Ingcaciso yeMveliso
Yintoni i-PT-141(Bremelanotide)?
PT-141, ekwabizwa ngokuba yibremelanotide,ligama eliqhelekileyo leklasi entsha yeepeptide ezifundiswayo ukuze zincede ukuphucula ukungasebenzi kwezesondo (i-erectile dysfunction, okanye ukungabi namandla) kumadoda kunye nokunceda ukuphucula ukungasebenzi kakuhle kwesondo (i-arousal disorder disorder) kubasetyhini.141 ayisebenzi kwi-vascular system. njengeekhompawundi ezimbini zangaphambili, kodwa iyaziwa kwaye ibonakaliswe ekuncedeni ukwandisa umsebenzi wesondo kwizilwanyana zamadoda nabasetyhini.Ngaphezu koko, i-peptide PT 141 ngoku ivunyiwe yi-FDA ukunyanga ukungasebenzi ngokwesondo kwabasetyhini.Ukuba abantu bafuna ukuthenga i-peptide PT. 141 kwi-intanethi,imithombo emininzi yolwazi,enje ngomvelisi we-PT 141 kunye nomthengisi,inokufunyanwa lula.
Isebenza njani i-PT-141(Bremelanotide)?
I-PT-141 (i-Bremelanotide) ngowokuqala kwiklasi yolunye uhlobo lwamachiza eyaziwa ngokuba yi-melanocortin agonists kwi-pathology yonyango.Indlela yokusebenza ye-PT-141 (iBremelanotide) inokubonelela ngokhuseleko olubalulekileyo kunye noncedo olusebenzayo xa kuthelekiswa neemveliso ezikhoyo ngoku kuba isebenza iindlela zemisebenzi yolawulo kunokuba ngokuthe ngqo kwinkqubo.Idatha yeClinical ibonisa ukuba i-PT-141 (i-Bremelanotide) inokuphinda iphathe ngokufanelekileyo izigulane ezahlukeneyo ezingenamandla.Ukwenziwa kweempumlo ze-PT-141 (Bremelanotide) phantsi kophuhliso kulula njengonyango lomlomo, kakhulu. isigulane xa kuthelekiswa nonyango oluhlaselayo olufana neenaliti kunye neepellets ze-transurethral, kwaye kubonakala ngathi kunokuqalisa ngokukhawuleza kwesenzo.
I-Bremelanotide PT-141 kuthiwa isebenza ngokuvula i-melanocortin receptors kwingqondo, ngaloo ndlela inceda ukunyusa i-arousal yesondo.Yi-peptide esekwe kwi-melanocortin ebonise ukusebenza kwizifundo zeklinikhi kwiigundane zamadoda nabasetyhini.Iimpuku zamadoda zibonise iimpendulo ze-erectile kwiidosi. ephantsi njenge-1-2 mg, ngelixa iigundane ezininzi zabasetyhini zibonise iimpendulo ezintle kwiidosi eziphezulu njenge-2-3 mg.
Kubalulekile ukuqaphela ukuba indlela yokusebenza kwemveliso inxulumene nomgangatho wayo. Kuphela ziimveliso ezikumgangatho ophezulu kuphela ezinokuba neyona ndlela ifanelekileyo yokwenza. Ukuqinisekisa umgangatho we-PT-141, kubalulekile ukuyifumana kumntu othembekileyo. umthombo.AASraw, umenzi ohloniphekileyo kunye nomthengisi we-PT-141, unikezela ngemveliso ye-peptide ephezulu yophando oluzimeleyo kunye namaziko ophuhliso kunye neefektri.Ukuba uneemfuno ezithile, ukukhetha ukuthengisa i-PT-141 kwi-AASraw yindlela efanelekileyo kakhulu.
Izibonelelo zokusebenzisa i-peptide PT-141(Bremelanotide)
I-PT-141 (i-Bremelanotide) ibonelela ngeenzuzo eziphambili ekunyangeni ukungasebenzi kakuhle ngokwesondo kumadoda nakwabasetyhini.Xa ilawulwa ngenaliti, ibonise iziphumo ezithembisayo kwizifundo zovavanyo lwabasetyhini. Nangona kunjalo, ikwangqina iluncedo kumadoda ahlangabezana nemiba efana ne-erectile dysfunction, i-libido ephantsi, kunye nokungabi namandla.
