I-Anabolic steroids, i-hormone yesondo, i-SARMS, ukulahlekelwa kweoli,
I-AASraw ivelisa i-Cannabidiol (CBD) ipowder kunye ne-Hemp ebalulekileyo yeoyile ngobuninzi!

I-Urolithin A yangemva

Izibonelelo zentliziyo yePomegranate zikhokelele kubaphandi ukuba baphande ngeendlela esi siqhamo sibomvu sinokusigcina sisempilweni ngayo. Kuphando lwakutsha nje, abaphandi baseSwitzerland bachonge imolekyuli entsha ebangelwa kukwetyisa iikhompawundi ezimbini ezifumaneka kwiirharnate: i-punicalagins kunye ne-ellagitannins. Le molekyuli iyingqayizivele, eyaziwa ngokuba yi-urolithin A, inceda ukuvuselela i-mitochondria, izindlu zethu zamandla zeselula. I-Urolithin A ivula ucango lonyango olunokubakho kunyango ngokuchasene nokuphazamiseka okunxulumene nobudala, kubandakanya ubuthathaka, okuyimeko yomngcipheko wokukhubazeka, ukulaliswa esibhedlele, kunye nokufa.

Urolithin Isishwankathelo

I-Urolithin A yinkomfa yemetabolite, eyiklasi yeekhompawundi eziphilayo ezibizwa ngokuba yi-benzo-coumarins. Yimveliso yokugqibela eveliswa kukutya okuqulathe i-ellagitannins (polyphenols) kwaye inyanzeliswa ngumzimba wamathumbu. Ngamanye amagama, i-Urolithin A iveliswa xa umntu engenisa imithombo yokutya ene-ellagitannins.

I-Urolithin A ayenzeki ngokwendalo kwifom yayo yokugqibela. Imithombo yokutya ye-Ellagitannin, njengeentlobo ezithile zamajikijolo kunye neerharnati, kufuneka zixutywe namathumbu ebacteria ukuba enziwe. Ukuze ikhompawundi ibe nokusetyenziswa okusebenzayo, kufuneka yenziwe elebhu, okanye ngamanye amagama, i-Urolithin A engeyiyo kufuneka iveliswe ukuze isetyenziswe.

Izifundo zesayensi zibonise ukuba i-Urolithin A inezinto ezichasene nokwaluphala. Kuthiwa iyanceda ekubunjweni kobunzima bemisipha, ineempawu ezichasayo, kwaye ikwabonakalise amandla ekuphuculeni impilo yokuqonda kubantu abadala.

I-Urolithin Indlela yokuSebenza

Urolithin usebenza njani? I-Ellagic acids kunye nee-Ellagitannins zii-Urolithin A zandulelayo.

I-Ellagitannins ifakwe i-hydrolyzed ukusuka emathunjini ukuze ikhuphe i-Ellagic acid, kwaye oku kuyasetyenzwa ukusuka kwi-gut microflora ukuya kwii-urolithins ngokulahleka okwandayo kwi-1 yayo yelactones ukususwa ngokulandelelana kwamaqela ehydroxyl. Nje ukuba ityiwe emathunjini, emva koko i-Urolithin A powder ingena kwinkqubo yokuhamba kwesi sifo.

IMitophagy, ngokwenkcazo yeWikipedia, kukuthotywa okukhethiweyo kwemitochondria yakho ngokuzimela. Ihlala isenzeka kwi-mitochondria enesiphene kulandela umonakalo okanye uxinzelelo. Nangona kunjalo, njengoko sikhula, umsebenzi weMitophagy uye ungasebenzi kakuhle. Ngethamsanqa, i-Urolithin A ivunyiwe ukukhuthaza i-mitophagy ngendlela egciniweyo kwiindidi ezahlukeneyo.

Izibonelelo / Iziphumo ze-Urolithin A.

