Ingcaciso yeMveliso
Orlistat Umda yokuzonwabisa-AASraw
Orlistat Umda Abalinganiswa abasisiseko
| igama: | I-Orlistat powder |
| CAS: | 96829-58-2 |
| Ifomula yeMolekyuli: | C29H53NO5 |
| Ubunzima Ezinto: | 495.7 |
| Melt Point: | Ngama-50 ° C |
| Isitoreji sokugcina: | 2-8 ° C |
| umbala: | Powder |
Yintoni i-Orlistat Powder?
I-Orlistat powder iyisiyobisi esisetyenziselwa unyango lokunyameka okanye izigulane ezigqithiseleyo.Yaqala ukuphuhliswa nguRoche kwaye yasungulwa e-United States kwi-1999.Yona kuphela i-counter-counter-counter loss loss drug evunyiweyo yi-FDA, i-CFDA kunye ema kwihlabathi.Isebenza ngokuthintela i-pancreatic kunye ne-gastric lipases, ii-enzymes ezinoxanduva lokuqhekeza amafutha okutya kwi-gastrointestinal tract.Oku kubangela ukuba amanqatha angagatywanga akhutshelwe kwindle, okukhokelela kwiikhalori ezimbalwa ezifunxa kumafutha.
EUnited States,i-orlistat ivunyiwe kunyango lwe-body mass index (BMI,Body Mass Index,unit kg/㎡) efikelela okanye edlula i-30 (umgangatho wokutyeba kakhulu wase-US).Kwaye, abantu abanesalathiso sobunzima bomzimba phakathi kwe-27 kunye ne-30 kunye nezinye izinto ezinobungozi empilweni ezifana noxinzelelo lwegazi oluphezulu okanye isifo seswekile.
Isebenza njani i-Orlistat Powder?
I-Orlistat powder isebenza ngokuvimbela i-gastric kunye ne-pancreatic lipases, eziyi-enzymes ezijongene nokuphula i-triglycerides ibe yi-fatty acids encinci enokuthi ifakwe ngumzimba. ukuncipha kwenani lamafutha afunxayo ekutyeni.
Ekubeni i-triglycerides ayichithwanga kwi-fatty acids yamahhala, ikhutshwe ingatshintshi kwi-feces.Le nkqubo ikhokelela ekunciphiseni i-caloric intake kwaye ikhuthaza ukulahleka kwesisindo.I-Orlistat iboniswe ukukhusela malunga ne-30% yamafutha okutya ukuba afakwe.
Ukongeza ekuvimbeleni i-lipases, i-orlistat iphinda inqanda i-thioesterase domain ye-fatty acid synthase (FAS) .Le enzyme ibandakanyeka ekwandeni kweeseli zomhlaza kodwa kungekhona iiseli eziqhelekileyo.Nangona kunjalo, iziphumo ezinokuthi zenzeke ze-orlistat, ezifana nokuvinjelwa kwamanye amaselula. -ekujoliswe kuzo okanye ukungafumaneki kakuhle kwe-bioavailability, kunokuthintela ukusetyenziswa kwayo njenge-agent esebenzayo ye-antitumor.
Ngokubanzi, inkqubo ye-orlistat yesenzo ibandakanya ukuvinjelwa kwee-enzymes ezibandakanyekayo kwi-fat digestion, ekhokelela ekunciphiseni inani lokutya okufunxayo kunye nokukhuthaza ukunciphisa umzimba.
Izibonelelo zokusebenzisa i-Orlistat Powder
I-Orlistat powder iyiyeza elisetyenziselwa ukuphatha ukukhuluphala, ngokukodwa ngokuthintela ukunyuswa kwamafutha ekudleni komntu.Ukongezelela, kunokunciphisa ngokuthobekileyo uxinzelelo lwegazi kwaye kubonakala kukuthintela ukuqala kohlobo lwe-2 yeswekile, nokuba kukulahlekelwa ubunzima ngokwawo okanye enye. iziphumo.
· Unyango lo kukhulula
I-Orlistat powder isetyenziselwa ngokukodwa unyango lokukhuluphala ngokubambisana nomboneleli wezempilo-ophantsi kolawulo oluncitshisiweyo lwekhalori. ngokuthintela i-gastric kunye ne-pancreatic lipases, i-enzymes ejongene nokuphula i-triglycerides emathunjini.
Idatha ehlanganisiweyo evela kulingo lwezonyango icebisa ukuba abantu abanikwe i-orlistat ukongeza kuhlengahlengiso lwendlela yokuphila, njengokutya kunye nokuzilolonga, balahlekelwe malunga neekhilogram ezingama-2-3 (4-7 lb) ngaphezulu kwabo bangalithathi ichiza ekuhambeni konyaka. Phakathi kwe-35.5 I-% kunye ne-54.8% yezifundo iphumelele i-5% okanye iyancipha ngaphezulu kobunzima bomzimba, nangona kungengabo bonke obu bunzima bebunzima. I-orlistat yamiswa, inani elibalulekileyo lezifundo zaphinda zafumana ubunzima-ukuya kuthi ga kwi-16.4% yesisindo esilahlekileyo.
