I-2018 ye-World Best-Selling Loss Weight Loss Supplement-Orlistat

 

Ukuhla ukusinda Imbali Yezobisi

 

Isisindo sokulahlekelwa kwesisindo sokuqala, esibizwa ngokuba yi-fat reduction at the time, safumaneka emva kwee-1800. Nangona eso sigqirha sabangela imiphumo emibi kakhulu, saqhubeka sifumaneka ukusetyenziswa kuze kube yi-1960.
Iyeza elitsha elaziwa ngokuba yiDinropropol lafakwa kwii-1930 kwaye yaziwa kakhulu ekulawuleni ukulahleka kwesisindo. Isilwanyana senze i-thermogenic effect ngaphakathi emzimbeni, ukuququzelela ukulahleka kwesisindo.
Phakathi kwe-1950s, i-amphetamines yafumaneka kwaye yaba yinto yokulahleka kwesisindo esinqunyiwe. Yenza ukulahleka kwesisindo ngokunciphisa ukutya. Ngokudabukisayo, yandisa ingozi yomshukela wegazi, okwenza ukuba ihoxiswe kwi-market ye-1968.

Kwi-1970s, i-ephedrin yaba yonyango olumiselweyo lokulahleka kwesisindo. Noko ke, isichengisisi senza ukuba kubekho ukuphazamiseka okubangelwa ukuba kubhengezwe ukuba yingozi.
Kwi-1973, i-fenfluramine yavunywa njenge-supplementary weight loss supplement. Udumo lwayo lwaphakama kwi-1992 xa ludibaniswe ne-phentermine ukudala isilwanyana esilahlekelwa sisisindo esibizwa ngokuba yi-fen-phen. Ngokudabukisayo, le nkunkuma yabangela imiphumo emibi, eyabangela ukurhoxiswa kwayo kwimarike kwi-1997. Kwiminyaka ye-21X, isisindo sokulahlekelwa kwesisindo, amaninzi esekelwe kwimimiselo yamanzi, ikhukhula kwiimarike.

 


 

Isisindo sokulahlekelwa kwezidakamizwa

 

Ubunzima bokulahlekelwa kwezidakamizwa zihlulwa zibe ziintlobo ezi-3 ezinkulu ngokubhekiselele kwindlela yazo yokusebenza kwaye zilandelayo:

 

(1) Ukunciphisa ukutya (ukutya)

 

Iziyobisi ezinokuthi ukutya okunciphisa ukutya kuthiwa yi-sympathomimetic agents. Ngokuqhelekileyo banqanda ukuthanda ukutya ngelixa besondeza i-satiety ngaphambi kwexesha eliqhelekileyo. I-Satiety yiyo "epheleleyo" invakalelo okanye ukwaneliseka okufumaneka ekutheni ukutya. Ukunciphisa ukutya kusebenza ngokulinganisa i-neurotransmitter kwingqondo yomntu elawula isondlo, eyaziwayo njenge-noradrenaline (NA).

Ezi zi yobisi zibandakanya isakhiwo samachiza esifanayo ne-NA kwaye sinako; ngenxa yoko zibophelela kwiimceivers ezifanayo njenge-noradrenaline.

Isakhiwo seMichiza se-sympathomimetic agents.

Amachiza aphucula nomsebenzi we-noradrenaline "kwiziko lokondla" lobuchopho bomntu, i-hypothalamus. Ihypothalamus yomntu ilawula ukulingana kwamandla kwinkqubo yomzimba. Ulwazi malunga nevenkile zamandla oluntu luhlanganisiwe kwi-hypothalamus elawula ukutya kunye nokutya. Ukubopha kwe-Noradrenaline kunye nomsebenzi kwi-hypothalamus kunesiphumo sokunciphisa ukutya. Ezi ziyobisi zibandakanya:

I-Sibutramine HCL (iMeridia) I-CAS: 84485-00-7

ILorcaserin HCL (Belviq) CAS: 1431697-94-7

③ Rimonabant HCL CAS: 158681-13-1

I-DNP CAS: 119-26-6 

 

(2) Ukutshiswa kwamafutha

 

Ukutshiswa kwezidakamizwa zokutshisa ukunyusa umzimba kunokuncedisa Ukulahlekelwa ngamatye ngokunciphisa iinqweno, ukuphucula umthambo, nokugcina ukutya okunomsoco. Zingakwandisa nokukwazi ukuqhuba umsebenzi ngokukhuthaza amandla kunye nokugxila. Ezi zi yobisi ziquka:

1. I-Synephrine CAS: 94-07-5

2. I-DMAA / 1,3-Dimethylpentylamine CAS: 13803-74-2

3. I-Clenbuterol HCL CAS: 21898-19-1

4. I-Salbutamol (i-Albuterol) I-CAS: 18559-94-9

 

(3) Ukuphucula ukugonya

 

Ezi zithintelo zokusetyenziswa kweziyobisi zisebenza ngokuphazamisa amandla okugcoba inkqubo yokugcoba izondlo ezithile kwisondlo. Ngokomzekelo, i-Orlistat iyaziwa ngokuthintela ukuphazamiseka kwamafutha kwaye oko kukuthintela ukunyuswa kwamafutha. Ezinye izongezelo ezininzi ziye zafakwa ekunciphiseni i-caloric absorption kunye nokukhutshwa kwamanzi. Kule post, siza kuxubusha ngaphezulu malunga nezi zilandelayo zibisi:

I-Orlistat CAS: 96829-58-2

I-CAS Ceististat: 282526-98-1

 


 

I-2018 ye-World Best-Selling Loss Weight Loss Supplement-Orlistat

 

Ukunyusa ukulahlekelwa ngcaciso yeziyobisi

 

Ngaphantsi kweenkcazo ezimfutshane kodwa zichazwe kuzo zonke iziyobisi ezikhankanywe ngasentla.

 

(1) Ukunciphisa ukutya (ukutya)

 

I-Sibutramine HCL (iMeridia) I-CAS: 84485-00-7

I-Sibutramine i-HCL yenye yezona zinto zifunwa kakhulu. Iphakamisa zombini i-serotonin kunye ne-NA kumbindi, emva koko zibophelela kwi-receptors yazo ukulawula ukukhathazeka nokutya.

I-Sibutramine unyango kunye nokutya kunye nokuzivocavoca kunokubangela i-4.6 kg ukulahlekelwa kwesisindo ngaphezu kwesenzo nokutya kuphela. Ngokunciphisa ukunciphisa ukutya, sibutramine sele ifunyenwe:

• Ukukhulisa i-thermogenesis
• Ukuphucula iimeko zomngcipheko we-cardiovascular
• Ukwandisa ukukhuluphala kwamanzi
• Ukwandisa i-blood glucose kwizigulane eziphila nesifo sikashukela se-comorbid
• Ukuphucula iipiliti
• Ukwandisa amanqanaba e-C-peptide, i-insulini kunye ne-uric acid

Isakhiwo seKhemikhali yeSibutramine HCL

 

ILorcaserin HCL (Belviq) CAS: 1431697-94-7

Isakhiwo seKhemikhali seLorcaserin HCL (iBelviq)

Imisebenzi yezidakamizwa i-Lorcaserin HCl ukulawula isantabolism nesidlo. Isilwanyana savunywa yi-FDA ngonyaka we-2012 kubantu abane-BMI ye-30, kunye nezigulane ezine-Index Mass Mass ye-27 okanye abaninzi abane-cholesterol ephezulu, uxinzelelo lwegazi, kunye nohlobo lwe-2 yesifo sikashukela. Isilwayo sisebenza kwakhona ukuphucula i-serotonin 2CV receptor ebuchosheni bomntu obungabancedisa izigulane ukuba zizive zizele emva kokuthatha ngaphantsi.

Kwizilingo zonyango, i-38% yabantu abadala (ngaphandle kohlobo lwe-2 isifo sikashukela) lahlekelwa ngaphezu kwe-5% yesisindo somzimba, xa kuthelekiswa ne-16% yabantu abadala baphathwa nge-placebo.

 

I-Rimonabant HCL CAS: 158681-13-1

Isakhiwo seKhemikhali seRimonabant HCL

Isidakamizwa se-Rimonabant HCL simbulelo ngokucacileyo kwimoya yayo yesenzo njengendlela ekhethekileyo yokukhetha isifo senwaba-1 (CB-1). I-Endocannabinoids ikhutshwe kwi-CNS kwaye ivuselela i-lipogenesis, isondlo, kunye nokuqokelela kwamafutha kwipheriphery. Imisebenzi ye-Rimonabant HCL yokuvimba i-endocannabinoids.
Isilwanyana sithatha ngokukhawuleza emva kokulawulwa komlomo. Ukuphumelela kwesi sigulo ukunyanga izigulane ezithinteleyo okanye ezigqithiseleyo zifunyenwe kwinkqubo yezilingo ezine ezilawulwayo, ezilandelwayo, ezibizwa ngokuba yiRIO (Rimonabant in Obesity). Kule mvavanyo, le nkunkuma ifumaneke ukuba iphumelele njenge-orlistat ne-sibutramine.