Yandisa umnqweno wesini
Enye yeenzuzo eziphambili ze-PT-141 kukukwazi ukunyusa umnqweno wesini ngokusebenzisa inkqubo ye-nervous central ngaphandle kokuchaphazela kakubi inkqubo ye-vascular.Xa kuthelekiswa namanye amayeza okungasebenzi ngokwesondo, i-AASraw PT-141 ithathwa njengenamandla ngakumbi ngelixa igcina ukhuseleko olufanelekileyo. Iprofayili.Ayibeki umngcipheko omkhulu kwimpilo yomntu jikelele.
Kunyango lokungasebenzi kakuhle kwezesondo, i-PT-141 ibonakaliswe ukuba yongeza ngokufanelekileyo umnqweno wesondo kubasetyhini, kwaye iziphumo zinokuhlala ixesha elide. Abanye abantu bafumana izibonelelo ukuya kuthi ga kwiiyure ezingama-72 emva kokutofwa kwe-PT-141.
Ukwandisa amandla
Ukongeza kwindima yayo ekujonganeni nokungasebenzi kakuhle ngokwesondo, i-PT-141 ibonise amandla okunyusa ngokwendalo amanqanaba amandla.Iiklinikhi zehomoni zamadoda zikwasebenzisa i-PT-141 ukujongana neempawu ezinxulumene ne-testosterone ephantsi.Umxube we-peptide we-PT-141 unokuba luncedo kumntu ngamnye. abasoloko benengxaki yokudinwa, ukudinwa, okanye ukuphelelwa ngamandla.
Nyanga iziphazamiso ze-pigmentation zesikhumba.
Ngaphaya koko, i-PT-141 ijongiwe ukuba inganakho ukunyanga iziphazamiso zebala lolusu kwaye isetyenziswe njengendalo, iarhente yokutshisa ngaphandle kwelanga.Noko kunjalo, ukuthambekela kwe-PT-141 ukubangela ukuvuseleleka ngokwesondo kubasebenzisi kuthintele ukusetyenziswa kwayo kwiimveliso zokushuka. Kubalulekile ukuqaphela ukuba eyona njongo iphambili yokusebenzisa i-PT-141 ihlala ilunyango lokungasebenzi kakuhle kunye nokuphucula umnqweno wesondo kumadoda nabasetyhini.
Ingundoqo ekuthengeni i-PT-141 kwimithombo ehloniphekileyo; Ngaphandle koko, awukwazi ukufumana ukusebenza kakuhle kwi-PT-141.Njengomenzi we-PT-141 oqeqeshiweyo kunye nomthengisi, i-AASraw ijolise ukubonelela nge-PT-141 ecocekileyo emhlabeni wonke.Ukuba unezidingo, i-peptide ye-AASraw PT-141 yinto ekhethekileyo kuwe.
Iziphumo ebezingalindelekanga ze-peptide PT-141(Bremelanotide)
Ngelixa i-PT-141 (i-Bremelanotide) inyamezeleke kakuhle, kubalulekile ukuba uqaphele iziphumo ezinokuthi zenzeke.Ezinye zeziphumo ebezingalindelekanga ze-PT-141 ziquka:
I sizathu:Isicaphucaphu sesinye seziphumo ebezingalindelekanga ezixelwe ngokuqhelekileyo ze-PT-141.
intloko ebuhlungu:Abanye abantu banokufumana intloko ebuhlungu njengesiphumo se-PT-141.
Ukuphendula kwendawo yenalitiEkubeni i-PT-141 ilawulwa ngenaliti, kukho ithuba lokufumana ukusabela kwendawo yokutofa njengentlungu, ububomvu, okanye ukudumba kwindawo yokutofa.
Utywala:Isiyezi okanye intliziyo ekhaphukhaphu inokuthi yenzeke njengempembelelo yecala le-PT-141.Kubalulekile ukuphepha imisebenzi efuna uqwalaselo ukuba ufumana isiyezi.
UkukhathalaAbanye abantu banokudinwa okanye badinwe emva kokuthatha i-PT-141.
