Ingcaciso yeMveliso
IVardenafil Hydrochloride Ividiyo yomgubo-AASraw
ekrwada Vardenafil HCL Iimpawu zePowder Basic
| igama: | UVardenafil hydrochloride (Levitra) powder |
| CAS: | 224785-91-5 |
| Ifomula yeMolekyuli: | C22H19N3O4 |
| Ubunzima Ezinto: | 389.4 |
| Melt Point: | 298-300 ° C |
| Isitoreji sokugcina: | 20ºC |
| umbala: | Powder |
Yintoni iVardenafil hydrochloride Powder?
I-Vardenafil hydrochloride powder, ebizwa ngokuba yi-vardenafil HCL powder, yenye ye-enzyme phosphodiesterase uhlobo lwe-5 (PDE5Le enzyme inoxanduva lokuthotywa kwe-cyclic guanosine monophosphate (cGMP), i-molecule edlala indima ebalulekileyo kwinkqubo ye-erectile.
Ngexesha lokuvuselela ngokwesondo, i-nitric oxide ikhutshwa kwizicubu ze-erectile zepenis (i-corpus cavernosum), ethi emva koko ivuselele i-enzyme guanylate cyclase. kwezi zihlunu zivumela igazi elininzi ukuba lingene kwilungu lobudoda, elikhokelela ekumiseni.
Ngokuvimbela i-PDE5, i-AASraw vardenafil hydrochloride powder ikhusela ukuphuka kwe-cGMP, ngaloo ndlela igcina amanqanaba aphezulu ale molekyuli kunye nokwandisa iziphumo zayo.Oku kubangela ukuphumla kwemisipha kunye nokuhamba kwegazi, ngaloo ndlela kunceda ekugcineni ukulungiswa kwe-erection ngexesha lomsebenzi wesondo.
I-Vardenafil hydrochloride Powder isebenza njani?
I-Vardenafil hydrochloride powder isebenza njenge-inhibitor ekhethiweyo ye-enzyme ebizwa ngokuba yi-phosphodiesterase type 5 (PDE5) .Nantsi isikhokelo sesinyathelo-nge-nyathelo malunga nendlela esebenza ngayo:
①Ukuvuselela ngokwesondo kubangela ukukhutshwa kwe-nitric oxide kwi-corpus cavernosum, ummandla welungu lobudoda.
②Le nitric oxide ibangela i-enzyme ebizwa ngokuba yi-guanylate cyclase ukuguqula i-guanosine triphosphate (GTP) ibe yi-cyclic guanosine monophosphate (cGMP).
③I-cGMP ibangela ukuba izihlunu ezigudileyo kwi-corpus cavernosum ziphumle, evumela ukuba imithambo yegazi ivuleke.
④Ukwandiswa kwemithambo yegazi kwandisa ukuhamba kwegazi kwilungu lobudoda, okukhokelela ekumeni.
⑤ Ngokuqhelekileyo, i-enzyme ye-PDE5 idiliza i-cGMP, iphetha i-erection.Vardenafil hydrochloride isebenza ngokuvimbela isenzo se-PDE5, ngaloo ndlela ivumela i-cGMP ukuba ihlale ixesha elide kwaye yandise ukwakhiwa.
⑥Ekugqibeleni, i-vardenafil hydrochloride yongeza kwaye igcine inkqubo yebhayoloji ekhokelela ekumiseni ekuphenduleni ukuvuselela ngokwesondo.
Kubalulekile ukuqonda ukuba i-vardenafil hydrochloride ayibangeli ukulungiswa ngokuthe ngqo.Endaweni yoko, iphakamisa impendulo yendalo yomzimba ekuvuseleleni ngokwesondo.Kwakhona, kubalulekile ukuthenga i-vardenafil hydrochloride powder kumthengisi onokwethenjelwa njenge-AASraw, eye yanikezela i-verdenafil ecocekileyo ye-hcl powder kuninzi. iminyaka.
