Pregabalin powder

1. yokuzonwabisa

 

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2. Abalinganiswa abasisiseko

Igama lemveliso:	Pregabalin powder
Inombolo ye-CAS:	148553-50-8
I-molecular Formula:	C8H17NO2
Isisindo somzimba:	159.23
Melt Point:	194-196 ° C
umbala:	Umgubo omhlophe okanye omhlophe wekristale
Isitoreji sokugcina:	RT

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3. HNMR

Yintoni i-HNMR kwaye ikuxelela ntoni i-spectrum ye-HNMR? H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bohlalutyo lwekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokufumanisa umxholo kunye nokusulungeka kwesampulu kunye nokwakheka kwemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.

4.Yintoni i-Pregabalin Powder kwaye isetyenziselwa ntoni?

I-Pregabalin powder ngumgubo omhlophe osetyenziswa njengechiza elichasayo ukuxhuzula, ukwabizwa ngokuba sisithinteli sokuxhuzula. Isebenza ngokunciphisa iimpembelelo kwingqondo ezibangela ukuxhuzula. I-Pregabalin powder nayo ichaphazela iikhemikhali kwingqondo ezithumela iimpawu zentlungu kwi-nervous system.

I-Pregabalin powder isetyenziselwa ukunyanga iintlungu ezibangelwa yi-fibromyalgia, okanye intlungu ye-nerve kubantu abanesifo sikashukela (i-diabetic neuropathy), i-herpes zoster (i-post-herpetic neuralgia), okanye ukulimala kwentambo yomgogodla.

I-Pregabalin powder iphinda isetyenziswe kunye namanye amayeza ukunyanga ukutshatyalaliswa kwenxalenye yabantu abadala kunye nabantwana ubuncinane ubuncinane benyanga ye-1. I-Pregabalin ipowder eluhlaza ingasetyenziselwa iinjongo ezingadweliswanga kwesi sikhokelo sonyango.

5.Isebenza njani iPregabalin?

I-Pregabalin iyeza le-anticonvulsant elisetyenziselwa ukunyanga intlungu ye-neuropathic kunye ne-fibromyalgia, kunye nokubanjwa kwenxalenye yokuqala ngokudibeneyo kunye nezinye i-anticonvulsants.

Nangona indlela yokusebenza ingaqondwa ngokupheleleyo, izifundo ezibandakanya iziyobisi ezinxulumene nolwakhiwo zibonisa ukuba ukubopha i-presynaptic ye-pregabalin kwi-voltage-gated calcium channels kubaluleke kakhulu kwi-antiseizure kunye ne-antinociceptive iziphumo ezibonwa kwiimodeli zezilwanyana.

I-Pregabalin imodareyitha ukukhululwa kwee-neurotransmitters ezininzi ezivuselelayo, ezibandakanya i-glutamate, i-substance-P, i-norepinephrine, kunye ne-calcitonin ye-peptide ehambelana nejini, ngokubopha i-presynaptically kwi-alpha2-delta subunit ye-voltage-gated calcium channels kwinkqubo ye-nervous central.

Ngaphezu koko, i-pregabalin inqanda ukuthengiswa kwe-alpha2-delta subunit ukusuka kwi-dorsal root ganglia ukuya kwi-spinal dorsal horn, enokuthi ibe negalelo kwindlela yokusebenza. Ngaphandle kokuba yi-derivative derivative ye-inhibitory neurotransmitter gamma-aminobutyric acid (GABA), i-pregabalin ayibopheleli kwi-GABA okanye i-benzodiazepine receptors.

6.Yintoni ukusetyenziswa kwePregabalin Powder?

❶ Ukusebenza kwe-Pharmacological: I-Pregabalin yi-novelγ-aminobutyric acid (GABA) i-receptor agonist, inokuthintela iziteshi ze-calcium ezixhomekeke kwi-voltage ukunciphisa ukukhululwa kwe-neurotransmitter.

❷ Eyona kliniki yonyango lweentlungu ze-peripheral neuropathic kunye nenxalenye yonyango lwe-adjuvant ye-focal seizures.

❸ Unyango lwesifo sokuxhuzula ekuphuhliseni elona yeza lithembisayo kunyango lwechiza olungcono nolulula ngakumbi. Ingasetyenziselwa ukunyanga iintlungu kunye nokuxhalaba.

7.Zithini iziphumo ebezingalindelekanga zePregabalin?

Njengamachiza amaninzi, iLyrica inokubangela iziphumo ezibi okanye ezimbi kakhulu. Olu ayiloluhlu olupheleleyo lweziphumo ebezingalindelekanga kwaye ezinye zinokwenzeka. Umboneleli wezempilo unokukucebisa ngeziphumo ebezingalindelekanga. Ukuba ufumana ezinye iziphumo, qhagamshelana nosokhemesti okanye umboneleli wezempilo.

Iziphumo eziPhakathi

Unokufumana iziphumo ebezingalindelekanga ngelixa uthatha i-pregabalin. Iziphumo ebezingalindelekanga eziqhelekileyo ze-pregabalin ziquka:

▪ isiyezi

▪ ukozela

▪ ukubhideka

▪ ukungaboni kakuhle

▪ ukungcangcazela

▪ ukungazinzi xa uhamba

▪ ukutyeba

▪ ukuqhinwa

▪ umlomo owomileyo.

