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Ithathi-438

Akukho kalo Udidi:

I-TAK438, ekwabizwa ngokuba yiVonoprazan Fumarate, iyeza elitsha lokunyanga izifo ezinxulumene neasidi ngendlela yentshukumo ebizwa ngokuba ziibhlokhi zeasidi ye-potassium-yokhuphiswano (P-CABs) ethintela ukhuphiswano ngokubopha ion ze-potassium ku-H +, K + -ATPase ( ekwabizwa ngokuba yimpompo yeproton) kwinqanaba lokugqibela lokufihla i-asidi esiswini kwiiseli zesisu separietali, ukulawula ukugcinwa kwe-asidi esiswini. Inika isiphumo sokuthintela ukhuseleko esomeleleyo kunye nokuzinzileyo.

Ingcaciso yeMveliso

Iimpawu ezisisiseko

Igama lemveliso I-TAK-438 powder
Inani leCAS 1260141-27-2
I-Molecular Formula C21H20FN3O6S
Ubukhulu beFormula 461.46
Iintetho ezifanayo I-Vonoprazan Fumarate;
I-TAK-438 powder;
1260141-27-2;
IVonoprazan fumurate;
TAK438.
Kubonakala Umhlophe ukuya kutsho-omhlophe
Ukugcina nokuPhatha Okomileyo, omnyama kunye no-0 ukuya ku-4 C okwexesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).

 

Ingcaciso ye powder TAK-438

I-TAK438, ekwabizwa ngokuba yiVonoprazan Fumarate, iyeza elitsha lokunyanga izifo ezinxulumene neasidi ngendlela yentshukumo ebizwa ngokuba ziibhlokhi zeasidi ye-potassium-yokhuphiswano (P-CABs) ethintela ukhuphiswano ngokubopha ion ze-potassium ku-H +, K + -ATPase ( ekwabizwa ngokuba yimpompo yeproton) kwinqanaba lokugqibela lokufihla i-asidi esiswini kwiiseli zesisu separietali, ukulawula ukugcinwa kwe-asidi esiswini. Inika isiphumo sokuthintela ukhuseleko esomeleleyo kunye nokuzinzileyo.

Kwimimandla yamathumbu esisu, i-TAK-438 yonyango olungumgubo ikhokelele kuthintelo olude kunye nolomeleleyo lwe-asidi. Isiphumo sokuthintela i-TAK-438 powder kwimfihlo ye-asidi kubonakala ngathi inxulunyaniswa ne-gastric parietal cell physiology.

 

I-TAK-438 powder Indlela yokuSebenza

I-TAK-438 powder (iVonoprazan fumarate) sisiphumo se-pyrole kunye ne-potassium-yokhuphiswano lwe-acid blocker (P-CAB) ekhuphisana ngokuthintela indawo yokubopha ye-potassium yesisu esiswini H (+), K (+) - ATPase, i-enzyme ephambili inkqubo ye-gastric acid secretion. Ikhompawundi inokuqokelelana kwindawo yeasidi kwaye kufuneka inike ixesha elide lokuthintela ngenxa ye-alkaline pKa ye-9.06.

Kwimimandla yamathumbu esisu, i-TAK-438 yonyango olungumgubo ikhokelele kuthintelo olude kunye nolomeleleyo lwe-asidi. Isiphumo sokuthintela i-TAK-438 powder kwimfihlo ye-asidi kubonakala ngathi inxulunyaniswa ne-gastric parietal cell physiology.

 

Isicelo se powder TAK-438

I-TAK-438 powder (iVonoprazan fumarate okanye iVonoprazan) iyeza elitsha lokunyanga izifo ezinxulumene neasidi ngendlela yentshukumo ebizwa ngokuba yi-potassium-competent acid blockers (P-CABs) ekhuphisana ngokubophelelayo ukubopha ion ze-potassium ku-H +, K + - I-ATPase (ekwabizwa ngokuba yimpompo yeproton) kwisinyathelo sokugqibela sokugcina i-asidi esiswini kwiiseli zesisu separietal. Iyeza lamkelwe eJapan kunyango lwezifo ezinxulumene neasidi, kubandakanya isilonda esiswini, isilonda esiswini, i-reflux esophagitis kunye ne-Adjunct kwi-Helicobacter pylori eradication kwimeko ye-Helicobacter pylori gastritis.

 

I-TAK-438 Iziphumo ebezingalindelekanga kunye nesilumkiso

Iziphumo eziqhelekileyo zibandakanya:

▪ urhudo,

▪ isicaphucaphu nokugabha,

▪ ukuqhina,

▪ iintlungu esiswini,

▪ irhashalala,

▪ isisu.

 

Ayizizo zonke iziphumo ebezingalindelekanga ezinokubakho ze-TAK438. Ngolwazi oluthe kratya, cela ugqirha wakho okanye usokhemesti. Shayela ugqirha wakho malunga neengcebiso. Unokuxela iziphumo ebezingalindelekanga kwi-FDA ngo-1-800-FDA-1088.

 

isingqiniso

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M.Ukufumanisa kwe Isiphumo esivela kwinoveli 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 powder) njenge potassium ibhlokhi yeasidi (P-CAB). UJ Med Chem. Ngo-2012 ngoMeyi 10; 55 (9): 4446-56. ikhonkco: 10.1021 / jm300318t. Epub 2012 Epreli 30. PubMed PMID: 22512618.

[2] I-Kondo M, i-Kawamoto M, i-Hasuoka A, i-Kajino M, i-Inatomi N, i-Tarui N. Ukuvavanywa okuphezulu kwe-acid ye-potassium. Isikrini seJ Biomol. NgoFebruwari 2012; 17 (2): 177-82. ikhonkco: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711 (PubMed) (Umnqamlezo)

[3] I-Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Ukubonakaliswa kwenqaku le-potassium-yokhuphiswano lwe-acid blocker ye-gastric H, K-ATPase, 1- [5- (2-) I-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 powder). J Pharmacol Exp Ther. NgoNovemba 2011; 339 (2): 412-20. ikhonkco: 10.1124 / jpet.111.185314. Epub 2011 Aug 9. I-PMID edlulisiweyo: 21828261; Ipapashwe kwi-PMCID eseMbindini: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. Uphononongo ngokuthelekisa umphumo we-antisecretory we-TAK-438 powder, inoveli ye-potassium-yokhuphiswano lwe-acid blocker, ene-lansoprazole kwizilwanyana. J Pharmacol Exp Ther. NgoJuni ka-2011; 337 (3): 797-804. ikhonkco: 10.1124 / jpet.111.179556. Epub 2011 Mar 16. PubMed PMID: 21411494 (PubMed) (Umnqamlezo)

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. Uphononongo lokuthelekisa kwiindlela zokwenza i-TAK-438 powder, inoveli ye-potassium-yokhuphiswano lwe-acid blocker, kunye ne-lansoprazole kwizidalwa zesisu zemivundla esiswini. Biochem Pharmacol. Ngo-2011 ngoMeyi 1; 81 (9): 1145-51. ikhonkco: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mar 1. Ipapashwe ngu-PMID: 21371447.

[6] UHori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl). -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 powder), inoveli kunye ne-potassium enokhuphiswano lwe-acid blocker kunyango lwezifo ezinxulumene ne-asidi. J Pharmacol Exp Ther. Ngo-2010 ngo-Okthobha; 335 (1): 231-8. ikhonkco: 10.1124 / jpet.110.170274. Epub 2010 Jul 12. I-PMID edlulisiweyo: 20624992.


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