Vardenafil VS.Avanafil VS.Tadalafil VS.Sildenafil
Ezona ziqhelekileyo ii-PDE5 inhibitors kwimarike yi-sildenafil,tadalafil,vardenafil, kunye avanafayile.La mayeza amane onke ayi-PDE5 inhibitors kwaye ngumgca wokuqala wonyango lwe-ED.Nangona kunjalo, izakhiwo ze-molecular molecular zala mayeza amane ziyahluka, ezikhokelela kwizenzo ezahlukeneyo zeekhemikhali kunye nezomzimba.Ngenxa yoko, ukufunxa, ukusabalalisa, i-metabolism, kunye Ukukhutshwa emzimbeni kuyahluka, njengoko kunjalo ngeziphumo zabo zokunyanga.
| I-PDE5 Inhibitor | Ukuqalisa Kwesenzo | Tmax (h) | Cmax (ng/ml) | T1/2 (h) | Ubude bexesha (h) | Iimpendulo ezimbi ezingundoqo |
| Sildenafil | 30min-1h | 0.8-1 | 560 | 2.6-3.7 | 4 | Intloko ebuhlungu, ukugungxulwa kobuso, ukungatyi ukutya, ukuxinana kweempumlo, isiyezi, ukubona ngendlela engaqhelekanga |
| Vardenafil | 15 min | 0.9 | 200 | 3.9 | 8 | Intloko ebuhlungu, ukugungxulwa kobuso, ukungatyi ukutya, ukuxinana kweempumlo, isiyezi, ukubona ngendlela engaqhelekanga |
| Tadalafil | 1h | 2 | 378 | 17.5 | 36 | Intloko ebuhlungu, ukugungxulwa kobuso, ukungatyi ukutya, ukuxinana kweempumlo, isiyezi, akukho ziphako zibonwayo |
| Avanafil | 10-15 min | / | > 1000 | 3-5 | 6-8 | Intloko ebuhlungu, ukugungxulwa kobuso, ukuqunjelwa, ukuxinana kweempumlo, ukuba nesiyezi (ingaphantsi qho xa kuthelekiswa nabanye) |
Phawula:
I-Tmax = ixesha lokufikelela kwi-concentration enkulu ye-plasma
I-Cmax = i-concentration enkulu ye-plasma
T1/2 = isiqingatha sobomi
Le theyibhile ishwankathela iimpawu ze-pharmacokinetic ze-PDE5 inhibitors ezine ezixoxwe.Kuhlala kubalulekile ukuba ababoneleli bezempilo baqwalasele lo mahluko xa bechaza la mayeza, kwaye izigulane kufuneka zihlale zisebenzisa la mayeza phantsi kweliso likagqirha.Ngaphezu koko, ukuthenga i-vardenafil hcl powder kwi-powder umthengisi othembekileyo onjengo-AASraw uqinisekisa ukuba ufumana imveliso yomgangatho ogqwesileyo kunye nococeko.AASraw, njengomsebenzi we-vardenafil hcl powder umthengisi, unokubonelela nge-vardenafil hydrochloride powder kunye nomgangatho ophezulu emhlabeni jikelele.
Ungazikhetha njani i-PDE5 inhibitors?
Ukukhetha i-PDE5 inhibitor efanelekileyo kunokuxhomekeka kwizinto ezahlukeneyo, kubandakanywa impilo yonke yesigulane, ubukho bezinye iimeko, indlela yabo yokuphila, kunye nokuphendula kwabo ngabanye kumayeza.Nantsi isikhokelo esiqhelekileyo sokukhetha i-PDE5 inhibitor kwireferensi, kodwa khumbula ukuhlala ubonisana nomboneleli wezempilo ukwenza ukhetho olungcono kwiimfuno zomntu ngamnye.
