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I-Lapatinib powder (231277-92-2)

Akukho kalo
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi
SKU: 231277-92-2. Udidi:

I-AASraw ikunye kunye nokukwazi ukuvelisa kwigram ukuya kwi-Lapatinib powder (231277-92-2), phantsi komgaqo weCGMP kunye nolawulo lwekhwalithi ephezulu.

Ingcaciso yeMveliso

Lapatinib powder ividiyo


ILapatinib powder Abalinganiswa basisiseko

igama: ILapatinib powder
CAS: 231277-92-2
I-molecular Formula: C29H26ClFN4O4S
Isisindo somzimba: 581.05
Melt Point: 136-140 ° C
Isitoreji sokugcina: Ifriji
umbala: I-White okanye i-white powstalline powder


I-Raw Lapatinib powder kwi-Antineoplastic Agent cycle

Amagama

Igama loGeneric: i-Lapatinib powder (la PA tin ib)
Igama leBrama: iTykerb

Ukusetyenziswa kwe-Raw Lapatinib powder

I-Lapatinib powder yile mithi yonyango esetyenziswe ngenye iyeza (capcitabine) ukuphatha abantu ngesifo somhlaza wesibeleko esasasazeka kwezinye iindawo zomzimba ongu-HER2 positive (izicubu ezivelisa inani elikhulu leprotheni elibizwa ngokuba yi-epidermal growth factor receptor-2) , kwaye ngubani oye wafumana ezinye izifo zonyango lwebele.

I-lapatinib powder isetyenziswe ngolunye uhlobo lweyeza elibizwa ngokuba yi-letrozole kunyango lwabasetyhini be-postmenopausal nge-hormone receptor positive, umdlavuza webele we-HER2 onomdla we-metastatic breast.

I-Lapatinib powder yile mithi yonyango esetyenziselwa ukunyanga umdlavuza webele. Isetyenziselwa ukudibanisa namanye amayeza ukunyanga uhlobo oluthile lomhlaza wesifuba oluye lwasasazeka kwezinye iindawo zomzimba kwaye aluphendulanga kwamanye unyango lomhlaza.

I-Lapatinib powder yile iqela leziyobisi ezibizwa ngokuthi i-kinase inhibitors ezisebenza ngokuthintela isenzo seprotheyini ethile esibonisa ukuba iseli somhlaza landa.

Eli nyanga liza kwifom yethebhulethi kwaye ithathwa kanye rhoqo ngosuku kwisisu esingenalutho.

Iziphumo eziqhelekileyo zePapatinib powder zibandakanya izandla ezibomvu, ezibuhlungu kunye neenyawo, isifo sohudo, ukugqithisa, kunye nesiphithiphithi.

Iyiphi imilinganiselo yePapatinib powder

Ukusebenzisa i-Adult Dose kwiCatalcer Breast

I-CANCER-I-HER2-POSITIVE BETASTATIC BREAST CANCER (ngokudibanisa ne-capecitabine): 1250 mg ngomlomo kanye ngosuku ngemini ye-1 ukuya kwi-21 ngokuqhubekayo ngokuphinda imijikelezo yeentsuku ze-21 kude kube nokunyuka kwesifo okanye isicatshulwa esingavumelekanga.

-HORMONE I-RECEPTOR-POSITIVE, I-HER2-POSITIVE METASTATIC BREAST CANCER (ngokudibanisa ne-letrozole): 1500 mg ngomlomo kanye ngosuku.

Amazwana:
-Consa ulwazi lomveliso lomenzi we-capecitabine kunye neencomo ze-letrozole dosing.
-Izigulane zomhlaza zesifo se-metastatic ze-HER2 kufuneka zibe ne-disease progression kwi-trastuzumab ngaphambi kokuqaliswa unyango kunye nale nkunkuma kunye ne-capecitabine.

Ukusetyenziswa:
-Ukudibanisa ne-capecitabine unyango lwezigulane ezineomhlaza ophezulu okanye wesifo se-metastatic ephethe i-tumor overexpress i-HER2 kunye nabaye bafumana unyango ongaphambili ngaphambi kwe-anthracycline, i-taxane kunye ne-trastuzumab.
-Kubandakanyeka ne-letrozole kunyango lwabasetyhini be-postmenopausal abane-hormone-receptor-positive umdlavuza webele we-hormone ophazamisa i-HER2 receptor ekuboniswa ngayo unyango lwe-hormonal.