· Ukuncitshiswa koxinzelelo lwegazi
Ukongezelela ekuncedeni ukulahleka kwesisindo, izifundo zibonise ukuba i-orlistat powder ingakhokelela ekunciphiseni okuthobekileyo kwixinzelelo lwegazi.Idatha edibeneyo evela kwizilingo zeklinikhi ibonisa ukuba i-orlistat iyanciphisa uxinzelelo lwegazi lwe-systolic kunye ne-diastolic ngomlinganiselo we-2.5 kunye ne-1.9 mmHg, ngokulandelanayo. Indlela yokunciphisa uxinzelelo lwegazi icingelwa ukuba ihambelana nokulahlekelwa kwesisindo esiphunyeziweyo ngokusetyenziswa kwe-orlistat, njengoko ukukhuluphala yinto eyaziwayo yomngcipheko we-hypertension.Nangona kunjalo, kubalulekile ukuba uqaphele ukuba ukunciphisa uxinzelelo lwegazi oluphunyeziweyo ngokusebenzisa i-orlistat Incinci ngokwentelekiso kwaye akufuneki kuxhomekeke kuyo njengonyango lodwa loxinzelelo lwegazi.
· Ukuthintelwa kokuQala kweSifo seswekile sesi-2
I-Orlistat powder ibonakaliswe ukuba inefuthe lokuthintela ekuqaleni kohlobo lwe-2 yeswekile, ngaphandle kokulahlekelwa kwesisindo kunye nemiphumo yokunciphisa uxinzelelo lwegazi. Oku kunokwenzeka ngenxa yokuba ukukhuluphala kuyingozi enkulu yokuphuhlisa uhlobo lwe-2 yeswekile, kwaye I-orlistat inokunceda ekulahlekeni kwesisindo kubantu abatyebileyo.Uphononongo lubonise ukuba i-orlistat inokunciphisa iziganeko ze-2 yeswekile kubantu abatyebileyo malunga nomlinganiselo ofanayo wokuguqula indlela yokuphila. ayiqondwa kakuhle, kodwa kucatshangelwa ukuba inxulumene nokukwazi kweziyobisi ukunciphisa i-caloric intake ngokuvimbela ukufunxa kwamafutha okutya, oku kunokukhokelela ekuphuculeni i-glucose metabolism kunye nokukhathazeka kwe-insulin.Kubalulekile ukuba uqaphele ukuba i-orlistat ayithathi indawo. Ukuphila impilo enempilo, kwaye ukusetyenziswa kwayo kufuneka kuhlale kudityaniswa nokutya okuncitshisiweyo kwekhalori kunye nokuzilolonga ukuze usebenze kakhulu.
Amanqaku:Ukwandisa inzuzo ye-Orlistat powder, kubalulekile ukuyithenga kumboneleli othembekileyo.I-AASraw inikezela nge-Orlistat powder ephezulu ngamaxabiso afanelekileyo, njengomthengisi we-Orlistat oyingcali kunye neziko elizimeleyo le-R & D kunye ne-factory.Xa uthenga i-Orlistat powder ukusuka kwi-AASraw, unokuqiniseka ukuba ufumana imveliso ecocekileyo, ephezulu ehambelana neemfuno ezingqongqo zomgangatho.
Iimpembelelo zecala ze-Orlistat Powder?
I-Orlistat powder, njengawo nawaphi na amayeza, ineempembelelo ezinokuthi zibe nemiphumo.Nangona ichaphazela kuphela i-gastrointestinal tract kwaye kungekhona i-cardiovascular or central nervous systems, imiphumo emibi ayinakuhoywa.
Iziphumo eziqhelekileyo
Izitulo ezinamafutha okanye izitulo ezinamabala anamafutha
- Flatulence
- Ukungahambi kakuhle esiswini
- Ukungxamiseka kwesitulo
- Ukonyuka rhoqo kwesitulo
- Ukungabikho kwamaFecal
- Oily spotting
- Ukunyuka kwe-flatus yesisu
- Izitulo ezityebileyo (ezinamafutha).
- Steatorrhea
Njengoko umxholo wamafutha ekutyeni ukhula, izinga lezehlo likwanyuka ngokufanelekileyo.Izigulane ezininzi zinokuphucula emva kokuthatha iyeza ixesha elithile.
