JW 642

I-AASraw ihamba kunye nokukwazi ukuvelisa kwigram ukuya ku-JW 642 (1416133-89-5), phantsi komgaqo we-CGMP kunye nolawulo lwekhwalithi ephezulu.

I-Endocannabinoids efana ne-2-arachidonoyl glycerol (i-2-AG) kunye ne-arachidonoyl ethanolamide ziyi-lipids ezisebenzayo ezibandakanyekayo kwiinkqubo ezili-synaptic ezibandakanya ukuphunyezwa kwee-receptors ze-cannabinoid. I-JW 642 inhibitor enamandla ye-monoacylglycerol lipase (MAGL) ebonisa ixabiso le-IC50 ye-7.6, i-14, kunye ne-3.7 nM ukuchithwa kwe-MAGL kwi-mouse, i-rat, kunye ne-brain membranes, ngokulandelanayo. I-JW642is ikhetha i-MAGL, ifuna iindawo eziphezulu kakhulu ukwenzela ukuvimbela ngokufanelekileyo ukusebenza kwe-acid acid amide hydrolase (IC50s = 31, 14, kunye ne-20.6 μM nge mouse, i-rat, kunye ne-membrane yengqondo).

Ingcaciso yeMveliso

Ividiyo yeJW 642


I.JW 642 Abalinganiswa basisiseko:

igama: JW 642
CAS: 1416133-89-5
I-molecular Formula: C21H20F6N2O3
Isisindo somzimba: 462.4
Melt Point:
Isitoreji sokugcina: kwi -20 ° C iminyaka eyi-3 Ubuninzi
umbala: OMhlophe


II. Umjikelo weJW 642

1. Amagama:

Amagama eKhemikhali:
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) e-ester ester
Iintetho:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

2. Ukusetyenziswa kweJW 642:

Kwiinkqubo zelabhoratri, ukugcinwa kwexesha elide, siphakamisa ukuba i-JW 642be igcinwe ifakwe kwi-20 ℃. Kumele kube nokuzinza okungenani ngonyaka omnye.
I-JW 642 inikezelwa njengesisombululo kwi-methyl acetate. Ukutshintsha i-solvent, ivele ikhuphe i-acetate ye-methyl phantsi kwe-nitrogen emnene kwaye ngokukhawuleza yongeza isisombululo sokhetho. I-asethanol, i-DMSO kunye ne-dimethyl formamide ehlanjululwe ngegesi ye-inert ingasetyenziswa. I-solubility ye-JW 642 kulezi zixazululwazi i-13,5, kunye ne-11mg / ml, ngokulandelanayo.
I-JW 642 inqabile i-soluble kwiindawo zokuxhamla. Ukufumana ubunqamle obukhulu kwiimvula ezixakekileyo, isisombululo se-JW 642should sinokuhlanjululwa kunye ne-tochoice encane. I-JW 642 ine-solubility malunga ne-0.3 mg / ml kwi-1: I-2 isisombululo se-ethanol: I-PBS (pH 7.2) usebenzisa le ndlela. Asinakucebisa ukugcina isisombululo esinamandla esingaphezu kosuku olunye.

3.Yintoni umlinganiselo weJW 642?

I-DMSO kwi-100 mM
I-Ethanol kwi-100 mM
Iseluleko kunye nesisombululo: Ezinye izisombululo zinokuba nzima ukuzifumana kwaye ziyakuchukunyiswa ngokukhawuleza, ukutshathisa okanye ukufudumala okunene (kwi-45-60 ° C yamanzi okugeza). Ulwazi olumalunga nokuzinza kwemveliso, ngokukodwa kwisisombululo, aluzange luchazwe ngokukhawuleza kwaye kwiimeko ezininzi sinokunika isikhokelo esipheleleyo. Iziphakamiso zethu eziqhelekileyo zilandelayo: I-SOLIDS: Ukugcinwa okunikezelwayo njengoko kuchazwe kwileyibhile yemveliso kwaye i-vial igcinwe ngokuqiniweyo, umkhiqizo ungagcinwa ukuya kwiinyanga ze-6 ukususela ngomhla wokufumana. ISOLUTIONS: Sincoma ukuba izisombululo zesitokisi, xa zilungiselelwe, zigcinwe ngokulandelelana kwi-vialsat eqiniweyo -20 ° C okanye ngaphantsi kwaye zisetyenziswe kwinyanga ye-1.Kuphi na izisombululo ezinokwenzeka ukuba zenziwe kwaye zisetyenziswe ngosuku olufanayo.

4.How JW 642 isebenza njani?

I-JW 642 inamandla kwaye ikhetha i-monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Ubonisa> Ukhetho lwe-1000-fold for MAGL phezu kwe-acid acid amidehydrolase (IC = 20.6 μM). I-Monoacylglycerol lipase (MAGL) i-serine hydrolase ejongene ne-hydrolysis ye-2-AG i-arachidonic acid kunye ne-glycerol, ngaloo ndlela iphelisa umsebenzi wayo wezinto eziphilayo. Iziphumo ezinobungozi zingabangelwa nje ngezantsi: I-Methyl Acetate - Idatha yeTyxicity: Oral LD50 (rat):> 5,000 mg / kg; I-Oral LD50 (umvundla): 3,705 mg / kg; I-Skin LD50 (umvundla):> 5,000 mg / kg; Inhalation TCLO (abantu): 15,000 mg / m3; I-Methyl Acetate - Idatha ye-Irritation: Isikhumba (umvundla): 500 mg (24h) ilula; Amehlo (umvundla): 100 mg (24h) i-moderation.

