Tirzepatide

Yintoni iTirzepatide?

I-Tirzepatide liyeza elinoveli elivunywe yi-FDA kunyango lohlobo lwe-2 yeswekile mellitus.Ngenxa yeempawu zayo ezinamandla zokunciphisa umzimba, thenga i-tirzepatide isetyenziswe ngaphandle kweleyibhile yonyango lokutyeba.

Isebenza njenge-agonist ye-GLP-1 kunye ne-GIP agonist ukwandisa izibonelelo ezifanayo ezibonwa ngamayeza e-GLP-1 anje semaglutide.Okwangoku liphunyezwa njengeyeza lesibini lesifo seswekile, elifana namayeza e-GLP-1, kwaye linikezelwa njengetofu engaphantsi kwesikhumba kanye ngeveki.I-FDA yamkele i-peptide iTirzepatide ngoMeyi ka-2022.

Isebenza njani iTirzepatide?

I-Tirzepatide yi-peptide yokwenziwa; kunye ne-polypeptide ye-gastric inhibitory inhibitory (GIP) kunye ne-glucagon-like peptide 1 (GLP-1) i-receptor agonist.Iqulunqwe ngama-amino acids angama-39 kwaye i-analog ye-gastric inhibitory polypeptide.Ngokusebenzayo, ivuselela ukukhululwa kwe-insulin kwi-pancreas kwaye kukhokelela ekunciphiseni kwe-hyperglycemia.Ukongezelela, i-Tirzepatide iphinda inyuse amanqanaba e-adiponectin.Ikhono layo eliphindwe kabini le-agonism likhokelela ekunciphiseni okuphawulekayo kwe-hyperglycemia kune-GLP-1 i-agonist agents yodwa kwaye yehlisa umdla womsebenzisi.

IiNzuzo zeTirzepatide

I-Tirzepatide yi-glucose exhomekeke kwi-insulinotropic polypeptide (GIP) receptor kunye ne-glucagon-like peptide-1 (GLP-1) receptor agonist, evunywe yi-FDA ukunyanga uhlobo lwe-2 yesifo seswekile. Kubalulekile ukuqaphela ukuba i-tirzepatide ayivunywanga ukuphatha uhlobo lwe-1 yesifo sikashukela kwaye aluzange lufundwe kwizigulane ezine-pancreatitis.I-Tirzepatide i-GIP receptor kunye ne-GLP-1 i-receptor agonist, ekhokelela ekuphuculeni kakhulu ukulawulwa kwe-glycemic kwi-2 yesifo sikashukela kunye nokunciphisa ubunzima obunzima.

Iziphumo zeTirzepatide

Izigulane ezinobunzima kunye nohlobo lwe-2 yeswekile (T2D) okanye ngokugqithisileyo kunye ne-T2D ilahlekelwe yi-34.4 pounds (15.7%) yobunzima bomzimba kunye ne-10 mg kunye ne-15 mg ye-tirzepatide (i-Mounjaro; u-Eli Lilly kunye neNkampani), ngokweziphumo ezivela kwi-SURMOUNT -I-2 isigaba sehlabathi jikelele isilingo se-3. Ngokukodwa, i-tirzepatide kwi-10 mg yanciphisa ubunzima bomzimba nge-5% okanye ngaphezulu kwi-79.2% yezigulane kunye nokunciphisa umyinge wobunzima bomzimba nge-12.8%, ngelixa i-15 mg dose yanciphisa ubunzima kwi-82.7% yezigulane kunye nokunciphisa umyinge ubunzima bomzimba nge-14.7%.

I-Tirzepatide esetyenziselwa ukuncipha kobunzima

I-Tirzepatide, yinaliti eyenzeka kanye ngeveki yokunciphisa iswekile yegazi. Ukusukela ngo-2022 ibonise iziphumo ezimangalisayo zokwehla kobunzima, kwaye ikwindlela ekhawulezayo yokuchongwa ukuze iqwalaselwe unyango lokutyeba ngokugqithisileyo. ngaphezu kwe-20% yobunzima bomzimba wabo bokuqala.

Tirzepatide kunye BPC 157 inceda ekunciphiseni umzimba ngokunciphisa ukutya kunye nokucotha indlela okukhawuleza ngayo ukutya kwindlela yakho yokugaya.Oku kunokukunceda uzive ugcwele ixesha elide kwaye unciphise ukutya okutyayo.Izifundo zibonisa ukuba esi senzo singenzeka engqondweni.

Ingaba isebenza kanjani:

● Nciphisa ukutya okutyiwayo.

●Ithintela isibindi ekwenzeni nasekukhupheni iswekile eninzi kakhulu.

●Yehlisa indlela ukutya okuphuma ngokukhawuleza ngayo esiswini.

● Umzimba ukhupha i-insulin xa iswekile esegazini iphezulu.

●Umzimba uyayisusa iswekile eninzi egazini.

Uthini umahluko phakathi kweTirzepatide kunye neSemaglutide?

I-Tirzepatide isebenza kwi-BOTH GIP kunye ne-GLP-1 receptors, ngelixa i-Semaglutide isebenza kuphela kwi-GLP-1 receptors.Zombini iziyobisi zonyango olusebenzayo lokulahlekelwa kwesisindo. -njenge-peptide-1) i-agonist ye-receptor.Bobabini bakwiklasi yeziyobisi ezibizwa ngokuba yi-incretin mimetics kodwa banezinye iiyantlukwano.