Iintshukumo ezibukhali zesisu
- Iintlungu zesisu / ukungonwabi
- Ilindle elinamanzi
- Izicathulo eziphantsi
- Iintlungu ze-rectal / ukungonwabi,
- Ukungakhululeki kwamazinyo
- Ukungakhululeki kwentsini
Amanqaku:Kuyafaneleka ukuba uqaphele ukuba umgangatho we-orlistat powder uhambelana ngokusondeleyo nemiphumo emibi, kwaye umgangatho ophezulu we-orlistat powder unokunciphisa umngcipheko wemiphumo emibi.Ukuthenga kumthengisi wepowder ohloniphekileyo njenge-AASraw kunokunceda ukunciphisa umngcipheko wemiphumo emibi. ngempumelelo.I-AASraw inikezela ngekhwalithi ephezulu ye-Orlistat powder eyenziwe phantsi kwemigangatho engqongqo ye-GMP eqinisekisa ukucoceka kunye potency.Nangona kunjalo, kubalulekile ukuba uhlale ubonisana nochwepheshe bezempilo ngaphambi kokuba uqale nawaphi na amayeza amatsha okanye irejimeni yokuncedisa.
Umthamo kunye noLawulo lwe-Orlistat Powder yokuReference
I-Orlistat powder yonyango yonyango esetyenziselwa ukulawula ukulahlekelwa kwesisindo kunye nokugcinwa kwesisindo xa isetyenziswe kunye nokutya okuncitshisiweyo kwekhalori.I-dosage ephakanyisiweyo kunye nokulawulwa kwe-Orlistat powder zilandelayo.
Isistim
I-dose ephakanyisiweyo ye-Orlistat powder yi-120 mg ethathwe ngomlomo ngamaxesha e-3 ngosuku kunye nesidlo ngasinye esiyintloko esiqulethe i-fat.I-dose yemihla ngemihla ayifanele idlule i-360 mg.
Administration
I-Orlistat powder kufuneka ithathwe ngomlomo ngexesha, okanye ukuya kuthi ga kwiyure enye emva koko, isidlo ngasinye esine-fat.Ukuba isidlo silahlekile okanye singenayo i-fat, i-dose ye-Orlistat powder inokuthi igqitywe.Izigulane kufuneka zicetyiswe ukuba zithathe i-multivitamin equkethe i-multivitamin iivithamini ezinyibilikayo ngamanqatha ubuncinane iiyure ezimbini ngaphambi okanye emva kokuthatha i-Orlistat powder.
Ukulungiswa Kwedosi
Akukho hlengahlengiso lwedosi oluyimfuneko kwizigulane ezinokukhubazeka kwezintso okanye zesibindi.Nangona kunjalo, izigulane ezine-diabetes mellitus zinokufuna ukulungiswa kwedosi kumayeza abo eswekile, kwaye ulawulo lwe-glycemic kufuneka lubekwe esweni ngokusondeleyo.
Ukuqapha
Kubalulekile ukuba uqaphele ukuba i-Orlistat powder ayifanele isetyenziswe ngexesha lokukhulelwa okanye ngabo banesifo esingapheliyo se-malabsorption syndrome, i-cholestasis, okanye i-hypersensitivity kwinto esebenzayo okanye nayiphi na imveliso ye-excipients. ngokusondeleyo.
amaNqaku
I-dosage kunye nolwazi lokulawula olunikeziweyo malunga ne-Orlistat powder yenzelwe iinjongo zolwazi kuphela kwaye akufanele isetyenziswe njengento ethatha indawo yeengcebiso zezobuchwephesha.Soloko udibana nomboneleli wezempilo ngaphambi kokuba uqale nawaphi na amayeza okanye isongezelelo, kubandakanywa ne-Orlistat powder.I-dosage kunye nokulawulwa kwe-Orlistat. Umgubo kufuneka unqunywe ngokusekelwe kwimbali yonyango lomntu ngamnye, amayeza angoku, kunye nezinye izinto ezifanelekileyo.Ngaphezu koko, ukuthenga i-orlistat powder enomgangatho ophezulu kumthengisi we-Orlistat othembekileyo okanye umthengisi kubaluleke kakhulu.
Ukusebenzisana kwe-Orlistat kunye namanye amayeza
- I-Orlistat inokunciphisa ukuxutywa kwamavithamini A, D kunye no-E. Ngoko ke, ukuba uthatha amalungiselelo aqukethe iivithamini A, D kunye ne-E (njengamalungiselelo athile e-multivitamin), kufuneka uthathe iivithamini kwiiyure ze-2 emva kokuthatha i-orlistat.
- Izigulane ezinesifo sikashukela sohlobo lwe-2 zingadinga ukunciphisa umthamo we-oral hypoglycemic agents (ezifana ne-sulfonylureas).