 

I-DNP CAS: 119-26-6

I-2,4-Dinitrophenol (i-DNP okanye i-2,4-DNP o) yikhemikhali yendalo kunye nale fom kunye nesakhiwo seekhemikhali: HOC6H3 (NO2) 2.

Imisebenzi ye-DNP njengeprotonophore, ukuvumela iiproton ukuvuza kwi-membrane yangaphakathi kunye ne-ATP synthase. Oku kuya kwenza ukuba i-ATP yokusebenza kwamandla ingasebenzi kakuhle. Ngenxa yoko, ezinye zamandla eziveliswa ekuphefumulweni zichitheka ngendlela yokushisa.

Ukungaphumeleli kulungelelaniswe ngokuthe ngqo kumthamo weziyobisi ezithathiweyo. Njengoko idosi yamachiza inyuka, ukuveliswa kwamandla kuya kungasebenzi kakuhle, izinga lokunciphisa umzimba liyenyuka (kunye nenani eliphezulu lamafutha liyatshiswa) ukuhlangabezana neemfuno zamandla kunye nokuhlawulela ukungasebenzi. I-DNP yenye yezona arhente zibalaseleyo zaziwayo ngokudibanisa iphosphorylation ye-oxidative. I-Phosphorylation ye-ADP yi-ATP synthase ifumana "ukungadityaniswa okanye ukunqunyanyiswa kwi-oxidation.

 


 

(2) Indlela yokuHlangana kwamafutha

 

I-Synephrine CAS: 94-07-5

I-p-synephrine i-Compound i-alkaloid. Oku kuthetha ukuba yinkomfa yezinto eziphilayo ezinokufumaneka kwindalo kodwa eziphantsi. I-compound ine-nitrogen njengesiseko.

Isakhiwo seMichiza se-synephrine

I-caffeine, i-nicotine kunye ne-morphine nayo ikwaseklasini yama-alkaloids ngokutsho kwabaphandi. I-Synephrine ibonakala ngokubonakalayo kwizondlo zokutya zokulawula ubunzima okanye ukulahleka kunye nokusebenza kwezemidlalo.

USynephrine usebenza njani kumzimba wethu?
Iikhemikhali kwi-p-synephrine zithintela inkqubo ye-nervous by stimulating β3 adrenergic receptors ezenza indima ebalulekileyo kwi-thermogenesis ne-lipolysis ngamafutha omdaka. Oku kuthetha ukuba ezi zifunyenwe ziyakwenza ukuba inkqubo yakho iqhumisele i-fat for energy.

 

I-DMAA / 1,3-Dimethylpentylamine CAS: 13803-74-2

1,3-Dimethylpentylamine

I-Dimethylamylamine yilezi zixhobo ezenziwe ngokukodwa kwilebhu. I-1,3-dimethylamylamine (i-DMAA) isiphumo se-amphetamine esisetyenziselwa kakhulu kwiimveliso ezithengiswa kwi-US. Ngamhla, i-dimethylamylamine ithengiswa njengesichengiso sokusetyenziswa kwemfuyo esetyenziselwa ukulahleka kwesisindo, i-ADHD (ingqalelo yokulahleka kwesifo esiyingozi), ukwakha umzimba, nokuphucula ukusebenza.

 

I-Clenbuterol HCL CAS: 21898-19-1

I-Clenbuterol, Eyaziwa nangokuthi yiClen, i-decongestant ne-bronchodilator. Ngokuqhelekileyo kusetyenziswa ukukhusela ukuhlaselwa kwe-asthma. Le ngxube efana ne-steroid, kodwa ayikho i-steroid yangempela. Iwela kwicandelo lama-agonists β2.