Ukudibanisa kwamanzi:Ukuba i-PT-141 ilawulwa ngendlela yokutshiza ngeempumlo, ukuxinana kweempumlo okanye ukuxinana kunokuthi kwenzeke njengeziphumo ebezingalindelekanga.
Kubalulekile ukuqaphela ukuba ayinguye wonke umntu oya kuba nazo ezi ziphumo bezingalindelekanga, kwaye ubukhali kunye nokuphindaphindwa kweziphumo ebezingalindelekanga zinokwahluka phakathi kwabantu. .Ngaphezu koko, xa uthenga i-PT-141, kufuneka ukhethe ngokucophelela umthengisi we-PT-141 ukuqinisekisa umgangatho wemveliso.Ngexesha elifanayo, kufuneka lisetyenziswe phantsi kwesikhokelo seengcali ukuphepha iziphumo ezibi.
PT-141 vs Melanotan II (MT-2)
I-PT-141 (i-Bremelanotide) kunye ne-Melanotan II (MT-2) inomahluko othile kwimiphumo yabo kunye neendlela zokwenza xa kuziwa kunyango lwe-erectile dysfunction (ED) .Nantsi uthelekiso phakathi kwe-PT-141 kunye ne-MT-2 iziphumo kwi-ED.
①Indlela yokwenza
I-PT-141
I-PT-141 ngokuyintloko isebenza kwinkqubo ye-nervous central ngokujolisa kwi-melanocortin receptors, ngakumbi i-melanocortin 4 receptor (MC4R) ebuchosheni. umsebenzi ophuculweyo we-erectile.
IMelanotan II
I-Melanotan II isebenza ngokuyinhloko ngokujolisa i-melanocortin receptors, ngokukodwa i-melanocortin 1 receptor (MC1R) . umsebenzi we-erectile awukho ngqo ngokuthe ngqo xa kuthelekiswa ne-PT-141.
②Gxininisa kwi-Erectile Dysfunction
I-PT-141
I-PT-141 ifundwe ngokukodwa kwaye yaphuhliswa kunyango lwe-erectile dysfunction, kumadoda kunye nabasetyhini.Izilingo zekliniki zibonise iziphumo ezithembisayo ekuphuculeni umsebenzi we-erectile kunye nomnqweno wesini.
IMelanotan II
Nangona i-Melanotan II ichazwe ngokungaqhelekanga ukuba ibe nemiphumo ethile ekusebenzeni ngokwesondo kunye ne-libido, injongo yayo ephambili ayigxininisi ekuphatheni i-erectile dysfunction.
③Ubungqina bezonyango
I-PT-141
I-PT-141 iye yafumana iimvavanyo zeklinikhi ngokukodwa ukuvavanya ukusebenza kwayo ekuphatheni i-erectile dysfunction.Ezi zilingo zibonise iziphumo ezilungileyo, ezibonisa amandla ayo njengendlela yonyango ye-ED.
IMelanotan II
I-Melanotan II inobungqina obuncinane bekliniki obuxhasa ukuphumelela kwayo ekuphatheni i-erectile dysfunction.Ininzi yedatha ekhoyo kwimiphumo yayo yokusebenza ngokwesondo isekelwe kwiingxelo ze-anecdotal kunezifundo zeklinikhi ezingqongqo.
Isishwankathelo, i-PT-141 ifundwe ngokubanzi kwaye yaphuhliswa kunyango lwe-erectile dysfunction kunye nokungasebenzi ngokwesondo kumadoda nabasetyhini.Indlela yokusebenza kwayo ijolise ngokuthe ngqo kwinkqubo ye-nervous central kwaye ibonise iziphumo ezithembisayo kwiimvavanyo zeklinikhi. Isandla, iMelanotan II igxile ikakhulu kubumnyama bolusu kwaye inobungqina obuthe ngqo obuncinci bokusebenza kwayo kunyango lwe-erectile dysfunction.
UngayiThenga phi i-PT-141(Bremelanotide)?
Xa kuziwa kwi-PT-141 (Bremelanotide), kubalulekile ukubeka phambili ukhuseleko kunye nokunyaniseka xa uqwalasela ukuthenga kubathengisi be-intanethi.Imithombo enyanisekileyo nethembekileyo kufuneka ifunwe ukuqinisekisa umgangatho kunye nokusebenza kwemveliso kwizicelo zayo zempilo ezijoliswe kuyo.Ukuqinisekisa isidima somboneleli sibalulekile, njengokubambelela kwabo kwimigangatho yolawulo lomgangatho kunye nonikezelo lwamaxwebhu ayimfuneko njengeSiqinisekiso soHlahlelo.