❶ I-Urolithin A inceda ukulwa umhlaza

Ngaphandle kokhathalelo olunobundlongondlongo kunye ne-chemotherapy, phantse iipesenti ezingama-50 zabantu abanomdlavuza ongqalileyo bakhula amathumba aphindaphindiweyo. Oku kusenokubangelwa yinxalenye yokusinda kweeseli ezinomhlaza zomhlaza wekolon ezinqanda ichemotherapy eqhelekileyo kwaye isebenze njenge `` mbewu '' yeekhensa ezilandelayo.
Ekufumaniseni okunomdla, abaphandi baveza iiseli ezinomhlaza womhlaza wekolon ukusuka kwisigulana esinomhlaza ocoliweyo ukuya kumxube one-85% ye-urolithin A okanye i-30% ye-urolithin A. Iziphumo zazimangalisa. Umxube ophezulu we-urolithin Umxube woxinaniso ubusebenza kakhulu ekuthinteleni inani kunye nobungakanani beeseli ezinomhlaza womhlaza kunye nokuthintela umsebenzi wealdehyde dehydrogenase, umakishi wokuchasa.
Le ndlela yonyango inomdla kuba unyango lwesiqhelo ngokuchasene nomhlaza alunakho ukubulala okanye ukumisa ukwanda kweeseli ezinomhlaza. Ezi ziphumo zintsha zixhasa umbono wokuba indlela yezondlo inokungqina ibalulekile njengolunye unyango okanye ungenelelo kuthintelo ekujolise kwezi seli ziyingozi.

❷ I-Urolithin A -Iziphumo zeNeuroprotective

Unxibelelwano phakathi kwepomegranate kunye neempembelelo zalo zokuthintela isifo se-Alzheimer sele zimiselwe kakuhle kwizifundo zezilwanyana.8 Nangona kunjalo, izinto ezazisenziwa yile nto ayaziwa kude kube ngoku.
Isifo i-Alzheimer kulindeleke ukuba sichaphazele ngaphezulu kwezigidi ezili-115 zabantu kwihlabathi liphela ngonyaka wama-2050, Iqela labaphandi lijonge kwisifundo sangaphambili sezilwanyana esichaze ngeziphumo ezichasene ne-Alzheimer kwiziphumo zerharnate.
Iqela livavanye amandla ala macandelo okuwela isithintelo segazi-ngengqondo kwaye lafumanisa ukuba uhlobo lwe-methylated ye-urolithin A (mUA), ethathwe kwirharnate, kunye nezinye ii-urolithin zazinokwenza njalo.
Kwaye, nangona uphando oluthe kratya luyafuneka, ababhali baqukumbele ukuba ii-urolithins zezona zinto zinokubangela uxinzelelo lwe-Alzheimer ezibandakanya ukukhuselwa kwi-neurotoxicity kunye ne-b-amyloid fibrillation. Ezi ziphumo ziyathembisa, kwaye ziphakamisa isidingo sokujonga ezinye iindlela zongenelelo ezisekwe kwindalo zokuthintela okanye ukucothisa ukuqhubela phambili kwe-Alzheimer's.
Iziphumo kunye nedatha evela kwezi zifundo zahlukeneyo ukuxhasa ngakumbi ukubaluleka kwe-polyphenol metabolite iikhompawundi ezinje nge-urolithin A evela kwirharnate nendima yabo kumlo wokulwa nomhlaza wekolon kunye nezifo ezingenayo imithambo-luvo.
Izifundo zikwabonakalisile ukuba i-Urolithin A inokuphucula amandla emisipha kunye nokunyamezela kubantu abalupheleyo. Uphando lwamva nje lubonisa ukuba ubungqina bokuqala bunika ezinye izibonelelo ze-Urolithin A, ezibandakanya oku kulandelayo:

-Anti-ukudumba
-Anticarcinogenic
-Izinto ezichasayo
-Ukucingela
-Iintsholongwane


I-Urolithin A ikwabonwa ngokuqinileyo njengesongezelelo kwiimveliso zeprotein zokuphucula iziphumo zokuzilolonga, kunye nokunciphisa ukutyeba kakhulu.

I-Urolithin A Iziphumo ebezingalindelekanga

Kolu vavanyo lweklinikhi luchazwe apha ngasentla, akukho miphumo mibi ichaziweyo. Kuphando ngaphezulu kothotho lwezifundo zangaphambi kokubeleka kunye neklinikhi, kubonakala ngathi kukho ubungqina benkxaso kukhuseleko lwe-Urolithin A yokusetyenziswa.

Akukho ziphumo zinetyhefu zixeliweyo, nkqu nakwizifundo ezibandakanya idosi ephezulu enikwe iigundane kwezi zifundo.

I-Urolithin A isetelwe ukuguqula ishishini lokulwa ukwaluphala. Izifundo zeklinikhi zisekwinqanaba labo lokuqala kodwa uninzi lwezilingo lubonisa iziphumo ezilungileyo ngaphandle kweziphumo ebezingalunganga. Ukusuka ekutyeni ukuya kwizongezelelo, i-Urolithin A inyanzelekile ukuba ibe yinto entsha elandelayo yokufumanisa ukutya okuphezulu ekufuneka kuthathwe ngumntu wonke.