5.Waphela:

I-stability and reactivity

5.1 Reactivity

Uzinzo phantsi kweemeko zokuthutha okanye zokugcina.

5.2 Ukuzinza kweMichiza

Uzinzo phantsi kweemeko zokugcina ezicetywayo.

I-5.3 Ukufumaneka kwamandla ezinobungozi

Impendulo enobungozi ayiyi kwenzeka phantsi kweendlela eziqhelekileyo zokuthutha okanye zokugcina. Ukuqhekeza kungase kwenzeke xa kuvela kwiimeko okanye izinto ezibhalwe ngezantsi.

Iimeko ze-5.4 zokuphepha ukushisa, ukunyakaza.
Izinto ze-5.5 ezingahambelaniyo

I-acids enamandla / i-alkalis, i-oxidising / ukunciphisa i-agents.

I-5.6 Iingcombolo ezinobungozi obuyingozi

Ebushushu kunokuphuma imfucu enobuthi. Akukho lwazi lokuchithwa kolwazi.

II.Ukugcina nokugcina

I-5.1 Iinkcukacha zokukhusela ngokukhuselekileyo

Sebenzisa kwi-fume hood hood, kunye nomoya owanikwa yinkqubo ezimeleyo. Gwema ukukhubaza, uqhagamshelana namehlo, isikhumba kunye
iimpahla. Gwema ukubunjwa kothuli kunye nama-aerosol. Sebenzisa kwindawo efanelekileyo yomoya. Hlala kude nemithombo yokutshaya. Kuphephe
ukugqithiswa ixesha elide okanye ngokuphindaphindiweyo.

Iimeko ze-5.2 zokugcina okukhuselekileyo, kubandakanywa naziphi na izinto ezingahambelaniyo.

Gcina kwindawo epholile, efanelekileyo umoya. Hlala kude nelanga elithe ngqo. Gcina isitya esitywinwe kuze kube yilungele ukusetshenziswa.
Ukunciphisa ubushushu bokugcina: Gcina kwi -20 ° C

I-5.3 isebenzise ngokugqithiseleyo ukuphela

Sebenzisa kwi-hood fume hood apho kunokwenzeka khona.

6.JW 642 Ubuninzi obunamandla:

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umyalelo omkhulu ungathunyelwa kwiintsuku zokusebenza ze-3 emva kokuhlawula.

7.JW I-642 Raw Powder Recipes:

Ukubuza ummeli wethu ummeli (Representative Representative) (CSR) ngeenkcukacha, ngokubhekiselele kuyo.

8.JW 642 Ukuthengisa:

Ukubonelelwa kwikamva elizayo.

I-9.Ingaba i-JW 642 Unayo nayiphi na imiphumo yangaphandle?

Izinto eziphathekayo zinokucasula kwiimbumba ezinobumba kunye nephezulu eliphezulu; Inokuthi ingonakaliswe ngokufuthwa, ukungena okanye ukunqanda isikhumba; Inokubangela ukugungqeka okanye utywala; Inokubangela ukuba isikhumba okanye ukuphefumula kwesohlwayo. Ukuvezwa okuphindaphindiweyo kunokubangela ukomisa isikhumba okanye ukucima.
Ulawulo lokuzimela / ukhuseleko lomntu

XMUMX Control parameters

Iimpawu zendawo yokulawula indawo yokusebenza
Ayinazo izinto kunye nemilinganiselo yokunciphisa umsebenzi.

Ulawulo lwe-9.2 Ukuboniswa

Ulawulo lwezobunjineli ezifanelekileyo
Sebenzisa kwindawo yokuvutha apho kusebenza khona. Qinisekisa ukuba zonke izicwangciso zobunjineli ezichazwe phantsi kweCandelo 7 le-SDS zikhoyo.
Qinisekisa ukuba i-laboratory ixhotywe ngesitya sokukhusela kunye nesitishi sokuhlamba kweso.
Izinto zokukhusela

Ukukhuselwa kweso / ubuso
Sebenzisa iziglasi zokukhusela ezifanelekileyo.
Ukukhusela isikhumba
Sebenzisa iiglavu ezichanekileyo zemichiza (ubuncinane bemfuneko yokusebenzisa i-BS EN 374: 2003). Iiglavu kufuneka zibe
zihlolwe ngaphambi kokusetyenziswa. Geza kwaye unomileyo izandla emva kokuphatha.
Ukukhuselwa komzimba
Gqoka iimpahla zokukhusela ezifanelekileyo.
Ukukhusela ukuphefumula
Ukuba ukuhlolwa kweengozi kubonisa imfuneko, sebenzisa i-breath respirator.

phakathi kwabanye


III. I-JW 642 HNMR


IV. Indlela yokuthenga i-JW 642 kwi-AASraw?

1.Qhagamshelana nathi nge-imeyile yethuinkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


Cinga ibhlogi yakho yomkhiqizo oyintandokazi:

Indlela yokusebenzisa i-Clenbuterol yokulahleka kwesisindo Yintoni i-nandrolone powder esetyenziselwa i-nandrolone inzuzo?


Ingcaciso engakumbi ngemveliso echaphazelekayo,wamkele ukucofa apha.


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