I-Clenbuterol inokuqalisa izimpendulo zomzimba ezifana ne-adrenaline. Yenza i-beta-2 receptor subtypes isebenze kwinkqubo ye-adrenergic. Oku kubangela ukunyuka kwekampu (i-ATP eyimfuneko efunekayo kwi-cross-talk talk). Ngenxa yoko, iprotheni kinase A iyanda. Iprotheni kinase A yi-enzyme elawula ipilid, glycogen, kunye nomsebenzi we-sugarabetism. Ukunyuka kwalo kukhuthaza umbane ovuthayo kumzimba. Iphakamisa ezinye iindlela eziza kuncedisa ekutyeni okutyelayo ngeprogram yezinto eziphilayo ezibizwa ngokuba yi-fatty acid oxidation.

Amafutha atshiswayo asetyenziswa njengomthombo wamandla okwenza imisebenzi yomzimba. Ikhuthaza i-mitochondria ukukhulula i-ATPs, ekhokelela ekunyuseni kwinqanaba lomlinganiselo. Kukwaziwa ngokubanzi ukuba ukwanda kwinqanaba le-metabolism kunceda ekulahlekeni kwesisindo.

 

I-Salbutamol (i-Albuterol) I-CAS: 18559-94-9

isakhiwo samakhemikhali saseSalbutamol (iAlbentuterol)

I-Salbutamol yipilisi ephethe isifo esingapheliyo sesifo se-pulmary and asthma kunye nezinye izifo ezinxulumene neCOPD. Imodi yezenzo zamachiza ivula okanye ihlaziye imiphepha ephefumlayo yamaphaphu ngexesha lokuhlaselwa kwe-asthma. Ekubeni i-Salbutamol inefuthe elikhuthazayo, abanye abantu basebenzisa lesi sigqirha se-asthma ukunyusa amafutha okanye ukulahleka kwesisindo.

I-Albuterol ilungele ukusetyenziswa kwenkqubo yokulahlekelwa kwesisindo kuba ineempembelelo ezifanayo kwi-androgenic inkqubo efana nokuzivocavoca umzimba. Yakha ubuninzi beemisipha kwaye iyanciphise ubunzima bonke.
Isetyenzisiwe ngabakhi bezakhiwo ukuze banqunyulwe amanqatha amaninzi kwiindawo zomzimba wabo onokuba nzima ukulawula okanye ukulahlekelwa ngamafutha ngezinye iindlela. Xa uthabatha le nkunkuma yokwakha umzimba kunye nemisebenzi yokulahleka kwemithwalo, idlalwa rhoqo kwipilisi okanye kwifom yefayili. Nangona ungasebenzisa i-Salbutamol inhaler ubunzima okanye Ukulahlekelwa ngamatye ukuba ngaba kuphela okukhethwa kukho.

 


 

(3) Ukuphucula ukugonya

 

I-Orlistat CAS: 96829-58-2

I-Orlistat yindlela enamandla ye-pancreatic kunye ne-gastric lipase inhibitor. Zonke i-triglycerides zondlo zixhaswa nge-pancreatic and gastric lipases. I-lipases i-enzymatically idiliza i-triglycerides ibe ngamafutha e-free acids angaphinda afakwe emathunjini amancinci. I-gastric ne-pancreatic lipase inhibitors zenza izibophelelo kunye ne-pancreatic kunye ne-gastric lipases kwi-lumen yesisu esincinci nesisu esenza ezi enzyme zingakwazi ukusebenza ngokuchanekileyo.

Ngendlela yokuvimbela ukusebenza kwee lipases, ukutya okugcobileyo okunamafutha kunqatshelwe, kwaye i-triglycerides ixutywe emanzini. I-Orlistat yokulahleka kwesisindo ikhubaza i-30 ekhulwini yefuthe lezondlo ekudleni ekungeneni kumzimba womntu (xa iipesenti ze-30 zamandla ekudleni zibonelelwa nge-triglycerides). Ukunciphisa umlinganiselo wesisindo emva komnyaka omnye kunye ne-Xenical (orlistat) kunye nokutshintsha kwindlela yokuphila kujikeleze i-8.5 kg.

Ngokunciphisa ukunciphisa i-triglycerides yokutya, i-orlistat ukulahleka kwe-powder ifunyenwe:
• Unesiphumo esihle kwixinzelelo legazi;
• Ukunciphisa ukuchithwa kwe-cholesterol kwaye ngoko amazinga e-cholesterol (kunye ne-LDL cholesterol);
• Ukwandisa ukuxhatshazwa kwe-insulin; kwaye
• Ukwandisa ulawulo lwe-glycemic.