Iziphumo ezibi kakhulu

Shayela umnikezeli wakho ngokukhawuleza ukuba unemiphumo emibi kakhulu. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unengxakeko yonyango. Iziphumo ezibi kakhulu kunye neempawu zazo zinokubandakanya oku kulandelayo:

▪ Iingcinga zokuzibulala okanye ukuzama ukuzibulala: Iimpawu zisenokuquka ukuzama ukuzibulala, ukuxhalaba okanye ukudandatheka okutsha okanye okuya kuqatsela, ukungalali kakuhle, ukuphazamiseka, ukwenza izinto ngenxa yeminqweno eyingozi nokutshintsha ngendlela engaqhelekanga kwisimo sengqondo okanye ukuziphatha.

▪ Ukwaliwa kakhulu: Iimpawu zayo zisenokuquka ukuphefumla nzima, ukurhabaxa, ukudumba kolwimi, imilebe, umlomo okanye umqala.

▪ Iingxaki zentliziyo

▪ Iingxaki ezinzulu zokuphefumla

Ezinye iziphumo ebezingalindelekanga zinokubangcono ekuhambeni kwexesha, ngelixa ezinye ezifana nokuba nesiyezi kunye nokozela zinokuhlala logama uthatha iyeza.

8.Indlela yokugcina iPregabalin Powder?

Abantu kufuneka bagcine eli liyeza kwindawo yokushisa elawulwayo, malunga ne-68 degrees ukuya kwi-77 degrees Fahrenheit.

Ukuba uhamba, hlala uphethe iyeza lakho kunye nawe kwaye ugcine ibhotile okanye ibhokisi ebhalwe ngugqirha kwi-bag yakho. Musa ukushiya eli yeza kwimoto yakho, ngakumbi kubanda kakhulu okanye kushushu.

9.Ungamfumana njani umthengisi wePowder wePregabalin kwi-intanethi?

Baninzi ababoneleli be-pregabalin powder abafumaneka kwi-intanethi nakwiivenkile ezibonakalayo kwihlabathi jikelele. Nangona kunjalo, kufuneka uqaphele kakhulu ukuba ufuna ukufumana i-powder ephezulu eya kukuqinisekisa iziphumo ezisemgangathweni ekupheleni kwemijikelezo yakho. Ayiyiyo yonke imveliso ye-pregabalin ecocekileyo yomgubo oyifumene kwi-intanethi yeyokwenyani, abanye bakho nje ukwenza imali, kwaye abakhathali ngeziphumo oza kuzifumana emva kokuthatha iidosi zakho. Ngaphambi kokuba uthenge i-pregabalin powder, qala wenze uphando lwakho. Qinisekisa ukuba uyayiqonda indlela umthengisi we-pregabalin powder osebenza ngayo ngaphambi kokuba wenze nayiphi na iodolo. Funda uphononongo olwahlukileyo lwabathengi kunye nokujonga iireyithingi zenkampani.

Singoyena mthengisi we-pregabalin ohamba phambili kunye nomenzi kwingingqi. Iwebhusayithi yethu (aasraw.com) isebenziseka lula, ngoko ke unokwenza iodolo yakho ngokulula usebenzisa i-smartphone yakho, ithebhulethi, okanye idesktop ukusuka kubutofotofo bekhaya okanye iofisi yakho. Sihlala siqinisekisa ukuba sihambisa zonke iimveliso ngexesha elifutshane kakhulu. Unokuthenga i-pregabalin powder ngobuninzi okanye ngokwaneleyo kwishishini lakho. Khumbula, nokuba ungalifumana ngokulula kangakanani iyeza, ungaqalisi ukulithatha ngaphandle kwesikhokelo sikagqirha wakho.

10.Ingxelo

[1] Dworkin RH, O'Connor AB, Backonja M, et al. Ulawulo lwe-Pharmacologic yeentlungu ze-neuropathic: iingcebiso ezisekelwe kubungqina. Iintlungu 2007;132:237-51.

[2] Finnerup NB, Jensen TS. Ukusetyenziswa kweklinikhi ye-pregabalin ekulawuleni intlungu ye-neuropathic ephakathi. Izifo ze-Neuropsychiatric kunye noNyango 2007; 3: 885-91.

[3] Kalso E, Aldington DJ, Moore RA. Iziyobisi zentlungu ye-neuropathic. BMJ 2013;347:f7339.

[4] Mannix, Liam (Disemba 18, 2018). “Esi siyobisi sithandwayo sinento yokwenza nokuba likhoboka nokuzibulala. Kutheni oogqirha besoloko beyiyalela?” Amaxesha eCanberra. Igcinwe ukusuka kweyoqobo ngoDisemba 18, 2018. Ifunyenwe ngoDisemba 18, 2018.

[5] Nangona, uJames W.; Willmore, James; UBrumback, uRoger A. (2009). Unyango oluPhezulu kwiSithuthwane. PMPH-USA. p. 302. ISBN 978-1-60795-004-2.

11. Indlela yokuthenga i-Pregabalin Powder kwi-AASraw?

❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.

❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.

❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuhanjiswa kunye nomhla wokufika oqikelelweyo (ETA).

❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.

❺Impahla efunyenweyo kwaye unike izimvo.

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