Ulungiso lweNtambo
Idatha ayifumanekanga malunga nokulungiswa kwemilinganiselo; Nangona kunjalo, i-pharmacokinetics yale nkunkuma ayinakwenzeka ukuba inokuchaphazeleka ngenxa yokuba ngaphantsi kwe-2% ye-dose elawulwayo ichithwa yizintso.

Isilwanyana soMbane
UKUPHILA KWAMANZI OKUHLAWULAYO ​​UKUQHUBA IMPENDULO YENYATHELO (ENYANA-PUGH A / B): Iinkcukacha azifumaneki.

UKUPHILA KWE-HEPATIC IMPAIRMENT PRE-EXISING (PREVENT IMPAIRMENT (CHILD-PUGH C): Ukunciphisa umthamo:
-HER2-Positive Canast Metastatic Breast Cancer (kunye ne-capecitabine): 750 mg / ngosuku.
-Bonakalisa i-Receptor-Positive, i-HER2-Positive Canastzotic Breast Cancer (kunye ne-letrozole): 1000 mg / ngosuku

HLAWULA I-HEPATOTOXICITY I-OCCURS NGOKWESIPHAPHA: Ukuyeka unaphakade unyango.

Iingxelo: Iingcebiso zokulungiswa kweentambo zisekelwe kwizifundo ze-pharmacokinetic; akukho datha yolwazi ekhoyo.

Ulungiso lweentambo
UMTHETHO WOKUSETYENZISWA NOKUBHALA KWI-CYP450 3A4 INHIBITORS NE / OKANYE KWI-CYP450 3A4 ABASEBENZI: Gweba ukusetyenziswa okuhambisanayo xa kunokwenzeka. Iziphakamiso zokulungiswa kweentambo zisekelwe kwizifundo ze-pharmacokinetic; akukho datha yolwazi ekhoyo.
UMTHETHO WOKUSETYENZISWA NENXAXXUMUMXA450 INHIBITOR: Ukunciphisa umthamo kwi-3 mg / ngosuku; vumela ixesha lokubhukuda malunga neveki ye-4 ngaphambi kokuhlengahlengiswa kwesi siza kwi-dose ephakanyiswayo eqhelekileyo ukuba i-inhibitor ingayeki.
UMTHETHO WOKUSETYENZISWA NENXA YOKUPHUMA KWI-CYP450 3A4 INDICER: Ngokukhawuleza i-dose isitifiketi esiphezulu esekelwe ukunyamezela; ukunciphisa umthamo kwakhona kwi-dose ephakanyisiweyo eqhelekileyo ukuba i-inducer iyanqanyulwa.
-HER2-Positive Canast Metastatic Breast Cancer (kunye kunye ne capecitabine): Ukwandisa umthamo ukuya kwi-4500 mg / ngosuku.
-Bonakalisa i-Receptor-Positive, i-HER2-Positive Canastzotic Breast Cancer (kunye ne-letrozole): Ukwandisa umthamo ukuya kwi-5500 mg / ngosuku.

IBANGA 2 okanye ICANDELO ELIKHULULEKILEYO LOKUPHATHISWA KWENKQUBO YOKUPHATHWA KWEENKQUBO (LVEF) OKANYE LVEF LOKUPHATHA UKUBHALA KWAMAZIKO EMFUNDO OKUQHELEKILEYO: Ukuyeka unyango; inokuqalisa kwakhona kwi-dose enciphise emva kweeyure ze-2 iiveki ukuba i-LVEF ibuyisele kwisiganeko kunye nesigulane singabonakali.
Amanani okunciphisa:
- I-HER2-Positive Canast Metastatic Breast Cancer (kunye kunye ne capecitabine): 1000 mg / ngosuku
-Bonakalisa i-Receptor-Positive, i-HER2-Positive Canastzotic Breast Cancer (kunye ne-letrozole): 1250 mg / ngosuku

IBANGA 3 OKANYE IBAKALA 1 okanye i-2 DIARRHEA NEZIKHONO EZIPHUMELEKILEYO (ukulinganisela ukuya kukhwabanisa kwesisu, iBakala 2 okanye ukukhwabanisa okukhulu okanye ukuhlanza, ukunciphisa izinga lokusebenza, umkhuhlane, i-sepsis, i-neutropenia, ukuphuma kwamanzi okanye ukukhulelwa kwamanzi): Ngamana ungaphinda uvuselele umthamo ophantsi xa unesifo sohudo sigqibo kwiBakala 1 okanye ngaphantsi.
Amanani okunciphisa:
-I-HER2-Positive I-Metastatic Breast Cancer Iziguli (kunye kunye ne-capecitabine): 1000 mg / ngosuku
-Bonakalisa i-Receptor-Positive, I-HER2-Positive Canast Metastatic Breast Cancer: I-1250mg / imini
I-GRADE 4 DIARRHEA: Ukuyeka unaphakade unyango.

