenzi yayo yezilwanyana kwizilwanyana.
I-147, ephuma kwi-curry engxenyeni ye-curry, ine-toxicity ephantsi kwaye ibuyisela umonakalo kwi-neurons ehambelana ne-Alzheimer's.

J 147 (1146963-51-0) yiprotheni ye-mitochondrial ebizwa ngokuba yi-ATP synthase, ngokukodwa i-ATP5A, i-subunit yale protein. I-ATP synthase ibandakanyeka kwisizukulwana se-mitochondrial se-ATP, ezisebenzisa iiseli zamandla.

Abaphandi babonisa ukuba ngokunciphisa umsebenzi we-ATP synthase, bakwazi ukukhusela iiseli ze-neuronal ezininzi zetyhefu ezinxulumene nokuguga kwengqondo. Esinye isizathu sokuba le mphulo ye-neuroprotective icingelwa ukuba yindlalifa ye-excitotoxicity kumonakalo we-cell neuronal.

I-excitotoxicity yinkqubo ye-pathological ye-neurons eyonakaliswe ngayo kwaye ibulawe yi-overptivation of receptors ye-glutamate ye-neurotransmitter ye-excitatory. Cinga ngento efana nomtshini wokukhanya ovuliwe kwaye ucime ngokukhawuleza kangangokuthi iqukumbele ibangela ukuba i-bulb light iqhume.

Kungekudala, indima ye-ATP synthase inhibition ye-neuroprotection against umonakalo we-excitotoxic iboniswe kwisifundo se mouse (4]. Uphando lwesibini lubonisa ukuba imifanekiso yamagundane ebonisa uhlobo lomntu we-ATPase engummiselo we-1 (hIF1), obangela ukukhuseleka okuqhubekayo kwe-ATP synthase, bebanokuphelela ekufeni kwe-neuronal emva kokulimala kwe-excitotoxic. Olu datha luhambelana nale ntsha ye-J 147 yophando lwepowder, apho ukwanda kwe-IF1 kwimicebe kuncitshiswe umsebenzi we-ATP synthase (ngokukodwa i-ATP5A) kwaye yayingenayo i-neuroprotective.

Isilumkiso kwi-Raw J 147 powder

Iinkcukacha eziboniswe apha zibonisa ukuba i-J-147 powder inokukwazi ukuhlangula ukulahlekelwa kwengqondo xa ilawulwa kwisithuba esikude kwisifo. Ikhono le-J-147 ipowder ukuphucula imemori kwiimichiza ze-AD ezindala zihambelana nokufakelwa kwayo kweengxaki ze-NGF (i-nerve growth factor) kunye ne-BDNF (ubuchopho obuthatha i-neurotrophic factor) kwakunye neeprotheni ezininzi eziphendulayo ze-BDNF ezibalulekileyo ekufundeni kunye nememori. Ukufanisa phakathi kwe-J-147 (1146963-51-0) ipowder kunye neeferepezil kwimodeli ye-scopolamine ibonise ukuba ngelixa zombini izixhobo zifaniswa nokuhlangula imemori yesikhashana, i-J-147 powder yayiphambili ekuhlanguleni imemori yendawo kunye nokudibanisa kwabo babini basebenza okusemgangathweni kwimemori yenkcazo kunye nekerubhi.

I mi yalelo

Isifo se-Alzheimer sisifo sengqondo esiqhubekayo, esandula kubalwa njengesihlandlo sesithathu sokufa e-United States kwaye sichaphazela izigidi ezingaphezu kwezigidi zaseMerika. Kwakhona kuyona nto ibangela ukugula komzimba kubantu abadala, ngokutsho kweeNational Institutes of Health. Nangona ezininzi iziyobisi ziphuhlisiwe kwixesha elidlulileyo le-20 ekujoliswe kuyo i-amyloid plaque kwiingqondo (okuyiyona nto ibonakalisa isifo), bambalwa baye bafakazela ngokusebenzayo kwiklinikhi.

Ngexesha elidlulileyo i-20 iminyaka ijolise i-amyloid plaque kwiingqondo (okuyiyona nto ibonakalisa isifo), akukho nanye ibonakalise ukuba isebenzayo kwikliniki, "kusho uSchubert, umbhali ophezulu wolu cwaningo.

Kwiminyaka emininzi edlulileyo, u-Schubert kunye nabalingane bakhe baqalisa ukunyanga kweso sifo ukusuka kwinqanaba elitsha. Esikhundleni sokujolisa kwi-amyloid, ibhabhi inqume ukuba ibe yinto enobungozi obudala bokugula. Ukusebenzisa izikrini ezisekelwe kwiseli ezinxulumene nobutshongo beengqondo ezindala ubudala, zidibanisa i-X XUMUMX (147-1146963-51) ipowder.

Ngaphambili, iqela lafumanisa ukuba i-J-147 powder inokuthintela kwaye ibuye ibuye ibuye ibuye ilahlekelwe imemori yokulahleka kunye ne-Alzheimer's pathology kwiigundane ezine-version of inherited form of Alzheimer's, imodeli esele isetyenziswa kakhulu. Nangona kunjalo, le fomu yesifo iquka kuphela iipesenti ze-1 ze-Alzheimers. Kuwo wonke umntu, ukuguga kungumngcipheko omkhulu, uthi uSchubert. Eli qela lafuna ukuphonononga imiphumo yesigqirha sogqirha kwiintlobo zeegundana ezithatha ixesha ngokukhawuleza kwaye zifumane inguqu yokudemeka kwengqondo ehambelana ngokugqithiseleyo ngokungafani nengxaki yomntu.

I-147 Powder

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umlinganiselo omkhulu (ngaphakathi kwe-1kg) ungathunyelwa kwimihla yokusebenza ye-3 emva kokuhlawula.

I-Raw J 147 yePowder Marketing

Ukubonelelwa kwikamva elizayo.

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Indlela yokuthenga i-X XUMUMX powder kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.

ISIQINISEKISO NESIBONELELO: Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.

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