I-Urolithin A Imithombo yokutya

Njengoko sele kukhankanyiwe, iUrolithin A kwifom yayo yokugqibela ayiveli ngokwendalo. Ayaziwa ukuba ifumaneka kuyo nayiphi na imithombo yokutya. Nangona kunjalo, i-precursor ye-compound ingafumaneka kwiziqhamo ezithile kunye namantongomane. Imithombo yokutya equlathe i-ellagitannins enjengeerharnate, iirasibheri, amaqunube, i-cloudberries kunye nama-walnuts yimizekelo ethile.

I-ellagitannins kwezi ziqhamo kunye namandongomane afakwe i-hydrolyzed emathunjini ukuze avelise i-ellagic acid, ethi ke iphinde iqhubekeke emathunjini kwaye yenziwe ityhubele microflora iye kwi-Urolithin A.

Kubalulekile ukuba uqaphele ukuba i-Urolithin A ayisoloko isenzeka xa ungenile. Amathumbu abanye abantu awanawo umxube osempilweni we-microflora efunekayo ukuguqula i-ellagic acid kwi-Urolithin A. Oku kuthetha ukuba ayinguye wonke umntu oya kuvelisa i-Urolithin A emathunjini abo ukuba batya iirharnate, i-walnuts, okanye amaqunube. Konke kuxhomekeke kumathumbu ebacteria akhoyo emzimbeni wakho.

Inkqubo ye-Urolithin A yokuThengisa

I-Urolithin A yenziwa ngokudityaniswa kweekhemikhali kusetyenziswa enye yeenkqubo ezimbini ezichazwe apha ngezantsi. Zombini ezi nkqubo zibandakanya ukuphendula ngokudibanisa u-Ullmann, kulandele unyango lwe-asidi ye-asidi ukuvelisa imveliso ye-urolithin ecoceke kakhulu.

Imveliso yokugqibela ihlanjululwa ngeendlela zonyango olusulungekileyo kwisinyibilikisi, sihluziwe, sihlanjwe, kwaye somiswe ukuze sifumane i-urolithin emsulwa A. Imveliso kamva iphantsi kokuncitshiswa kobungakanani bamasuntswana.

Ngokwenkqubo esekwe kakuhle, i-Urolithin A powder yenziwe yenziwa kwaye yahlanjululwa kumanyathelo aphambili ukuya kwinkcazo emsulwa ye-99%. Izinto zokwenza imveliso kunye namanyathelo okulungisa abandakanyekayo kuthungelwano lwe-urolithin A ibandakanya i-2-Bromo-5-methoxy benzoic acid, 2-Bromo-5-hydroxy benzoic acid, Resorcinol, 50% sodium hydroxide, Copper sulfate pentahydrate, Methanol, Aluminium chloride, Toluene , DMSO, Methanol, Acetic Acid, kunye ne-TBME (tert-butyl-methyl ether).

I-Urolithin ye-Synthetic A VS Urolithin A yendalo

Njengoko sele kukhankanyiwe apha ngasentla, i-Urolithin A sisisu se-bacterial metabolite ye-ellagitannins (ET) okanye i-ellagic acid (EA). Ukuba ufuna ukufumana isixa esikhulu se-Urolithin A, kufuneka uqale utye iziqhamo ezinobuninzi, emva koko ulinde ukuba badlulise ukusuka kwi-ellagitannins kunye ne-ellagic acid ukuya kwi-Urolithin A. Le nkqubo inde, kwaye isulungekile iphantsi, kwaye okona kubaluleke kakhulu , kuyakubiza kakhulu ukwenza njalo.

Asinguye wonke umntu onemicroflora elungileyo enokwenza imetabolite. Ukongeza, le nkqubo ayinakuze isetyenziswe kwimveliso yobuninzi kwindawo yokuvelisa ehambelana ne-GMP.

Iindaba ezimnandi zezokuba, njengesithako esinoveli, i-Urolithin A ekugqibeleni iyathengiswa ngo-2019 kwi-Cima Science. Ngoku inokudityaniswa elebhu kunye nomzi mveliso. I-urolithin A yokwenziwa iyafana nokwakheka kwe-urolithin yendalo A. Amandla okuvelisa afikelela kwi-3000 kgs okanye kwiitoni ezi-2.5 / ngenyanga.

Urolithin ukhuseleko

I-Urolithin A yamkelwe yi-EU njengesixhobo sokutya esinoveli.

I-US Food and Drug Administration (i-FDA) ngo-2018 inike i-urolithin A imeko yayo ye-GRAS esetyenziswa kwifomula yokutya. I-GRAS ithetha ukuba i-Urolithin A ithathwa ngokubanzi njengekhuselekileyo nge-500mg ukuya kwi-1 gram ngokusebenza.

