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I-Lorcaserin HCL powder

Akukho kalo SKU: 1431697-94-7. Udidi:

I-AASraw ngumenzi oqeqeshiweyo we-Lorcaserin hydrochloride powder eluhlaza enelebhu ezimeleyo kunye nefektri enkulu njengenkxaso, yonke imveliso iya kwenziwa phantsi kolawulo lweCGMP kunye nenkqubo yokulawula umgangatho olandelwayo. Inkqubo yokubonelela izinzile, zombini ii-odolo zokuthengisa kunye ne-wholesale ziyamkeleka.Wamkelekile ukuba ulandele kwi-AASraw!

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Ingcaciso yeMveliso

1. I-Lorcaserin hydrochloride Powder Video-AASraw

 


2. I-Lorcaserin hydrochloride eluhlaza i-Powder Iimpawu eziSiseko

igama: Lorcaserin hydrochloride powder
CAS: 1431697-94-7
Ifomula yeMolekyuli: C11H15Cl2N
Ubunzima Ezinto: 232.1525
Melt Point: 212 ° C
Isitoreji sokugcina: -20 ℃
umbala: Powder

 


3. I-Lorcaserin hydrochloride eluhlaza iNgxelo yoVavanyo lwePowder-HNMR

I-Lorcaserin hydrochloride HNMR

Yintoni i-HNMR kwaye ikuxelela ntoni i-spectrum ye-HNMR? H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bohlalutyo lwekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokufumanisa umxholo kunye nokusulungeka kwesampulu kunye nokwakheka kwemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.

4. Intoni is Lorcaserin hydrochloride Umda?

I-Lorcaserin hydrochloride i-hydrochloride efunyenwe ngokuphendula i-lorcaserin kunye nelinye elilingana ne-hydrochloric acid. Isetyenziswa njengechiza elichasene nokutyeba. Inendima njenge-agonist ye-serotonergic kunye ne-appetite depressant.

I-Lorcaserin hydrochloride powder ichaphazela iimpawu zeekhemikhali kwingqondo elawula ukutya. I-Lorcaserin HCL powder isebenza ngokukunceda uzive ugcwele ngokutya okuncinci.I-Lorcaserin hydrochloride powder isetyenziselwa kunye nokutya kunye nokuzivocavoca ukunyanga ukukhuluphala.I-Lorcaserin hydrochloride powder ngamanye amaxesha isetyenziselwa ukuphatha ukukhuluphala okunokuthi kuhambelana nesifo sikashukela, i-cholesterol ephezulu, okanye uxinzelelo lwegazi oluphezulu. .

5. Yintoni iLorcaserin hydrochloride efanelekileyo?

I-Lorcaserin hydrochloride isetyenziselwa ukunceda abantu abadala abatyebileyo okanye abagqithiseleyo kwaye baneengxaki zonyango ezinxulumene nesisindo sokunciphisa umzimba kwaye bagcine ekubuyiseleni ubunzima. I-Lorcaserin kufuneka isetyenziswe kunye nokunciphisa ukutya kwekhalori kunye nesicwangciso sokuzivocavoca. I-Lorcaserin ikwiklasi yeyeza ebizwa ngokuba yi-serotonin receptor agonists. Isebenza ngokwandisa iimvakalelo zokuhlutha ukuze kutyiwe ukutya okuncinci.

I-Lorcaserin hydrochloride isetyenziselwa kunye nokutya okuncitshisiweyo kweekhalori kunye nokuzivocavoca okufanelekileyo ukukunceda ukuba ulahlekelwe isisindo. Ikwasetyenziswa nakubantu abatyebe kakhulu abanokuba nesifo seswekile, uxinzelelo lwegazi oluphezulu, icholesterol ephezulu, okanye isifo sentliziyo.

6. The Iinzuzo zeLorcaserin hydrochloride

I-Lorcaserin hydrochloride yonyango elawulwa ngomlomo ekhuthaza ukulahleka kwesisindo. Isetyenziswa ngokutya kunye nokuzivocavoca kubantu abadala abatyebileyo abanengxaki yonyango enxulumene nobunzima okanye abantu abadala abatyebileyo ukuba banciphise umzimba kwaye bayigcine.

I-Lorcaserin hydrochloride i-serotonin 2C (5-HT2C) i-receptor agonist. I-lorcaserin icingelwa ukuba ikhethe i-5-HT2C i-receptors kwi-hypothalamus, indawo yengqondo eyaziwayo ukuba idlala indima enkulu ekulawuleni indlala kunye nokutya. Ngokusebenzisa la ma-receptors, i-lorcaserin inokunciphisa ukusetyenziswa kokutya ngokunciphisa ukutya kunye nokwenza umntu azive egcwele nasemva kokutya ukutya okuncinci kunesiqhelo.