- Ukusetyenziswa ngokubambisana kwe-orlistat kunye ne-cyclosporine kunokubangela ukuhla kwe-plasma yoxinaniso lwamva.
- Xa i-orlistat isetyenziswa ngokudibeneyo ne-amiodarone, inokunciphisa ukufunxa kokugqibela kunye nokunciphisa umphumo wonyango.
- Ukuba isetyenziswa namanye amachiza ngaxeshanye, ukusebenzisana kweziyobisi kunokwenzeka, nceda udibane nogqirha wakho okanye usokhemesti ngeenkcukacha.
Ungayithenga phi i-Orlistat Powder?
Ukufumana umthengisi we-Orlistat onokwethenjelwa kunye nohloniphekileyo we-powder powder kubalulekile kulabo abakumashishini amayeza okanye imboniselo yezempilo abafuna eli liyeza kwiimveliso zabo okanye izigulane.Kubalulekile ukukhetha umthengisi onokubonelela ngekhwalithi ephezulu ye-Orlistat powder ehambelana nemigangatho kunye nemimiselo efunekayo. .Umthengisi kufuneka kwakhona abe nerekhodi elungileyo malunga nolawulo lomgangatho, ukupakishwa, ukuthumela, kunye nenkonzo yabathengi.Ngokukhetha umthengisi othembekileyo, abathengi banokuqinisekisa ukuba bafumana imveliso ekhuselekileyo nesebenzayo kwiimfuno zabo.
AASraw ngumboneleli osekwe kakuhle wezinto ezisetyenziswayo zamachiza, kuquka i-Orlistat powder.Banenkqubo engqongqo yokulawula umgangatho wokuqinisekisa ukuba iimveliso zabo zikumgangatho ophezulu kwaye zihlangabezana nemigangatho efunekayo.Bakwabonelela abathengi ngesatifikethi sokuhlalutya nganye nganye. i-batch ye-Orlistat powder abayithengisayo, ngoko unokuqiniseka ngokucoceka kunye nomgangatho wemveliso.Ngaphezu koko, i-AASraw inikezela ngexabiso elikhuphisanayo kunye nokuhanjiswa okuthembekileyo, okuyizinto ezibalulekileyo ekufuneka ziqwalaselwe xa ukhetha umthengisi.Kuko konke, i-AASraw ngumthengisi ohloniphekileyo. ye-Orlistat powder enikezela ngeemveliso ezikumgangatho ophezulu, amaxabiso akhuphisanayo, kunye nokuhanjiswa okuthembekileyo.
Orlistat Umda Ingxelo yoVavanyo-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
I-Orlistat powder (96829-58-2)-COA
I-Orlistat powder (96829-58-2)-COA
Indlela yokuthenga Ubungakanani bePowder ukusuka kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. Xiongcai Feng
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
2. Jovana V. Jovankić
University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovića 12, 34000, Kragujevac, Serbia
3. Sandhya R. Bassin MD
Icahn School of Medicine at Mount Sinai, Department of Endocrine, Diabetes, and Bone Disease
4. Vian Ahmed Wasta Esmail
Department of Clinical Pharmacy, College of Pharmacy, University of Sulaimani, Sulaimani, Iraq
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
Ucaphulo
[1] Siebenhofer A,Winterholer S,Jeitler K,Horvath K,Berghold A,Krenn C,Semlitsch T (ngoJanuwari 2021). "Iimpembelelo zexesha elide zeziyobisi zokunciphisa umzimba kubantu abanoxinzelelo lwegazi". I-Database ye-Cochrane yoPhononongo oluCwangcisiweyo. 1 (1):CD007654.
[2] UMancini MC,Halpern A (April 2006). "Unyango lwe-Pharmacological of obesity". Arquivos Brasileiros de Endocrinologia kunye neMetabologia. 50 (2):377–389.
[3] Heck AM,Yanovski JA,Calis KA (Matshi 2000). "I-Orlistat, i-lipase inhibitor entsha yokulawula ukutyeba". Pharmacotherapy. 20 (3):270–279.
[4] UGarcia SB, uBarros LT, uTuratti A, uMartinello F, uModiano P, uRibeiro-Silva A, et al. (Agasti 2006).” I-Agent anti-obesity i-Orlistat inxulunyaniswa nokunyuka kweempawu ze-colonic preneoplastic kwiigundane eziphathwa ngekhemikhali ye-carcinogen. ”. Iileta zoMhlaza. 240 (2):221–224.
[5] "I-FDA ivuma i-Orlistat yokusetyenziswa ngaphezulu kwe-Counter" (Ukukhutshwa kweCofa) .USFood and Drug Administration (FDA) .7 February 2007.Igcinwe kwi-Archived from yokuqala nge-13 May 2009.Ifunyenwe nge-7 February 2007.
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