I-Urolithin Ukhuseleko lwaphandwa kuthotho lwezilingo zangaphambi kokubeleka kunye neeklinikhi, ezikhuthaza ukhuseleko lwempilo yazo kusetyenziselwa iinjongo zayo. Ukuphindaphinda idosi yeentsuku ezingama-28 kunye nezifundo zeentsuku ezingama-90 ze-urolithin A kwiigundane azibonisanga nayiphi na ifuthe lobungozi kwezinye zeeparameter ezilinganiswe nangayiphi na indlela iidosi ezivavanyiweyo.

Ukongezwa ukuya kwiintsuku ezingama-90 nge-urolithin A ayikhokelelanga kuyo nayiphi na imiqondiso yetyhefu ye-neurological okanye yokuzala kumaxesha ophuculo oluphuculweyo lwezifundo zedosi ephindiweyo njengokuvavanywa kweespermatogenesis okanye imijikelezo ye-oestrus, iimviwo ze-ophthalmoscopic, ukuboniswa kwebhetri yokusebenza, kunye nokusebenza kwemoto iimvavanyo.

Wamkelekile ukuthenga i-Urolithin A / Urolithin i-8-Methyl Ether Bulk Powder evela kwi-AASraw!

Ukufunyanwa kwe-urolithin A, ebangelwa ziipunicalagins kunye ne-ellagitannins iikhompawundi ezifumaneka kwiirharnate, kubonelela ngamathuba amatsha okulwa ukwehla okunxulumene nobudala bemisebenzi ye-mitochondrial kunye nesiphumo sobuthathaka kunye nelahleko yemisipha.

Ngokunceda iiseli zizihlaziye kwaye zisebenzise ukusebenza kwesihlunu, ukukhupha ipomegranate kunye ne-metabolite yayo esandula kuchongwa, i-urolithin A-inokuphumelela.

Kunye nezi ziphumo, kukho ubungqina obuxhasayo beziphumo ezinamandla i-urolithin A enesifo se-Alzheimer kunye nomhlaza, enikezela esinye isixhobo sokulwa nezi meko zitshabalalisayo zichaphazela abantu abaninzi abalupheleyo.

Le ndlela yokutya okunesondlo ivula amathuba okungenziwa ziindlela zokuxuba amayeza emveli. Ukuba ufuna ukuthenga i-Urolithin A powder / Urolithin I-8-Methyl Ether powder, i-AASraw mhlawumbi ilungile.

Inkcazo ye-Urolithin B

I-Urolithin B yi-urolithin, luhlobo lwezinto ezixutywe kwi-gut yomntu emva kokufakwa kweellagitannins-enokutya okufana nepomegranate, amagwebu, iidpons ezibomvu, iialnuts okanye i-oak-ubudala ebomvu yeewayini. I-Urolithin B ifumaneka kumchamo ngendlela ye-urolithin B glucuronide.

I-Urolithin B nayo iyimveliso yendalo ene-antiproliferative kunye ne-antioxidant. I-Urolithin B yenziwa yimetabolism evela kwiipolyphenol ezifumaneka kumantongomane nakwiziqhamo, ngakumbi iirharnate. I-Urolithin B ibonakalisiwe ukuba inqumle isithintelo sobuchopho begazi, kwaye inokuba nefuthe le-neuroprotective ngokuchasene neSifo se-Alzheimer's.

Indlela yeUrolithin B yokuSebenza

Iyanciphisa ukonakaliswa kweprotein kwaye inciphisa i-hypertrophy yemisipha. I-Urolithin B inqanda umsebenzi we-aromatase, i-enzyme eguqula i-estrogen kunye ne-testosterone.

I-Urolithin B yimveliso yendalo ene-antiproliferative kunye ne-antioxidant. I-Urolithin B yenziwa yimetabolism evela kwiipolyphenol ezifumaneka kumantongomane nakwiziqhamo, ngakumbi iirharnate. I-Urolithin B ibonakalisiwe ukuba inqumle isithintelo sobuchopho begazi, kwaye inokuba nefuthe le-neuroprotective ngokuchasene neSifo se-Alzheimer's.

I-Urolithin B inqanda umsebenzi we-NF-κB ngokunciphisa i-phosphorylation kunye nokuthotywa kwe-I VerBcy, kwaye icinezela i-phosphorylation ye-JNK, i-ERK, ne-Akt, kwaye yonyusa iphosphorylation ye-AMPK. I-Urolithin B ikwangumlawuli wesixokelelwano samathambo, kwaye i-Urolithin B yenye yeethumbu zeemilabolites ze-ellagitannins, kwaye inefuthe lokuchasana nokudumba kunye ne-antioxidant.