| Imeko Yesigulane | Kucetyiswa i-PDE5 Inhibitor | isizathu |
| Ukufuna ixesha lokuqala ngokukhawuleza | Avanafil | Ukuqala ngokukhawuleza phakathi kwe-PDE5 inhibitors |
| Abaneminyaka ephakathi kunye nabadala abane-ED kunye nezifo ezingapheliyo (uxinzelelo lwegazi, i-hyperlipidemia) | Sildenafil | Umndilili weparamitha ze-pharmacokinetic, ukuvuselela okuncinci emzimbeni |
| Ubudala obuphakathi kunye nabadala abane-ED kunye ne-vascular endothelial dysfunction (umzekelo, isifo sikashukela) | Tadalafil | Ixesha elide lesenzo, linokuphucula umsebenzi we-vascular endothelial kunye neempawu zendlela yomchamo ngokuhamba kwexesha |
| Abaneminyaka ephakathi kunye nabakhulileyo abane-ED, akukho zifo ze-vascular | Vardenafil | Isiphumo esincinci, ukuqala ngokukhawuleza, ukufumaneka kwe-bioavailability encinci, ukusabela okungalunganga okumbalwa |
| Abaneminyaka ephakathi kunye nabakhulileyo abane-ED, ukungasebenzi kakuhle kwe-vascular endothelial, i-sildenafil ingasebenzi | Avanafil | Uxinzelelo lwegazi oluphezulu, umphumo onamandla |
| Abancinci nabaphakathi ubudala abane-ED, akukho nto icacileyo ye-organic etiology | Sildenafil | Isebenza kakuhle kwi-ED ebangelwa yimiba yezengqondo |
| Umsebenzi ongaqhelekanga wokubonwayo kunye ne-ED | Tadalafil | Akukho kuphambana okubonakalayo phakathi kweziphumo ezibi |
| Ukhetho lwamayeza emva kokutya | Avanafil, iVardenafil | Izinga lokufunxa alichatshazelwa lula kukutya |
Amanqaku: Olu lwazi malunga ne-PDE5 inhibitors lunikezelwa kwiinjongo zolwazi jikelele kuphela kwaye alubandakanyi iingcebiso zonyango.Ukhetho lwe-PDE5 inhibitor kufuneka luhlale lwenziwa ngokubonisana nomboneleli wezempilo onokuthi athathele ingqalelo impilo yomntu wonke, amanye amayeza. ezithathiweyo, kunye nobume obuthile kunye nobukhulu be-erectile dysfunction.Nangona la mayeza anokusebenza ekunyangeni ukungasebenzi kakuhle kwe-erectile, aneziphumo ebezingalindelekanga kunye nobungozi, kwaye azifanelekanga kumntu wonke.Iimeko ezithile zempilo kunye namanye amayeza anokunxibelelana nawo. I-PDE5 inhibitors, ekhokelela kwiziphumo ezibi ezinokubakho.Soloko ufuna ingcebiso kumnikezeli wezempilo kuyo nayiphi na imibuzo onokuba nayo malunga nemeko yempilo.
Umthamo kunye nokulawulwa kweVardenafil hydrochloride Powder ukuze kubhekiselwe kuyo
Umlinganiselo we-vardenafil HCL powder unokuhluka ngokuxhomekeka kwimpilo yomntu, impendulo kunyango, kunye namanye amayeza anokuthi athathe.Nazi iingcebiso eziqhelekileyo, kodwa kubalulekile ukulandela imiyalelo ethile yomboneleli wakho wezempilo.
①umgangatho dose for eumqolo dukungasebenzi
I-dose yokuqala ephakanyisiweyo ye-vardenafil yi-10 mg, ithathwe ngomlomo malunga nemizuzu ye-60 ngaphambi kokusebenza ngokwesondo.I-dose inokwenyuka ukuya kwi-20 mg okanye iyancipha ukuya kwi-5 mg, ngokusekelwe ekusebenzeni komntu kunye nokunyamezela. ngosuku.
②Izigulane mngcathu hepatic iukonakala
Kwizigulane ezinokukhubazeka okuphakathi kwe-hepatic (Umntwana-Pugh B), i-dose yokuqala ye-5 mg ye-vardenafil iyanconywa.I-dose ephezulu kwizigulane ezinokukhubazeka okuphakathi kwesibindi akufanele zidlule i-10 mg.
③Izigulane snaphakade renal iukonakala
Kwizigulane ezinobunzima (CLcr <30 mL / min) ukukhubazeka kwezintso, i-dose yokuqala ye-5 mg ye-vardenafil iyanconywa.
