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I-Ethynyl estradiol (57-63-6)

Akukho kalo SKU: 57-63-6. Udidi:

I-AASraw ine-synthesis kunye nobuchule bokuvelisa ukusuka kwigram ukuya kwi-oda ye-Ethynyl estradiol (57-63-6), phantsi kommiselo we-CGMP kunye nenkqubo yolawulo lomgangatho olandelwayo.

nganto

Ingcaciso yeMveliso

Ividiyo ye-Ethynyl estradiol (57-63-6) ividiyo


I-Ethynyl estradiol (57-63-6) Sukufunyanwa:

Ulwakhiwo lweKhemikhali: Igama lemveliso: I-Ethynyl estradiol
Thenga i-Ethynyl estradiol (57-63-6) hplc≥98% | I-AASraw Cas No.: 57-63-6
I-Molecular Formula: C20H24O2
Isisindo somzimba: 296.4
SIliso: I-CP, i-EP, i-USP, i-IP
Ukugcina: Yomile, imnyama kwaye ku-0 - 4 C yexesha elifutshane (iintsuku ukuya kwiiveki)
Amaxwebhu (COA & HPLC njl.njl): iyafumaneka

I-Ethynyl estradiol (57-63-6) Dkubhala:

I-Ethinyl Estradiol powder yi-estisisisis ye-semisynthetic. Indlela yokusebenza ye-ethinyl estradiol injenge-estrogen Receptor Agonist. Ine-potency ephezulu ye-estrogenic xa ilawulwa ngomlomo, kwaye ihlala isetyenziswa njengecandelo le-estrogenic kwizicwangcisi zomlomo. I-Ethinyl estradiol ibopha kwi-estrogen receptor tata kwaye ingena kwi-nucleus, isebenze ukukhutshwa kwe-DNA yemfuza ebandakanyeka kwiimpendulo zeseli ye-estrogen. Le arhente ikwathintela i-5-alpha reductase kwizicubu zesifo sephepha, esehlisa amanqanaba e-testosterone kwaye inokulibazisa ukuqhubela phambili komhlaza we-prostatic. Ukongeza kwiziphumo zayo ze-antineoplastic, i-ethinyl estradiol ikhusela kwi-osteoporosis. Kwimodeli yezilwanyana, unyango lwexesha elifutshane kunye nale arhente ibonakalisiwe ukubonelela ngokhuseleko lwexesha elide kumhlaza webele, ukulingisa iimpembelelo ze-antitumor zokukhulelwa.

Imbekiselo:

  • I-1: I-Archer DF, uThomas MA, uConard J, Merkatz RB, uCreasy GW, uRoberts K, uPlagianos M, uBlithe D, uSitruk-Ware R. Impembelelo kwiiproteni ezinobuthathaka be-estrojeni ngumnxeba wokukhusela inzala wonyaka wokuqala uhambisa i-Nestorone® kunye ethinyl estradiol. Ukuthintela inzalo. Ngo-1 uJan; 2016 (93): 1-58. doi: 64 / j.contraception.10.1016. Epub 2015.09.008 Sep 2015. I-PubMed PMID: 25.
  • I-2: U-Lobo Abascal P, uLuzar-Stiffler V, uGiljanovic S, uHoward B, u-Weiss H, uTrussell J. Umahluko ekunikezeleni ingxelo kwiPearl Indices e-United States naseYurophu: Gxila kwinkqubo yeentsuku ezingama-91 ezandisiweyo ze-regimen edibeneyo yokuthintela inzala ngomlomo kunye ne-low- idosi ye-ethinyl estradiol isongezelelo. Ukhathalelo lwempilo ye-Eur J Contracept Reprod. Ngo-2016 uFeb; 21 (1): 88-91. doi: 10.3109 / 13625187.2015.1059416. Epub 2015 Jun 26. I-PubMed PMID: 26115381.
  • I-3: I-Waellnitz K, i-Duijkers I, iKlipping C, i-Rautenberg T, i-Rohde B, iZurth C. iZiko ezimbini, ilebhile evulekileyo, ukufundwa okungahleliwe kwe-ovulation inhibition kunye ne-patdermal contracept patches, nganye inamanani ahlukeneyo e-ethinyl estradiol kunye ne-gestodene kwi usempilweni, bafazi abancinci. J Obstet Gynaecol. Ngo-2016 Jan; 36 (1): 106-13. doi: 10.3109 / 01443615.2015.1041882. Epub 2015 Sep 30. I-PubMed PMID: 26421957.
  • I-4: Patel G, King A, Dutta S, Korb S, Wade JR, Foulds P, Sumeray M. Ukuvavanywa kweziphumo ze-CYP3A inhibitors ze-atorvastatin kunye ne-ethinyl estradiol / norchedimate ye-lomitapide pharmacokinetics kwizifundo ezisempilweni. J Clin Pharmacol. Ngo-2016 uJan; 56 (1): 47-55. I-Doi: 10.1002 / jcph.581. Epub 2015 Sep 10. I-PubMed PMID: 26120010.