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I-2-Methoxyestradiol (362-07-2)

Akukho kalo SKU: 362-07-2. Udidi:

I-AASraw ine-synthesis kunye nobuchule bokuvelisa ukusuka kwigram ukuya kwi-oda ye-2-Methoxyestradiol (362-07-2), phantsi kommiselo we-CGMP kunye nenkqubo yokulawulwa komgangatho olandelelweyo.

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Ingcaciso yeMveliso

Ividiyo ye-2-Methoxyestradiol (362-07-2) ividiyo


I-2-Methoxyestradiol (362-07-2) Sukufunyanwa:

Ulwakhiwo lweKhemikhali: Igama lemveliso: I-2-Methoxyestradiol
Thenga i-2-Methoxyestradiol (362-07-2) hplc≥98% | I-AASraw Cas No.: 362-07-2
I-Molecular Formula: C19H26O3
Isisindo somzimba: 302.4
Iintetho: I-2-Methoxyestradiol

362-07-2

IPanzem

I-2-Methoxyestradiol-17beta

I-2-Hydroxyestradol 2-methyl ether

Ukugcina: Emile, emnyama
Amaxwebhu (COA & HPLC njl.njl): iyafumaneka

I-2-Methoxyestradiol (362-07-2) Dkubhala:

I-methoxyestradiol powder, ekwabizwa ngokuba yi-2-ME, yinto e-estradiol yomlomo efumaneka ngokwasemthethweni enokubakho kwezinto ezinokubakho ze-antineoplastic, kungoko in-inhibitor ye-angiogeneisKwenza njenge-vasodilator.

I-2-Methoxyestradiol inhibits angiogenesis ngokunciphisa ukukhula kweeseli ze-endothelial kunye ne-endothelial cell apoptosis. Le arhente ikwathintela ukukhula kweseli ye-tumor ngokubopha i-tubulin, kukhokelela kwimisebenzi ye-antimitotic, kunye nokuphelisa ukusebenza kwe-caspase, okubangela ukubanjwa komjikelezo weseli kwisigaba se-G2, ukwahlulwa kwe-DNA, kunye ne-apoptosis.

Imbekiselo:

  • 1: UPerez-Sepulveda A, uEspaà ± a-Perrot PP, uNorwitz ER, u-Illanes SE. Iindlela ze-Metabolic ezichaphazelekayo kwi-2-methoxyestradiol synthesis kunye nendima yabo kwi-preeclampsia. Ukuvelisa kwakhona inzululwazi. Ngo-2013 uSep; 20 (9): 1020-9. doi: 10.1177 / 1933719113477483. Epub 2013 Mar 1. Uphononongo. I-PubMed PMID: 23456663; I-PubMed Central PMCID: PMC3745713.
  • I-2: IMachado-Linde F, iPelegrin P, iSanchez-Ferrer ML, uLeon J, uCascales P, uParrilla JJ. I-2-methoxyestradiol kwi-pathophysiology ye-endometriosis: gxila kwi-angiogeneis kunye nonyango olunokubakho. Ukuvelisa kwakhona inzululwazi. Ngo-2012 Oct; 19 (10): 1018-29. doi: 10.1177 / 1933719112446080. Epub 2012 Aug 8. Uphononongo. I-PubMed PMID: 22875846.
  • I-3: I-Peyrat JF, i-Brion JD, i-Alami M. I-2-methoxyestradiol ye-derivatives: ubudlelwane bomsebenzi wolwakhiwo. Umchiza weMetr weKhem. Ngo-2012; 19 (24): 4142-56. Uphononongo. I-PubMed PMID: 22709003.
  • I-4: Verenich S, Gerk PM. Izithembiso zonyango lwe-2-methoxyestradiol kunye nemingeni yokuchaphazela iziyobisi. I-Mol Pharm. I-2010 ngo-6; i-7 (6): 2030-9. doi: 10.1021 / mp100190f. Epub 2010 Oct 21. Uphononongo. I-PubMed PMID: 20831190; I-PubMed Central PMCID: PMC3059899.
  • I-5: I-Mueck AO, i-Jongager H. 2-Methoxyestradiol-biology kunye neendlela zokusebenza. Iiasteroids. I-2010 Oct; 75 (10): 625-31. I-Doi: 10.1016 / j.steroids.2010.02.016. Epub 2010 Mar 7. Uphengululo. I-PubMed PMID: 20214913.