④Izigulane zivuliwe sitafile alpha-bilokhari tunyango
I-dose yokuqala ephakanyisiweyo ye-vardenafil kwizigulane ezifumana unyango oluzinzile lwe-alpha-blocker yi-5 mg.
⑤Izigulane cehambelanayo use yeCYP3A4 iiihibitors
Kwizigulane ezithatha i-CYP3A4 inhibitors enamandla (efana ne-ketoconazole, i-itraconazole, i-ritonavir, i-indinavir, i-saquinavir, kunye ne-atazanavir), i-dose yokuqala ye-5 mg vardenafil akufanele igqithwe.
amaNqaku
Kubalulekile ukuba uqaphele ukuba ukuvuselela ngokwesondo kuyadingeka ekuphenduleni unyango.I-Vardenafil ayinyusi umnqweno wesini kwaye ayiyi kuvelisa i-erection ngaphandle kokuvuselela ngokwesondo.Ukuthenga i-vardenafil HCL powder kumthengisi othembekileyo unokuqinisekisa ukuba ufumana umgangatho ophezulu. imveliso eya kunceda ukufezekisa ukusebenza kakuhle ekujoliswe kuyo.I-AASraw ijolise ekunikezeni umgangatho ophezulu we-vardenafil hcl powder emhlabeni wonke phantsi kommiselo weCGMP.Ukuba unezidingo, i-AASraw yinto ekhethekileyo yokuthenga i-vardenafil hcl powder.
Apho ukuthenga iVardenafil hydrochloride Powder?
I-Vardenafil hydrochloride powder inokuthengwa kwiintlobo ezahlukeneyo zababoneleli be-intanethi abakhethekileyo ekuthengiseni izithako zonyango.Xa uthatha isigqibo sokuthenga kumthengisi we-intanethi, kubalulekile ukuqinisekisa ukuba bangumthombo ohloniphekileyo, onikwe ukubaluleka komgangatho kunye nokucoceka komgangatho. imveliso yezicelo zezempilo.Ukuqinisekisa ukuba umthengisi ubonelela ngeenkcukacha zemveliso kunye namaxwebhu okuqinisekisa umgangatho, njengeSatifikethi sokuHlalutya.
Ukuba ufuna umthombo othembekileyo wokuthenga i-vardenafil powder,AASraw inokuba yinto efanelekileyo.I-AASraw yinkampani enika uluhlu olubanzi lwezinto ezibonakalayo zebakala leyeza, kubandakanywa ne-vardenafil powder.Imveliso yabo isetyenziswa ngokuqhelekileyo ngamabhubhoratri kunye namaziko ophando ekuphuhliseni nasekuveliseni iimveliso ezahlukeneyo zempilo.
ekrwada Vardenafil HCL Ingxelo yoVavanyo lwePowder-HNMR
Yintoni i-HNMR kwaye Ikuxelela ntoni i-spectrum ye-HNMR?H I-Nuclear Magnetic Resonance (NMR) ispectroscopy bubuchule bokuhlalutya bekhemistri esetyenziswa kulawulo lomgangatho kunye nophando lokumisela umxholo kunye nokusulungeka kwesampulu kunye nobume bayo bemolekyuli. Umzekelo, i-NMR inokuhlalutya ngokobungakanani imixube equlathe iikhompawundi ezaziwayo. Kwiikhompawundi ezingaziwayo, i-NMR inokusetyenziselwa ukuthelekisa ngokuchasene neelayibrari ezibonwayo okanye ukuqikelela ulwakhiwo olusisiseko ngokuthe ngqo. Nje ukuba ulwakhiwo olusisiseko lwaziwe, i-NMR inokusetyenziselwa ukumisela ulungelelwaniso lwemolekyuli kwisisombululo kunye nokufunda iipropathi ezibonakalayo kwinqanaba lemolekyuli ezifana notshintshiselwano oluhambelanayo, utshintsho lwesigaba, ukunyibilika, kunye nokusasazwa.
I-Vardenafil Hydrochloride powder (224785-91-5) -COA
I-Vardenafil Hydrochloride powder (224785-91-5) -COA
Indlela yokuthenga i-Vardenafil HCL Powder kwi-AASraw?