Ukuba ufuna umthombo othembekileyo wokuthenga i-PT-141, i-AASraw ingaba yinto efanelekileyo. I-AASraw yinkampani enika uluhlu olubanzi lweepeptides, kuquka i-PT-141.Imveliso yazo isetyenziswa ngokuqhelekileyo ngamabhubhoratri kunye namaziko ophando kwi- uphuhliso kunye nokuveliswa kweemveliso ezahlukeneyo zempilo.
Ingxelo yoVavanyo lwe-PT-141-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
Indlela yokuthenga i-PT-141 kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. Anita H. Clayton MD
ISebe leNgqondo yengqondo kunye neNzululwazi ye-Neurobehavioral, iYunivesithi yaseVirginia, eCharlottesville, eVirginia
2. UFrançois Giuliano MD, PhD
Isibhedlele saseRaymond Poincaré-iSebe lezoNyango loNyango kunye noBuyiselo, eGarches, eFransi
3. Mohammad Reza Safarinejad
IZiko loPhando lweUrology kunye neNephrology, iSibhedlele saseShaheed Modarress, iYunivesithi yaseShaheed Beheshti yeSayensi yezoNyango, eTehran, eIran.
4. URaymond C. Rosen PhD
ISebe lezeNgqondo, iYunivesithi yezoNyango kunye neDentistry yaseNew Jersey, iRobert Wood Johnson Medical School, iPiscataway, NJ, USA
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
Ucaphulo
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[2] Idayimane LE, uEarle DC, uHeiman JR, uRosen RC, uPerelman MA, uHarning R.” Impembelelo ekuphenduleni ngokwesondo kwabasetyhini abangaphambi kokumenopausal abanengxaki yokuvuselela ngokwesondo nge-bremelanotide (PT-141), i-melanocortin receptor agonist. J Sex Med.2006 Jul; PMID:16839319.
[3] Ückert S, Bannowsky A, Albrecht K, Kuczyk MA (Novemba 2014).” I-Melanocortin i-receptor agonists kunyango lwe-dysfunctions yesini yamadoda nabasetyhini: iziphumo zophando olusisiseko kunye nezifundo zeklinikhi ".Uluvo lweNgcali kwiZiyobisi zoPhando.23 ( 11): 1477–83.doi:10.1517/13543784.2014.934805.PMID 25096243.
[4] Pfaus J, Giuliano F, Gelez H. ”Bremelanotide: uphononongo lweziphumo ze-CNS zangaphambi kweklinikhi ekusebenzeni ngokwesondo kwabasetyhini. "J Sex Med.2007 Nov.PMID: 17958619.
[5] Mintzes B,Tiefer L,Cosgrove L.”I-Bremelanotide kunye ne-flibanserin yomnqweno wesondo ophantsi kwabasetyhini:ubuxoki be-precedent yokulawula.
[6] I-Molinoff PB, uShadiack AM, u-Earle D, i-Diamond LE, i-Quon CY. "PT-141: i-agonist ye-melanocortin yonyango lokungasebenzi ngokwesondo"Ann NY Acad Sci.2003 Jun.PMID:12851303.
[7] Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB.” Uvavanyo lokhuseleko, i-pharmacokinetics kunye neziphumo ze-pharmacodynamic ze-PT-141 elawulwa ngaphantsi kwe-subcutaneous, i-agonist ye-melanocortin receptor, kwizifundo zamadoda ezinempilo kunye nakwizigulane ezineenganekwane. impendulo kwiViagra.”Int J Impot Res.2004 Apr.PMID:14999221.
[8] Idayimane LE, i-Earle DC, i-Garcia WD, i-Spana C.” Ulawulo oluhlangeneyo lweedosi eziphantsi ze-intranasal PT-141, i-melanocortin receptor agonist, kunye ne-sildenafil kumadoda ane-erectile dysfunction iphumela kwimpendulo ephuculweyo ye-erectile. "Urology. 2005 Epreli;PMID:15833522.