Isicelo seUrolithin B

Ngelixa befunda iipropathi ezichasene nokuvuvukala kunye ne-antioxidant ye-urolithins A kunye no-B, abaphandi be-UCL kwenzeke bafumanisa ukuba le yokugqibela inefuthe lokhuselo kwimisipha. Iiseli zemisipha kwinkcubeko ezazinxibelelana ne-urolithin B zaba nkulu kunezo zazingenjalo. Sasifuna ukwazi ukuba kutheni.

Kuqala, bafundisisa into kwi-vitro kwaye bafumanisa ukuba i-urolithin B ineziphumo ezibini: iyenza ukuhlanganiswa kweprotein yemisipha kunye nokucothisa ukuthotywa.

Okwesibini, abaphandi bafunda isiphumo se-urolithin B kwi-vivo, kwiimpuku. 'Kukonyuse ukukhula kwemisipha yabo', utshilo uNjingalwazi Francaux. 'Sikwayilawule nakwiimpuku nge-sciatic nerve ekhutshiweyo ekhokelela ekukhubazekeni komlenze, kwaye ukulahleka kwemisipha okulandelayo kwenzeka i-20 ukuya kwi-30% kancinci ngokukhawuleza nakwinqanaba elincinci.'

Iziphumo ze-Urolithin B

I-Urolithin B yenye yeethumbu zeemetabolites ezincinci ze-ellagitannins, kwaye ineziphumo ezichasene nokudumba kunye ne-antioxidant. I-Urolithin B inqanda umsebenzi we-NF-κB ngokunciphisa i-phosphorylation kunye nokuthotywa kwe-I VerBcy, kwaye icinezela i-phosphorylation ye-JNK, i-ERK, ne-Akt, kwaye yonyusa iphosphorylation ye-AMPK. I-Urolithin B ikwangumlawuli wobunzima bemisipha.

(1). I-Urolithin B inciphisa ukulahleka kobunzima bemisipha obangelwa kukuchongwa
(2). I-Urolithin B-inesisu semathambo sehypertrophy kwiimpuku
(3). Iziphumo ze-anabolic ze-urolithin B zixolelaniswe ne-androgen receptor
(4). I-Urolithin B ivuselela ukuhlanganiswa kweprotein kwi-C2C12 myotubes ngokwenza umqondiso we-MTORC1
(5). I-Urolithin B inqanda ukonakaliswa kweprotein ngokuhlisa umgaqo we-ubiquitin-proteasome
(6). I-Urolithin B inyusa umahluko we-C2C12 myotubes

Imbekiselo:

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[4] USingh, R. et al. Ukuphuculwa kokuqina kwesithintelo esiswini ngemetabolite ye-microbial ngokusebenzisa indlela yeNrf2. Nat. Commun. I-10, 89 (2019).
[5] UAndreux, PA et al. Umsebenzi weMitochondrial uphazamisekile kwimisipha yamathambo abantu abadala ababuthathaka. Inzululwazi. Impendulo 8, 8548 (2018).
[6] Gong, Z. okqhubekayo. I-Urolithin A inciphisa ukukhubazeka kwememori kunye neuroinflammation kwi-APP / iimpuku zePS1. J.Neuroinfigueation 16, 62 (2019).
[7] UFelder, TK okqhubekayo. Ukujikeleza ngokuthe ngqo kwe-phospholipids, ii-acylcarnitines, ii-amino acid kunye ne-biogenic amines ziimpawu zokuzilolonga ze-aerobic. J. Sci. IMed. Imidlalo 20, 700-705 (2017).
[8] Schooneman, MG, Vaz, FM, Houten, SM & Soeters, MR Acylcarnitines: ibonakalisa okanye ifaka ukunganyangeki kwe-insulin? Iswekile 62, 1-8 (2013).
[9] Isikhokelo kumaqhinga okuchonga kunye nokuNciphisa umngcipheko wovavanyo lokuqala lwezonyango lomntu kunye neMveliso zoPhando ngeMveliso ye-EMEA / CHMP / SWP / 28367/07 (i-Arhente yamaYeza yaseYurophu, 2007).
[10] I-Keefe, i-DM GRAS Isaziso esingu-GRN 000791 (uLawulo lwezoKutya noLawulo lweziyobisi, 2018).
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[12] Choi, AM, Ryter, SW & Levine, B. Ukuzenzekelayo kwimpilo yabantu kunye nezifo. N. Engl. J. Med. 368, 651-662 (2013).