EZINYE AMAXICITI, IBAKALA 2 okanye ABAKHULU: Kungathatha ukuyeka ukuyeka okanye ukuphazanyiswa kwe-dosing; inokuqalisa kwakhona kwi-dose ephakanyisiweyo ngokuqhelekileyo xa utyhefu luphucula kwiBakala 1 okanye ngaphantsi.
UKUBA I-TOXICITY RECURS: Nciphise umthamo:
- I-HER2-Positive Canast Metastatic Breast Cancer (kunye kunye ne capecitabine): 1000 mg / ngosuku
-Bonakalisa i-Receptor-Positive, I-HER2-Positive Canast Metastatic Breast Cancer: I-1250mg / imini

Indlela eluhlaza iLapatinib powder isebenza ngayo

I-Lapatinib powder isetyenziswe nge-capecitabine (Xeloda) ukunyanga uhlobo oluthile lomhlaza wesifuba esiphezulu kubantu abaye baphathwa ngamanye amayeza e-chemotherapy. I-Lapatinib powder eklasini yemithi ebizwa ngokuthi i-kinase inhibitors. Isebenza ngokuthintela isenzo seprotheni engavumelekanga esayinayo iseli somhlaza. Oku kunceda ukuma okanye ukucotha ukusabalala kweeseli zomhlaza.

isilumkiso

Tshela bonke ababonelela ngempilo yakho ukuba uthathe i-Lapatinib powder. Oku kubandakanya oogqirha bakho, abahlengikazi, amayeza kunye namazinyo.
Ukuba udidekile ngesisu, ukuphosa, izitshixo ezikhululekile (uhudo), okanye ulambile, khuluma nodokotela wakho. Kukho iindlela zokunciphisa iziphumo zecala.
Izitulo ezilahlayo (ihudo) zenzeke nePapatinib powder. Ngamanye amaxesha, urhudo luye lwaba lubi kakhulu kwaye kufe. Thetha nogqirha wakho.
Ukuba unesihlalo esilukileyo (urhudo), thetha nodokotela wakho. Ungazami ukuphatha isifo sohudo ngaphandle kokuhlola kuqala ugqirha wakho.
Yenza umsebenzi wegazi uhlolwe njengoko uxelelwe ngugqirha. Thetha nogqirha.
Uzakufuna ukuba neemvavanyo zomsebenzi wenhliziyo ngenkathi uthatha i-Lapatinib powder. Thetha nogqirha.
Gwema iidipefruit kunye nejusi yamagilebhisi.
Ukuba uthatha i-digoxin, thetha nodokotela wakho. Ungadinga ukuba umsebenzi wakho wegazi uhlolisiswe ngakumbi xa uthabatha nge-Lapatinib powder.
Eli liyeza lingafaka ingozi kumntwana ongakazalwa xa uyithatha xa ukhulelwe.
Sebenzisa ulawulo lokuzalwa onokuyithemba ukukhusela ukukhulelwa ngelixa uthabatha i-Lapatinib powder.
Ukuba ukhulelwe okanye ukhulelwe ngenkathi uthatha i-Lapatinib powder, biza ugqirha wakho ngokuchanekileyo.

Powderini Raw Powder

I-10grams encinci.
Uphando malunga nobukhulu obuqhelekileyo (ngaphakathi kwe-1kg) lungathunyelwa kwiiyure ze-12 emva kokuhlawula.
Ukwenza umyalelo omkhulu ungathunyelwa kwiintsuku zokusebenza ze-3 emva kokuhlawula.

I-Lapatinib powder Marketing

Ukubonelelwa kwikamva elizayo.

Ingaba i-Lapatinib powder ebomvu inayo nayiphi na imiphumo yangaphandle

Kanye neempembelelo ezifunekayo, i-Lapatinib powder ingabangela ezinye iimpembelelo ezingafunekiyo. Nangona zonke iziphumo zecala zingenzeka, ukuba zenzeke zingadinga ukunikwa ngonyango.