❶Ukuqhagamshelana nathi ngenkqubo yethu yokubuza nge-imeyile, okanye usishiyele inombolo yakho ka-whatsapp, ummeli wethu wenkonzo yabathengi (CSR) uya kuqhagamshelana nawe kwiiyure ezili-12.
❷Ukusinika ubungakanani obubuziweyo kunye nedilesi.
❸I-CSR yethu iya kukubonelela ngekoteyishini, ixesha lokuhlawula, inombolo yokulandelela, iindlela zokuthunyelwa kunye nomhla wokufika oqikelelweyo (ETA).
❹Intlawulo yenziwe kwaye iimpahla ziya kuthunyelwa kwiiyure ezili-12.
❺Impahla efunyenweyo kwaye unike izimvo.
Umbhali weli nqaku:
UGqr Monique UHong uthweswe isidanga kwiKholeji yase-UK Imperial yaseLondon kwiFakhalthi yezoNyango
Umbhali wephepha leJenali yeNzululwazi:
1. UHazem M. Abu Shawish
ISebe leKhemistri, iKholeji yeSayensi, iYunivesithi yaseAl-Aqsa, eGaza, ePalestina
2. E. BISCHOFF
Ukususela kwiZiko le-Cardiovascular Research II, kunye namaSebe oPhando lweMichiza, kunye noPhuhliso lweMveliso kunye ne-Preclinical Pharmacokinetics, i-BAYER AG Pharmaceutical Business Group, Wuppertal, eJamani.
3. MM Mabrouk
Isebe lekhemistri yokuhlalutya amayeza, iFaculty of Pharmacy, iYunivesithi yaseTanta, eTanta, eYiputa.
4. Engin Yurtcu
ISebe lokuBelekisa kunye neGynecology yeZekai Tahir Burak yezeMpilo yabasetyhini kunye neSibhedlele soPhando, e-Ankara, eTurkey
5. USilvia Limoncella
Iyunithi ye-Endocrinology, iSebe le-Biomedical, i-Metabolic and Neural Sciences, iYunivesithi yaseModena kunye neReggio Emilia, i-Modena, eItali
Lo gqirha/ingcali yenzululwazi ayinakuvuma okanye ithethelele ukuthengwa, ukuthengiswa, okanye ukusetyenziswa kwale mveliso nangasiphi na isizathu. I-Aasraw ayinayo indibaniselwano okanye ubudlelwane, ichazwa okanye ngenye indlela, kunye nalo gqirha. Injongo yokucaphula lo gqirha kukuvuma, ukuvuma kunye nokuncoma uphando olupheleleyo kunye nomsebenzi wophuhliso owenziwe ngoososayensi abasebenza kule nto.
isingqiniso
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[2] Izikolo zeKhemesti (Glen L.Stimmel,D.,kunye noMary A.Gutierrez,Pharm.D.) kunye neMedicine (Glen L.Stimmel,Pharm.D.), iYunivesithi yaseSouthern California,Los Angeles,California. "Izigulana zokucebisa malunga neMiba yezeSondo: I-Drug-Induced Priapism" .Medscape.Retrieved 2010-12-06.
[3] “Unyango olutsha lokungasebenzi kakuhle kwe-erectile Staxyn evunyiweyo e-US.-Ukwenziwa kweMichiza”. com.2010-06-21.Igcinwe kwintsusa ngo-2012-04-06.
[4] Tucker J,Fischer T,Upjohn L,Mazzera D,Kumar M (Okthobha 2018). "Izithako ezingavunywanga zoXhobo eziBandakanywe kwizongezo zokutya eziNxulunyaniswe nezilumkiso zoKutya kunye noLawulo lweziyobisi zase-US". JAMA Network Open. 1(6):
[5] Lepor H,Lepor NE,Hill LA,Trohman RG (2008). "Ithuba le-QT kunye noKhetho lwee-Alpha-Blockers ze-Benign Prostatic Hyperplasia". Uphononongo kwiUrology. 10 (2):85–91.