I-Lorcaserin hydrochloride i-serotonin 2C i-receptor agonist eboniswe kunyango lokulawulwa kwesisindo esingapheliyo kubantu abadala abane-index mass body (BMI) ye-30 okanye enkulu (obese) njengongeziweyo kwi-calorie yokutya kunye nokuzivocavoca. I-lorcaserin iphinda ivunywe ukuba isetyenziswe ngabantu abadala abane-BMI ye-27 okanye ngaphezulu (i-overweight) kunye nobuncinci besimo esinxulumene nesisindo esifana noxinzelelo lwegazi oluphezulu (i-hypertension), uhlobo lwe-2 yeswekile, okanye i-cholesterol ephezulu (dyslipidemia).

7. Lorcaserin hydrochloride isetyenziswe njengechiza elichasene nokutyeba

Ukutyeba kakhulu yeyona nto iphambili kwimpilo efuna iindlela ezikhuselekileyo nezisebenzayo zokujongana nobhubhane wokutyeba. I-Lorcaserin i-agonist ye-serotonergic ekhethekileyo kwi-receptor ye-5HT-2C evunyiweyo yokulawulwa okungapheliyo kokukhuluphala kwizigulane ezine-BMI ≥ 30 kg / m (2) okanye i-BMI ≥ 27 kg / m (2) kunye ne-comorbidities ehambelana nokukhuluphala.

I-Lorcaserin yi-agonist ekhethekileyo ekhethiweyo kakhulu ye-serotonergic eyenzelwe ukunciphisa iingozi ezinxulumene nama-agent angaphambili kule klasi. Kwiidosi zonyango, inyamezeleka kakuhle kwaye ivelisa ukwehla kobunzima obuthobekileyo kodwa obunentsingiselo ngokweklinikhi ngophuculo olubalulekileyo kwiparamitha ze-cardiometabolic. Ukuphumelela konyango kufuneka kuhlolwe kwiiveki ze-12 (≥ 5% ukulahleka kwesisindo) ukuchonga abaphenduli abaza kufumana ukulahlekelwa kwesisindo esiphezulu kunye nenzuzo ye-metabolic kunyango lwexesha elide. Iziphumo zovavanyo oluqhubekayo lweziphumo ze-cardiovascular (CAMELLIA TIMI 61) ziya kugqiba indima ye-lorcaserin ekukhuselweni okuphambili kwesifo sikashukela kubantu abagqithisileyo / abagqithiseleyo kunye nokusetyenziswa kwayo kwimingcipheko ephezulu yezigulane ezine-cardiovascular disease ezisekelwe kwi-cardiovascular disease okanye iimeko ezininzi ze-cardiovascular risk.

8. Kuphi ukuthenga Lorcaserin hydrochloride Umgubo?

I-Lorcaserin isetyenziselwa ukunceda abantu abadala abatyebileyo okanye abagqithiseleyo kwaye baneengxaki zonyango ezinxulumene nesisindo sokunciphisa umzimba kunye nokugcina ukubuyisela ubunzima. I-Lorcaserin kufuneka isetyenziswe kunye nokunciphisa ukutya kwekhalori kunye nesicwangciso sokuzivocavoca. I-Lorcaserin ikwiklasi yeyeza ebizwa ngokuba yi-serotonin receptor agonists. Isebenza ngokwandisa iimvakalelo zokuhlutha ukuze kutyiwe ukutya okuncinci.

9.Ingxelo

[1] Belviq (lorcaserin hydrochloride) tablet [Eisai, Inc]”. DailyMed. Eisai, Inc. Agasti 2012. Igcinwe kweyoqobo ngomhla wama-21 kuOkthobha 2013. Ibuyiselwe ngomhla wama-21 kuOktobha 2013.

[2] "I-FDA icela ukuhoxiswa kweyeza lokunciphisa ubunzima beBelviq, Belviq XR (lorcaserin) kwimarike". Ulawulo loKutya kunye neziyobisi lwase-US (FDA). Nge-14 kaJanuwari 2020. Ibuyiselwe nge-1 ka-Epreli 2020.

[3] "I-FDA Ngamafutshane: I-FDA icela ukuhoxiswa ngokuzithandela kweyeza lokuLahla ubunzima emva kovavanyo lweklinikhi lubonisa ukwenzeka kweCancer". I-FDA. Nge-13 kaFebruwari 2020.

[4] "I-Belviq XR (i-lorcaserin hydrochloride) iipilisi zokukhululwa okwandisiweyo". Ulawulo loKutya kunye neziyobisi lwase-US (FDA). 26 Okthobha 2016. Ibuyiselwe nge-14 kaJanuwari 2020.

[5] "Ipakethi yokuVunywa kweziyobisi: Belviq (lorcaserin hydrochloride) Iipilisi NDA #022529". Ulawulo loKutya kunye neziyobisi lwase-US (FDA). 7 Agasti 2012. Ibuyiselwe nge-14 kaJanuwari 2020.

10. Indlela yokuthenga Lorcaserin hydrochloride Umgubo ovela kwi-AASraw?

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