Hlola kunye nogqirha wakho ngokukhawuleza ukuba kukho nawuphi na umphumo wesiganeko esilandelayo xa uthatha i-Lapatinib powder:

Engaqhelekanga
Ukuphefumula okunzima okanye okusebenza nzima
ukuphelelwa amandla
ngokukhawuleza okanye ngokungaqhelekanga kwentliziyo
isifo sohudo
ukuqina kwisifuba
ukukhathala okanye ukungaphelele
Kudala

Intlungu okanye isisu okanye intlungu
izibonda ezinobumba zobumba
umchamo omnyama
nciphisa ukutya
umkhuhlane
intloko
ukubetheka okanye ukukhwabanisa isikhumba
ukulahleka kwesidlo
isicupunu kunye nokuhlanza
ukuvuvuka kweenyawo okanye imilenze ephantsi
amehlo aphuzi okanye isikhumba
Ingozi engaziwa
Ukutshatyalaliswa, ukukhangela, ukukhulula kwesikhumba
iintlungu zesifuba
bhinqa
ukhohlokhohlo
isifo sohudo
ubunzima ngokugwinya
ukungcola
Uvakalelo oluqhelekileyo lokugula okanye ukugula
mihlathi
intlungu edibeneyo okanye yomzimba
ubuqhophololo okanye ukuvuvukala kweentloko zeentloko okanye malunga namehlo, ubuso, imilomo okanye ulwimi
izibilini zesikhumba ebomvu, ngokuqhelekileyo kunye neziko elibomvu
obomvu, amehlo agxekayo
umqala obuhkungu
izilonda, izilonda, okanye amabala amhlophe emlonyeni okanye emlonyeni
ukwanda kweemfihlo zentsimbi
Ezinye iziphumo ezichaphazelekayo zePapatinib powder zingenzeka eziqhelekanga azidingeki unyango. Ezi mpembelelo zingase zihambe ngexesha lonyango njengoko umzimba wakho uguqula iyeza. Kwakhona, umqeqeshi wakho wezempilo unokwazi ukukuxelela iindlela zokukhusela okanye ukunciphisa ezinye zeziphumo zecala. Hlola kunye neengcali zonyango lwenkonzo ukuba ngaba nayiphi na imiphumo emibi elandelayo iqhubeka okanye ingxaki okanye ukuba unemibuzo malunga nabo:

Okuqhelekileyo
I-Acid okanye isisu esiswini
umqolo obuhlungu
bhinqa
milebe e
uhudo (obumnene)
isikhumba
ukuguquka
ukunyanzelisa
intlungu ezandleni okanye emilenzeni
ubomvu, ukuvuvukala, okanye isikhumba esibuhlungu
ukunyuselwa kwesikhumba ezandleni nasezinyaweni
izilonda, izilonda, okanye amabala amhlophe emlonyeni, ulwimi, okanye ngaphakathi emlonyeni
esiswini, ukungakhathazeki, okanye intlungu
ukuvuvukala okanye ukuvuvukala komlomo
ukubetha kwezandla kunye neenyawo
i ngxaki yokulala


Indlela yokuthenga i-Lapatinib powder esuka kwi-AASraw

1.Qhagamshelana nathi nge-imeyile yethu inkqubo yophando, okanye i-skype ye-intanethiummeli wenkonzo yamakhasimende (CSR).
2.Ukusibonelela ngobuninzi bakho kunye neadesi.
I-3.I-CSR yethu iya kukunika isingeniso, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhambisa kunye nomhla wokufika oqikelelwayo (i-ETA).
I-4.Inkokhelo eyenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ze-12 (Ukuze ulandelwe ngaphakathi kwe-10kg).
5.Goods zifunyenwe kwaye zinike izimvo.


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IAAA

I-COA 231277-92-2 I-Lapatinib powder I-AASRAW

HNMR

Siyi-Lapatinib powder supplie, i-Lapatinib powder yokuthengisa, i-Raw Lapatinib powder (231277-92-2) hplc =98% | Ukurhoxisa iR & D Reagents

Recipes

I-Lapatinib Raw Powder Recipes:

Ukubuza ummeli wethu ummeli (Representative Representative) (CSR) ngeenkcukacha, ngokubhekiselele kuyo.

Iziqulatho kunye nokuqulunqwa kwemveliso

U-Tykerb (231277-92-2) -Umbulali webele

ngokutsha 1 ngenxa I-Lapatinib powder (231277-92-2)

  1. ikaliwe 5 ngaphandle 5

    Aasraw -

    I-Lapatinib powder iyinhlakanipho

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