Kuye kucatshulwa ngokubanzi ukuba i-orlistat yomdla wesisu esisemngciphekweni isenza ngendlela efanayo ekuqiniseni ukunganyaniseki, okukhuthaza abo bala mayeza ukuba banamathele ngokuthe ngqo kwidlo ephantsi.

 

I-CAS Ceististat: 282526-98-1

I-Cetilistat inomlomo osebenzayo, inoveli, i-pancreatic kunye nesisu esiswini se-lipase.

I-Cetilistat ukulahlekelwa kwesisindo semfuyo yilezi zixhobo ezenziwe ukuphatha ukukhuluphala. Isebenza ngendlela efana neziyobisi ezixutywe ngaphambili ezaziwa ngokuba yi-Xenical (orlistat) ngokulawula i-pancreatic lipase, i-enzyme ephula i-triglycerides emathumbu. Ngaphandle kwezi nzyzy, i-triglycerides ekudleni kwethu inqandwa ukuba igalelwe kwi-fatty acid acids engabonakaliswa kwaye isuswe emzimbeni ongagqithwanga.

Kwizilingo zeekliniki ezibandakanya izigulane ezinamafutha angenawo uhlobo lwe-2 sikashukela kunye nezigulane ezigqithisileyo eziphila nohlobo lwe-2 yeswekile. Xa i-Cetilistat yokulahleka kwesisindo i-powder yalawulwa iiveki ezilishumi elinambini, iyanciphisa kakhulu umzimba, i-cholesterol epheleleyo, i-serum low-density lipoprotein cholesterol ngokukhawuleza ngokuthelekisa ne-placebo.

Ipesenteji yezigulane ezigqithiseleyo zibonisa ukunciphisa kakhulu ubunzima bomzimba obuncinane bokuba ubuncinane bepesenti ze-5 ziphezulu kuzo zonke iingalo ezisebenzayo xa kuthelekiswa ne-placebo. Kwizigulane zesifo sikasifo sikasifo sikashukela, i-HbA1c (i-glycosylated hemoglobin) namanqanaba ayehliswa kakhulu. I-Cetilistat ukulahlekelwa kwesisindo semfuyo ibonise imodareyitha kwimiphumo emibi kakhulu, ebangela ukuba i-steatorrhea (imvelo yesisu) ibe nesiganeko esincinane kunokuba i-orlistat. Esi sigqirha satshatyelwa eJapan ukuba siphathe ukukhuluphala kunye nezinye iingxaki.

 


 

I-2018 ye-World Best-Selling Loss Weight Loss Supplement-Orlistat

 

Isisishwankathelo sokulahlekelwa kwesisindo

 

Njengoko kuboniswe kwingxoxo yethu enzulu, kukho izidakamizwa ezininzi zokulahlekelwa kwezilwanyana eziphuma apho ezivela kwiinkalo ezahlukeneyo zezinto eziphilayo. Uninzi lwale michiza lufunyenwe lusebenza kakuhle, kwaye amanye awo avunywe ngamagunya athile afana ne-FDA kunye neJapan, ukukhankanya ambalwa, kunyango lokunyanya.

Emva kokuchitha iiyure ezininzi siphanda ngamachiza okuphulukana nobunzima, sikwazile ukufumanisa iZongezo zePowder zokuNciphisa iMithambo yokuNcipha yokuNciphisa ubunzima be-2018. Ezi zongezelelo zokuphulukana nomgubo zibandakanya i-orlistat yokulahleka kobunzima be powder kunye ne-lorcaserin yokulahleka kwesisindo somgubo. Ngokungafaniyo ne-crap yokunciphisa ilahleko efumaneka nakweyiphi na ivenkile yeziyobisi, la mayeza okuphulukana nobunzima aye amiselwa ziingcali zonyango aye kwiminyaka yovavanyo ukuze afumane isitampu sokwamkelwa kwi-FDA nakweminye imimandla. Sincoma kakhulu ukuba uzame la machiza kuba kubonakalisiwe ukuba ayisebenzi kuphela kodwa ikhuselekile nokuwasebenzisa.

 

Ukhankanywe uluhlu:

 

0 azithandayo
7281 Views

Ungathanda

Amagqabantshintshi zivaliwe.