Ukuguqulwa kwendlela yokuphila kunye nokuthintelwa kwekhalori kuya kukhokelela kwiziphumo ezingcono kakhulu. Izibonelelo zokunciphisa umzimba ziphuculwe ukutyeba okufana nesifo seswekile, uxinzelelo lwegazi oluphezulu, i-lipids yegazi engaqhelekanga kunye nesifo senhliziyo esinokubonwa kunye ne-5% yokunciphisa umzimba.

I-Tirzepatide i-Side Effects

Ezona ziphumo zixhaphakileyo zeTirzepatide ziquka isicaphucaphu, urhudo, ukuncipha kokutya, ukugabha, ukuqhina, ukungagayeki, kunye nesisu (esisu) intlungu. Ezi ayizizo zonke iziphumo ebezingalindelekanga zeTirzepatide.Thetha nomboneleli wakho wezempilo malunga naziphi na iziphumo ebezingalindelekanga onokuthi ube nazo. amava.

Ungayithenga phi iTirzepatide?

I-AASraw yindawo engcono kakhulu yokuthenga i-Tirzepatide i-wholesale.Zonke iimveliso zethu ziza kunye neSitifiketi esizimeleyo, esikhutshwe ngumntu wesithathu sokuhlalutya ukuchongwa, ukucoceka, kunye nokugxininiswa.Kwaye sineTirzepatide eninzi ethengiswa kwisitokhwe!

I-AASraw ngumthengisi weTirzepatide kunye nomenzi weTirzepatide onelebhu ezimeleyo kunye nefektri enkulu njengenkxaso, yonke imveliso iya kwenziwa phantsi kolawulo lweCGMP kunye nenkqubo yokulawula umgangatho olandelwayo. ukuthenga iTirzepatide kwi-intanethi, wamkelekile ukutyelela iwebhusayithi yethu (aasraw.com).

Ingxelo yoVavanyo lweTirzepatide-HNMR

Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.

Indlela yokuthenga iTirzepatide kwi-AASraw?

❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.

❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.

❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).

❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.

❺Impahla efunyenweyo kwaye unike izimvo.

Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango

Umbhali wephepha leJenali yeNzululwazi:
1. Qi Liu
ISebe leCardiology, isibhedlele saseRenmin seYunivesithi yaseWuhan, eWuhan 430060, Hubei, PR China
2. Sidar Copur
ISebe lezoNyango, iSikolo seYunivesithi yaseKoc yezoNyango, i-Istanbul 34010, eTurkey
3. URouchan Ali
ISebe leKhemistri yeKhemikhali kunye noHlalutyo, iKholeji ye-ISF ye-Pharmacy, eMoga 142001, ePunjab, eIndiya.
4. V. Thieu
Eli Lilly, kwiMicimbi yezoNyango, e-Indianapolis, eU.SA
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.

Ucaphulo

[1] Lilly :Iziphumo zeSigaba sesi-3 zeTirzepatide ziBonisa i-A1C ePhezulu kunye nokuNcitshiswa koMzimba kuHlobo lwesi-2 seSifo seswekile”.Business Insider.RTTNews.19 Okthobha 2021.Igcinwe kwindawo yokuqala ngomhla wama-28 Okthobha 2021.Yafunyanwa ngomhla wama-28 kuOktobha 2021.

[2] I-Tirzepatide yanciphisa kakhulu i-A1C kunye nobunzima bomzimba kubantu abanesifo seswekile se-2 kwizilingo ezimbini zesigaba sesi-3 ukusuka kwinkqubo ye-SURPASS kaLilly” (Ukukhutshwa kweendaba) .Eli Lilly kunye neNkampani.17 February 2021.Igcinwe kwi-original kwi-28 Okthobha 2021.Ifunyenwe nge-28 ka-Okthobha ka-2021. – nge PR Newswire.

[3] Kellaher,Colin (28 April 2022).”Eli Lilly's Tirzepatide Udibana neNkalo eziPhambili kwiSigaba sesi-3 soFundo lokutyeba”.IMarketWatch.Dow Jones Newswires.Igcinwe kwintsusa yomhla wama-29 kuTshazimpuzi 2022.Ifunyenwe ngomhla wama-29 kuTshazimpuzi 2022.

[4] Willard FS,Douros JD,Gabe MB,Showalter AD,Wainscott DB,Suter TM,et al.(Septemba 2020).”I-Tirzepatide ayilungelelaniswanga kwaye inomkhethe kwi-GIP emibini kunye ne-GLP-1 receptor agonist”.JCI Insight.5 (17) .doi:10.1172/jci.insight.140532.PMC 7526454.PMID 32730231.

[5] Frederick MO,Boyse RA,Braden TM,Calvin JR,Campbell BM,Changi SM,et al.(2021).”IKilogram-Scale GMP Ukwenziwa kweTirzepatide Ukusebenzisa iHybrid SPPS/LPPS Indlela yokuVelisa”.UPhando lweNkqubo yeOrganic & Development .25 ( 7 ): 1628–1636.

[6] UFrías JP, uDavies MJ, uRosenstock J, uPérez Manghi FC, uFernández Landó L, uBergman BK, et al. (Agasti 2021) "Tirzepatide versus Semaglutide Kanye ngeveki kwizigulane ezine-Type 2 Diabetes ".The New England Journal of Medicine.385 (6): 503-515.doi:10.1056/NEJMoa2107519.

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